Month: October 2022

《Structural characterization of a hybrid terpyridine-pyrazine ligand and its one-dimensional ZnII coordination polymer: a computational approach to conventional and nonconventional intermolecular interactions》 was written by Granifo, Juan; Gavino, Ruben; Suarez, Sebastian; Baggio, Ricardo. Product Details of 1122-54-9This research focused onzinc terpyridine pyrazine coordination polymer crystal structure intermol interaction; Hirshfeld surface; computational chemistry; crystal structure; energy framework; enrichment ratio; interaction strength hierarchy; one-dimensional coordination polymer; terpyridine-pyrazine. The article conveys some information:

The structures of a new hybrid terpyridine-pyrazine ligand, namely 4′-[4-(pyrazin-2-yl)phenyl]-4,2′:6′,4′′-terpyridine (L2), C25H17N5, and its one-dimensional coordination polymer catena-poly[[bis(acetylacetonato-κ2O,O′)zinc]-μ-4′-[4-(pyrazin-2-yl-κN4)phenyl]-4,2′:6′,4′′-terpyridine-κN1], [Zn(C5H7O2)2(C25H17N5)]n or [Zn(acac)2(L2)]n (Hacac is acetylacetone), are reported. Packing interactions in both crystal structures are analyzed using Hirshfeld surface and enrichment ratio techniques. For the simpler structure of the monomeric ligand, further studies on the interaction hierarchy using the energy framework approach were made. The result was a complete picture of the intermol. interaction landscape, which revealed some subtle details, for example, that some weak (at first sight negligible) C-H···N interactions in the structure of free L2 play a relevant role in the crystal stabilization. After reading the article, we found that the author used 4-Acetylpyridine(cas: 1122-54-9Product Details of 1122-54-9)

4-Acetylpyridine(cas: 1122-54-9) belongs to pyridine. Pyridine-based materials are valued for their optical and physical properties as well as their medical potential. Additionally, pyridine-based natural products continue to be discovered and studied for their properties and to understand their biosynthesis.Product Details of 1122-54-9

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

The author of 《A boron-centered radical: a potassium-crown ether stabilized boryl radical anion》 were Yuan, Ningning; Wang, Wenqing; Wu, Ziye; Chen, Sheng; Tan, Gengwen; Sui, Yunxia; Wang, Xinping; Jiang, Jun; Power, Philip P.. And the article was published in Chemical Communications (Cambridge, United Kingdom) in 2016. Safety of 4-Bromo-3,5-dimethylpyridine hydrochloride The author mentioned the following in the article:

A boron radical contact ion-pair Mes2B{4-(3,5-dimethylpyridinyl)}K(18-crown-6)(THF) (1K) was isolated and characterized by ESR spectroscopy, UV-visible absorption spectroscopy and single crystal x-ray diffraction. The geometry, bonding and spin d. distribution are affected by the N···K interaction. The unpaired electron resides mainly on the boron atom and falls between those of triarylboron radical anions and neutral boron radicals. The work provides a novel boron-centered radical intermediate, connecting anionic and neutral boryl radicals. The experimental part of the paper was very detailed, including the reaction process of 4-Bromo-3,5-dimethylpyridine hydrochloride(cas: 1794738-16-1Safety of 4-Bromo-3,5-dimethylpyridine hydrochloride)

4-Bromo-3,5-dimethylpyridine hydrochloride(cas: 1794738-16-1) belongs to pyridine. Pyridine, its benzo and pyridine-based compounds play diverse roles in organic chemistry. As ligands, solvents, and catalysts they facilitate reactions; thus descriptions of these new ligands and their applications abound each year.Safety of 4-Bromo-3,5-dimethylpyridine hydrochloride

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

van Veldhoven, Jacobus P. D.; Campostrini, Giulia; van Gessel, Constantijn J. E.; Ward-van Oostwaard, Dorien; Liu, Rongfang; Mummery, Christine L.; Bellin, Milena; IJzerman, Adriaan P. published an article on February 15 ,2021. The article was titled 《Targeting the Kv11.1 (hERG) channel with allosteric modulators. Synthesis and biological evaluation of three novel series of LUF7346 derivatives》, and you may find the article in European Journal of Medicinal Chemistry.Computed Properties of C6H8N2 The information in the text is summarized as follows:

Three novel series of substituted benzophenones for their allosteric modulation of the human Kv11.1 (hERG) channel were synthesized and evaluated. Effects of this is compared with reference compound LUF7346 previously shown to shorten the action potential of cardiomyocytes derived from human stem cells. Most compounds behaved as neg. allosteric modulators (NAMs) of [3H]dofetilide binding to the channel. Compound III [R = 2-Cl; R1 = CH2cPr; X= Y = C] was the most potent amongst all ligands, remarkably reducing the affinity of dofetilide in competitive displacement assays. One of the other II [R = H; X = N] tested in a second radioligand binding set-up, displayed unusual displacement characteristics with a pseudo-Hill coefficient significantly distinct from unity, further indicative of its allosteric effects on the channel. Some compounds were evaluated in a more physiol. relevant context in beating cardiomyocytes derived from human induced pluripotent stem cells. Surprisingly, the compounds tested showed effects quite different from the reference NAM LUF7346. For instance, compound I [R = 3-Me] prolonged, rather than shortened, the field potential duration, while it did not influence this parameter when the field potential was already prolonged by dofetilide. In subsequent patch clamp studies on HEK293 cells expressing the hERG channel the compounds behaved as channel blockers. In conclusion, new allosteric modulators of the hERG channel were successfully synthesized and identified . Unexpectedly, their effects differed from the reference compound in functional assays on hERG-HEK293 cells and human cardiomyocytes, to the extent that the compounds behaved as stand-alone channel blockers.4-Amino-2-picoline(cas: 18437-58-6Computed Properties of C6H8N2) was used in this study.

4-Amino-2-picoline(cas: 18437-58-6) belongs to anime. Amines characteristically form salts with acids; a hydrogen ion, H+, adds to the nitrogen. With the strong mineral acids (e.g., H2SO4, HNO3, and HCl), the reaction is vigorous. Salt formation is instantly reversed by strong bases such as NaOH. Neutral electrophiles (compounds attracted to regions of negative charge) also react with amines; alkyl halides (R′X) and analogous alkylating agents are important examples of electrophilic reagents.Computed Properties of C6H8N2

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

In 2012,Delcamp, Jared H.; Yella, Aswani; Nazeeruddin, Mohammad K.; Graetzel, Michael published 《Modulating dye E(S+/S*) with efficient heterocyclic nitrogen containing acceptors for DSCs》.Chemical Communications (Cambridge, United Kingdom) published the findings.Category: pyridine-derivatives The information in the text is summarized as follows:

Acceptor motifs based on nitrogen containing heterocycles have been synthesized for use in dye-sensitized solar cells (DSCs). Through the selective addition of nitrogen atoms and increased conjugation of the nitrogen containing heterocycles the excited-state oxidation potential, E(S+/S*), may be conveniently tuned with minimal effect on the ground-state oxidation potential, E(S+/S), of the dye. The experimental process involved the reaction of Methyl 5-bromopicolinate(cas: 29682-15-3Category: pyridine-derivatives)

Methyl 5-bromopicolinate(cas: 29682-15-3) belongs to pyridine. Pyridine is very deactivated towards electrophilic substitution with respect to benzene. For this reason classical formylation, using methods such as the Gattermann or Vilsmeier reactions, are not generally successful. Category: pyridine-derivatives

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

In 2018,Wang, Yanfei; Liu, Nana; Liu, Qingyun; Yang, Liguo; Wei, Aimin published 《Crystal structure of tris(μ2-2-(pyridin-2-yl)ethan-1-olato-κ3N,O:O)-trithiocyanato-κN-dicobalt(III), C24H24Co2N6O3S3》.Zeitschrift fuer Kristallographie – New Crystal Structures published the findings.Quality Control of 2-(2-Hydroxyethyl)pyridine The information in the text is summarized as follows:

C24H24Co2N6O3S3, triclinic, P1[n.773] (number 2), a = 10.5658(9) Å, b = 11.1693(11) Å, c = 11.7054(14) Å, α = 79.200(1)°, β = 84.714(1)°, γ = 89.519(2)°, V = 1351.1(2) Å3, Z = 2, Rgt(F) = 0.0482, wRref(F2) = 0.1213, T = 298 K. In addition to this study using 2-(2-Hydroxyethyl)pyridine, there are many other studies that have used 2-(2-Hydroxyethyl)pyridine(cas: 103-74-2Quality Control of 2-(2-Hydroxyethyl)pyridine) was used in this study.

2-(2-Hydroxyethyl)pyridine(cas: 103-74-2) belongs to pyridine. Pyridine is very deactivated towards electrophilic substitution with respect to benzene. For this reason classical formylation, using methods such as the Gattermann or Vilsmeier reactions, are not generally successful. Quality Control of 2-(2-Hydroxyethyl)pyridine

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

In 2019,Austin Journal of Analytical and Pharmaceutical Chemistry included an article by Looga, A. M.; Ambassa, P.; Kamga, J.; Hortense, GK.; Ngadjui, B. T.; Ngameni, B.. COA of Formula: C7H7NO. The article was titled 《Synthesis and evaluation of antimicrobial properties of some novel indole pyridine based chalcones》. The information in the text is summarized as follows:

A series of novel substituted indolylchalcone derivatives (E)-I (R = H, Me, Ar = pyridin-3-yl, pyridin-4-yl) were synthesized via Claisen-Schmidt condensation between indole-3-carbaldehyde and N-methylindole-3-carbaldehyde and 3- and 4-pyridinylacetophenones. All the compounds were screened for their antibacterial and antifungal activity against six different bacterial strains – Escherichia coli ATCC 25922, Klebsiella pneumonia ATCC 700603, Staphylococcus aureus ATCC 25923, Proteus mirabilis, Salmonella typhi, Pseudomonas aeruginosa – and against one fungal strain, Candida albicans. The results reveal that all the compounds exhibited moderate to good antibacterial and antifungal activities. In the part of experimental materials, we found many familiar compounds, such as 4-Acetylpyridine(cas: 1122-54-9COA of Formula: C7H7NO)

4-Acetylpyridine(cas: 1122-54-9) belongs to pyridine. Pyridines are often used as catalysts or reagents; particular notice has been paid recently to how pyridine coordinates to metal centers enabling a wide range of valuable reactions. COA of Formula: C7H7NO

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

The author of 《Hexagonal array formation by intermolecular halogen bonding using a binary blend of linear building blocks: STM study》 were Kikkawa, Yoshihiro; Nagasaki, Mayumi; Koyama, Emiko; Tsuzuki, Seiji; Hiratani, Kazuhisa. And the article was published in Chemical Communications (Cambridge, United Kingdom) in 2019. SDS of cas: 2510-22-7 The author mentioned the following in the article:

Hexagonal arrays were fabricated via intermol. halogen bonding between two linear mol. building blocks in a bicomponent blend. The substitution position of the pyridine N atom involved in the halogen bond plays an important role in the formation of the hexagonal structures. The results came from multiple reactions, including the reaction of 4-Ethynylpyridine(cas: 2510-22-7SDS of cas: 2510-22-7)

4-Ethynylpyridine(cas: 2510-22-7) belongs to pyridine. Pyridines form stable salts with strong acids. Pyridine itself is often used to neutralize acid formed in a reaction and as a basic solvent. SDS of cas: 2510-22-7

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

《Optical detection of cyanide by palladium(II)-dithiazolopyridine probe at the parts per billion level》 was written by Ebadinia, Leila; Darabi, Hossein Reza; Ramazani, Ali. Quality Control of 2,6-Diaminopyridine And the article was included in Phosphorus, Sulfur and Silicon and the Related Elements in 2020. The article conveys some information:

The ensemble of 2,6-bis(2-chlorophenyl)dithiazolo[4,5-b:5′,4′-e]pyridine with Pd2+ ions (•Pd2+) was prepared for the detection of cyanide ions (CN-) in 50% aqueous methanol. Among the tested metal ions, only Pd2+ sensitively induced the red shift of the absorption bands and the complete decrease of fluorescence emission. The detection limit toward Pd2+ was 2 ppb. The ensemble •Pd2+ selectively and rapidly detected a low concentration of cyanide ions by a colorimetric change (40 ppb) as well as a “”turn-on”” fluorescent response (5 ppb). Job’s plot revealed the complex formation with 1:1 stoichiometry. The binding and replacement mode of •Pd2+ and CN- were also confirmed by 1H NMR titrations and IR anal. In general, a fast and selective recognition of CN- is reported. In the experiment, the researchers used 2,6-Diaminopyridine(cas: 141-86-6Quality Control of 2,6-Diaminopyridine)

2,6-Diaminopyridine(cas: 141-86-6) belongs to pyridine. Pyridine and its simple derivatives are stable and relatively unreactive liquids, with strong penetrating odours that are unpleasant.Quality Control of 2,6-Diaminopyridine

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

《Synthesis, structure and magnetic property of a tricapped trigonal prismatic TbIII -based 3d-4f complex》 was written by Zhuang, Jia-Jia; Chen, Ming-Guang; Sun, Yan-Bing; Hang, Pei; Sui, Yang; Tong, Jia-Ping. Safety of Picolinic acid And the article was included in IOP Conference Series: Materials Science and Engineering in 2020. The article conveys some information:

A novel 3d-4f CoII/TbIII cluster [Co6Tb(Pic)6O3Cl3](H2O)6 (1) (Pic = 2-Picolinic acid) has been synthesized and characterized via X-ray crystallog. and magnetic measurements. X-ray crystallog. and continued shape measurements anal. revealed that the central Terbium (III) is coordinated in TbO9 geometry with D3h symmetry. Magnetic studies indicated the complex presents a magnetic anisotropy with ferrimagnetic interactions. The results came from multiple reactions, including the reaction of Picolinic acid(cas: 98-98-6Safety of Picolinic acid)

Picolinic acid(cas: 98-98-6) is used in the preparation of 2-Aminodihydro[1,3]thiazines as BACE 2 inhibitors and their preparation and use in the treatment of diabetes.Safety of Picolinic acid

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Jmai, Momtez; Efrit, Mohamed Lotfi; Dubreuil, Didier; Blot, Virginie; Lebreton, Jacques; M’rabet, Hedi published their research in Phosphorus, Sulfur and Silicon and the Related Elements in 2021. The article was titled 《An efficient and simple strategy toward the synthesis of highly functionalized compounds》.Reference of 2-Bromonicotinaldehyde The article contains the following contents:

The expedient syntheses of small libraries of ((β-ethoxycarbonyl, -cyano and -acetyl)propyloxy) methylphosphonate scaffolds bearing olefin, sulfanyl, or amine functions are described. All these new derivatives are readily produced from easily available starting reagents (aldehydes, electron-poor olefins, and dialkylphosphites) following a three steps reaction sequence of condensations, SN2′-type reaction and a conjugated thia- or aza-Michael 1,4-addition with aromatic and aliphatic thiol or amine nucleophiles. The experimental part of the paper was very detailed, including the reaction process of 2-Bromonicotinaldehyde(cas: 128071-75-0Reference of 2-Bromonicotinaldehyde)

2-Bromonicotinaldehyde(cas: 128071-75-0) belongs to pyridine. Pyridine is widely used in the precursor to agrochemicals and pharmaceuticals. Also, it is used as an important reagent and organic solvent.Reference of 2-Bromonicotinaldehyde

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem