Month: October 2022

In 2022,Meena, Priyanka; Ayushee; Patel, Monika; Verma, Akhilesh K. published an article in Chemical Communications (Cambridge, United Kingdom). The title of the article was 《Transition-metal-free regioselective hydroamination of styrenes with amino-heteroarenes》.Safety of 6-Bromopyridin-3-amine The author mentioned the following in the article:

The base-mediated anti-Markovnikov hydroamination of functionally varied styrenes with amino-substituted pyridines, quinoline, pyrimidine, pyrazine with excellent regioselectivity to afford arylalkyl nitrogen heterocycles I [R1 = H, 4-Me, 6-Me, 4-CF3, etc; R2 = H, 4-Me, 4-Cl, etc.] and II [R3 = Ph, 4-MeC6H4, 1-naphthyl, 4-tBuC6H4; X = N; Y = N] was described. Double hydroamination was observed chemoselectively on the secondary amine, leaving the primary amine intact. The results came from multiple reactions, including the reaction of 6-Bromopyridin-3-amine(cas: 13534-97-9Safety of 6-Bromopyridin-3-amine)

6-Bromopyridin-3-amine(cas: 13534-97-9) belongs to anime. Nitrous acid converts secondary amines (aliphatic or aromatic) to N-nitroso compounds (nitrosamines): R2NH + HNO2 → R2N―NO. Some nitrosamines are potent cancer-inducing substances, and their possible formation is a serious consideration when nitrites, which are salts of nitrous acid, are present in foods or pharmaceutical preparations. Tertiary amines give rise to nitrosamines more slowly; an alkyl group is eliminated as an aldehyde or ketone, along with nitrous oxide, N2O.Safety of 6-Bromopyridin-3-amine

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

In 2022,Al-Sayed, Emir; Tanuhadi, Elias; Giester, Gerald; Rompel, Annette published an article in Acta Crystallographica, Section C: Structural Chemistry. The title of the article was 《Synthesis and characterization of the ′Japanese rice-ball′-shaped Molybdenum Blue Na4-[Mo2O2(OH)4(C6H4NO2)2]2[Mo120Ce6O366H12(OH)2(H2O)76]-200H2O》.Recommanded Product: 98-98-6 The author mentioned the following in the article:

The hybridized lanthanide-containing molybdenum blue (Ln-MB) wheel Na4[Mo2O2(OH)4(C6H4NO2)2]2[Mo120Ce6O366H12(OH)2(H2O)76]∼200H2O ({Mo2(C6H4NO2)2}2{Mo120Ce6}) was assembled in an aqueous one-pot synthesis. The Ln-MB was hybridized with 2-picolinic acid through the generation of the organometallic counter-ion [Mo2O2(OH)4(C6H4NO2)2]2+. Control experiments demonstrated that the position of the carboxylic acid group (2-position to the N atom) in the hybridization component is critical in yielding single crystals of Ln-MB. In addition to single-crystal X-ray diffraction (XRD) anal., which revealed a ′Japanese rice-ball′-shaped Ln-MB as the anion, elemental analyses, IR spectroscopy, and thermogravimetric anal. (TGA) were performed to confirm its structure and composition Bond-valence-sum calculations (BVS) revealed that ({Mo2(C6H4NO2)2}2{Mo120Ce6}) is composed of a 24-electron reduced anionic ring, which was confirmed by Vis-NIR spectroscopy. The results came from multiple reactions, including the reaction of Picolinic acid(cas: 98-98-6Recommanded Product: 98-98-6)

Picolinic acid(cas: 98-98-6) is used in the preparation of 2-Aminodihydro[1,3]thiazines as BACE 2 inhibitors and their preparation and use in the treatment of diabetes.Recommanded Product: 98-98-6

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

The author of 《High-turnover visible-light photoreduction of CO2 by a Re(I) complex stabilized on dye-sensitized TiO2》 were Ha, Eun-Gyeong; Chang, Jeong-Ah; Byun, Sung-Min; Pac, Chyongjin; Jang, Dong-Myung; Park, Jeunghee; Kang, Sang Ook. And the article was published in Chemical Communications (Cambridge, United Kingdom) in 2014. Name: 4,4′-Bis(chloromethyl)-2,2′-bipyridine The author mentioned the following in the article:

Hybrid systems prepared by fixing a Re(I) complex and a dye on three types of TiO2 nanoparticles in two different ways commonly revealed persistent photocatalysis of the CO2 reduction to CO with no leveling-off tendency under visible-light irradiation in DMF, giving a turnover number of ≥435. The experimental process involved the reaction of 4,4′-Bis(chloromethyl)-2,2′-bipyridine(cas: 138219-98-4Name: 4,4′-Bis(chloromethyl)-2,2′-bipyridine)

4,4′-Bis(chloromethyl)-2,2′-bipyridine(cas: 138219-98-4) belongs to pyridine derivatives. Several pyridine derivatives play important roles in biological systems. While its biosynthesis is not fully understood, nicotinic acid (vitamin B3) occurs in some bacteria, fungi, and mammals. Name: 4,4′-Bis(chloromethyl)-2,2′-bipyridine

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

In 2017,Colak, Alper Tolga; Gunay, Handan; Temel, Ersin; Buyukgungor, Orhan; Colak, Ferdag published 《Synthesis, crystal structures, characterization and antimicrobial activities of 5-hydroxyisophthalate complexes》.Transition Metal Chemistry (Dordrecht, Netherlands) published the findings.Quality Control of 2-(2-Hydroxyethyl)pyridine The information in the text is summarized as follows:

Two 5-hydroxyisophthalate complexes of nickel(II), formulated as [Ni(μ-Hhip)(2-hepy)2]n (1) and [Ni2(μ-Hhip)2(dap)4]n (2) (H3hip = 5-hydroxyisophthalic acid, 2-hepy = 2-(2-hydroxyethyl)pyridine, dap = 1,3-diaminopropane), have been synthesized and characterized by chem. and spectroscopic methods. The mol. structures of the complexes have been determined by single-crystal x-ray diffraction anal. The Ni(II) centers have distorted octahedral geometries in both crystals. Furthermore, both complexes have 1D chain structures in which the individual chains are linked together via hydrogen bonds to give 3D frameworks. Evaluation of the complexes by the agar diffusion method showed that they have weak antibiotic activities against the tested microorganisms. In the part of experimental materials, we found many familiar compounds, such as 2-(2-Hydroxyethyl)pyridine(cas: 103-74-2Quality Control of 2-(2-Hydroxyethyl)pyridine)

2-(2-Hydroxyethyl)pyridine(cas: 103-74-2) belongs to pyridine. When pyridine is adsorbed on oxide surfaces or in porous materials, the following species are commonly observed: (i) pyridine coordinated to Lewis acid sites, (ii) pyridine H-bonded to weakly acidic hydroxyls, and (iii) protonated pyridine. At high coverage, physisorbed pyridine and protonated dimers can also be observed.Quality Control of 2-(2-Hydroxyethyl)pyridine

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

In 2018,Gibson, Maya Z.; Nguyen, Minh A.; Zingales, Sarah K. published 《Design, Synthesis, and Evaluation of (2-(Pyridinyl)methylene)-1-tetralone Chalcones for Anticancer and Antimicrobial Activity》.Medicinal Chemistry (Sharjah, United Arab Emirates) published the findings.Category: pyridine-derivatives The information in the text is summarized as follows:

Background: Chalcones, natural products produced by plants as a natural defense mechanisms against various pathogens, are mols. with structures that include two aromatic rings joined by an α, β unsaturated carbonyl system. Previous research has demonstrated that chalcones exhibit a wide variety of biol. activities, including anticancer, antifungal, and antibiotic properties. Objective: Our goal is to synthesize novel heterocyclic-containing chalcones and have their biol. activities evaluated. Methods Sixteen chalcones were synthesized by the crossed aldol condensation of substituted tetralones with substituted pyridinylaldehydes. The products were purified by recrystallization in MeOH/H2O and characterized by 1H NMR, 13C NMR, and HRMS. Anticancer assays were performed by NCI (National Cancer Institute) against the NCI-60 panel of 60 different human cancer cell lines, including leukemia, non-small-cell lung cancer, colon, central nervous system, melanoma, ovarian, renal, prostate, and breast cancer. Antimicrobial assays were performed by COADD (Community for Open Antimicrobial Drug Discovery) against Escherichia coli, Klebsiella pneumonia, Acinetobacter baumannii, Pseudomonas aeruginosa, Staphylococcus aureus, Cryptococcus neoformans var. grubii, and Candida albicans. Result: Chalcone 3d had demonstrated growth inhibition greater than 60% against a variety of cancers: leukemia (MOLT-4, SR), non-small cell lung cancer (NCI-H522), colon cancer (HCT- 116), prostate cancer (DU-145), and breast cancer (MCF7, MDA-MB-468) and was also cytotoxic to three different cell lines (CCRF-CEM, RPMI-8226, and KM12). 5c was active against leukemia (CCRF-CEM, RPMI-8226, SR) and breast cancer (MCF7) and 5e was active only against leukemia (RPMI-8226, SR). 5h was partially active and the best compound with growth inhibition of MRSA by 75%. 3b was the best compound against EC, KP, and PA and 3f had the greatest activity against AB. For fungi, 3f and 3e demonstrated the best growth inhibition. Conclusion: A small library of heterocyclic-containing chalcones was developed and initial screening demonstrates modest activity against cancers, bacteria, and fungi. In the experiment, the researchers used many compounds, for example, 2-Bromonicotinaldehyde(cas: 128071-75-0Category: pyridine-derivatives)

2-Bromonicotinaldehyde(cas: 128071-75-0) belongs to pyridine. Pyridine is very deactivated towards electrophilic substitution with respect to benzene. For this reason classical formylation, using methods such as the Gattermann or Vilsmeier reactions, are not generally successful. Category: pyridine-derivatives

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

In 2019,Journal of Enzyme Inhibition and Medicinal Chemistry included an article by Elie, Jonathan; Vercouillie, Johnny; Arlicot, Nicolas; Lemaire, Lucas; Bidault, Rudy; Bodard, Sylvie; Hosselet, Christel; Deloye, Jean-Bernard; Chalon, Sylvie; Emond, Patrick; Guilloteau, Denis; Buron, Frederic; Routier, Sylvain. Related Products of 128071-75-0. The article was titled 《Design of selective COX-2 inhibitors in the (aza)indazole series. Chemistry, in vitro studies, radiochemistry and evaluations in rats of a [18F] PET tracer》. The information in the text is summarized as follows:

A series of novel derivatives exhibiting high affinity and selectivity towards the COX-2 enzyme in the (aza) indazole series was developed. A short synthetic route involving a bromination/arylation sequence under microwave irradiation and direct C-H activation were established in the indazole and azaindazole series resp. In vitro assays were conducted and structural modifications were carried out on these scaffolds to furnish compound which exhibited effective COX-2 inhibitory activity, with IC50 values of 0.409 μM and an excellent selectivity vs. COX-1. Radiolabeling of this most potent derivative [18F] was achieved after boron ester release and the tracer was evaluated in vivo in a rat model of neuroinflammation. All chem., radiochem. and biol. exptl. data are discussed. The experimental part of the paper was very detailed, including the reaction process of 2-Bromonicotinaldehyde(cas: 128071-75-0Related Products of 128071-75-0)

2-Bromonicotinaldehyde(cas: 128071-75-0) belongs to pyridine. Pyridine’s structure is isoelectronic with that of benzene, but its properties are quite different. Pyridine is completely miscible with water, whereas benzene is only slightly soluble. Like all hydrocarbons, benzene is neutral (in the acid–base sense), but because of its nitrogen atom, pyridine is a weak base.Related Products of 128071-75-0

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

《The conformational analyses of 2-amino-N-[2-(dimethylphenoxy)ethyl]propan-1-ol derivatives in different environments》 was published in Acta Crystallographica, Section C: Structural Chemistry in 2020. These research results belong to Nitek, Wojciech; Kania, Agnieszka; Marona, Henryk; Waszkielewicz, Anna M.; Zeslawska, Ewa. Application of 98-98-6 The article mentions the following:

Four crystal structures of 2-amino-N-(dimethylphenoxyethyl)propan-1-ol derivatives, characterized by X-ray diffraction anal., are reported. The free base (R,S)-2-amino-N-[2-(2,3-dimethylphenoxy)ethyl]propan-1-ol, C13H21NO2, 1, crystallizes in the space group P21/n, with two independent mols. in the asym. unit. The hydrochloride, (S)-N-[2-(2,6-dimethylphenoxy)ethyl]-1-hydroxypropan-2-aminium chloride, C13H21NO2+Cl-, 2c, crystallizes in the space group P21, with one cation and one chloride anion in the asym. unit. The asym. unit of two salts of 2-picolinic acid, namely, (R,S)-N-[2-(2,3-dimethylphenoxy)ethyl]-1-hydroxypropan-2-aminium pyridine-2-carboxylate, C13H22NO2+·C6H4NO2-, 1p, and (R)-N-[2-(2,6-dimethylphenoxy)ethyl]-1-hydroxypropan-2-aminium pyridine-2-carboxylate, C13H22NO2+·C6H4NO2-, 2p, consists of one cation and one 2-picolinate anion. Salt 1p crystallizes in the triclinic centrosym. space group P [inline formula omitted] , while salt 2p crystallizes in the space group P41212. The conformations of the amine fragments are contrasted and that of 2p is found to have an unusual antiperiplanar arrangement about the ether group. The crystal packing of 1 and 2c is dominated by hydrogen-bonded chains, while the structures of the 2-picolinate salts have hydrogen-bonded rings as the major features. In both salts with 2-picolinic acid, the specific R12(5) hydrogen-bonding motif is observed Structural studies have been enriched by the generation of fingerprint plots derived from Hirshfeld surfaces. In the experiment, the researchers used Picolinic acid(cas: 98-98-6Application of 98-98-6)

Picolinic acid(cas: 98-98-6) is used in the preparation of 2-Aminodihydro[1,3]thiazines as BACE 2 inhibitors and their preparation and use in the treatment of diabetes.Application of 98-98-6

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

《A lutidine-promoted photoredox catalytic atom-transfer radical cyclization reaction for the synthesis of 4-bromo-3,3-dialkyl-octahydro-indol-2-ones》 was written by Zhao, Quan-Sheng; Xu, Guo-Qiang; Xu, Ji-Tao; Wang, Zhu-Yin; Xu, Peng-Fei. Name: fac-Tris(2-phenylpyridine)iridium And the article was included in Chemical Communications (Cambridge, United Kingdom) in 2020. The article conveys some information:

Reported herein is a visible-light-catalyzed photoredox atom-transfer radical cyclization (ATRC) halo-alkylation of 1,6-dienes with α-halo-ketones as the ATRC reagent. This process exhibits high atom economy, high step economy, and high redox economy, which can directly construct a 4-bromo-3,3-dialkyl-octahydro-indol-2-one I (R1 = C6H5, 4-FC6H4, Ts, etc.; n = 0,1) core under mild conditions in one pot, and lutidine is found to be the key promoter for this ATRC process. In the part of experimental materials, we found many familiar compounds, such as fac-Tris(2-phenylpyridine)iridium(cas: 94928-86-6Name: fac-Tris(2-phenylpyridine)iridium)

fac-Tris(2-phenylpyridine)iridium(cas: 94928-86-6) belongs to pyridine. Pyridines form stable salts with strong acids. Pyridine itself is often used to neutralize acid formed in a reaction and as a basic solvent. Name: fac-Tris(2-phenylpyridine)iridium

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Cao, Bing-Jun; Li, Ran; Huang, Xi-He published their research in Acta Crystallographica, Section C: Structural Chemistry in 2021. The article was titled 《Synthesis, structure and photophysical properties of two tetranuclear copper(I) iodide complexes based on acetylpyridine and diphosphine mixed ligands》.Product Details of 1122-54-9 The article contains the following contents:

Two copper(I) iodide tetramers, namely, [μ2-1,3-bis(diphenylphosphanyl)propane-κ2P:P′]di-μ3-iodido-di-μ2-iodido-[1-(pyridin-3-yl)ethan-1-one-κN]tetracopper(I) dichloromethane disolvate, [Cu4I4(C6H7NO)2(C27H26P2)2]·2CH2Cl2 (CuL3), and [μ2-1,3-bis(diphenylphosphanyl)propane-κ2P:P′]di-μ3-iodido-di-μ2-iodido-[1-(pyridin-4-yl)ethan-1-one-κN]tetracopper(I), [Cu4I4(C6H7NO)2(C27H26P2)2] (CuL4), have been synthesized from reactions of CuI, 1,3-bis(diphenylphosphanyl)propane (dppp) and 3- or 4-acetylpyridine (3/4-acepy). The complexes were characterized by elemental anal., IR spectroscopy, single-crystal X-ray diffraction (XRD), powder XRD and photoluminescence spectroscopy. Both complexes possess a stair-step [Cu4I4] cluster structure with a crystallog. inversion center located in the middle of a Cu2I2 ring (Z′ = 1/2). The dppp ligands each adopt a bidentate coordination mode that bridges two CuI centers on one side of the [Cu4I4] cluster and the acepy ligands act as terminal ligands. The solid-state samples of similar complexes show highly efficiency thermally activated delayed fluorescence (TADF) at room temperature At ambient temperature, both CuL3 and CuL4 exhibit photoluminescence, with a maximum emission in the region 560-580 nm and with short emissive decay times, but only phosphorescence was observed at 77 K. The narrow gaps between the higher lying singlet state and the triplet state, ΔE(S1 – T1), also confirm the presence of TADF. Structure anal. and consideration of photoluminescence indicates that the position of the acetyl group on the heterocyclic ligand has an obvious influence on the structural arrangement, on intermol. interactions and on the observed photophys. properties. In the experimental materials used by the author, we found 4-Acetylpyridine(cas: 1122-54-9Product Details of 1122-54-9)

4-Acetylpyridine(cas: 1122-54-9) belongs to pyridine. Pyridines are often used as catalysts or reagents; particular notice has been paid recently to how pyridine coordinates to metal centers enabling a wide range of valuable reactions. Product Details of 1122-54-9

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Zhang, Yuanyuan; Xie, Chuan; Liu, Yang; Shang, Feng; Shao, Rushiya; Yu, Jing; Wu, Chunxia; Yao, Xinghui; Liu, Dongfang; Wang, Zhouyu published an article in 2021. The article was titled 《Synthesis, biological activities and docking studies of pleuromutilin derivatives with piperazinyl urea linkage》, and you may find the article in Journal of Enzyme Inhibition and Medicinal Chemistry.Product Details of 13534-97-9 The information in the text is summarized as follows:

Antibiotics resistance is becoming increasingly common, involving almost all antibiotics on the market. Diseases caused by drug resistant bacteria, such as MRSA, have high mortality and neg. affect public health. The development of new drugs would be an effective means of solving this problem. Modifications based on bioactive natural products could greatly shorten drug development time and improve success rate. Pleuromutilin, a natural product from the basidiomycete bacterial species, is a promising antibiotic candidate. In this study, a series of novel pleuromutilin derivatives possessing piperazinyl urea linkage were efficiently synthesized, and their antibacterial activities and bactericidal properties were evaluated via MIC, MBC and Time-kill kinetics assays. The results showed that all compounds exhibited potent activities against tested strains, especially MRSA strains with MIC values as low as 0.125μg/mL; 8 times lower than that of marketed antibiotic Tiamulin. Docking studies indicate substituted piperazinyl urea derivatives could provide hydrogen bonds and initiate π-π stacking between mols. and surrounding residues. The experimental part of the paper was very detailed, including the reaction process of 6-Bromopyridin-3-amine(cas: 13534-97-9Product Details of 13534-97-9)

6-Bromopyridin-3-amine(cas: 13534-97-9) belongs to anime. Acylation is one of the most important reactions of primary and secondary amines; a hydrogen atom is replaced by an acyl group (a group derived from an acid, such as RCOOH or RSO3H, by removal of ―OH, such as RC(=O)―, RS(O)2―, and so on). Reagents may be acid chlorides (RCOC1, RSO2C1), anhydrides ((RCO)2O), or even esters (RCOOR′); the products are amides of the corresponding acids.Product Details of 13534-97-9

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem