Month: October 2022

Li, Xiaolan; Zhang, Xiuqi; Zhang, Fukuan; Luo, Xuzhong; Luo, Haiqing published the artcile< Construction of Pyridine Ring Systems by Mn(OAc)2-Promoted Formal Dehydrative Dehydroaromatizing [4+2] Cycloaddition of Enamides with Maleimides>, Product Details of C7H7NO, the main research area is pyrrolopyridine preparation; enamide maleimide formal dehydrative dehydroaromatizing cycloaddition manganese acetate promoted.

A Mn(OAc)2-promoted formal dehydrative dehydroaromatizing [4+2] cycloaddition of enamides with maleimides for the construction of pyridine rings to access the diverse synthetically valuable pyrrolo[3,4-c]-pyridine derivatives I [R = Ph, 4-FC6H4, 2-naphthyl, etc.; R1 = Me, Et, Bn, etc.] was reported. This protocol allowed two C-C bond formation for the assembly of pyridine derivatives from enamides synthesizable in two steps and inexpensive maleimides, which exhibited broad substrate scope and good functional group compatibility.

Advanced Synthesis & Catalysis published new progress about [4+2] Cycloaddition reaction. 350-03-8 belongs to class pyridine-derivatives, and the molecular formula is C7H7NO, Product Details of C7H7NO.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Talik, Tadeusz; Talik, Zofia published the artcile< Nitraminopyridines. II. Reactions of nitraminomethylpyridines with phosphorus halides>, Electric Literature of 22280-62-2, the main research area is nitramino pyridines; pyridines nitramino.

Reactions of 2-(nitramino)pyridines and 4-(nitramino)pyridines with PCl3, PCl5, PBr3, PBr5, and PI3 were studied. The nitramino group was easily exchanged for Cl, Br, or iodine. A series of chloro-, bromo-, and iodopicolines was prepared The following pyridine homologs were used as the starting material: 2-(nitramino)-3-methylpyridine (I), 2-(nitramino)-4-methylpyridine (II), 2-(nitramino)-5-methylpyridine (III), 2-(nitramino)-6-methylpyridine (IV), 4-(nitramino)-3-methylpyridine (V), 4-(nitramino)-2-methylpyridine (VI), 4-(nitramino)-2,6-dimethylpyridine (VII), and 3-(nitramino)-2,6-dimethylpyridine (VIII). The reactions were carried out in CHCl3 with 0.5 mole excess phosphorous halide at the boiling temperature Thus, a suspension of 0.01 mole nitraminomethylpyridine in 10 ml. CHCl3 was treated, under cooling, with 2.1 g. PCl3 then refluxed 1 hr., concentrated in vacuo, decomposed with ice, neutralized with NaHCO3 and steam distilled When extracted with Et2O, and the extract worked up, the distillate gave a halopicoline. The following compounds were reported (substrate, phosphones halide, product, m.p., b.p., and % yield given): I, PCl3, 2-chloro-3-methylpyridine, -, 193°, 24.1, and 2-chloro-5-nitro-3-methylpyridine (IX) 48°, -, 11.5; II, PCl3, 2-chloro-4-methylpyridine (X), -, 194°, 72.3; III, PCl3, 2-chloro-5-methylpyridine (XI), -, 86-7°/15 mm., 60.2; IV, PCl3, 2-chloro-5-nitro-6-methylpyridine (XII), 52°, -, 11.7, and 2-amino-3-nitro-6-methylpyridine (XIII), 141°, -, 6.7, and 2-amino-5-nitro-6methylpyridine, 188°, -, 13.3; V, PCl3, 4-chloro-3-methylpyridine (XIV), -, 164°, 60.2; VI, PCl3, 4-chloro-2-methylpyridine (XV), -, 162°, 72.3; VII, PCl3, 4-chloro-2,6-dimethylpyridine (XVI), -, 177°, 86.5; I, PCl5, IX, 47°, -, 26.6, and 2-amino-5-nitro-3-methylpyridine, 254°, -, 60.2; II, PCl5, X, -, 194°, 60.2; III, PCl5, XI, -, 87°/15 mm., 56.2; IV, PCl5, XII, 52°, -, 41.2, and XIII, 141°, -, 46.7; V, PCl5, XIV, -, 164°, 84.3; VI, PCl5, XV, -, 162°, 84.3; VII, PCl5, XVI, -, 177°, 86.5; I, PBr3, 2-bromo-3-methylpyridine (XVII), -, 209°, 48.5; II, PBr3, 2-bromo-4-methylpyridine (XVIII), -, 213°, 63.6, III, PBr3, 2-bromo-5-methylpyridine (XIX), 48°, -, 62.3; IV, PBr3, 2-bromo-5-nitro-6-methylpyridine (XX), 69°, -, 32.8, and 2-amino-3-nitro-6-methylpyridine (XXI), 141°, -, 20, and 2-amino-5-nitro-6-methylpyridine (XXII), 188°, -, 40; V, PBr3, PBr3, 4-bromo-3-methylpyridine (XXIII), -, 76°/15 mm., 77.1; VI, PBr3, 4-bromo-2-methylpyridine (XXIV), -, 181°, 62.3; VII, PBr3, 4-bromo-2,6-dimethylpyridine (XXV), -, 193°, 49.4; I, PBr5, XVII, -, 209°, 71.2; II, PBr5, XVIII, -, 212°, 62.3; III, PBr5, XIX, 48°, -, 62.3; IV, PBr5, XX, 69°, -, 9.4, and XXI, 141°, -, 33.3, and XXII, 188°, -, 40.0; V, PBr5, XXIII, -, 76°/15 mm., 44.5; VI, PBr5, XXIV, -, 181°, 44.5; VII, PBr5, XXV, -, 193°, 49.4; I, PI3, 2-iodo-3-methylpyridine, -, 105°, 27; II, PI3, 2-iodo-4-methylpyridine, -, 112°, 65; III, PI3, 2-iodo-5-methylpyridine, 52°, -, 69.9; V, PI3, 4-iodo-3-methylpyridine, 46°, -, 55.9; VI, PI3, 4-iodo-2-methylpyridine, 42°, -, 83.6; VII, PI3, 4-iodo-2,6-dimethylpyridine, 99°, -, 65.7. VIII did not react with phosphorus halides. Under the conditions employed, decomposition of VIII and formation of 3-amino-2,6-dimethylpyridine was observed.

Roczniki Chemii published new progress about Group 15 element halides, phosphorus halides Role: RCT (Reactant), RACT (Reactant or Reagent). 22280-62-2 belongs to class pyridine-derivatives, and the molecular formula is C6H7N3O2, Electric Literature of 22280-62-2.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Iwaki, Kentaro; Maruno, Koki; Nagata, Osamu; Shibata, Norio published the artcile< Ethynyl-SF4-Pyridines: Reagents for SF4-Alkynylation to Carbonyl Compounds>, HPLC of Formula: 350-03-8, the main research area is propargylic alc tetrafluorosulfanyl pyridinyl preparation; ethynyl tetrafluoro sulfanyl pyridine preparation carbonyl compound tetrafluorosulfanyl alkynation.

The first synthesis of (ethynyl-trans-tetrafluoro-λ6-sulfanyl)pyridines I (R = H, F) and their use as versatile reagents for the first direct SF4-alkynation to carbonyl compounds R1C(O)Ar (R1 = H, Me, Ph, CF3, pyridin-2-yl; Ar = Ph, 2-methylphenyl, pyridin-3-yl, etc.) were reported. The addition reaction of t-ethynyl-SF4-pyridines I to the carbonyl group in the presence of MeLi smoothly afforded pyridine-SF4-propargylic secondary alcs. II nd tertiary alcs., e.g., III in high yields.

Journal of Organic Chemistry published new progress about Alcohols, propargyl Role: RCT (Reactant), SPN (Synthetic Preparation), RACT (Reactant or Reagent), PREP (Preparation). 350-03-8 belongs to class pyridine-derivatives, and the molecular formula is C7H7NO, HPLC of Formula: 350-03-8.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Rocco, Dalila; Manfroni, Giacomo; Prescimone, Alessandro; Klein, Y. Maximilian; Gawryluk, Dariusz J.; Constable, Edwin C.; Housecroft, Catherine E. published the artcile< Single and double-stranded 1D-coordination polymers with 4'-(4-Alkyloxyphenyl)-3,2':6',3''-terpyridines and {Cu2(μ-OAc)4} or {Cu4(μ3-OH)2(μ-OAc)2(μ3-OAc)2(AcOκO)2} motifs>, COA of Formula: C7H7NO, the main research area is alkyloxyphenyl terpyridine copper acetate coordination polymer; 1D-coordination polymer; 3,2’:6’,3”-terpyridine; copper(II) acetate; multinuclear cluster.

Five coordination polymers formed from combinations of copper(II) acetate and 4′-(4-alkyloxyphenyl)-3,2′:6′,3”-terpyridines with methoxy (1), n-butoxy (2), n-pentyloxy (3) and n-heptyloxy (4) substituents are reported. Reaction of 1 with Cu(OAc)2·H2O leads to the 1D-polymer [Cu2(μ-OAc)4(1)]n in which {Cu2(μ-OAc)4} paddle-wheel units are connected by ligands 1, or [{Cu4(μ3-OH)2(μ-OAc)2(μ3-OAc)2(AcO-κO)2(1)2}·2MeOH]n in which centrosym. tetranuclear clusters link pairs of ligands 1 to give a double-stranded 1D-polymer. Layering solutions of Cu(OAc)2·H2O (in MeOH) over 2, 3 or 4 (in CHCl3) leads to the assembly of the 1D-polymers [2{Cu2(μ-OAc)4(2)}·1.25MeOH]n, [Cu2(μ-OAc)4(3)]n and [{Cu2(μ-OAc)4(4)}·0.2CHCl3]n. In all compounds, the 3,2′:6′,3”-tpy unit coordinates only through the outer pyridine rings, but the conformation of the 3,2′:6′,3”-tpy responds to changes in the length of the alkyloxy tails leading to changes in the conformation of the polymer backbone and in the packing of the chains in the crystal lattice in the chains featuring {Cu2(μ-OAc)4} paddle-wheel linkers.

Polymers (Basel, Switzerland) published new progress about Coordination polymers Role: PRP (Properties), SPN (Synthetic Preparation), PREP (Preparation). 350-03-8 belongs to class pyridine-derivatives, and the molecular formula is C7H7NO, COA of Formula: C7H7NO.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Khan, Ismat Ullah; Kattela, Shivashankar; Hassan, Abbas; Correia, Carlos Roque Duarte published the artcile< Enantioselective total synthesis of the highly selective sphingosine-1-receptor VPC01091 by the Heck desymmetrization of a non-activated cyclopentene-fused spiro-pyrrolidinone>, Application of C13H15F3N2O, the main research area is stereoselective Heck Matsuda desymmetrization cyclopentene fused spiropyrrolidinone arenediazonium tetrafluoroborate; enantioselective total synthesis VPC01091.

A novel, efficient and enantioselective Heck-Matsuda desymmetrization of non-activated cyclopentene-fused spiro-pyrrolidinones was developed. The reaction provided the Heck products in good to excellent yields and selectivities and tolerated a variety of functional groups in arenediazonium tetrafluoroborates (12 examples) with respect to its electronics and substitution patterns. This methodol. was successfully applied in the concise enantioselective total synthesis of VPC01091 (I), a drug candidate for the treatment of multiple sclerosis.

Organic & Biomolecular Chemistry published new progress about Desymmetrization. 1428537-19-2 belongs to class pyridine-derivatives, and the molecular formula is C13H15F3N2O, Application of C13H15F3N2O.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Kress, Thomas J.; Moore, Larry L.; Costantino, Silvio M. published the artcile< Selective chlorinations in sulfuric acid. Synthesis of some 2-amino-5-chloro-, 2-amino-3-chloro-, and 2-amino-3,5-dichloropyridines>, Safety of 2-Amino-3-nitro-6-picoline, the main research area is pyridine amino chlorination; chlorination aminopyridine sulfuric acid.

Addnl. data considered in abstracting and indexing are available from a source cited in the original document. 2-Aminopyridine and a number of Me substituted 2-aminopyridines underwent selective chlorination. The chlorination of 2-aminopyridine at various H2SO4 concentrations and the distribution of chlorinated products was studied in detail. With increasing acidity dichlorination decreases, and in 72% H2SO4 only traces of dichlorination occur. The selectivity of the chlorination reaction is ascribed to differences in the rate of chlorination of protonated vs nonprotonated substrates.

Journal of Organic Chemistry published new progress about Chlorination. 21901-29-1 belongs to class pyridine-derivatives, and the molecular formula is C6H7N3O2, Safety of 2-Amino-3-nitro-6-picoline.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Fan, Qianqian; Si, Yubing; Guo, Wei; Fu, Yongzhu published the artcile< Insight into Chemical Reduction and Charge Storage Mechanism of 2,2'-Dipyridyl Disulfide toward Stable Lithium-Organic Battery>, Recommanded Product: 1,2-Di(pyridin-2-yl)disulfane, the main research area is chem reduction dipyridyl disulfide lithium organic redox flow battery.

In lithium-organic batteries, organic cathode materials could dissolve in a liquid electrolyte and diffuse through the porous separator to the active lithium-metal anode, resulting in cycling instability. However, 2,2′-dipyridyl disulfide (PyDS) can be cycled 5 times better than di-Ph disulfide (PDS) although both are soluble We believe this is related to their reactivity with lithium (Li0). Herein, we investigate the chem. reduction of PyDS by lithiated carbon paper (Li-CP) in ether electrolyte. It is found that only 6.3% of PyDS was reduced by Li-CP after 10 days, unlike PDS. Exptl. and computational results show that PyDS mols. are ionized by lithium ions of lithium salts delocalizing the charge on pyridine rings of PyDS, which can momentarily store Li0, thus keeping the S-S bond inert in chem. reaction with Li0. This finding is successfully utilized in a membrane-free redox flow battery with PyDS catholyte, showing long cycle life with high energy d. and energy efficiency. This work reveals the interesting charge storage mechanism and the different activity of organodisulfides toward electrochem. reduction and chem. reduction due to the organic groups, which can provide guidance for the design of stable lithium-organic batteries.

Journal of Physical Chemistry Letters published new progress about Battery capacity. 2127-03-9 belongs to class pyridine-derivatives, and the molecular formula is C10H8N2S2, Recommanded Product: 1,2-Di(pyridin-2-yl)disulfane.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Yi, Sijia; Kim, Sun-Young; Vincent, Michael P.; Yuk, Simseok A.; Bobbala, Sharan; Du, Fanfan; Scott, Evan Alexander published the artcile< Dendritic peptide-conjugated polymeric nanovectors for non-toxic delivery of plasmid DNA and enhanced non-viral transfection of immune cells>, COA of Formula: C10H8N2S2, the main research area is dendritic peptide polymeric nanovector toxic delivery plasmid DNA; plasmid DNA immune cell nonviral transfection; Biological sciences; Biotechnology; Drug delivery system; Health sciences; Immunology.

Plasmid DNA (pDNA) transfection is advantageous for gene therapies requiring larger genetic elements, including “”all-in-one”” CRISPR/Cas9 plasmids, but is limited by toxicity as well as poor intracellular release and transfection efficiency in immune cell populations. Here, we developed a synthetic non-viral gene delivery platform composed of poly(ethylene glycol)-b-poly(propylene sulfide) copolymers linked to a cationic dendritic peptide (DP) via a reduceable bond, PEG-b-PPS-ss-DP (PPDP). A library of self-assembling PPDP polymers was synthesized and screened to identify optimal constructs capable of transfecting macrophages with small (pCMV-DsRed, 4.6 kb) and large (pL-CRISPR.EFS.tRFP, 11.7 kb) plasmids. The optimized PPDP construct transfected macrophages, fibroblasts, dendritic cells, and T cells more efficiently and with less toxicity than a com. Lipo2K reagent, regardless of pDNA size and under standard culture conditions in the presence of serum. The PPDP technol. described herein is a stimuli-responsive polymeric nanovector that can be leveraged to meet diverse challenges in gene delivery.

iScience published new progress about Blood serum. 2127-03-9 belongs to class pyridine-derivatives, and the molecular formula is C10H8N2S2, COA of Formula: C10H8N2S2.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Graca, Catia A. L.; Mendes, Maria Anita; Teixeira, Antonio Carlos S. C.; Velosa, Adriana Correia de published the artcile< Anoxic degradation of chlorpyrifos by zerovalent monometallic and bimetallic particles in solution>, Safety of 6-Chloropyridin-2-ol, the main research area is chlorpyrifoszerovalent monometallic bimetallic particle anoxic degradation; Bimetallic particles; Chlorpyrifos; Reductive degradation; Zerovalent copper; Zerovalent metals.

The degradation of highly toxic and persistent chlorinated organic compounds by zerovalent metals (ZVMs) has received considerable attention for in situ groundwater remediation. Due to its abundance and low toxicity, iron has been mostly applied for such purposes, despite several limitations, such as rapid surface passivation and little efficacy towards certain contaminants. Given that, we evaluated monometallic zerovalent iron (ZVI), copper (ZVC) and zinc (ZVZ), and bimetallic copper-coated ZVI (ZVI/Cu) and ZVZ (ZVZ/Cu) for anoxic reductive degradation of chlorpyrifos (CP). Two approaches to enhance metal reactivity were investigated: the synthesis of bimetallic particles with copper and the comparison between micro and nanoparticles. All of the tested monometallic and bimetallic particles dechlorinated the target mol., although complete chlorine removal was not achieved by any metal during the 30-d treatment period. Coating the zerovalent monometallic particles with copper enhanced reactivity. Reactivity was ZVC > ZVZ > ZVI for monometallic particles and ZVZ/Cu > ZVI/Cu for bimetallic microparticles. The anal. of the degradation products indicated the presence of dechlorinated compounds as well as 3,5,6-trichloro-2-pyridinol, a hydrolysis product.

Chemosphere published new progress about Decomposition (anoxic). 73018-09-4 belongs to class pyridine-derivatives, and the molecular formula is C5H4ClNO, Safety of 6-Chloropyridin-2-ol.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Elawa, Sherif; Mirdell, Robin; Tesselaar, Erik; Farnebo, Simon published the artcile< The microvascular response in the skin to topical application of methyl nicotinate: Effect of concentration and variation between skin sites>, HPLC of Formula: 93-60-7, the main research area is skin microvascular response methyl nicotinate.

Me nicotinate (MN) induces a local cutaneous erythema in the skin and may be used as a local provocation in the assessment of microcirculation and skin viability. The aims were to measure the effects of increasing doses of MN, to find the concentration that yields the most reproducible effect from day to day and between sites, and to study the variation between skin sites. Microvascular responses to topically applied MN at different concentrations were measured in 12 subjects on sep. days and on contralateral sides, using laser speckle contrast imaging (LSCI). MN effects were measured in four different body sites. At 20 mmol/L, the response to MN was most reproducible day-to-day and site-to-site, and resulted in a plateau response between 5 and 20 min after application. The skin region of the lower back had a lower perfusion value compared to the epigastric region (p = 0.007). When responses were compared to nearby, unprovoked areas, a significantly larger increase in perfusion was seen in the forearm, compared to all other anatomical sites (p < 0.03). A concentration of 20 mmol/L MN generated the most reproducible microvascular response in the skin. The response varies between different body sites. Microvascular Research published new progress about Anatomy (anatomical site). 93-60-7 belongs to class pyridine-derivatives, and the molecular formula is C7H7NO2, HPLC of Formula: 93-60-7.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem