Month: October 2022

Adak, Laksmikanta; Jin, Masayoshi; Saito, Shota; Kawabata, Tatsuya; Itoh, Takuma; Ito, Shingo; Sharma, Akhilesh K.; Gower, Nicholas J.; Cogswell, Paul; Geldsetzer, Jan; Takaya, Hikaru; Isozaki, Katsuhiro; Nakamura, Masaharu published their research in Chemical Communications (Cambridge, United Kingdom) in 2021. The article was titled 《Iron-catalyzed enantioselective carbometalation of azabicycloalkenes》.Application In Synthesis of 5-Bromo-2-chloropyridine The article contains the following contents:

The first enantioselective carbometalation reaction of azabicycloalkenes has been achieved by iron catalysis to in situ form optically active organozinc intermediates, which are amenable to further synthetic elaborations. The observed chiral induction, along with the DFT and XAS analyses, reveals the direct coordination of the chiral phosphine ligand to the iron center during the carbon-carbon and carbon-metal bond forming step. This new class of iron-catalyzed asym. reaction will contribute to the synthesis and production of bioactive mols. The results came from multiple reactions, including the reaction of 5-Bromo-2-chloropyridine(cas: 53939-30-3Application In Synthesis of 5-Bromo-2-chloropyridine)

5-Bromo-2-chloropyridine(cas: 53939-30-3) belongs to pyridine. Pyridine’s structure is isoelectronic with that of benzene, but its properties are quite different. Pyridine is completely miscible with water, whereas benzene is only slightly soluble. Like all hydrocarbons, benzene is neutral (in the acid–base sense), but because of its nitrogen atom, pyridine is a weak base.Application In Synthesis of 5-Bromo-2-chloropyridine

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Richardson, Keith; Brown, Jeffery published an article in 2021. The article was titled 《in silico reagent design for electron-transfer dissociation on a Q-TOF》, and you may find the article in Journal of the American Society for Mass Spectrometry.HPLC of Formula: 100-48-1 The information in the text is summarized as follows:

Electron-transfer dissociation is an important technique capable of probing the primary and higher order structure of a wide variety of biomols. and yielding information that is often inaccessible using other common MS methods. The source of the electron used to initiate the fragmentation event is a radical anion, and the fragmentation process therefore depends intimately on the electronic properties of both the reagent and analyte ions. A good reagent must ionize easily and be sufficiently robust to survive transport to the reaction location, but must also be capable of donating an electron to analyte cations efficiently enough to overcome competition with other ion-ion reaction channels. Inspired by the work of Gunawardena et al. (), an in silico workflow to allow prescreening of potential electron-transfer reagents for use in glow-discharge sources is described. Approx. 150 candidate mols. have been characterized using this workflow. We discuss in detail the properties of a selected subset of singly and doubly substituted benzenes and introduce five effective new reagents that have been identified as a result of this work.4-Cyanopyridine(cas: 100-48-1HPLC of Formula: 100-48-1) was used in this study.

4-Cyanopyridine(cas: 100-48-1) belongs to pyridine. Pyridines form stable salts with strong acids. Pyridine itself is often used to neutralize acid formed in a reaction and as a basic solvent. HPLC of Formula: 100-48-1

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Siddique, Rashid G.; Arachchige, Kasun S. A.; AL-Fayaad, Hydar A.; Brock, Aidan J.; Micallef, Aaron S.; Luis, Ena T.; Thoburn, John D.; McMurtrie, John C.; Clegg, Jack K. published an article in 2021. The article was titled 《The kinetics and mechanism of interconversion within a system of [Fe2L3]4+ helicates and [Fe4L6]8+ cages》, and you may find the article in Chemical Communications (Cambridge, United Kingdom).Recommanded Product: 624-28-2 The information in the text is summarized as follows:

Nature builds simple mols. into highly complex assemblies, which are involved in all fundamental processes of life. Some of the most intriguing biol. assemblies are those that can be precisely reconfigured to achieve different functions using the same building blocks. Understanding the reconfiguration of synthetic self-assembled systems will allow us to better understand the complexity of proteins and design useful artificial chem. systems. Here the authors prepared a relatively simple system in which two distinct self-assembled structures, a [Fe2L3]4+ helicate and a [Fe4L6]8+ cage that are formed from the same precursors, coexist at equilibrium, L is bisbipyrinyldiethynylbenzene. The authors measured the rates of interconversion of these two species and propose a mechanism for the transformation. The results came from multiple reactions, including the reaction of 2,5-Dibromopyridine(cas: 624-28-2Recommanded Product: 624-28-2)

2,5-Dibromopyridine(cas: 624-28-2) belongs to pyridine. Pyridine is a relatively complex molecule and exhibits a number of different bands in IR spectra. Among others, the bands characterizing the ν8a and ν19b modes have been found to be sensitive to the coordination or protonation of the molecule. Note that the band that is diagnostic for the PyH+ ion at about 1545 cm− 1 (ν19b mode) does not overlap with any of the other bands.Recommanded Product: 624-28-2

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Shoair, Abdel Ghany F.; Shanab, Mai M. A. H.; Mahmoud, Mohamed H. H. published an article in 2021. The article was titled 《Electrochemical and catalytic properties of oxo-ruthenate(VI) in aqueous alkaline medium》, and you may find the article in International Journal of Electrochemical Science.HPLC of Formula: 100-48-1 The information in the text is summarized as follows:

The complex K2[Ru(III)Cl5(H2O)] has been prepared and characterized by different spectroscopic techniques (IR and UV-VIS). The electrochem. properties of this complex were investigated at different pH′s using Robinson buffer solutions The cyclic voltammograms exhibited three redox different oxidation and potential peaks due to generation of Ru(III), Ru(IV), Ru(V) and Ru(VI) ions. The catalytic activity of K2[Ru(III)Cl5(H2O)] towards the hydration of some aromatic and three heterocyclic nitriles to their corresponding amides was investigated with excess of three co-oxidants K2S2O8, NaOCl and KBrO3. A number of factors have been investigated and the best yields were obtained with K2S2O8 as a co-oxidant in a 1.0 M KOH at 80 °C. Both spectroscopic and electrochem. techniques were used to establish the nature of active species in this catalytic reaction and the active catalyst was found to be K2[Ru(VI)O3(OH)2], as well as to explain the possible reaction mechanism. The suggested mechanism included the coordination of nitrile to ruthenium center followed by liberation of the corresponding amide and the active complex again. In the part of experimental materials, we found many familiar compounds, such as 4-Cyanopyridine(cas: 100-48-1HPLC of Formula: 100-48-1)

4-Cyanopyridine(cas: 100-48-1) belongs to pyridine. When pyridine is adsorbed on oxide surfaces or in porous materials, the following species are commonly observed: (i) pyridine coordinated to Lewis acid sites, (ii) pyridine H-bonded to weakly acidic hydroxyls, and (iii) protonated pyridine. At high coverage, physisorbed pyridine and protonated dimers can also be observed.HPLC of Formula: 100-48-1

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Safety of 2,6-DiaminopyridineIn 2019 ,《Secondary Electrostatic Interaction Model Revised: Prediction Comes Mainly from Measuring Charge Accumulation in Hydrogen-Bonded Monomers》 was published in Journal of the American Chemical Society. The article was written by van der Lubbe, Stephanie C. C.; Zaccaria, Francesco; Sun, Xiaobo; Guerra, Celia Fonseca. The article contains the following contents:

The secondary electrostatic interaction (SEI) model is often used to predict and explain relative hydrogen bond strengths of self-assembled systems. The SEI model oversimplifies the hydrogen-bonding mechanisms by viewing them as interacting point charges, but nevertheless exptl. binding strengths are often in line with the model’s predictions. To understand how this rudimentary model can be predictive, we computationally studied two tautomeric quadruple hydrogen-bonded systems, DDAA-AADD and DADA-ADAD. Our results reveal that when the proton donors D (which are electron-donating) and the proton acceptors A (which are electron-withdrawing) are grouped together as in DDAA, there is a larger accumulation of charge around the frontier atoms than when the proton donor and acceptor groups are alternating as in DADA. This accumulation of charge makes the proton donors more pos. and the proton acceptors more neg., which enhances both the electrostatic and covalent interactions in the DDAA dimer. The SEI model is thus predictive because it provides a measure for the charge accumulation in hydrogen-bonded monomers. Our findings can be understood from simple phys. organic chem. principles and provide supramol. chemists with meaningful understanding for tuning hydrogen bond strengths and thus for controlling the properties of self-assembled systems. The results came from multiple reactions, including the reaction of 2,6-Diaminopyridine(cas: 141-86-6Safety of 2,6-Diaminopyridine)

2,6-Diaminopyridine(cas: 141-86-6) belongs to pyridine. Pyridine and its simple derivatives are stable and relatively unreactive liquids, with strong penetrating odours that are unpleasant.Safety of 2,6-Diaminopyridine

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

The author of 《A delocalized cobaltoviologen with seven reversibly accessible redox states and highly tunable electrochromic behaviour》 were Mansoor, Iram F.; Wozniak, Derek I.; Wu, Yilei; Lipke, Mark C.. And the article was published in Chemical Communications (Cambridge, United Kingdom) in 2020. Formula: C20H14N4 The author mentioned the following in the article:

CoII mediates electronic coupling between two N-Me-pyridinium-terpyridine ligands that are related to redox-active N,N-dialkyl-4,4′-bipyridinium dications (viologens). Borderline Class II/III electronic delocalization imparts the cobaltoviologen complex with distinct electronic properties (e.g., 7 accessible redox states) relative to those of viologens, leading to enhanced electrochromism. After reading the article, we found that the author used 4′-(4-Pyridyl)-2,2′:6′,2”-terpyridine(cas: 112881-51-3Formula: C20H14N4)

4′-(4-Pyridyl)-2,2′:6′,2”-terpyridine(cas: 112881-51-3) belongs to pyridine derivatives. The ring atoms in the pyridine molecule are sp2-hybridized. The nitrogen is involved in the π-bonding aromatic system using its unhybridized p orbital. Formula: C20H14N4The lone pair is in an sp2 orbital, projecting outward from the ring in the same plane as the σ bonds.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

《Rapid development of a bromochloropyridine regioisomer purity method enabled by strategic LC screening》 was published in Journal of Pharmaceutical and Biomedical Analysis in 2020. These research results belong to Borges-Munoz, Amaris; Li, Li; Tattersall, Peter. Product Details of 53939-30-3 The article mentions the following:

With the intent to provide aligned, impactful, and efficient strategies for liquid chromatog. method development, tier-based stationary/mobile phase screening workflows have been implemented in the Chem. Process Development department at Bristol Myers Squibb. These workflows are utilized as tools that enable more rapid method generation for early to mid-stage clin. development programs. An illustrative example of applying this approach was the method development for 3-bromo-2-chloropyridine and six of its positional isomeric impurities. Several parameters (gradient time, flow rate, column geometry, particle size, temperature, and solvent effects) were evaluated to achieve a baseline resolved separation for this challenging mixture The impact that the screening workflows have regarding timesavings, effort, and resourcing to develop and optimize this LC method will be discussed. In the experiment, the researchers used 5-Bromo-2-chloropyridine(cas: 53939-30-3Product Details of 53939-30-3)

5-Bromo-2-chloropyridine(cas: 53939-30-3) belongs to pyridine. Pyridine’s structure is isoelectronic with that of benzene, but its properties are quite different. Pyridine is completely miscible with water, whereas benzene is only slightly soluble. Like all hydrocarbons, benzene is neutral (in the acid–base sense), but because of its nitrogen atom, pyridine is a weak base.Product Details of 53939-30-3

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

In 2022,Ryan, Christopher A.; Baskevics, Vladislavs; Katkevics, Martins; Rozners, Eriks published an article in Chemical Communications (Cambridge, United Kingdom). The title of the article was 《2-Guanidyl pyridine PNA nucleobase for triple-helical Hoogsteen recognition of cytosine in double-stranded RNA》.Related Products of 141-86-6 The author mentioned the following in the article:

In triplex-forming peptide nucleic acid, a novel 2-guanidyl pyridine nucleobase (V) enables recognition of up to two cytosine interruptions in polypurine tracts of dsRNA by engaging the entire Hoogsteen face of C-G base pair. Ab initio and mol. dynamics simulations provided insights into H-bonding interactions that stabilized V·C-G triplets. Our results provided insights for future design of improved nucleobases, which is an important step towards the ultimate goal of recognition of any sequence of dsRNA. In the experiment, the researchers used many compounds, for example, 2,6-Diaminopyridine(cas: 141-86-6Related Products of 141-86-6)

2,6-Diaminopyridine(cas: 141-86-6) belongs to pyridine. Pyridine and its simple derivatives are stable and relatively unreactive liquids, with strong penetrating odours that are unpleasant.Related Products of 141-86-6

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Quality Control of 4,4′-Dimethyl-2,2′-bipyridineIn 2020 ,《Identification of descriptors for structure-activity relationship in ruthenium (II) mixed compounds with antiparasitic activity》 appeared in European Journal of Medicinal Chemistry. The author of the article were Cedillo-Gutierrez, Erika Lorena; Hernandez-Ayala, Luis Felipe; Torres-Gutierrez, Carolina; Reina, Miguel; Flores-Alamo, Marcos; Carrero, Julio C.; Ugalde-Saldivar, Victor M.; Ruiz-Azuara, Lena. The article conveys some information:

Herein is presented the synthesis, characterization, electrochem. studies, DFT calculations and in vitro evaluation of amoebicidal activity in trophozoites of Entamoeba histolytica of twenty ruthenium(II) mixed compounds with general formulas: [Ru(pdto)(E-E)]Clx (E-E bidentate, either neutral or neg. charged ligands). For compounds under study, O-O, N-O and N-N auxiliary donor ligands demonstrate to have a crucial impact on the electronic properties and that it is possible to modulate the antiparasitic activity. Among analyzed complexes, only four present a better performance compared to typically used metronidazole drug (IC50 < 6.80μmol/L) to treat amebiasis disease. For studied compounds, structure-activity relations are strongly determined by either the redox potential (E1/2) of RuII/RuIII and calculated molar volume (V) of the complexes. The experimental part of the paper was very detailed, including the reaction process of 4,4'-Dimethyl-2,2'-bipyridine(cas: 1134-35-6Quality Control of 4,4′-Dimethyl-2,2′-bipyridine)

4,4′-Dimethyl-2,2′-bipyridine(cas: 1134-35-6) is used in the synthesis of a series of o-phenanthroline-substituted ruthenium(II) complexes.Quality Control of 4,4′-Dimethyl-2,2′-bipyridine Furthermore, 4,4′-Dimethyl-2,2′-bipyridine is used as a chemical Intermediate. It can be used for the determination of ferrous and cyanide compounds.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

In 2022,Boiledieu, William; De Abreu, Maxime; Cuyamendous, Claire; Lamaa, Diana; Belmont, Philippe; Brachet, Etienne published an article in Chemical Communications (Cambridge, United Kingdom). The title of the article was 《Photoredox synthesis of 6- and 7-membered ring scaffolds via N-centered radicals》.Electric Literature of C6H4BrNO The author mentioned the following in the article:

N-Containing heterocycles are important scaffolds due to their ubiquitous presence in bioactive compounds Their synthesis has been considered as an important research field. In this work authors report the access to 6- and 7-membered rings via a photoinduced strategy. To authors knowledge, this work represents the first example of photo-induced 7-endo-trig cyclization with N-centered radicals. The experimental process involved the reaction of 2-Bromonicotinaldehyde(cas: 128071-75-0Electric Literature of C6H4BrNO)

2-Bromonicotinaldehyde(cas: 128071-75-0) belongs to pyridine. Pyridine’s structure is isoelectronic with that of benzene, but its properties are quite different. Pyridine is completely miscible with water, whereas benzene is only slightly soluble. Like all hydrocarbons, benzene is neutral (in the acid–base sense), but because of its nitrogen atom, pyridine is a weak base.Electric Literature of C6H4BrNO

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem