Month: October 2022

SDS of cas: 1158763-55-3On March 31, 2017, Wang, Min; Wu, Chunjiang; Xu, Shan; Zhu, Yan; Li, Wei; Zheng, Pengwu; Zhu, Wufu published an article in Medicinal Chemistry (Sharjah, United Arab Emirates). The article was 《Synthesis, Biological Evaluation and Docking Studies of Sorafenib Derivatives N-(3-fluoro-4-(pyridin-4-yloxy)phenyl)-4(5)-phenylpicolinamides》. The article mentions the following:

Sorafenib is an important VEGFR2/KDR inhibitor which is widely used for the treatment of cancer. In this paper, two series of sorafenib analogs N-(3-fluoro-4-(pyridin-4-yloxy)phenyl)-4- phenylpicolinamides(13a-k) and N-(3-fluoro-4-(pyridin-4-yloxy)phenyl)-5-phenylpicolinamides (14a-k) were designed and synthesized. Their structures were confirmed by various anal. methods, such as 1 H and 13 C NMR, m.p., MS, HRMS. All of them were evaluated for IC50 values against three cancer cell lines (A549, PC-3 and MCF-7). Eleven of the synthesized compounds showed moderate to excellent cytotoxicity activity against different cancer cells, whose potency from single-digit μM to nanomolar range. And five of them were equal to more potent than sorafenib against one or more cell lines. The most promising compound 14c showed excellent antitumor activities against PC-3 and MCF-7 cell lines with IC50 values of 2.62±1.07 μM and 1.14±0.92 μM, which were 1.15 to 2.75-fold more active than sorafenib (3.03±1.01 μM, 3.14±1.65 μM), resp. Structure-activity relationships (SARs) and docking studies indicated that the replacement of diarylurea of sorafenib with phenylpicolinamide moiety benefited to the activity. The position of aryl group and the substituents of aryl group had a great influence on antitumor activity and selectivity. The aryl groups with the substitute of alkyl groups (-CH3), halogen atoms (-F,Cl) were favorable to the cytotoxicity. However, this series of compounds showed moderate activity against VEGFR2/KDR kinase. Mechanism of target compounds was not quite clear and further study will be carried out to identify the possible target.5-(3-Fluorophenyl)picolinic acid(cas: 1158763-55-3SDS of cas: 1158763-55-3) was used in this study.

5-(3-Fluorophenyl)picolinic acid(cas: 1158763-55-3) belongs to pyridine derivatives. The ring atoms in the pyridine molecule are sp2-hybridized. The nitrogen is involved in the π-bonding aromatic system using its unhybridized p orbital. SDS of cas: 1158763-55-3The lone pair is in an sp2 orbital, projecting outward from the ring in the same plane as the σ bonds.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

In 2019,Journal of Biomolecular Structure and Dynamics included an article by Anjomshoa, Marzieh; Torkzadeh-Mahani, Masoud; Sahihi, Mehdi; Rizzoli, Corrado; Ansari, Mehdi; Janczak, Jan; Sherafat Esfahani, Sheila; Ataei, Farangis; Dehkhodaei, Monireh; Amirheidari, Bagher. Synthetic Route of C12H12N2. The article was titled 《Tris-chelated complexes of nickel(II) with bipyridine derivatives: DNA binding and cleavage, BSA binding, molecular docking, and cytotoxicity》. The information in the text is summarized as follows:

Two nickel(II) complexes with substituted bipyridine ligand of the type [Ni(NN)3](ClO4)2, where NN is 4,4′-dimethyl-2,2′-bipyridine (dimethylbpy) () and 4,4′-dimethoxy-2,2′-bipyridine (dimethoxybpy) (), have been synthesized, characterized, and their interaction with DNA and bovine serum albumin (BSA) studied by different phys. methods. X-ray crystal structure of shows a six-coordinate complex in a distorted octahedral geometry. DNA-binding studies of and reveal that both complexes sit in DNA groove and then interact with neighboring nucleotides differently; undergoes a partial intercalation. This is supported by mol.-docking studies, where hydrophobic interactions are apparent between and DNA as compared to hydrogen bonding, hydrophobic, and p-p interactions between and DNA minor groove. Moreover, the two complexes exhibit oxidative cleavage of supercoiled plasmid DNA in the presence of hydrogen peroxide as an activator in the order of >. In terms of interaction with BSA, the results of spectroscopic methods and mol. docking show that binds with BSA only via hydrophobic contacts while interacts through hydrophobic and hydrogen bonding. It has been extensively demonstrated that the nature of the methyl- and methoxy-groups in ligands is a strong determinant of the bioactivity of nickel(II) complexes. This may justify the above differences in biomol. interactions. The experimental process involved the reaction of 4,4′-Dimethyl-2,2′-bipyridine(cas: 1134-35-6Synthetic Route of C12H12N2)

4,4′-Dimethyl-2,2′-bipyridine(cas: 1134-35-6) is used as a chemical Intermediate. It can be used for the determination of ferrous and cyanide compounds.Synthetic Route of C12H12N2 Furthermore, 4,4′-Dimethyl-2,2′-bipyridine is used in the synthesis of a series of o-phenanthroline-substituted ruthenium(II) complexes.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

In 2019,Chemical Communications (Cambridge, United Kingdom) included an article by Xia, Peng-Ju; Ye, Zhi-Peng; Song, Dan; Ren, Ji-Wei; Wu, Han-Wen; Xiao, Jun-An; Xiang, Hao-Yue; Chen, Xiao-Qing; Yang, Hua. Recommanded Product: 94928-86-6. The article was titled 《Photocatalytic reductive radical-radical coupling of N,N’-cyclicazomethine imines with difluorobromo derivatives》. The information in the text is summarized as follows:

A visible-light-induced difluoroalkylation of N,N’-cyclicazomethine imine was successfully realized through a novel photoredox radical-radical cross-coupling reaction. This developed protocol exhibits high functional group tolerance and affords a variety of difluorinated 3-pyrazolidinone scaffolds. Extensive mechanistic investigations have been undertaken, well revealing the involvement of a reductive radical-radical coupling pathway. The experimental process involved the reaction of fac-Tris(2-phenylpyridine)iridium(cas: 94928-86-6Recommanded Product: 94928-86-6)

fac-Tris(2-phenylpyridine)iridium(cas: 94928-86-6) belongs to pyridine. Pyridine is very deactivated towards electrophilic substitution with respect to benzene. For this reason classical formylation, using methods such as the Gattermann or Vilsmeier reactions, are not generally successful. Recommanded Product: 94928-86-6

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

The author of 《Anion-π and H-Bonding Interactions Supporting Encapsulation of [Ln(NO3)6/5]3-/2- (Ln = Nd, Er) with a Triazine-Based Ligand》 were de Bettencourt-Dias, Ana; Beeler, Rose M.; Zimmerman, Joshua R.. And the article was published in Journal of the American Chemical Society in 2019. Related Products of 1539-42-0 The author mentioned the following in the article:

Reaction of NdIII and ErIII nitrate salts with a 1,3,5-tris(dipicolylamine)-triazine (dpat) ligand yielded two unprecedented examples of [Ln(NO3)6/5]3-/2- (Ln = Nd, Er) moieties completely encapsulated by the ligands. They are found in the two new complexes, [(H3dpat)2][(Nd(NO3)6)2]·2CH3CN (1), and the related [(H3dpat)2][(Er(NO3)5)3]·3CH3CN·2H2O (2). The structures of the complexes are similar and they crystallize in the triclinic P-1 space group with a 12.1630(3), b 12.2694(3), c 17.6357(5) Å, and a 14.3372(4), b 17.1271(4), c 25.2207(7) Å, resp. Anion-π interactions, which are reported here for the first time for LnIII ion complexes, hydrogen bonding interactions and π-π stacking support the formation of the encapsulated species. Evidence of the protonated dpat ligand in 1 and 2 was found through isolation of (H2dpat)(NO3)2. Finally, the pH-dependent ability of the ligand to extract LaIII and nitrate ions from aqueous into toluene solution is demonstrated. In the experiment, the researchers used Bis(pyridin-2-ylmethyl)amine(cas: 1539-42-0Related Products of 1539-42-0)

Bis(pyridin-2-ylmethyl)amine(cas: 1539-42-0) is a secondary amine with two picolyl substituents. As a tridentate ligand this compound provides three nitrogen donors that affords good selectivity for Zn2+ over biologically relevant metals such as Na+, K+, Mg2+ and Ca2+, and leaves coordination sites free for anion binding. Related Products of 1539-42-0

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

The author of 《Stress associated protein from Lobularia maritima: Heterologous expression, antioxidant and antimicrobial activities with its preservative effect against Listeria monocytogenes inoculated in beef meat》 were Ben Hsouna, Anis; Ben Saad, Rania; Zouari, Nabil; Ben Romdhane, Walid; Brini, Faical; Ben Salah, Riadh. And the article was published in International Journal of Biological Macromolecules in 2019. Formula: C6H5NO2 The author mentioned the following in the article:

Stress associated Protein from Lobularia maritima (LmSAP) transcripts showed up-regulation in response to wounding, Methyl-jasmonate acid, Picolinic acid, and ethephon treatments. The antioxidant activities of the purified LmSAP protein were evaluated using various in vitro and in vivo assays. LmSAP has an excellent DPPH scavenging ability and exhibits notable reducing power capacity and led to a decrease in TBARS values. The LmSAP showed an important antimicrobial activity against different pathogenic strains tested. In fact, the Inhibition Zone (IZ), Minimal Inhibitory Concentration (MIC) and The Min. Bactericidal Concentration (MCB) recorded were in the range of 14-22 mm, 62-250 μg/mL and 125-250 μg/mL, resp. The LmSAP protein successfully inhibited the growth of L. monocytogenes in minced beef meat. Furthermore, the LmSAP enhanced the sensory acceptability extending the shelf life of minced beef meat. Overall, the finding demonstrates that the application of LmSAP may open new promising opportunities for the prevention of bacterial contamination, particularly L. monocytogenes, during minced beef meat storage. In addition to this study using Picolinic acid, there are many other studies that have used Picolinic acid(cas: 98-98-6Formula: C6H5NO2) was used in this study.

Picolinic acid(cas: 98-98-6) is used in the preparation of 2-Aminodihydro[1,3]thiazines as BACE 2 inhibitors and their preparation and use in the treatment of diabetes.Formula: C6H5NO2

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

《Photocatalytic site-selective C-H difluoroalkylation of aromatic aldehydes》 was published in Chemical Communications (Cambridge, United Kingdom) in 2020. These research results belong to Tang, Wei-Ke; Tang, Fei; Xu, Jun; Zhang, Qi; Dai, Jian-Jun; Feng, Yi-Si; Xu, Hua-Jian. Name: fac-Tris(2-phenylpyridine)iridium The article mentions the following:

The direct photocatalyzed para-selective CAr-H difluoroalkylation of aromatic aldehyde derivatives has been accomplished using a newly explored catalytic system. In addition, when using para-substituted benzaldehydes as substrates, ortho-selective CAr-H difluoroalkylation was also accomplished. It is worth noting that all the above site-selectivity is opposite to traditional Friedel-Crafts reactions of aromatic aldehydes. The preliminary mechanistic investigations indicate that an electrophilic difluoroalkyl radical is involved in the catalytic cycle.fac-Tris(2-phenylpyridine)iridium(cas: 94928-86-6Name: fac-Tris(2-phenylpyridine)iridium) was used in this study.

fac-Tris(2-phenylpyridine)iridium(cas: 94928-86-6) belongs to pyridine. In industry and in the lab, pyridine is used as a reaction solvent, particularly when its basicity is useful, and as a starting material for synthesizing some herbicides, fungicides, and antiseptics.Name: fac-Tris(2-phenylpyridine)iridium

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

《New α-hydroxy-1,2,3-triazoles and 9H-fluorenes-1,2,3-triazoles: synthesis and evaluation as glycine transporter 1 inhibitors》 was published in Journal of the Brazilian Chemical Society in 2020. These research results belong to Da Silva, Veronica D.; Silva, Rafaela R.; Neto, Joao Goncalves; Lopez-Corcuera, Beatriz; Guimaraes, Marilia Z.; Noeel, Francois; Buarque, Camilla D.. HPLC of Formula: 128071-75-0 The article mentions the following:

Two series of new compounds containing 1,2,3-triazole moiety were designed as putative GlyT1 inhibitors aiming the discovery of new hits with activity in cognitive disorders. 1,4-disubstituted α-hydroxy-1,2,3-triazoles I [Ar = Ph, 4-BrC6H4, 4-C(O)MeC6H4, etc.; X = H, Br, Ph, etc.; Y = CH, N; Z = H, Br] were obtained as racemates in moderate to good yields by the copper-catalyzed azide-alkyne cycloaddition reaction (click chem.) as the key step between propargyl alcs. and aryl azides, previously prepared from anilines or boronic acids. Benzo[c]chromene-triazoles were planned to be obtained by palladium-catalyzed C-H activation using [bis(trifluoroacetoxy)iodobenzene] of some compounds I, since benzo[c]chromenes were also privileged groups with several biol. activities, including to the central nervous system. Unexpectedly, 9H-fluorenes-1,2,3-triazoles II [R = F, OMe, C(O)Me] instead of benzo[c]chromene-triazoles, were obtained by Friedel-Crafts alkylation reaction of compounds I [Ar = 4-MeOC6H4, 4-FC6H4, 4-C(O)MeC6H4; X = Ph; Y = CH; Z = H]. Two series of compounds I and II were tested for inhibition of the glycine transporter (rat GlyT1 isoform) but only compound I [Ar = 4-BrC6H4; X = Br; Y = CH; Z = H] was active (half maximal inhibitory concentration (IC50) = 8.0μM). The experimental part of the paper was very detailed, including the reaction process of 2-Bromonicotinaldehyde(cas: 128071-75-0HPLC of Formula: 128071-75-0)

2-Bromonicotinaldehyde(cas: 128071-75-0) belongs to pyridine. In industry and in the lab, pyridine is used as a reaction solvent, particularly when its basicity is useful, and as a starting material for synthesizing some herbicides, fungicides, and antiseptics.HPLC of Formula: 128071-75-0

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

《Rotaxanating Metallo-supramolecular Nano-cylinder Helicates to Switch DNA Junction Binding》 was published in Journal of the American Chemical Society in 2020. These research results belong to Hooper, Catherine A. J.; Cardo, Lucia; Craig, James S.; Melidis, Lazaros; Garai, Aditya; Egan, Ross T.; Sadovnikova, Viktoriia; Burkert, Florian; Male, Louise; Hodges, Nikolas J.; Browning, Douglas F.; Rosas, Roselyne; Liu, Fengbo; Rocha, Fillipe V.; Lima, Mauro A.; Liu, Simin; Bardelang, David; Hannon, Michael J.. Safety of 2-(Bromomethyl)pyridine hydrobromide The article mentions the following:

A class of rotaxane is created, not by encapsulating a conventional linear thread, but rather by wrapping a large cucurbit[10]uril macrocycle about a three-dimensional, cylindrical, nanosized, self-assembled supramol. helicate as the axle. The resulting pseudo-rotaxane is readily converted into a proper interlocked rotaxane by adding branch points to the helicate strands that form the surface of the cylinder (like branches and roots on a tree trunk). The supramol. cylinder that forms the axle is itself a member of a unique and remarkable class of helicate metallo-drugs that bind Y-shaped DNA junction structures and induce cell death. While pseudo-rotaxanation does not modify the DNA-binding properties, proper, mech.-interlocked rotaxanation transforms the DNA-binding and biol. activity of the cylinder. The ability of the cylinder to de-thread from the rotaxane (and thus to bind DNA junction structures) is controlled by the extent of branching: fully-branched cylinders are locked inside the cucurbit[10]uril macrocycle, while cylinders with incomplete branch points can de-thread from the rotaxane in response to competitor guests. The number of branch points can thus afford kinetic control over the drug de-threading and release. In the part of experimental materials, we found many familiar compounds, such as 2-(Bromomethyl)pyridine hydrobromide(cas: 31106-82-8Safety of 2-(Bromomethyl)pyridine hydrobromide)

2-(Bromomethyl)pyridine hydrobromide(cas: 31106-82-8) belongs to pyridine. Pyridine is very deactivated towards electrophilic substitution with respect to benzene. For this reason classical formylation, using methods such as the Gattermann or Vilsmeier reactions, are not generally successful. Safety of 2-(Bromomethyl)pyridine hydrobromide

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

《A highly sensitive “”ON-OFF”” optical sensor for the selective detection of cyanide ions in 100% aqueous solutions based on hydrogen bonding and water assisted aggregation induced emission》 was written by Nazarian, Ramo; Darabi, Hossein Reza; Aghapoor, Kioumars; Firouzi, Rohoullah; Sayahi, Hani. Reference of 2,6-Diaminopyridine And the article was included in Chemical Communications (Cambridge, United Kingdom) in 2020. The article conveys some information:

Nanoparticles N,N’-(pyridine-2,6-diyl)bis(2-(2,4-dichlorophenoxy)acetamide) exhibited an “”on-off”” emission response toward cyanide (CN-) ions in 100% aqueous solutions based on AIE features. AIEgen 1 is an easy-to-use probe that exhibits rapid response (5 s), extremely high sensitivity (limit of detection = 8.2 nM) and excellent selectivity. The sensing performance of CN- through a test kit and bitter seed solutions was good. The exptl. results show that compound 1 is planar and can self-assemble into a supramol. system and show blue emission. Then, CN- destroys both hydrogen bonds and the aggregates of 1 and quenches the emission. This process is reversible upon the addition of HCl solution In addition to this study using 2,6-Diaminopyridine, there are many other studies that have used 2,6-Diaminopyridine(cas: 141-86-6Reference of 2,6-Diaminopyridine) was used in this study.

2,6-Diaminopyridine(cas: 141-86-6) belongs to pyridine. Pyridine and its simple derivatives are stable and relatively unreactive liquids, with strong penetrating odours that are unpleasant.Reference of 2,6-Diaminopyridine

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

《Highly efficient and selective photocatalytic CO2 to CO conversion in aqueous solution》 was written by Chai, Xiaomin; Huang, Hai-Hua; Liu, Huiping; Ke, Zhuofeng; Yong, Wen-Wen; Zhang, Ming-Tian; Cheng, Yuan-Sheng; Wei, Xian-Wen; Zhang, Liyan; Yuan, Guozan. Reference of Bis(pyridin-2-ylmethyl)amine And the article was included in Chemical Communications (Cambridge, United Kingdom) in 2020. The article conveys some information:

Five mol. complexes with different non-noble metal centers were synthesized. The Co-based complex displays the highest photocatalytic performance for CO2 to CO conversion in aqueous media. It achieves high activity (TON = 41 017 and TOF = 3.80 s-1) and selectivity (87%) for the production of CO. In the part of experimental materials, we found many familiar compounds, such as Bis(pyridin-2-ylmethyl)amine(cas: 1539-42-0Reference of Bis(pyridin-2-ylmethyl)amine)

Bis(pyridin-2-ylmethyl)amine(cas: 1539-42-0) is a secondary amine with two picolyl substituents. As a tridentate ligand this compound provides three nitrogen donors that affords good selectivity for Zn2+ over biologically relevant metals such as Na+, K+, Mg2+ and Ca2+, and leaves coordination sites free for anion binding. Reference of Bis(pyridin-2-ylmethyl)amine

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem