Month: October 2022

Koovits, Paul J.; Dessoy, Marco A.; Matheeussen, An; Maes, Louis; Caljon, Guy; Mowbray, Charles E.; Kratz, Jadel M.; Dias, Luiz C. published an article in Bioorganic & Medicinal Chemistry Letters. The title of the article was 《Structure-activity relationship of 4-azaindole-2-piperidine derivatives as agents against Trypanosoma cruzi》.Safety of 2-Bromopyridin-3-amine The author mentioned the following in the article:

The structure-activity relationship of a 4-Azaindole-2-piperidine compound selected from GlaxoSmithKline’s recently disclosed open-resource “”Chagas box”” and possessing moderate activity against Trypanosoma cruzi, the parasite responsible for Chagas disease, is presented. Despite considerable medicinal chem. efforts, a suitably potent and metabolically stable compound could not be identified to advance the series into in vivo studies. This research should be of interest to those in the area of neglected diseases and in particular anti-kinetoplastid drug discovery. In the experimental materials used by the author, we found 2-Bromopyridin-3-amine(cas: 39856-58-1Safety of 2-Bromopyridin-3-amine)

2-Bromopyridin-3-amine(cas: 39856-58-1) belongs to anime. The reaction of alkyl halides, R―X, where X is a halogen, or analogous reagents with ammonia (or amines) is useful with certain compounds. Not all alkyl halides are effective reagents; the reaction is sluggish with secondary alkyl groups and fails with tertiary ones. Its usefulness is largely confined to primary alkyl halides (those having two hydrogen atoms on the reacting site).Safety of 2-Bromopyridin-3-amine

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Poisson, Thomas; Yamashita, Yasuhiro; Kobayashi, Shu published an article in Journal of the American Chemical Society. The title of the article was 《Catalytic Asymmetric Protonation of Chiral Calcium Enolates via 1,4-Addition of Malonates》.COA of Formula: C35H27N3O2 The author mentioned the following in the article:

Nonracemic imidazolidinones such as I are prepared enantioselectively in 72-90% yields and in 48-96% ee (all but one of the ten substrates in 93-96% ee) by the addition of dibenzyl malonate to α,β-unsaturated acylimidazolidinones such as II in the presence of Py-Box ligands such as III or its enantiomer, calcium ethoxide, phenol IV, and ethanol in cyclopentyl Me ether. I is converted to various nonracemic 1,5-dicarboxylic acid derivatives such as (R)-MeO2CCHMeCH2CH2CO2H without loss of enantiopurity. The reaction is optimized on the metal salt, Py-Box ligand, phenol catalyst, added alc., solvent, and the unsaturated acyl derivative used; based on deuterium labeling studies, a mechanism for the reaction is proposed. After reading the article, we found that the author used 2,6-Bis((4S,5S)-4,5-diphenyl-4,5-dihydrooxazol-2-yl)pyridine(cas: 410092-98-7COA of Formula: C35H27N3O2)

2,6-Bis((4S,5S)-4,5-diphenyl-4,5-dihydrooxazol-2-yl)pyridine(cas: 410092-98-7) belongs to pyridine derivatives. The ring atoms in the pyridine molecule are sp2-hybridized. The nitrogen is involved in the π-bonding aromatic system using its unhybridized p orbital. COA of Formula: C35H27N3O2The lone pair is in an sp2 orbital, projecting outward from the ring in the same plane as the σ bonds.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

The author of 《Rapid Asymmetric Synthesis of Disubstituted Allenes by Coupling of Flow-Generated Diazo Compounds and Propargylated Amines》 were Poh, Jian-Siang; Makai, Szabolcs; von Keutz, Timo; Tran, Duc N.; Battilocchio, Claudio; Pasau, Patrick; Ley, Steven V.. And the article was published in Angewandte Chemie, International Edition in 2017. Recommanded Product: 2,6-Bis((4S,5S)-4,5-diphenyl-4,5-dihydrooxazol-2-yl)pyridine The author mentioned the following in the article:

The authors report the asym. coupling of flow-generated unstabilized diazo compounds and propargylated amide derivatives, using a new pyridinebis(imidazoline) ligand, a copper catalyst, and base. The reaction proceeds rapidly, generating chiral allenes in 10-20 min with high enantioselectivity (89-98 % de/ee), moderate yields and a wide functional group tolerance. In the experiment, the researchers used many compounds, for example, 2,6-Bis((4S,5S)-4,5-diphenyl-4,5-dihydrooxazol-2-yl)pyridine(cas: 410092-98-7Recommanded Product: 2,6-Bis((4S,5S)-4,5-diphenyl-4,5-dihydrooxazol-2-yl)pyridine)

2,6-Bis((4S,5S)-4,5-diphenyl-4,5-dihydrooxazol-2-yl)pyridine(cas: 410092-98-7) belongs to pyridine derivatives. Several pyridine derivatives play important roles in biological systems. While its biosynthesis is not fully understood, nicotinic acid (vitamin B3) occurs in some bacteria, fungi, and mammals. Recommanded Product: 2,6-Bis((4S,5S)-4,5-diphenyl-4,5-dihydrooxazol-2-yl)pyridine

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

In 2011,Joshi, Girdhar; Adimurthy, Subbarayappa published 《Environment-Friendly Bromination of Aromatic Heterocycles Using a Bromide-Bromate Couple in an Aqueous Medium》.Industrial & Engineering Chemistry Research published the findings.HPLC of Formula: 13534-97-9 The information in the text is summarized as follows:

Selective monobromination of aromatic heterocyclic compounds through in-situ acid activation of 2:1 bromide/bromate couple as a benign brominating reagent is described. The in-situ acid activation of a bromide-bromate couple generates the reactive species BrOH, and it is proved to be an efficient for the bromination of various heterocycles under mild aqueous conditions without the use of any catalyst. Heterocycles that had electron-rich substituents provided good yields. In the part of experimental materials, we found many familiar compounds, such as 6-Bromopyridin-3-amine(cas: 13534-97-9HPLC of Formula: 13534-97-9)

6-Bromopyridin-3-amine(cas: 13534-97-9) belongs to anime. Left-handed and right-handed forms (mirror-image configurations, known as optical isomers or enantiomers) are possible when all the substituents on the central nitrogen atom are different (i.e., the nitrogen is chiral). With amines, there is extremely rapid inversion in which the two configurations are interconverted.HPLC of Formula: 13534-97-9

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

In 2016,Schmidt, Sven Olaf; Naggert, Holger; Buchholz, Axel; Brandenburg, Hannah; Bannwarth, Alexander; Plass, Winfried; Tuczek, Felix published 《Thermal and Light-Induced Spin Transitions of FeII Complexes with 4- and 5-(Phenylazo)-2,2′-bipyridine Ligands: Intra- vs. Intermolecular Effects》.European Journal of Inorganic Chemistry published the findings.Product Details of 13534-97-9 The information in the text is summarized as follows:

Five new spin crossover complexes with 4- and 5-(phenylazo)-2,2-bipyridine (4-/5-PAbipy) ligands were synthesized and investigated with respect to their spin crossover (SCO) behavior. The results are compared to the thermal and light-induced spin transition properties of the parent SCO complexes [Fe(bpz)2(bipy)] (1) and [Fe(bipy)2(NCS)2] (2) (bpz = dihydro(bispyrazolyl)borate). [Fe(bpz)2(4-PAbipy)] (1a) undergoes a stepwise spin transition whereas [Fe(bpz)2(5-PAbipy)] (1b) exhibits a 1-step transition with a 6 K-wide hysteresis. For [Fe(bpz)2(tBu5-PAbipy)] (1c) the spin transition to the low-spin state is incomplete. Qual. similar changes of the SCO behavior are observed for [Fe(4-PAbipy)2(NCS)2] (2a) and [Fe(5-PAbipy)2(NCS)2] (2b). In comparison to the parent system 2, a strengthening of intermol. interactions leads to a stabilization of the low-spin state. Evidence for the LIESST behavior could be obtained for all new compounds by magnetic susceptibility measurements as well as UV/visible and resonance Raman spectroscopy. The results came from multiple reactions, including the reaction of 6-Bromopyridin-3-amine(cas: 13534-97-9Product Details of 13534-97-9)

6-Bromopyridin-3-amine(cas: 13534-97-9) belongs to anime. Large quantities of aliphatic amines are made synthetically. The most widely used industrial method is the reaction of alcohols with ammonia at a high temperature, catalyzed by metals or metal oxide catalysts (e.g., nickel or copper). Mixtures of primary, secondary, and tertiary amines are thereby produced.Product Details of 13534-97-9

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

In 2017,Simmons, Bryan J.; Hoffmann, Marie; Champagne, Pier Alexandre; Picazo, Elias; Yamakawa, Katsuya; Morrill, Lucas A.; Houk, K. N.; Garg, Neil K. published 《Understanding and Interrupting the Fischer Azaindolization Reaction》.Journal of the American Chemical Society published the findings.Name: 6-Bromopyridin-3-amine The information in the text is summarized as follows:

Exptl. and computational studies pertaining to the Fischer azaindolization reaction are reported. These studies explain why pyridylhydrazines are poorly reactive in Fischer indolization reactions, in addition to the origin of hydrazine substituent effects. Addnl., an interrupted variant of Fischer azaindolization methodol. is disclosed, which provides a synthetic entryway into fused azaindoline scaffolds. In the experiment, the researchers used 6-Bromopyridin-3-amine(cas: 13534-97-9Name: 6-Bromopyridin-3-amine)

6-Bromopyridin-3-amine(cas: 13534-97-9) belongs to anime. Reduction of nitro compounds, RNO2, by hydrogen or other reducing agents produces primary amines cleanly (i.e., without a mixture of products), but the method is mostly used for aromatic amines because of the limited availability of aliphatic nitro compounds. Reduction of nitriles and oximes (R2C=NOH) also yields primary amines.Name: 6-Bromopyridin-3-amine

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

In 2017,Tung, Truong Thanh; Jakobsen, Tim Holm; Dao, Trong Tuan; Fuglsang, Anja Thoe; Givskov, Michael; Christensen, Soeren Broegger; Nielsen, John published 《Fusaric acid and analogues as Gram-negative bacterial quorum sensing inhibitors》.European Journal of Medicinal Chemistry published the findings.Product Details of 29682-15-3 The information in the text is summarized as follows:

Taking advantage of microwave-assisted synthesis, efficient and expedite procedures for preparation of a library of fusaric acid and 39 analogs are reported. The fusaric acid analogs were tested in cell-based screening assays for inhibition of the las and rhl quorum sensing system in Pseudomonas aeruginosa and the lux quorum sensing system in Vibrio fischeri. Eight of the 40 compounds in the library including fusaric acid inhibited lux quorum sensing and one compound inhibited activity of the las quorum sensing system. To the authors’ delight, none of the compounds showed growth inhibitory effects in the tested concentration ranges. In the part of experimental materials, we found many familiar compounds, such as Methyl 5-bromopicolinate(cas: 29682-15-3Product Details of 29682-15-3)

Methyl 5-bromopicolinate(cas: 29682-15-3) belongs to pyridine. Pyridine is very deactivated towards electrophilic substitution with respect to benzene. For this reason classical formylation, using methods such as the Gattermann or Vilsmeier reactions, are not generally successful. Product Details of 29682-15-3

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem