Month: October 2022

The author of 《Fluorescence Lifetime Imaging of p-tau Protein in Single Neuron with a Highly Selective Fluorescent Probe》 were Ge, Lihong; Tian, Yang. And the article was published in Analytical Chemistry (Washington, DC, United States) in 2019. HPLC of Formula: 1539-42-0 The author mentioned the following in the article:

Hyperphosphorylated tau (p-tau) protein is one of the key markers of Alzheimer’s disease (AD). However, a lack of anal. methods for p-tau protein with high selectivity and accuracy is the bottleneck to understand the pathol. processes of AD. In the present work, a highly selective fluorescence lifetime imaging microscopic (FLIM) probe (τ-p-tau) was rationally designed and developed for determination of p-tau protein, in which binuclear zinc units were designed as the recognition groups, and an improved cyanine was synthesized as the dye unit. The FLIM measurement is independent of the concentration of fluorescent probes, irradiation light sources, and measurement environments. Meanwhile, the developed τ-p-tau probe demonstrated strong affinity toward p-tau protein, thus enhancing the selectivity of determination of p-tau protein against Aβ, Aβ fibril, tau, protein kinases, ATP, and so on. The fluorescence lifetime of τ-p-tau probe showed a good linearity with the concentration of p-tau protein from 1.0 to 5.0 μM with a low detection limit of 85.15±0.03 nM. The response time of the present probe for p-tau protein was estimated to be less than 6.2 s. Furthermore, taking the advantages of low toxicity and good biocompatibility, the developed probe was successfully applied to monitor the fluctuation of concentration of p-tau protein by FLIM imaging at single neuron level. It was found that the concentration of p-tau protein inside live neurons obviously changed upon oxidative stress. In the experimental materials used by the author, we found Bis(pyridin-2-ylmethyl)amine(cas: 1539-42-0HPLC of Formula: 1539-42-0)

Bis(pyridin-2-ylmethyl)amine(cas: 1539-42-0) is a secondary amine with two picolyl substituents. As a tridentate ligand this compound provides three nitrogen donors that affords good selectivity for Zn2+ over biologically relevant metals such as Na+, K+, Mg2+ and Ca2+, and leaves coordination sites free for anion binding. HPLC of Formula: 1539-42-0

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

《The Suzuki-Miyaura Cross-Coupling as the Key Step in the Synthesis of 2-Aminobiphenyls and 2,2′-Diaminobiphenyls: Application in the Synthesis of Schiff Base Complexes of Zn》 was published in European Journal of Organic Chemistry in 2020. These research results belong to Hylland, Knut Tormodssoenn; Oien-Odegaard, Sigurd; Tilset, Mats. Computed Properties of C5H3Br2N The article mentions the following:

2-Nitrophenylboronic acids serve as interesting starting materials for the construction of biphenyl- and terphenyl-based amines if subjected to the Suzuki-Miyaura reaction. Unfortunately, these boronic acids suffer from low reactivity in Suzuki reactions, alongside their low stability in the presence of Pd. Herein, a general method for the construction of 2-nitro-substituted bi- and terphenyls is presented, with special emphasis on the synthesis of 2-amino-2′-nitrobi- and terphenyls. Comparisons are made with other boronic acids that have some of the aforementioned issues. Finally, the application of the obtained 2-amino-2′-nitrobi- and terphenyls as starting materials for the synthesis of bi- and terphenyl based di- and triamines is encountered for, with emphasis on the use of these amines as precursors for Schiff base ligands. In addition, the synthesis of some Zn complexes of these ligands is presented. In the part of experimental materials, we found many familiar compounds, such as 2,5-Dibromopyridine(cas: 624-28-2Computed Properties of C5H3Br2N)

2,5-Dibromopyridine(cas: 624-28-2) belongs to pyridine. In industry and in the lab, pyridine is used as a reaction solvent, particularly when its basicity is useful, and as a starting material for synthesizing some herbicides, fungicides, and antiseptics.Computed Properties of C5H3Br2N

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

《Efficient Transfer Hydrogenation of Ketones Catalyzed by a Phosphine-Free Cobalt-NHC Complex》 was written by Ibrahim, Jessica Juweriah; Reddy, C. Bal; Fang, Xiaolong; Yang, Yong. Computed Properties of C7H7NO And the article was included in European Journal of Organic Chemistry in 2020. The article conveys some information:

A simple phosphine-free cobalt-NHC pincer complex was synthesized and used for the transfer hydrogenation of ketones with 2-propanol as hydrogen donor. A broad range of ketones varying from aromatic, aliphatic and heterocyclic were effectively reduced to their corresponding alcs. in moderate to excellent yields with good tolerance of functional groups. In the part of experimental materials, we found many familiar compounds, such as 4-Acetylpyridine(cas: 1122-54-9Computed Properties of C7H7NO)

4-Acetylpyridine(cas: 1122-54-9) belongs to pyridine. Pyridine is a relatively complex molecule and exhibits a number of different bands in IR spectra. Among others, the bands characterizing the ν8a and ν19b modes have been found to be sensitive to the coordination or protonation of the molecule. Note that the band that is diagnostic for the PyH+ ion at about 1545 cm− 1 (ν19b mode) does not overlap with any of the other bands.Computed Properties of C7H7NO

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

《Imaging and therapeutic applications of Zn(II)-cryptolepine-curcumin molecular probes in cell apoptosis detection and photodynamic therapy》 was written by Qin, Qi-Pin; Wei, Zu-Zhuang; Wang, Zhen-Feng; Huang, Xiao-Ling; Tan, Ming-Xiong; Zou, Hua-Hong; Liang, Hong. Electric Literature of C12H13N3 And the article was included in Chemical Communications (Cambridge, United Kingdom) in 2020. The article conveys some information:

Novel red Zn(II) complex-based fluorescent probes featuring cryptolepine-curcumin derivatives, namely, [Zn(BQ)Cl2] (BQ-Zn) and [Zn(BQ)(Cur)]Cl (BQCur-Zn), were developed for the simple and fluorescent label-free detection of apoptosis, an important biol. process. The probes could synergistically promote mitochondrion-mediated apoptosis and enhance tumor therapeutic effects in vitro and vivo. The experimental part of the paper was very detailed, including the reaction process of Bis(pyridin-2-ylmethyl)amine(cas: 1539-42-0Electric Literature of C12H13N3)

Bis(pyridin-2-ylmethyl)amine(cas: 1539-42-0) is a secondary amine with two picolyl substituents. The compound is a tridentate ligand in coordination chemistry and commonly used to produce Zn-based chemosensors/probes, such as Zinpry.Electric Literature of C12H13N3

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

《Aggregation-Induced Electrochemiluminescence Bioconjugates of Apoferritin-Encapsulated Iridium(III) Complexes for Biosensing Application》 was written by Yang, Lei; Sun, Xu; Wei, Dong; Ju, Huangxian; Du, Yu; Ma, Hongmin; Wei, Qin. Recommanded Product: 94928-86-6 And the article was included in Analytical Chemistry (Washington, DC, United States) in 2021. The article conveys some information:

An intriguing aggregation-induced electrochemiluminescence (AIECL) bioconjugate was fabricated by encapsulating fac-tris(2-phenylpyridine)iridium(III) complexes [Ir(ppy)3] in the apoferritin (apoFt) cavity for biosensing application. Based on the unique pH-dependent disassembly/reassembly characteristic of apoFt, approx. 44.3 mols. of Ir(ppy)3 aggregated in the single cavity through both intermol. π-π-stacking interactions and hydrogen bonds that efficiently restricted the intramol. motions to trigger the AIECL effect. Compared to monomers, Ir(ppy)3 aggregates performed 5.3-fold-enhanced ECL emission using tri-n-propylamine (TPrA) as a coreactant. The fabricated Ir(ppy)3@apoFt bioconjugate was flexibly labeled with a detection antibody to act as a transducer for the immunosensor construction. To further catalyze the ECL reaction between the reductive TPrA• and the oxidative Ir(ppy)3+• radicals, a conductive and electroactive substrate of Fe2N and gold nanoparticle-codecorated reduced graphene oxide (Fe2N/rGO/Au) was established to incubate the capture antibody. Therefore, a “”signal on”” immunosensor was developed for sensitive assay of cytokeratin 19 fragment 21-1 (CYFRA 21-1), in which good linearity ranging from 1 pg/mL to 50 ng/mL with a low detection limit of 0.43 pg/mL (S/N = 3) was obtained. This study shares with an inspiration of using apoFt to design iridium(III)-based AIECL emitters, which will expand more possibilities of organic iridium(III) complexes in establishing innovative ECL immunoassays. In the experiment, the researchers used fac-Tris(2-phenylpyridine)iridium(cas: 94928-86-6Recommanded Product: 94928-86-6)

fac-Tris(2-phenylpyridine)iridium(cas: 94928-86-6) belongs to pyridine. Pyridine is widely used in the precursor to agrochemicals and pharmaceuticals. Also, it is used as an important reagent and organic solvent.Recommanded Product: 94928-86-6

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Stevenson, Bernard G.; Spielvogel, Ethan H.; Loiaconi, Emily A.; Wambua, Victor Mulwa; Nakhamiyayev, Roman V.; Swierk, John R. published their research in Journal of the American Chemical Society in 2021. The article was titled 《Mechanistic Investigations of an α-Aminoarylation Photoredox Reaction》.Electric Literature of C33H24IrN3 The article contains the following contents:

While photoredox catalysis continues to transform modern synthetic chem., detailed mechanistic studies involving direct observation of reaction intermediates and rate constants are rare. By use of a combination of steady state photochem. measurements, transient laser spectroscopy, and electrochem. methods, an α-aminoarylation mechanism that is the inspiration for a large number of photoredox reactions was rigorously characterized. Despite high product yields, the external quantum yield (QY) of the reaction remained low (15-30%). By use of transient absorption spectroscopy, productive and unproductive reaction pathways were identified and rate constants assigned to develop a comprehensive mechanistic picture of the reaction. The role of the cyanoarene, 1,4-dicyanobenzne, was found to be unexpectedly complex, functioning both as initial proton acceptor in the reaction and as a neutral stabilizer for the 1,4-dicyanobenzene radical anion. Finally, kinetic modeling was utilized to analyze the reaction at an unprecedented level of understanding. This modeling demonstrated that the reaction is limited not by the kinetics of the individual steps but instead by scattering losses and parasitic absorption by a photochem. inactive donor-acceptor complex. In the experiment, the researchers used many compounds, for example, fac-Tris(2-phenylpyridine)iridium(cas: 94928-86-6Electric Literature of C33H24IrN3)

fac-Tris(2-phenylpyridine)iridium(cas: 94928-86-6) belongs to pyridine. Pyridine is widely used in the precursor to agrochemicals and pharmaceuticals. Also, it is used as an important reagent and organic solvent.Electric Literature of C33H24IrN3

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Harenberg, Johannes H.; Weidmann, Niels; Wiegand, Alexander J.; Hoefer, Carla A.; Annapureddy, Rajasekar Reddy; Knochel, Paul published an article in 2021. The article was titled 《(2-Ethylhexyl)sodium: A Hexane-Soluble Reagent for Br/Na-Exchanges and Directed Metalations in Continuous Flow》, and you may find the article in Angewandte Chemie, International Edition.Application of 3510-66-5 The information in the text is summarized as follows:

We report the on-demand generation of hexane-soluble (2-ethylhexyl)sodium (1) from 3-(chloromethyl)heptane (2) using a sodium-packed-bed reactor under continuous flow conditions. Thus, the resulting solution of 1 is free of elemental sodium and therefore suited for a range of synthetic applications. This new procedure avoids the storage of an alkylsodium and limits the handling of metallic sodium to a min. (2-Ethylhexyl)sodium (1) proved to be a very useful reagent and undergoes in-line Br/Na-exchanges as well as directed sodiations. The resulting arylsodium intermediates are subsequently trapped in batch with various electrophiles such as ketones, aldehydes, Weinreb-amides, imines, allyl bromides, disulfides and alkyl iodides. A reaction scale-up of the Br/Na-exchange using an in-line electrophile quench was also reported. The experimental part of the paper was very detailed, including the reaction process of 2-Bromo-5-methylpyridine(cas: 3510-66-5Application of 3510-66-5)

2-Bromo-5-methylpyridine(cas: 3510-66-5) belongs to pyridine. Pyridines form stable salts with strong acids. Pyridine itself is often used to neutralize acid formed in a reaction and as a basic solvent. Application of 3510-66-5

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Lin, Simin; Chang, Xingmao; Wang, Zhaolong; Zhang, Jing; Ding, Nannan; Xu, Wenjun; Liu, Ke; Liu, Zhongshan; Fang, Yu published an article in 2021. The article was titled 《High-Performance NMHC Detection Enabled by a Perylene Bisimide-Cored Metallacycle Complex-Based Fluorescent Film Sensor》, and you may find the article in Analytical Chemistry (Washington, DC, United States).Application In Synthesis of 4-Ethynylpyridine The information in the text is summarized as follows:

Non-methane hydrocarbons (NMHCs) can serve as precursors of ozone and photochem. smog, and hence their highly efficient detection is of great importance for air quality monitoring. Here, we synthesized a new fluorescent perylene bisimide (PBI)-cored metallacycle complex through coordination-driven self-assembly and used it for the production of a fluorescent film sensor. The unique rectangular structure of the developed fluorophore endows the sensor with enhanced sensing performance and discriminability to n-alkanes (C5-10). Specifically, the exptl. detection limits for n-pentane, n-hexane, and n-decane are 39, 7, and 1.4 mg/m3, resp., and the corresponding linear ranges are from 39 to 2546, 7 to 1745, and 1.4 to 85 mg/m3, resp. Moreover, the sensing is fully reversible. In tandem with a gas chromatog. separation system, the film sensor showed comparable detection ability for the n-alkanes with a com. flame ionization detector (FID), while the film sensor needs no hydrogen; it occupies a much smaller size (30 x 30 x 44 mm3) and consumes less energy (0.215 W). Further studies demonstrated that the developed sensor can be used for on-site and real-time quantification of NHMCs, laying the foundation for developing into a portable detector. In addition to this study using 4-Ethynylpyridine, there are many other studies that have used 4-Ethynylpyridine(cas: 2510-22-7Application In Synthesis of 4-Ethynylpyridine) was used in this study.

4-Ethynylpyridine(cas: 2510-22-7) belongs to pyridine. Pyridines form stable salts with strong acids. Pyridine itself is often used to neutralize acid formed in a reaction and as a basic solvent. Application In Synthesis of 4-Ethynylpyridine

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Martinez-Vollbert, Emiliano; Philouze, Christian; Gautier-Luneau, Isabelle; Moreau, Yohann; Lanoe, Pierre-Henri; Loiseau, Frederique published an article in 2021. The article was titled 《Study of a phosphorescent cationic iridium(III) complex displaying a blue-shift in crystals》, and you may find the article in Physical Chemistry Chemical Physics.Related Products of 1134-35-6 The information in the text is summarized as follows:

We report the synthesis and the characterization of a new cationic iridium(III) complex featuring two 1-(p-methoxyphenyl)-5-methoxybenzimidazole cyclometallating ligands and a dimethylbipyridine ancillary ligand. The complex has been fully characterized by 1D and 2D NMR (1H, 13C, 19F and 31P), elemental anal. and high-resolution mass spectrometry (HRMS). The photoluminescence studies performed in a solution, on amorphous powder and on crystals revealed an unexpected behavior. Indeed, the emission spectra observed in both solution (CH2Cl2) and amorphous powder samples are centered at around 580 nm, whereas in crystals the emission displays a large hypsochromic shift of ~800 cm-1 (λem = 558 nm). X-ray diffraction experiments, photophys. studies and DFT calculations allow for rationalizing the hypsochromic shift. After reading the article, we found that the author used 4,4′-Dimethyl-2,2′-bipyridine(cas: 1134-35-6Related Products of 1134-35-6)

4,4′-Dimethyl-2,2′-bipyridine(cas: 1134-35-6) is used in the synthesis of a series of o-phenanthroline-substituted ruthenium(II) complexes.Related Products of 1134-35-6 Furthermore, 4,4′-Dimethyl-2,2′-bipyridine is used as a chemical Intermediate. It can be used for the determination of ferrous and cyanide compounds.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

In 2022,Kandhasamy, Mohanraj; Shanmugam, Ganesan; Selvaraj, Balamurugan; Kamaraj, Santhosh; Gunasekeran, Ahalya; Sambandam, Anandan published an article in Optical Materials (Amsterdam, Netherlands). The title of the article was 《A locust bean and pectin polymer blend integrated with thio-bridged pyridinyl additive as a novel cobalt and copper gel electrolyte system for dye-sensitized solar cells》.Quality Control of 2-Bromo-5-methylpyridine The author mentioned the following in the article:

An intensive correlation has been attempted on 2-(pyridin-2-yl)-1-(4-(trifluoromethyl)phenyl)-1H-benzo[d]imidazole ligand-coordinated cobalt and copper metal complex electrolytes (Co2+/3+[ptpbi]3 and Cu1+/2+[ptpbi]2) with blend biopolymer electrolyte based on Locust Bean Gum and Pectin (LP) as a host matrix to enhance the performance of organic DPTCY sensitizer (2D-π-D′-A-π-A). Comparatively, the ligand coupled bulky CF3 acceptor on the para position of benzyl moiety-substituted 2-(pyridin-2-yl)-benzimidazole (on the N-H position) [ptpbi]-coordinated copper metal complex shows a higher redox potential (0.62 V vs NHE) compare to Co2+/3+ redox system. The photovoltaic performance of thio-bridged pyridinyl based organic compounds (MPP and DSP) with/without highly electron-donating substituents (Me group) as an additive in QSSE host for dye-sensitized solar cell applications has been employed. A thorough investigation has been made for blending polysaccharide polymer-based electrolytes E1 to E4 through DSC, FTIR, UV-Vis spectroscopic techniques. The anal. of assembled device as [TiO2/DPTCY Dye/Mn+/m + redox/additive/LP blend biopolymer/Pt] has achieved a maximum PCE of 5.97% under 1 sun (100 mW cm-2) condition with 1.5AM. These results signify a record for copper complex with methyl-substituted thio-bridged pyridinyl (MPP) with higher efficiency. These devices had shown a higher chem. capacitance (6.06 x 10-6 F), recombination resistance (25.5 Ω), charge transfer resistance (5.67 Ω), ionic conductivity (1.568 (S cm-1) x 10-3), electron lifetime (48.97 ms), diffusion coefficient (2.63 x 10-7 cm-2 s), dielec. constant (2.76 x 102) and dielec. loss (4.41 x 103) compared with other substitution-based additives. These additives have trapped the diffusion of Cu2+ and Co3+ ion species has resulted in the constraint resistance and enhancement of the catalytic effect of the counter electrode. The higher charge relaxation time and a neg. shift in the Quasi-Fermi level of TiO2 arise by correlating photocurrent and photovoltage in suppression of recombination reaction. In the experiment, the researchers used many compounds, for example, 2-Bromo-5-methylpyridine(cas: 3510-66-5Quality Control of 2-Bromo-5-methylpyridine)

2-Bromo-5-methylpyridine(cas: 3510-66-5) belongs to pyridine. Pyridine is a relatively complex molecule and exhibits a number of different bands in IR spectra. Among others, the bands characterizing the ν8a and ν19b modes have been found to be sensitive to the coordination or protonation of the molecule. Note that the band that is diagnostic for the PyH+ ion at about 1545 cm− 1 (ν19b mode) does not overlap with any of the other bands.Quality Control of 2-Bromo-5-methylpyridine

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem