Month: October 2022

In 2019,International Journal of Molecular Sciences included an article by Marx, Sebastien; Bodart, Laurie; Tumanov, Nikolay; Wouters, Johan. Electric Literature of C6H7Br2N. The article was titled 《Design and synthesis of a new soluble natural β-carboline derivative for preclinical study by intravenous injection》. The information in the text is summarized as follows:

Harmine is a natural β-carboline compound showing several biol. activities, including antiproliferative properties, but this soluble natural mol. lacks selectivity. Harmine derivatives were reported to overcome this problem, but they are usually poorly soluble Here, we designed and synthesized a new 2, 7, 9-trisubstituted mol. (1-methyl-7-(3-methylbutoxy)-9- propyl-2-[(pyridin-2-yl)methyl]-9H-pyrido[3,4-b]indol-2-ium bromide) with a solubility of 1.87 ± 0.07 mg/mL in a simulated injection vehicle. This compound is stable for at least 72 h in acidic and physiol. conditions (pH 1.1 and 7.4) as well as in a simulated injection vehicle (physiol. liquid + 0.1% Tween 80). Solubility in those media is 1.06 ± 0.08 mg/mL and 1.62 ± 0.13 mg/mL at pH 7.4 and 1. The synthesized mol. displays a significant activity on five different cancer cell lines (IC50 range from 0.2 to 2 μM on A549, MDA-MB-231, PANC-1, T98G and Hs683 cell lines). This compound is also more active on cancer cells (MDA-MB-231) than on normal cells (MCF-10a) at IC50 concentrations Due to its high activity at low concentration, such solubility values should be sufficient for further in vivo antitumoral activity evaluation via i.v. injection. The experimental process involved the reaction of 2-(Bromomethyl)pyridine hydrobromide(cas: 31106-82-8Electric Literature of C6H7Br2N)

2-(Bromomethyl)pyridine hydrobromide(cas: 31106-82-8) belongs to pyridine. Pyridine’s structure is isoelectronic with that of benzene, but its properties are quite different. Pyridine is completely miscible with water, whereas benzene is only slightly soluble. Like all hydrocarbons, benzene is neutral (in the acid–base sense), but because of its nitrogen atom, pyridine is a weak base.Electric Literature of C6H7Br2N

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

The author of 《A combined computational/experimental study on HSA binding of two water-soluble Schiff base ligands derived from pyridine derivative and ethylendiamine》 were Molaee, Hajar; Sahihi, Mehdi; Moghadam, Majid; Mirkhani, Valiollah; Tangestaninejad, Shahram; Mohammadpoor-Baltork, Iraj; Amiri Rudbari, Hadi. And the article was published in Journal of Biomolecular Structure and Dynamics in 2019. Name: 4-Acetylpyridine The author mentioned the following in the article:

In this paper, two water-soluble Schiff bases were synthesized by the reaction of 4-pyridinecarbaldehyde or 4-pyridylmethyl ketone with ethylenediamine. Then, the bidentate Schiff base compounds were characterized by 1H NMR spectroscopy and elemental anal. In addition, the mol. structure of one of these compounds was determined by single crystal X-ray diffraction technique. Then, the binding ability of these two Schiff bases with HSA was investigated using UV-vis and fluorescence spectroscopy, mol. docking, and mol. dynamics simulation methods. The experimental part of the paper was very detailed, including the reaction process of 4-Acetylpyridine(cas: 1122-54-9Name: 4-Acetylpyridine)

4-Acetylpyridine(cas: 1122-54-9) belongs to pyridine. Pyridines form stable salts with strong acids. Pyridine itself is often used to neutralize acid formed in a reaction and as a basic solvent. Name: 4-Acetylpyridine

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

The author of 《Generation of N-Centered Radicals via a Photocatalytic Energy Transfer: Remote Double Functionalization of Arenes Facilitated by Singlet Oxygen》 were Soni, Vineet Kumar; Hwang, Ho Seong; Moon, Yu Kyung; Park, Sung-Woo; You, Youngmin; Cho, Eun Jin. And the article was published in Journal of the American Chemical Society in 2019. Safety of fac-Tris(2-phenylpyridine)iridium The author mentioned the following in the article:

An unprecedented approach to the generation of an N-centered radical via a photocatalytic energy-transfer process from readily available heterocyclic precursors is reported, which is distinctive of the previous electron transfer approaches. In combination with singlet oxygen, the in-situ-generated nitrogen radical from the oxadiazoline substrate in the presence of fac-Ir(ppy)3 undergoes a selective ipso addition to arenes to furnish remotely double-functionalized spiro-azalactam products. The mechanistic studies provide compelling evidence that the catalytic cycle selects the energy-transfer pathway. A concurrent activation of mol. oxygen to generate singlet oxygen by energy transfer is also rationalized. Furthermore, the occurrence of the electron transfer phenomenon is excluded on the basis of the neg. driving forces for one-electron transfer between oxadiazoline and the excited state of fac-Ir(ppy)3 with a consideration of their redox potentials. The necessity of singlet oxygen as well as the photoactivated oxadiazoline substrate is clearly supported by a series of controlled experiments D. functional studies have also been carried out to support these observations. The scope of substrates is explored by synthesizing diversely functionalized cyclohexadienone moieties in view of their utility in complex organic syntheses and as potential targets in pharmacol. After reading the article, we found that the author used fac-Tris(2-phenylpyridine)iridium(cas: 94928-86-6Safety of fac-Tris(2-phenylpyridine)iridium)

fac-Tris(2-phenylpyridine)iridium(cas: 94928-86-6) belongs to pyridine. Pyridine derivatives lend themselves to many roles in the spirited field of supramolecular chemistry – whether as the ligand backbone of metal-organic polymers or presiding over the key electronic stations of nanodevices. In biochemistry, pyridine-containing cofactors are necessary nutrients on which our lives depend. Safety of fac-Tris(2-phenylpyridine)iridium

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

The author of 《Polyamine-co-2, 6-diaminopyridine covalently bonded on chitosan for the adsorptive removal of Hg(II) ions from aqueous solution》 were Liang, Wen; Li, Manlin; Jiang, Shuncheng; Ali, Amjad; Zhang, Zengqiang; Li, Ronghua. And the article was published in International Journal of Biological Macromolecules in 2019. Formula: C5H7N3 The author mentioned the following in the article:

In the present study, 2, 6-diaminopyridine (PD) and polyamine compounds (ethylenediamine (EDA), triethylenetetramine (TETA), and tetraethylenepentamine (TEPA)) were used to modify chitosan (CS). The obtained derivatives (PD-CS, PD-EDA-CS, PD-TETA-CS, and PD-TEPA-CS) were identified and employed as adsorbents in batch experiments for the removal of Hg(II) from aqueous solutions The results confirmed that successful modification improves the Hg(II) adsorption significantly compared to pristine CS. The adsorbed amounts of Hg(II) increased gradually and reached maxima at pH values above 4.0 for all derivatives The Hg(II) adsorption equilibrium state was achieved within 12 h, with the process driven by a pseudo-second-order kinetic model. The Langmuir model effectively interpreted the Hg(II) adsorption isotherms; the maximum adsorption capacities for Hg(II) ions at 295 K were 172.7, 303.6, 276.0, and 230.6 mg/g for PD-CS, PD-EDA-CS, PD-TETA-CS, and PD-TEPA-CS, resp. High temperature and low ionic strength favored Hg(II) adsorption. The Hg(II)-loaded CS derivative was easily regenerated and showed acceptable reusability. The further FT-IR and XPS analyses indicate that the Hg(II) adsorption is governed by a process combining electrostatic attraction and a coordination reaction. The CS derivatives produced from polyamine-co-2, 6-diaminopyridine covalently bonded onto CS are promising adsorbents for the adsorptive removal of Hg(II) from an aqueous solution In the part of experimental materials, we found many familiar compounds, such as 2,6-Diaminopyridine(cas: 141-86-6Formula: C5H7N3)

2,6-Diaminopyridine(cas: 141-86-6) belongs to pyridine. Pyridine and its simple derivatives are stable and relatively unreactive liquids, with strong penetrating odours that are unpleasant.Formula: C5H7N3

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

《Carbazole-Based Tetrapodal Anchor Groups for Gold Surfaces: Synthesis and Conductance Properties》 was published in Angewandte Chemie, International Edition in 2020. These research results belong to O’Driscoll, Luke J.; Wang, Xintai; Jay, Michael; Batsanov, Andrei S.; Sadeghi, Hatef; Lambert, Colin J.; Robinson, Benjamin J.; Bryce, Martin R.. Application of 2510-22-7 The article mentions the following:

As the field of mol.-scale electronics matures and the prospect of devices incorporating mol. wires becomes more feasible, it is necessary to progress from the simple anchor groups used in fundamental conductance studies to more elaborate anchors designed with device stability in mind. This study presents oligo(phenylene-ethynylene) wires with one tetrapodal anchor and a Ph or pyridyl head group. The new anchors are designed to bind strongly to Au surfaces without disrupting the conductance pathway of the wires. Conductive probe at. force microscopy (cAFM) was used to determine the conductance of self-assembled monolayers (SAMs) of the wires in Au-SAM-Pt and Au-SAM-graphene junctions, from which the conductance per mol. was derived. For tolane-type wires, mean conductances per mol. of up to 10-4.37 G0 (Pt) and 10-3.78 G0 (graphene) were measured, despite limited electronic coupling to the Au electrode, demonstrating the potential of this approach. Computational studies of the surface binding geometry and transport properties rationalize and support the exptl. results. The experimental process involved the reaction of 4-Ethynylpyridine(cas: 2510-22-7Application of 2510-22-7)

4-Ethynylpyridine(cas: 2510-22-7) belongs to pyridine. Pyridines are often used as catalysts or reagents; particular notice has been paid recently to how pyridine coordinates to metal centers enabling a wide range of valuable reactions. Application of 2510-22-7

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

《In situ formation of nitrogen-doped carbon-wrapped Co3O4 enabling highly efficient and stable catalytic reduction of p-nitrophenol》 was written by Huang, Lu; Zhang, Hang; He, Zhiqiao; Chen, Jianmeng; Song, Shuang. Computed Properties of C5H7N3 And the article was included in Chemical Communications (Cambridge, United Kingdom) in 2020. The article conveys some information:

This study presents a novel nitrogen-doped carbon-wrapped Co3O4 prepared by a facile impregnation-carbonization process using low-cost raw materials. The optimized catalyst exhibits the highest activity reported to date for Co-based catalysts used in the reduction of p-nitrophenol to p-aminophenol with NaBH4 and remains highly stable over seven continuous runs. In the part of experimental materials, we found many familiar compounds, such as 2,6-Diaminopyridine(cas: 141-86-6Computed Properties of C5H7N3)

2,6-Diaminopyridine(cas: 141-86-6) belongs to pyridine. Pyridine and its simple derivatives are stable and relatively unreactive liquids, with strong penetrating odours that are unpleasant.Computed Properties of C5H7N3

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Bhattacharyya, Arnab; Jameei, Aida; Karande, Anjali A.; Chakravarty, Akhil R. published their research in European Journal of Medicinal Chemistry in 2021. The article was titled 《BODIPY-attached zinc(II) complexes of curcumin drug for visible light assisted photo-sensitization, cellular imaging and targeted PDT》.Quality Control of Bis(pyridin-2-ylmethyl)amine The article contains the following contents:

Boron-dipyrromethene (BODIPY) based photosensitizers as porphyrinoids and curcumin as natural product possess exciting photophys. features suitable for theranostic applications, namely, imaging and photodynamic therapy (PDT). Limited aqueous solubility and insufficient physiol. stability, however, reduce their efficacy significantly. We have designed a novel strategy to deliver these two unusable cytotoxins simultaneously in cancer cells and herein, report the synthesis, characterization and imaging-assisted photocytotoxicity of three zinc(II) complexes containing N3-donor dipicolylamine (dpa) ligands (L1-3) and O,O-donor curcumin (Hcur) viz. [Zn(L1)(cur)]Cl (1), [Zn(L2)(cur)]Cl (2) and [Zn(L3)(cur)]Cl (3), where L2 and L3 have pendant fluorescent BODIPY and non-emissive di-iodo-BODIPY moieties. Metal chelation imparted remarkable biol. stability (pH ∼7.4) to the resp. ligands and induces significant aqueous solubility These ternary complexes could act as replacements of the existing metalloporphyrin-based PDT photosensitizers as their visible-light photosensitizing ability is reinforced by the dual presence of blue light absorbing curcumin and green light harvesting BODIPY units. Complex 2 having emissive BODIPY unit L2 and curcumin, showed mitochondria selective localization in HeLa, MCF-7 cancer cells and complex 3, the di-iodinated analog of complex 2, exhibited type-I/II PDT activity via inducing apoptosis through mitochondrial membrane disruption in cancer cells while being significantly nontoxic in dark and to the healthy cells. After reading the article, we found that the author used Bis(pyridin-2-ylmethyl)amine(cas: 1539-42-0Quality Control of Bis(pyridin-2-ylmethyl)amine)

Bis(pyridin-2-ylmethyl)amine(cas: 1539-42-0) is a secondary amine with two picolyl substituents. As a tridentate ligand this compound provides three nitrogen donors that affords good selectivity for Zn2+ over biologically relevant metals such as Na+, K+, Mg2+ and Ca2+, and leaves coordination sites free for anion binding. Quality Control of Bis(pyridin-2-ylmethyl)amine

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

In 2022,Reddivari, Chenna Krishna Reddy; Devineni, Subba Rao; Nemallapudi, Bakthavatchala Reddy; Sravya, Gundala; Avula, Balakrishna; Shaik, Nayabrasool; Badavath, Vishnu Nayak; Zyryanov, Grigory V.; YellalaVenkata, Rami Reddy; Chamarthi, Naga Raju published an article in Polycyclic Aromatic Compounds. The title of the article was 《Design, Synthesis, Biological Evaluation and Molecular Docking Studies of 1,4-Disubstituted 1,2,3-Triazoles: PEG-400:H2O Mediated Click Reaction of Fluorescent Organic Probes under Ultrasonic Irradiation》.Application of 624-28-2 The author mentioned the following in the article:

A PEG-400:H2O mediated highly versatile, efficacious and selective “”Click reaction”” of fluorescent organic Probes under ultrasonic irradiation were reported. A rapid and efficient approach for the synthesis of 1,4-Disubstituted 1,2,3-triazoles I [R = (4-fluorophenyl)methyl, 2,4-dioxo-pyrimidin-5-yl, etc.] under Copper (I)-Catalyzed Azide-Alkyne [3 + 2] Cycloaddition (CuAAC) conditions in good to excellent yields in less time were described. This synthetic protocol were proved to endorse easy work-up under benign reaction conditions. The green solvent system employed was efficaciously reused several times without any loss of its activity in an aqueous medium. All the title compounds were characterized by using elemental anal., 1HNMR, 13CNMR, FTIR, and mass spectral data. The newly synthesized compounds were biol. evaluated for their antioxidant activity. The antioxidant activity resulted demonstrate that all compounds showed good to excellent antioxidant activity, particularly the compounds I [R = (4-bromophenyl)methyl, 5-bromo-2-pyridyl, pyrimidin-2-yl, 2,4-dioxo-pyrimidin-5-yl] exhibited promising radical scavenging activity. Further, photophys. properties of the compounds were accomplished using spectrofluorimeter. Compounds I [R = (3-chlorophenyl)methyl, (4-nitrophenyl)methyl, (4-cyanophenyl)methyl, thiazol-2-yl, 5-bromo-2-pyridyl, pyrimidin-2-yl, 2,4-dioxo-pyrimidin-5-yl] exhibited fluorescence in the visible region. Mol. docking studies suggested the antioxidant activity of synthesized compounds were due to the inhibition of neuronal nitric oxide synthase (HnNOS). In the experiment, the researchers used 2,5-Dibromopyridine(cas: 624-28-2Application of 624-28-2)

2,5-Dibromopyridine(cas: 624-28-2) belongs to pyridine. In industry and in the lab, pyridine is used as a reaction solvent, particularly when its basicity is useful, and as a starting material for synthesizing some herbicides, fungicides, and antiseptics.Application of 624-28-2

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

In 2022,Elsebaie, Mohamed M.; El-Din, Hanzada T. Nour; Abutaleb, Nader S.; Abuelkhir, Abdelrahman A.; Liang, Hsin-Wen; Attia, Ahmed S.; Seleem, Mohamed N.; Mayhoub, Abdelrahman S. published an article in European Journal of Medicinal Chemistry. The title of the article was 《Exploring the structure-activity relationships of diphenylurea as an antibacterial scaffold active against methicillin- and vancomycin-resistant Staphylococcus aureus》.Application In Synthesis of Pyridin-3-ylboronic acid The author mentioned the following in the article:

A set of structurally related diphenylurea derivatives I [R = Ph, furan-2-yl, cyclohexyl, iso-Bu, etc.] bearing aminoguanidine moiety was synthesized, and their antibacterial activity was assessed against a panel of multi-drug resistant Gram-pos. clin. isolates. Two compounds I [R = furan-2-yl, 4-methyl-pent-1-en-1-yl] were identified with better bacteriol. profile than the lead I [R = I]. The multi-step resistance development studies indicated that MRSA are less likely to develop resistance toward diphenylurea compounds I. Moreover, these compounds I demonstrated a prolonged post-antibiotic effect than that of vancomycin. Furthermore, compounds I [R = furan-2-yl, 4-methyl-pent-1-en-1-yl] were able to re-sensitize VRSA to vancomycin, resulting in 8- to more than 32-fold improvement in vancomycin MIC values against clin. VRSA isolates. Finally, when assessed in an in vivo skin infection mouse model, the efficacy of I [R = 4-methyl-pent-1-en-1-yl] was very comparable to that of the com. available fusidic acid ointment. Addnl., the diphenylurea I [R = 4-methyl-pent-1-en-1-yl] did not have a pronounced effect on the animal weights along the experiment indicating its safety and tolerability to mice. Taken together, these results indicate that the diphenylurea scaffold merits further investigation as a promising anti-staphylococcal treatment option. In the experimental materials used by the author, we found Pyridin-3-ylboronic acid(cas: 1692-25-7Application In Synthesis of Pyridin-3-ylboronic acid)

Pyridin-3-ylboronic acid(cas: 1692-25-7) belongs to pyridine. Pyridine is very deactivated towards electrophilic substitution with respect to benzene. For this reason classical formylation, using methods such as the Gattermann or Vilsmeier reactions, are not generally successful. Application In Synthesis of Pyridin-3-ylboronic acid

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

In 2022,McFadden, Timothy Patrick; Nwachukwu, Chideraa Iheanyi; Roberts, Andrew George published an article in Organic & Biomolecular Chemistry. The title of the article was 《An amine template strategy to construct successive C-C bonds: synthesis of benzo[h]quinolines by a deaminative ring contraction cascade》.Reference of 2-Bromonicotinaldehyde The author mentioned the following in the article:

A convergent strategy to build, cyclize and excise nitrogen from tertiary amines for the synthesis of polyheterocyclic aromatics was developed. Biaryl-linked azepine intermediates underwent a deaminative ring contraction cascade reaction, excising nitrogen with the formation of an aromatic core. This strategy and deaminative ring contraction reaction was useful for the synthesis of benzo[h]quinolines. In the part of experimental materials, we found many familiar compounds, such as 2-Bromonicotinaldehyde(cas: 128071-75-0Reference of 2-Bromonicotinaldehyde)

2-Bromonicotinaldehyde(cas: 128071-75-0) belongs to pyridine. Pyridines form stable salts with strong acids. Pyridine itself is often used to neutralize acid formed in a reaction and as a basic solvent. Reference of 2-Bromonicotinaldehyde

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem