Month: October 2022

Recommanded Product: 2,6-DibromopyridineIn 2020 ,《Spin transition in a ferrous chloride complex supported by a pentapyridine ligand》 appeared in Chemical Communications (Cambridge, United Kingdom). The author of the article were Boniolo, Manuel; Shylin, Sergii I.; Chernev, Petko; Cheah, Mun Hon; Heizmann, Philipp A.; Huang, Ping; Salhi, Nessima; Hossain, Kamal; Thapper, Anders; Lundberg, Marcus; Messinger, Johannes. The article conveys some information:

Ferrous chloride complexes [FeIILxCl] commonly attain a high-spin state independently of the supporting ligand(s) and temperature Herein, authors present the first report of a complete spin crossover with T1/2 = 80 K in [FeII(Py5OH)Cl]+ (Py5OH = pyridine-2,6-diylbis[di(pyridin-2-yl)methanol]). Both spin forms of the complex are analyzed by x-ray spectroscopy and DFT calculations2,6-Dibromopyridine(cas: 626-05-1Recommanded Product: 2,6-Dibromopyridine) was used in this study.

2,6-Dibromopyridine(cas: 626-05-1) belongs to pyridine. The basicity and metallophilic high donor number of these π-deficient systems has long favored them as ligands in metal catalysis. The last decade saw pyridine assume a stronger role as functional group for directed C–H oxidation/activation.Recommanded Product: 2,6-Dibromopyridine

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Safety of 2-(2-Hydroxyethyl)pyridineIn 2018 ,《Polydentate 4-Pyridyl-terpyridine Containing Discrete Cobalt Phosphonate and Polymeric Cobalt Phosphate as Catalysts for Alcohol Oxidation》 appeared in Zeitschrift fuer Anorganische und Allgemeine Chemie. The author of the article were Bhat, Gulzar A.; Rajendran, Antony; Murugavel, Ramaswamy. The article conveys some information:

Mononuclear discrete cobalt phosphonate [Co(pytpy)(tBuPO3H)2(H2O)]·H2O (1) and 1D zigzag polymeric cobalt phosphate [Co(pytpy)2(dipp)(MeOH)·2MeOH]n (2) were prepared from the reactions of tert-Bu phosphonic acid (tBuPO3H2) and organic-soluble 2,6-diisopropylphenyl phosphate (dippH2) ligands with Co(OAc)2·4H2O in the presence of 4-pyridyl 2,2:6,2-terpyridine in MeOH/CHCl3(1:1 volume/volume) solvent mixture at 25 °C. The new compounds were characterized by anal., thermo-anal., and spectroscopic techniques. Further, the mol. structures were established by single-crystal X-ray diffraction studies. Mass spectrometry anal. reveal that both the compounds exist in the solution phase as dimers. Compound 1 was employed as homogeneous catalysts for alc. oxidation reactions using tert-Bu hydroperoxide (TBHP) as the oxidant. In addition to this study using 2-(2-Hydroxyethyl)pyridine, there are many other studies that have used 2-(2-Hydroxyethyl)pyridine(cas: 103-74-2Safety of 2-(2-Hydroxyethyl)pyridine) was used in this study.

2-(2-Hydroxyethyl)pyridine(cas: 103-74-2) belongs to pyridine. Pyridine and pyridine-derived structures are privileged pharmacophores in medicinal chemistry and an essential functionality for organic chemists. As the prototypical π-deficient heterocycle, pyridine illustrates distinctive chemistry as both substrate and reagent. Safety of 2-(2-Hydroxyethyl)pyridine

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

《Theoretical exploration of 2,2′-bipyridines as electro-active compounds in flow batteries》 was written by Sanchez-Castellanos, Mariano; Flores-Leonar, Martha M.; Mata-Pinzon, Zaahel; Laguna, Humberto G.; Garcia-Ruiz, Karl M.; Rozenel, Sergio S.; Ugalde-Saldivar, Victor M.; Moreno-Esparza, Rafael; Pijpers, Joep J. H.; Amador-Bedolla, Carlos. Formula: C12H10Cl2N2 And the article was included in Physical Chemistry Chemical Physics in 2019. The article conveys some information:

Compounds from the 2,2′-bipyridine mol. family were investigated for use as redox-active materials in organic flow batteries. For 156 2,2′-bipyridine derivatives reported in the academic literature, we calculated the redox potential, the pKa for the second deprotonation reaction, and the solubility in aqueous solutions Using exptl. data on a small subset of derivatives, we were able to calibrate our calculations We find that functionalization with electron-withdrawing groups leads to an increase of the redox potential and to an increase of the mol. acidity (as expressed in a reduction of the pKa value for the second deprotonation step). Furthermore, calculations of solubility in water indicate that some of the studied derivatives have adequate solubility for flow battery applications. Based on an anal. of the physico-chem. properties of the 156 studied compounds, we down-select five mols. with carbonyl- and nitro-based functional groups, whose parameters are especially promising for potential applications as neg. redox-active materials in organic flow batteries. In addition to this study using 4,4′-Bis(chloromethyl)-2,2′-bipyridine, there are many other studies that have used 4,4′-Bis(chloromethyl)-2,2′-bipyridine(cas: 138219-98-4Formula: C12H10Cl2N2) was used in this study.

4,4′-Bis(chloromethyl)-2,2′-bipyridine(cas: 138219-98-4) belongs to pyridine derivatives. The ring atoms in the pyridine molecule are sp2-hybridized. The nitrogen is involved in the π-bonding aromatic system using its unhybridized p orbital. Formula: C12H10Cl2N2 Pyridine has a conjugated system of six π electrons that are delocalized over the ring.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

In 2017,Wang, Xin; Lv, Huichao; Yang, Liguo; Dai, Yuqiang published 《Crystal structure of bis(μ2-azido-κ2N:N)-dichlorido-bis(μ2-2-(pyridin-2-yl)ethan-1-ol-κ2O,N)dicopper(II), C14H18Cl2Cu2N8O2》.Zeitschrift fuer Kristallographie – New Crystal Structures published the findings.Quality Control of 2-(2-Hydroxyethyl)pyridine The information in the text is summarized as follows:

C14H18Cl2Cu2N8O2, monoclinic, P21/n (number 14), a = 6.0166(6) Å, b = 15.2792(14) Å, c = 11.5833(12) Å, β = 100.295(1)°, V = 1047.70(18) Å3, Z = 2, Rgt(F) = 0.0412, wRref(F2) = 0.0884, T = 298 K. In the experiment, the researchers used 2-(2-Hydroxyethyl)pyridine(cas: 103-74-2Quality Control of 2-(2-Hydroxyethyl)pyridine)

2-(2-Hydroxyethyl)pyridine(cas: 103-74-2) belongs to pyridine. Pyridine is very deactivated towards electrophilic substitution with respect to benzene. For this reason classical formylation, using methods such as the Gattermann or Vilsmeier reactions, are not generally successful. Quality Control of 2-(2-Hydroxyethyl)pyridine

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

In 2018,Chemical Communications (Cambridge, United Kingdom) included an article by Fieser, Megan E.; Schimler, Sydonie D.; Mitchell, Lauren A.; Wilborn, Emily G.; John, Alex; Hogan, Levi T.; Benson, Brooke; LaPointe, Anne M.; Tolman, William B.. Application In Synthesis of 2-(2-Hydroxyethyl)pyridine. The article was titled 《Dual-catalytic decarbonylation of fatty acid methyl esters to form olefins》. The information in the text is summarized as follows:

The homogeneous dehydrative decarbonylation of fatty acid Me esters (FAMEs) to form olefins was reported. In order to facilitate cleavage of the unactivated acyl C-O bond of the alkyl ester, a one pot dual-catalytic directing group strategy was developed through optimization of the individual transesterification and decarbonylation reaction steps. The experimental part of the paper was very detailed, including the reaction process of 2-(2-Hydroxyethyl)pyridine(cas: 103-74-2Application In Synthesis of 2-(2-Hydroxyethyl)pyridine)

2-(2-Hydroxyethyl)pyridine(cas: 103-74-2) belongs to pyridine. Pyridine derivatives lend themselves to many roles in the spirited field of supramolecular chemistry – whether as the ligand backbone of metal-organic polymers or presiding over the key electronic stations of nanodevices. In biochemistry, pyridine-containing cofactors are necessary nutrients on which our lives depend. Application In Synthesis of 2-(2-Hydroxyethyl)pyridine

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

The author of 《Synthesis of ethyl 4-(4-nitrophenoxy) picolinate》 were Xiong, Hehua; Gao, Yanli; Yang, Qi; Tang, Qidong; Zheng, Pengwu. And the article was published in IOP Conference Series: Materials Science and Engineering in 2019. Category: pyridine-derivatives The author mentioned the following in the article:

Et 4-(4-nitrophenoxy) picolinate 4 is an important intermediate for the synthesis of many biol. active compounds The compound Et 4-(4- nitrophenoxy) picolinate was obtained by three simple steps to synthesis from 2- picoliniacid. In this paper, three novel chloropicolinoyl chloride derivatives were prepared The structure was confirmed by MS and 1H NMR. Furthermore, the synthetic method was optimized. The total yield of the target product was 78.57%. The experimental part of the paper was very detailed, including the reaction process of Picolinic acid(cas: 98-98-6Category: pyridine-derivatives)

Picolinic acid(cas: 98-98-6) is used in the preparation of 2-Aminodihydro[1,3]thiazines as BACE 2 inhibitors and their preparation and use in the treatment of diabetes.Category: pyridine-derivatives

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

《Crystal structure of 5-((bis(pyridin-2-ylmethyl)amino)methyl)quinolin-8-ol, C22H20N4O》 was published in Zeitschrift fuer Kristallographie – New Crystal Structures in 2020. These research results belong to Liu, Jia; Nie, Xu-Liang; Yin, Zhong-Ping; Peng, Da-Yong; Shi, Xu-Gen. Synthetic Route of C12H13N3 The article mentions the following:

C22H20N4O, monoclinic, P21/n (number 14), a = 11.1861(14) Å, b = 8.1418(10) Å, c = 20.461(3) Å, β = 97.433(1)°, V = 1847.8(4) Å3, Z = 4, Rgt(F) = 0.0357, wRref(F2) = 0.1002, T = 296(2) K. CCDC number: 1967398. To a mixture of 8-hydroxyquinoline-5-carbaldehyde (1.04 g, 6 mmol) and bis(pyridin-2-ylmethyl)amine (1.22 g, 6 mmol) in CH2Cl2 (50 mL) was added sodium triacetoxyborohydride (1.4 g, 6.6 mmol) at 0 °C. The mixture was stirred for 24 h at room temperature Dichloromethane was removed by evaporation and the residue was purified by chromatog. on silica gel (eluent: Et acetate) to give the yellow solid [5, 6]. m.p. 102 °C-106 0C; 1H NMR (400 MHz, CDCl3) δ [ppm] 8.78-8.73 (m, 1H), 8.65-8.57 (m, 1H), 8.56-8.51 (m, 2H), 7.67- 7.60 (m, 2H), 7.55-7.49 (m, 1H), 7.48-7.42 (m, 1H), 7.41-7.35 (m, 2H), 7.21-7.13 (m, 2H), 7.06 (d, j = 7.8 Hz, 1H), 4.25-4.14 (m, 2H), 4.06-3.95 (m, 4H); 13C NMR (100 MHz, CDCl3) δ [ppm] 158.07, 152.08, 148.51, 147.48, 138.48, 136.81, 133.99, 129.86, 127.77,124.02,123.65,122.31,121.53,108.94, 59.681, 56.29. After reading the article, we found that the author used Bis(pyridin-2-ylmethyl)amine(cas: 1539-42-0Synthetic Route of C12H13N3)

Bis(pyridin-2-ylmethyl)amine(cas: 1539-42-0) is a secondary amine with two picolyl substituents. As a tridentate ligand this compound provides three nitrogen donors that affords good selectivity for Zn2+ over biologically relevant metals such as Na+, K+, Mg2+ and Ca2+, and leaves coordination sites free for anion binding. Synthetic Route of C12H13N3

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

《Structures and photophysical properties of two luminescent bipyridine compounds: 2′,6′-difluoro-6-[3-(pyridin-2-yloxy)phenyl]-2,3′-bipyridine and 2′,6′-dimethoxy-6-[3-(pyridin-2-yloxy)phenyl]-2,3′-bipyridine》 was published in Acta Crystallographica, Section C: Structural Chemistry in 2020. These research results belong to Park, Ki-Min; Yang, Kiyull; Moon, Suk-Hee; Kang, Youngjin. Related Products of 626-05-1 The article mentions the following:

The title compounds, C21H13F2N3O (1) and C23H19N3O3 (2), have been synthesized by typical cross-coupling reactions. Both compounds have been characterized by single-crystal X-ray diffraction. Bipyridine 1 exhibits a fully extended structure in which the terminal pyridine rings are oriented away from each other, while bipyridine 2 displays a bent structure in which terminal pyridine rings are oriented in the same direction. Several intermol. interactions lead to the formation of two- and three-dimensional supramol. networks in the crystal structures of 1 and 2, resp. Compound 1 bears fluorine substituents and emits a strong fluorescence with λmax = 325 nm, while methoxy-substituted compound 2 displays red-shifted emissions with λmax = 366 nm. The emissions observed in both compounds originate from phenyl- and 2,3′-bipyridine-based π-π* transitions, according to theor. calculations Both compounds have high triplet energies (T1) ranging from 2.64 to 2.65 eV, which makes them potential host materials in organic light-emitting diodes (OLEDs). In the experimental materials used by the author, we found 2,6-Dibromopyridine(cas: 626-05-1Related Products of 626-05-1)

2,6-Dibromopyridine(cas: 626-05-1) belongs to pyridine. Pyridine is very deactivated towards electrophilic substitution with respect to benzene. For this reason classical formylation, using methods such as the Gattermann or Vilsmeier reactions, are not generally successful. Related Products of 626-05-1

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

In 2022,Peng, Sasa; Wang, Huaxin; Ding, Haichang; Fan, Congbin; Liu, Gang; Pu, Shouzhi published an article in Journal of Photochemistry and Photobiology, A: Chemistry. The title of the article was 《A high selective chemosensor for detection of Al3+ based on diarylethene with a hydrazide unit》.Recommanded Product: 2510-22-7 The author mentioned the following in the article:

Al3+ plays an indispensable role in different physiol. processes. However, excess Al3+ is destructive to health. Here, a diarylethene-based fluorescent sensor (1O) was synthesized by attaching a hydrazide group to diarylethene moiety through Schiff base structure. In acetonitrile, 1O displayed excellent selectivity and sensitivity to Al3+. The fluorescence intensity increased by 70-fold and accompanied by the color of the solution changed from dark to blue with the addition of Al3+. Further, the potential response mechanism of 1O toward Al3+ was proposed and verified by 1H NMR titrations and mass spectrometry anal., the stoichiometric ratios of the sensor with Al3+ appeared to be 1:1 with the detection limit of 0.073 μM. In addition, 1O has been successfully applied to the detection of Al3+ in real water samples, and it also has successfully designed as mol. logic circuit and test strips. In the experiment, the researchers used many compounds, for example, 4-Ethynylpyridine(cas: 2510-22-7Recommanded Product: 2510-22-7)

4-Ethynylpyridine(cas: 2510-22-7) belongs to pyridine. Pyridine is very deactivated towards electrophilic substitution with respect to benzene. For this reason classical formylation, using methods such as the Gattermann or Vilsmeier reactions, are not generally successful. Recommanded Product: 2510-22-7

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

SDS of cas: 1134-35-6In 2020 ,《Unexpected disruption of the dimensionality-driven two-photon absorption enhancement within a multipolar polypyridyl ruthenium complex series》 was published in Chemical Communications (Cambridge, United Kingdom). The article was written by Durand, Nicolas; Mhanna, Rana; Savel, Paul; Akdas-Kilic, Huriye; Malval, Jean-Pierre; Soppera, Olivier; Fillaut, Jean-Luc. The article contains the following contents:

The dimensionality-driven 2-photon absorption (2PA) enhancement effect is studied in functionalized bipyridyl Ru complexes. The design strategy leads to very high 2PA responses up to ~1500 GM. The 2PA performance vs. dimensionality correlation reaches an unexpected limit stemming from anti-cooperative interchromophoric couplings. The experimental process involved the reaction of 4,4′-Dimethyl-2,2′-bipyridine(cas: 1134-35-6SDS of cas: 1134-35-6)

4,4′-Dimethyl-2,2′-bipyridine(cas: 1134-35-6) is used in the synthesis of a series of o-phenanthroline-substituted ruthenium(II) complexes.SDS of cas: 1134-35-6 Furthermore, 4,4′-Dimethyl-2,2′-bipyridine is used as a chemical Intermediate. It can be used for the determination of ferrous and cyanide compounds.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem