Month: October 2022

《Facile Synthesis of Amphiphilic Bottlebrush Block Copolymers Bearing Pyridine Pendants via Click Reaction from Protected Alkyne Side Groups》 was published in Macromolecules (Washington, DC, United States) in 2020. These research results belong to Kim, Myung-Jin; Yu, Yong-Guen; Chae, Chang-Geun; Seo, Ho-Bin; Lee, Jae-Suk. Reference of 2-(Bromomethyl)pyridine hydrobromide The article mentions the following:

We present the facile synthetic platform for the production of amphiphilic bottlebrush block copolymers bearing pyridine pendants through combination of living anionic polymerization (LAP), ring-opening metathesis polymerization (ROMP), and copper-catalyzed azide-alkyne cycloaddition (CuAAC). ω-Norbornenyl poly(4-((trimethylsilyl)ethynyl)styrene) (NBPTMSESt) with controlled mol. weights (Mn = 3-4 kDa) and low dispersity (D = 1.03-1.08) was synthesized by LAP and the subsequent end-capping reaction with exo-N-(n-decyl-10-phenylacrylate)-5-norbornene-2,3-dicarboximide. Well-defined bottlebrush block copolymers (Mn = 134-548 kDa, D = 1.04-1.14) were achieved through sequential ROMP of ω-norbornenyl polystyrene with NBPTMSESt and subsequently deprotected with the clickable alkyne group. Amphiphilic bottlebrush block copolymers were obtained by the click reaction of alkyne and azide functional pyridines in the presence of the organic-soluble catalyst/ligand system of CuBr(PPh3)3 and N,N,N’,N”,N”-pentamethyldiethylenetriamine. These polymers exhibited the three-dimensional ordered porous films through breath-figure self-assembly. The experimental part of the paper was very detailed, including the reaction process of 2-(Bromomethyl)pyridine hydrobromide(cas: 31106-82-8Reference of 2-(Bromomethyl)pyridine hydrobromide)

2-(Bromomethyl)pyridine hydrobromide(cas: 31106-82-8) belongs to pyridine. Pyridine’s structure is isoelectronic with that of benzene, but its properties are quite different. Pyridine is completely miscible with water, whereas benzene is only slightly soluble. Like all hydrocarbons, benzene is neutral (in the acid–base sense), but because of its nitrogen atom, pyridine is a weak base.Reference of 2-(Bromomethyl)pyridine hydrobromide

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

《A low symmetry cluster meets a low symmetry ligand to sharply boost MOF thermal stability》 was published in Chemical Communications (Cambridge, United Kingdom) in 2020. These research results belong to Gao, Yajun; Zhang, Mingxing; Chen, Cong; Zhang, Yong; Gu, Yuming; Wang, Qian; Zhang, Wenwei; Pan, Yi; Ma, Jing; Bai, Junfeng. Recommanded Product: 1692-25-7 The article mentions the following:

A new approach in which a low symmetry cluster meets a low symmetry ligand to sharply boost the thermal stability of a MOF via addnl. inter-linker interactions is presented for the first time, leading to the successful synthesis of a novel binuclear Co-based MOF, {[Co2(L1)2DMF]·1.5DMF·0.75MeOH·1.5H2O}∞ (H2L1 = 5-(pyridin-3-yl)isophthalic acid, NJU-Bai62: NJU-Bai for Nanjing University Bai group), with exceptional thermal stability of up to 450°. This work may open up a new avenue for constructing robust MOFs from abundant, unstable, and low symmetry binuclear clusters, which have usually been ignored by most MOF chemists. In the experimental materials used by the author, we found Pyridin-3-ylboronic acid(cas: 1692-25-7Recommanded Product: 1692-25-7)

Pyridin-3-ylboronic acid(cas: 1692-25-7) belongs to pyridine. Pyridines are often used as catalysts or reagents; particular notice has been paid recently to how pyridine coordinates to metal centers enabling a wide range of valuable reactions. Recommanded Product: 1692-25-7

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

《Simultaneous Fluorescence Imaging Reveals N-Methyl-D-aspartic Acid Receptor Dependent Zn2+/H+ Flux in the Brains of Mice with Depression》 was written by Wang, Xin; Bai, Xiaoyi; Su, Di; Zhang, Yandi; Li, Ping; Lu, Shuyi; Gong, Yulin; Zhang, Wen; Tang, Bo. Category: pyridine-derivatives And the article was included in Analytical Chemistry (Washington, DC, United States) in 2020. The article conveys some information:

Depression is immensely attributed to the overactivation of N-methyl-D-aspartic acid (NMDA) receptor in the brains. As regulatory binding partners of NMDA receptor, both Zn2+ and H+ are intimately interrelated to NMDA receptor’s activity. Therefore, exploring synergistic changes on the levels of Zn2+ and H+ in brains will promote the knowledge and treatment of depression. However, the lack of efficient, appropriate imaging tools limits simultaneously tracking Zn2+ and H+ in living mouse brains. Thus, a well-designed dual-color fluorescent probe (DNP) was fabricated for the simultaneous monitoring of Zn2+ and H+ in the brains of mice with depression. Encountering Zn2+, the probe evoked bright blue fluorescence at 460 nm. Meanwhile, the red fluorescence at 680 nm was decreased with H+ addition With blue/red dual fluorescence signal of DNP, we observed the synchronous increased Zn2+ and H+ in PC12 cells under oxidative stress. Notably, in vivo imaging for the first time revealed the simultaneous reduction of Zn2+ and pH in brains of mice with depression-like behaviors. Further results implied that the NMDA receptor might be responsible for the coinstantaneous fluctuation of Zn2+ and H+ during depression. Altogether, this work is conducive to the knowledge of neural signal transduction mechanisms, advancing our understanding of the pathogenesis in depression. In the part of experimental materials, we found many familiar compounds, such as Bis(pyridin-2-ylmethyl)amine(cas: 1539-42-0Category: pyridine-derivatives)

Bis(pyridin-2-ylmethyl)amine(cas: 1539-42-0) is a secondary amine with two picolyl substituents. As a tridentate ligand this compound provides three nitrogen donors that affords good selectivity for Zn2+ over biologically relevant metals such as Na+, K+, Mg2+ and Ca2+, and leaves coordination sites free for anion binding. Category: pyridine-derivatives

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

《Functionalization of partially reduced graphene oxide by metal complex as electrode material in supercapacitor》 was written by Bakhshandeh, Mohammad Bagher; Kowsari, Elaheh. COA of Formula: C5H7N3 And the article was included in Research on Chemical Intermediates in 2020. The article conveys some information:

High elec. conductivity and high surface area are two main parameters which affect supercapacitor electrode performance. Graphene has gained prominence in electrode of elec. double-layer capacitor due to its high elec. conductivity and high sp. surface area. Functionalization of partially reduced graphene oxide is the state-of-the-art method in synthesis of graphene system which is used in electrode of elec. double-layer capacitors (EDLCs). In this study, graphene system was functionalized by 2,6-diaminopyridine cobalt complex with a simple method in available and engineered porous surface area to eliminate agglomeration of graphene sheets and enhance elec. conductivity of them which is suitable for EDLCs. Curved and porous structure that obtained high and available surface area for supercapacitor electrodes was approved by structural anal. such as X-ray diffraction, Raman spectroscopy, SEM and Brunauer-Emmett-Teller. Furthermore, the XPS and Fourier-transform IR were used for elemental anal. Also, galvanostatic charge/discharge (GCD), cyclic voltammetry and electrochem. impedance spectroscopy were applied to specify electrochem. behavior of the prepared electrode. Accordingly, the elec. resistance obtained was 5.23 Ω. The specific capacitance obtained was 192 F/g by cyclic voltammetry and 107 F/g by GCD methods.2,6-Diaminopyridine(cas: 141-86-6COA of Formula: C5H7N3) was used in this study.

2,6-Diaminopyridine(cas: 141-86-6) belongs to pyridine. Pyridine and its simple derivatives are stable and relatively unreactive liquids, with strong penetrating odours that are unpleasant.COA of Formula: C5H7N3

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

《Transition metal-free B(dan)-installing reaction (dan: naphthalene-1,8-diaminato): H-B(dan) as a B(dan) electrophile》 was written by Li, Jialun; Seki, Michinari; Kamio, Shintaro; Yoshida, Hiroto. Related Products of 3510-66-5 And the article was included in Chemical Communications (Cambridge, United Kingdom) in 2020. The article conveys some information:

H-B(dan) was demonstrated to serve as a B(dan) electrophile, despite its highly diminished boron-Lewis acidity, leading to direct and transition metal-free approach to R-B(dan) of high synthetic utility upon treatment with Grignard reagents. Iterative cross-coupling of 5-bromo-2-pyridyl-B(dan), synthesized by the present method, was also achieved. After reading the article, we found that the author used 2-Bromo-5-methylpyridine(cas: 3510-66-5Related Products of 3510-66-5)

2-Bromo-5-methylpyridine(cas: 3510-66-5) belongs to pyridine. When pyridine is adsorbed on oxide surfaces or in porous materials, the following species are commonly observed: (i) pyridine coordinated to Lewis acid sites, (ii) pyridine H-bonded to weakly acidic hydroxyls, and (iii) protonated pyridine. At high coverage, physisorbed pyridine and protonated dimers can also be observed.Related Products of 3510-66-5

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

《Heteroleptic NiII complexes: Synthesis, structural characterization, computational studies and amoebicidal activity evaluation》 was written by Hernandez-Ayala, Luis Felipe; Toledano-Magana, Yanis; Ortiz-Frade, Luis; Flores-Alamo, Marcos; Galindo-Murillo, Rodrigo; Reina, Miguel; Garcia-Ramos, Juan Carlos; Ruiz-Azuara, Lena. Synthetic Route of C12H12N2 And the article was included in Journal of Inorganic Biochemistry in 2020. The article conveys some information:

In this work, we present the synthesis, characterization, electrochem. studies, DFT calculations, and in vitro amoebicidal effect of seven new heteroleptic NiII coordination compounds The crystal structures of [H2(pdto)](NO3)2 and [Ni(pdto)(NO3)]PF6 are presented, pdto = 2,2′-[1,2-ethanediylbis-(sulfanediyl-2,1-ethanediyl)]dipyridine. The rest of the compounds have general formulas: [Ni(pdto)(N-N)](PF6) where N-N = 2,2′-bipyridine (bpy), 4,4′-dimethyl-2,2′-bipyridine (44dmbpy), 5,5′-dimethyl-2,2′-bipyridine (55dmbpy), 1,10-phenanthroline (phen), 4,7-dimethyl-1,10-phenanthroline (47dmphen) and 5,6-dimethyl-1,10-phenanthroline (56dmphen). The size of N-N ligand and its substituents modulate the compound electronic features and influence their antiproliferative efficiency against Entamoeba histolytica, 56dmphen derivative, shows the biggest molar volume and presents a powerful amoebicidal activity (IC50 = 1.2μM), being seven times more effective than the first-line drug for human amoebiasis metronidazole. Also, increases the reactive oxygen species concentration within the trophozoites. This could be the trigger of the E. histolytica growth inhibition. The antiparasitic effect is described using NiII electron d., molar volume, estimated by DFT, as well as the exptl. redox potential and diffusion coefficients In general, amoebicidal efficiency is directly proportional to the increment of the molar volume and decreases when the redox potential becomes more pos. The experimental part of the paper was very detailed, including the reaction process of 4,4′-Dimethyl-2,2′-bipyridine(cas: 1134-35-6Synthetic Route of C12H12N2)

4,4′-Dimethyl-2,2′-bipyridine(cas: 1134-35-6) is used as a chemical Intermediate. It can be used for the determination of ferrous and cyanide compounds.Synthetic Route of C12H12N2 Furthermore, 4,4′-Dimethyl-2,2′-bipyridine is used in the synthesis of a series of o-phenanthroline-substituted ruthenium(II) complexes.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Li, Ru-Jin; Marcus, Adam; Fadaei-Tirani, Farzaneh; Severin, Kay published an article in 2021. The article was titled 《Orientational self-sorting: formation of structurally defined Pd4L8 and Pd6L12 cages from low-symmetry dipyridyl ligands》, and you may find the article in Chemical Communications (Cambridge, United Kingdom).Product Details of 1692-25-7 The information in the text is summarized as follows:

Tetra- and hexanuclear coordination cages were obtained in reactions of [Pd(CH3CN)4](BF4)2 with low-symmetry dipyridyl ligands. In both cases, only one structurally defined complex was formed out of a vast pool of potential isomers. After reading the article, we found that the author used Pyridin-3-ylboronic acid(cas: 1692-25-7Product Details of 1692-25-7)

Pyridin-3-ylboronic acid(cas: 1692-25-7) belongs to pyridine. When pyridine is adsorbed on oxide surfaces or in porous materials, the following species are commonly observed: (i) pyridine coordinated to Lewis acid sites, (ii) pyridine H-bonded to weakly acidic hydroxyls, and (iii) protonated pyridine. At high coverage, physisorbed pyridine and protonated dimers can also be observed.Product Details of 1692-25-7

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Zhou, Gui-Juan; Tang, Yi-Yun; Zuo, Jin-Xi; Yi, Tao; Tang, Jun-Peng; Zhang, Ping; Zou, Wei; Tang, Xiao-Qing published an article in 2022. The article was titled 《Itaconate alleviates β2-microglobulin-induced cognitive impairment by enhancing the hippocampal amino-β-carboxymuconate-semialdehyde-decarboxylase/picolinic acid pathway》, and you may find the article in Biochemical Pharmacology (Amsterdam, Netherlands).Synthetic Route of C6H5NO2 The information in the text is summarized as follows:

β2-microglobulin (B2M) has been established to impair cognitive function. However, no treatment is currently available for B2M-induced cognitive dysfunction. Itaconate is a tricarboxylic acid (TCA) cycle intermediate that exerts neuroprotective effects in several neurol. diseases. The amino-β-carboxymuconate-semialdehyde-decarboxylase (ACMSD)/picolinic acid (PIC) pathway is a crucial neuroprotective branch in the kynurenine pathway (KP). The present study sought to investigate whether Itaconate attenuates B2M-induced cognitive impairment and examine the mediatory role of the hippocampal ACMSD/PIC pathway. We demonstrated that 4-Octyl Itaconate (OI, an itaconate derivative) significantly alleviated B2M-induced cognitive dysfunction and hippocampal neurogenesis impairment. OI treatment also increased the expression of ACMSD, elevated the concentration of PIC, and decreased the level of 3-HAA in the hippocampus of B2M-exposed rats. Furthermore, inhibition of ACMSD by TES-991 significantly abolished the protections of Itaconate against B2M-induced cognitive impairment and neurogenesis deficits. Exogenous PIC supplementation in hippocampus also improved cognitive performance and hippocampal neurogenesis in B2M-exposed rats. These findings demonstrated that Itaconate alleviates B2M-induced cognitive impairment by upregulation of the hippocampal ACMSD/PIC pathway. This is the first study to document Itaconate as a promising therapeutic agent to ameliorate cognitive impairment. Moreover, the mechanistic insights into the ACMSD/PIC pathway improve our understanding of it as a potential therapeutic target for neurol. diseases beyond B2M-associated neurocognitive disorders. In the experimental materials used by the author, we found Picolinic acid(cas: 98-98-6Synthetic Route of C6H5NO2)

Picolinic acid(cas: 98-98-6) is used in the preparation of 2-Aminodihydro[1,3]thiazines as BACE 2 inhibitors and their preparation and use in the treatment of diabetes.Synthetic Route of C6H5NO2

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

In 2022,Sutherland, Hamish S.; Lu, Guo-Liang; Tong, Amy S. T.; Conole, Daniel; Franzblau, Scott G.; Upton, Anna M.; Lotlikar, Manisha U.; Cooper, Christopher B.; Palmer, Brian D.; Choi, Peter J.; Denny, William A. published an article in European Journal of Medicinal Chemistry. The title of the article was 《Synthesis and structure-activity relationships for a new class of tetrahydronaphthalene amide inhibitors of Mycobacterium tuberculosis》.Quality Control of Methyl 5-bromopicolinate The author mentioned the following in the article:

Drug resistant tuberculsosis (TB) is global health crisis that demands novel treatment strategies. Bacterial ATP synthase inhibitors such as bedaquiline and next-generation analogs (such as TBAJ-876) have shown promising efficacy in patient populations and preclin. studies, resp., suggesting that selective targeting of this enzyme presents a validated therapeutic strategy for the treatment of TB. In this work, we report tetrahydronaphthalene amides (THNAs) as a new class of ATP synthase inhibitors that are effective in preventing the growth of Mycobacterium tuberculosis (M.tb) in culture. Design, synthesis and comprehensive structure-activity relationship studies for approx. 80 THNA analogs are described, with a small selection of compounds exhibiting potent (in some cases MIC90 <1 μg/mL) in vitro M.tb growth inhibition taken forward to pharmacokinetic and off-target profiling studies. Ultimately, we show that some of these THNAs possess reduced lipophilic properties, decreased hERG liability, faster mouse/human liver microsomal clearance rates and shorter plasma half-lives compared with bedaquiline, potentially addressing of the main concerns of persistence and phospholipidosis associated with bedaquiline. In the part of experimental materials, we found many familiar compounds, such as Methyl 5-bromopicolinate(cas: 29682-15-3Quality Control of Methyl 5-bromopicolinate)

Methyl 5-bromopicolinate(cas: 29682-15-3) belongs to pyridine. When pyridine is adsorbed on oxide surfaces or in porous materials, the following species are commonly observed: (i) pyridine coordinated to Lewis acid sites, (ii) pyridine H-bonded to weakly acidic hydroxyls, and (iii) protonated pyridine. At high coverage, physisorbed pyridine and protonated dimers can also be observed.Quality Control of Methyl 5-bromopicolinate

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Name: 4-EthynylpyridineIn 2022 ,《Discovery of the First Highly Selective Antagonist of the GluK3 Kainate Receptor Subtype》 appeared in International Journal of Molecular Sciences. The author of the article were Chalupnik, Paulina; Vialko, Alina; Pickering, Darryl S.; Hinkkanen, Markus; Donbosco, Stephanie; Moeller, Thor C.; Jensen, Anders A.; Nielsen, Birgitte; Bay, Yasmin; Kristensen, Anders S.; Johansen, Tommy N.; Latka, Kamil; Bajda, Marek; Szymanska, Ewa. The article conveys some information:

In search of selective ligands for the GluK3 kainate receptor subtype, a series of I [R = 3-Me Ph, 4-Me Ph, 4-Et Ph, etc] analogs was synthesized and pharmacol. characterized at selected recombinant ionotropic glutamate receptors. Among them, compound I [R = imidazo[1,2-b]pyridazin-3-ylmethyl] was found to be a competitive GluK3 antagonist with submicromolar affinity and unprecedented high binding selectivity, showing a 400-fold preference for GluK3 over other homomeric receptors GluK1, GluK2, GluK5 and GluA2. Furthermore, in functional assays performed for selected metabotropic glutamate receptor subtypes, I [R = imidazo[1,2-b]pyridazin-3-ylmethyl] did not show agonist or antagonist activity. The mol. determinants underlying the observed affinity profile of I [R = imidazo[1,2-b]pyridazin-3-ylmethyl] were analyzed using mol. docking and mol. dynamics simulations performed for individual GluK1 and GluK3 ligand-binding domains.4-Ethynylpyridine(cas: 2510-22-7Name: 4-Ethynylpyridine) was used in this study.

4-Ethynylpyridine(cas: 2510-22-7) belongs to pyridine. Pyridine and pyridine-derived structures are privileged pharmacophores in medicinal chemistry and an essential functionality for organic chemists. As the prototypical π-deficient heterocycle, pyridine illustrates distinctive chemistry as both substrate and reagent. Name: 4-Ethynylpyridine

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem