Month: October 2022

Kuehn, Laura; Huang, Mingming; Radius, Udo; Marder, Todd B. published the artcile< Copper-catalysed borylation of aryl chlorides>, Recommanded Product: 3-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)pyridine, the main research area is catalytic borylation aryl chloride preparation arylboronic acid copper NHC; copper NHC catalyst borylation aryl chloride pinacoldiboronate.

We report herein the first Cu-catalyzed borylation of a wide range of aryl chlorides with different electronic and steric properties using a readily prepared NHC-stabilized Cu catalyst and KOtBu as the base with B2pin2 (pin = pinacolato) as the boron reagent. The aryl chlorides are converted into their corresponding arylboronic esters in good yields. The new procedure shows broad functional group tolerance, and B2neop2 (neop = neopentyl glycolato) can also be applied as the boron reagent.

Organic & Biomolecular Chemistry published new progress about Aryl chlorides Role: RCT (Reactant), RACT (Reactant or Reagent). 329214-79-1 belongs to class pyridine-derivatives, and the molecular formula is C11H16BNO2, Recommanded Product: 3-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)pyridine.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Werner, Erik W.; Mei, Tian-Sheng; Burckle, Alexander J.; Sigman, Matthew S. published the artcile< Enantioselective Heck Arylations of Acyclic Alkenyl Alcohols Using a Redox-Relay Strategy>, Name: (S)-4-(tert-Butyl)-2-(5-(trifluoromethyl)pyridin-2-yl)-4,5-dihydrooxazole, the main research area is beta gamma delta aryl ketone aldehyde enantioselective regioselective preparation; allylic homoallylic alc enantioselective Heck reaction aryldiazonium salt; palladium pyridinyloxazolidine catalyst enantioselective Heck reaction aryldiazonium salt alkenol; stereospecificity Heck reaction aryldiazonium salt alkenol olefin geometry; safety aryldiazonium salt potential explosive.

Nonracemic β-, γ-, and δ-aryl ketones such as (S)-4-MeO2CC6H4CHMeCH2COMe were prepared in 52-85% yields, 90:10-99:1 er, and with high regioselectivities by Heck reactions of phenyldiazonium tetrafluoroborate or aryldiazonium hexafluorophosphates (generated from the corresponding arylamines) with acyclic allylic, homoallylic, or bishomoallylic alcs. such as (E)-MeCH(OH)CH:CHMe in the presence of tris(dibenzylideneacetone)dipalladium [Pd2(dba)3] and the nonracemic trifluoropyridinyl oxazolidine I. I and Pd2(dba)3 imparted notable regioselectivity during migratory insertion and promoted migration of alkene unsaturation toward the alc. to form ketones or aldehydes. (E)- and (Z)-allylic and homoallylic alcs. underwent stereospecific Heck reactions to give enantiomeric products; the alc. stereochem. in the racemic unsaturated alcs. did not affect the enantioselectivities of their reactions. The aryldiazonium salts used as reactant can be explosive and should be handled with caution.

Science (Washington, DC, United States) published new progress about Alcohols, unsaturated Role: RCT (Reactant), SPN (Synthetic Preparation), RACT (Reactant or Reagent), PREP (Preparation). 1416819-91-4 belongs to class pyridine-derivatives, and the molecular formula is C13H15F3N2O, Name: (S)-4-(tert-Butyl)-2-(5-(trifluoromethyl)pyridin-2-yl)-4,5-dihydrooxazole.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Juma, Jamil A. published the artcile< The effect of organic additives in electrodeposition of Co from deep eutectic solvents>, Application In Synthesis of 93-60-7, the main research area is cobalt chloride organic additive deep eutectic solvent electrodeposition.

A range of organic/ inorganic additives have traditionally been added to electroplating solutions to improve brightness and encourage leveling. A limited number of studies have shown that some brighteners function in ionic liquids In this study the effect of four additives; nicotinic acid (NA), Me nicotinate (MN), 5,5-di-Me hydantoin (DMH) and boric acid (BH), have been measured on the electrodeposition of cobalt in the 1choline chloride (ChCl): 2 ethylene glycol (EG) based deep eutectic solvent (DES). In general the addition of these additives causes the deposition potential of Co to be shifted to more neg. over-potentials. No apparent change in speciation and coordination environment around the CoII center was observed The surface morphol. was significantly changed by the addition of each of the additives, suggesting that they function by modifying the double layer. The nucleation and growth mechanism of Co deposition was found to change in the presence of these additives. Flat, shiny and high uniform cobalt layers were obtained with the additives whereas in their absence the deposit was black and dull. The additives significantly increased the hardness of the cobalt deposit and this was shown to be related to the crystal structure of the deposit which was determined using XRD.

Arabian Journal of Chemistry published new progress about Brightening agents. 93-60-7 belongs to class pyridine-derivatives, and the molecular formula is C7H7NO2, Application In Synthesis of 93-60-7.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Li, Ya-Lan; Pang, Jin-Yu; Lou, Ji-Cong; Sun, Wen-Wu; Liu, Ji-Kai; Wu, Bin published the artcile< Chemo- and Site-Selective Fischer Esterification Catalyzed by B(C6F5)3>, SDS of cas: 53636-56-9, the main research area is ester preparation chemoselective; carboxylic acid alc Fischer esterification tris pentafluorophenyl borane catalyst.

A direct and catalytic dehydrative esterification of carboxylic acids RC(O)OH [R = hept-1-yn-1-yl, 2-(naphthalen-2-yl)ethyl, (1-methyl-1H-indol-3-yl)methyl, 1-([(benzyloxy)carbonyl]amino)ethyl, etc.] with alcs. R1OH (R1 = Et, cyclohexyl, 2,3-dihydroxypropyl, etc.) is described. B(C6F5)3 is shown to be a highly effective catalyst for the Fischer esterification, providing esters RC(O)OR1 in high to excellent yields. This esterification shows excellent chemo- and site-selective monoesterification of various polyols R1OH without any protection step, including bio-derived mol. glycerol.

Asian Journal of Organic Chemistry published new progress about Alcohols Role: RCT (Reactant), SPN (Synthetic Preparation), RACT (Reactant or Reagent), PREP (Preparation). 53636-56-9 belongs to class pyridine-derivatives, and the molecular formula is C7H6BrNO2, SDS of cas: 53636-56-9.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Tyagi, Adish; Karmakar, Gourab; Mandal, B. P.; Dutta Pathak, Dipa; Wadawale, Amey; Kedarnath, G.; Srivastava, A. P.; Jain, Vimal K. published the artcile< Di-tert-butyltin(IV) 2-pyridyl and 4,6-dimethyl-2-pyrimidyl thiolates: versatile single source precursors for the preparation of SnS nanoplatelets as anode material for lithium ion batteries>, Computed Properties of 3811-73-2, the main research area is pyrimidylthiolate tin sulfide nanoplatelet lithium ion battery anode.

New air and moisture stable di-tert-butyltin complexes derived from 2-mercaptopyridine (HSpy), [tBu2Sn(Spy)2], [tBu2Sn(Cl)(Spy)] and 4,6-dimethyl-2-mercaptopyrimidine (HSpymMe2) [tBu2Sn(Cl)(SpymMe2)], have been prepared and utilized as single-source mol. precursors for the preparation of orthorhombic SnS nanoplatelets by a hot injection method and thin films by aerosol assisted chem. vapor deposition (AACVD). The complexes were characterized by NMR (1H, 13C, 119Sn) and elemental anal. and their structures were unambiguously established by the single crystal X-ray diffraction technique. Thermolysis of these complexes in oleylamine (OAm) produced SnS nanoplatelets. The morphologies, elemental compositions, phase purity and crystal structures of the resulting Oam-capped nanoplatelets were determined by electron microscopy (SEM, TEM), energy dispersive X-ray spectroscopy (EDS) and pXRD, while the band gaps of the nanoplatelets were evaluated by diffuse reflectance spectroscopy (DRS) and were blue shifted relative to the bulk material. The morphol. and preferential growth of the nanoplatelets were found to be significantly altered by the nature of the mol. precursor employed. The synthesized SnS nanoplatelets were evaluated for their performance as anode material for lithium ion batteries (LIBs). A cell comprised of an SnS electrode could be cycled for 50 cycles. The rate capability of SnS was investigated at different current densities in the range 0.1 to 0.7 A g-1 which revealed that the initial capacity could be regained.

Dalton Transactions published new progress about Battery anodes. 3811-73-2 belongs to class pyridine-derivatives, and the molecular formula is C5H4NNaOS, Computed Properties of 3811-73-2.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Zhou, Jiancheng; Zheng, Xiangui; Li, Jiongxian; Li, Xiuyan; Lu, K. published the artcile< Electrodeposited Al mesocrystal with high thermal stability and high hardness>, SDS of cas: 93-60-7, the main research area is thermal stability aluminum mesocrystal high hardness electrodeposited.

Mesocrystal, composed of same-oriented nanocrystals separated by organics, is a promising structure for superior chem. and mech. properties, in which the high d. of nanocrystal-organic interfaces plays a crucial role. The stability of the interfaces determines the service temperature and strength of the material. Here, we synthesized aluminum mesocrystal using electrodeposition in ionic liquids with Me nicotinate additive and investigated its thermal and mech. stability. In contrast to the low stability of nanograined metals and nanoporous metals with comparable grain sizes, the Al mesocrystal is found to be stable up to 320°C (0.63 Tm, Tm: the m.p.) and has a recorded high hardness of 2.27 GPa. The high stability originates from the suppression of migration and free diffusion of the interfaces.

Scripta Materialia published new progress about Electrodeposition. 93-60-7 belongs to class pyridine-derivatives, and the molecular formula is C7H7NO2, SDS of cas: 93-60-7.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Zhang, Chun; Tutkowski, Brandon; DeLuca, Ryan J.; Joyce, Leo A.; Wiest, Olaf; Sigman, Matthew S. published the artcile< Palladium-catalyzed enantioselective Heck alkenylation of trisubstituted allylic alkenols: a redox-relay strategy to construct vicinal stereocenters>, Safety of (S)-4-(tert-Butyl)-2-(5-(trifluoromethyl)pyridin-2-yl)-4,5-dihydrooxazole, the main research area is alkenyl aldehyde ketone preparation enantioselective diastereoselective; allylic alkenol alkenyl triflate redox relay Heck palladium catalyst.

An enantioselective, redox-relay Heck alkenylation of trisubstituted allylic alkenol substrates with alkenyl triflates was developed to afford alkenyl aldehydes/ketones e.g., I. This process enabled the construction of vicinal stereocenters in high diastereo- and enantioselectivity and allowed the formation of enolizable α-carbonyl methyl-substituted stereocenters with no observed epimerization under the reported reaction conditions.

Chemical Science published new progress about Alkenals Role: SPN (Synthetic Preparation), PREP (Preparation). 1416819-91-4 belongs to class pyridine-derivatives, and the molecular formula is C13H15F3N2O, Safety of (S)-4-(tert-Butyl)-2-(5-(trifluoromethyl)pyridin-2-yl)-4,5-dihydrooxazole.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Dhankhar, Priyanka; Bedi, Manisha; Khanagwal, Jyoti; Taxak, Vinod B.; Khatkar, Satyender P.; Doon, Priti Boora published the artcile< Photoluminescent report on red light emitting europium(III) complexes with heterocyclic acid>, Recommanded Product: 2,2′-Bipyridine, the main research area is red light emitting europium complex heterocyclic acid photoluminescence.

Five luminescent europium (III) carboxylate complexes have been synthesized by using ligand 3-isopropylpyrazole-5-carboxylic acid as primary ligand and 4,4′-dimethyl-2,2′-bipyridyl, 2,2′-bipyridyl, 5,6-dimethyl-1,10-phenanthroline and 1,10-phenanthroline as secondary ligands and characterized through various techniques. These complexes exhibit excellent thermal stability and characteristic europium centered photoemission spectra under the excitation of UV light. Luminescence decay curves, Judd-Ofelt anal., internal quantum efficiency and energy transfer mechanism have also been discussed. The color coordinates and color purity are calculated to investigate red emission of the complexes. The study results reveal that these complexes can be potentially used as red light emitting materials in various optoelectronic devices.

Spectroscopy Letters published new progress about Energy transfer. 366-18-7 belongs to class pyridine-derivatives, and the molecular formula is C10H8N2, Recommanded Product: 2,2′-Bipyridine.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Chitti, Surendar; Pulya, Sravani; Nandikolla, Adinarayana; Patel, Tarun Kumar; Karan Kumar, Banoth; Murugesan, Sankaranarayanan; Ghosh, Balaram; Sekhar, Kondapalli Venkata Gowri Chandra published the artcile< Design, synthesis and biological evaluation of 7-(5-((substituted - amino)-methyl)-thiophen-2-yl)-spiro-[chroman-2,4'-piperidin]-4-one hydrochloride analogues as anticancer agents>, Recommanded Product: 3-(Aminomethyl)-6-(trifluoromethyl)pyridine, the main research area is spiro chromanpiperidinone hydrochloride preparation antitumor SAR ADME; Anticancer; Apoptosis; Cytotoxicity; Spiro-[chroman–2,4′–piperidin]–4–one.

A series of thirty-one novel 7-(5-((amino)-methyl)-thiophen-2-yl)-spiro-[chroman-2,4′-piperidin]-4-one analogs I (R = isopropylamine, tert-butylamine, 3,3-dimethylbutylamine, etc.) have been designed and synthesized as their hydrochloride salts. Here, the anticancer potential and biol. results of low-mol.-weight bridgehead oxygen and nitrogen-containing spirochromanones on proliferation and apoptosis of the human breast cancer cell line (MCF-7) and murine melanoma (B16F10) is evaluated . The anticancer activity ranged from 2.9 to 35.0μM. The most potent compounds I (R = thiophen-2-yl methanamine, benzyl amine, and Me amine) were found to be less toxic against human embryonic kidney (HEK-293) cell lines. Compounds I (R = benzyl amine and Me amine) were found to be causing significant cytotoxicity through apoptotic cell death and also G2 phase arrest of cell cycle in B16F10 cells. In-silico ADME prediction studies of the titled compounds were found within the rules outlined, and these compounds may not face any pharmacokinetic associated issues in the mere future upon developmental stage. These conjugates may serve as a lead for the discovery of potential anticancer drug candidate with better therapeutic profile.

Bioorganic Chemistry published new progress about Antitumor agents. 387350-39-2 belongs to class pyridine-derivatives, and the molecular formula is C7H7F3N2, Recommanded Product: 3-(Aminomethyl)-6-(trifluoromethyl)pyridine.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Dharuman, Suresh; Wallace, Miranda J.; Reeve, Stephanie M.; Bulitta, Jurgen B.; Lee, Richard E. published the artcile< Synthesis and Structure-Activity Relationship of Thioacetamide-Triazoles against Escherichia coli>, Electric Literature of 387350-39-2, the main research area is thioacetamide triazole preparation SAR antibacterial; 1,2,3-triazoles; antibiotics; antimetabolite; gram-negative active compounds.

Infections due to Gram-neg. bacteria are increasingly dangerous due to the spread of multi-drug resistant strains, emphasizing the urgent need for new antibiotics with alternative modes of action. Authors have previously identified a novel class of antibacterial agents, thioacetamide-triazoles, using an antifolate targeted screen and determined their mode of action which is dependent on activation by cysteine synthase A. Herein, authors report a detailed examination of the anti-E. coli structure-activity relationship of the thioacetamide-triazoles. Analogs of the initial hit compounds were synthesized to study the contribution of the aryl, thioacetamide, and triazole sections. A clear structure-activity relationship was observed generating compounds with excellent inhibition values. Substitutions to the aryl ring were generally best tolerated, including the introduction of thiazole and pyridine heteroaryl systems. Substitutions to the central thioacetamide linker section were more nuanced; the introduction of a Me branch to the thioacetamide linker substantially decreased antibacterial activity, but the isomeric propionamide and N-benzamide systems retained activity. Changes to the triazole portion of the mol. dramatically decreased the antibacterial activity, further indicating that 1,2,3-triazole is critical for potency. From these studies, authors have identified new lead compounds with desirable in-vitro ADME properties and in-vivo pharmacokinetic properties.

Molecules published new progress about Acetamides Role: PAC (Pharmacological Activity), SPN (Synthetic Preparation), THU (Therapeutic Use), BIOL (Biological Study), PREP (Preparation), USES (Uses) (Thio). 387350-39-2 belongs to class pyridine-derivatives, and the molecular formula is C7H7F3N2, Electric Literature of 387350-39-2.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem