Month: October 2022

《H3PW12O40: an efficient and green catalyst for the facile and selective oxidation of sulfides to sulfoxides, applied to the last step of the synthesis of omeprazole》 was published in Iranian Journal of Chemistry & Chemical Engineering in 2017. These research results belong to Esfandyari, Maryam; Heravi, Majid; Oskooie, Hossein; Fotouhi, Lida; Tajbakhsh, Mahmood; Bamoharram, Fatemeh. Name: 2-(Chloromethyl)-3,5-dimethyl-4-nitropyridine The article mentions the following:

Omeprazole, (6-methoxy-2-((4-methoxy-3,5-dimethylpyridin-2-yl)methylsulfinyl)-1H-benzimidazole) is a well-established prescribed drug, exhibits proton pump inhibitor activity. In this work, a novel, facile, economical and selective oxidation approach using H3PW12O40 as Keggin type heteropolyacids along with H2O2 in the last step of the conventional synthesis of this compound as well as its derivatives under environmental-benign conditions, is reported. This protocol can be well adopted for pilot plant scale giving a high pure pharmacopeia grade material. Our synthetic route involves the use of various heteropolyacids as heterogeneous catalysts. Due to the obtained results, it was concluded that Keggin type heteropolyacid , is an effective catalyst for this purpose. The optimized condition for the last step of this synthesis was applied to the synthesis of lansoprazole, pantoprazole, and rabeprazole. The experimental part of the paper was very detailed, including the reaction process of 2-(Chloromethyl)-3,5-dimethyl-4-nitropyridine(cas: 153476-68-7Name: 2-(Chloromethyl)-3,5-dimethyl-4-nitropyridine)

2-(Chloromethyl)-3,5-dimethyl-4-nitropyridine(cas: 153476-68-7) belongs to pyridine. Pyridine-based materials are valued for their optical and physical properties as well as their medical potential. Additionally, pyridine-based natural products continue to be discovered and studied for their properties and to understand their biosynthesis.Name: 2-(Chloromethyl)-3,5-dimethyl-4-nitropyridine

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

HPLC of Formula: 138219-98-4On November 25, 2013 ,《Structure-Activity Relationships and Identification of Optmized CC-Chemokine Receptor CCR1, 5, and 8 Metal-Ion Chelators》 appeared in Journal of Chemical Information and Modeling. The author of the article were Chalikiopoulos, Alexander; Thiele, Stefanie; Malmgaard-Clausen, Mikkel; Rydberg, Patrik; Isberg, Vignir; Ulven, Trond; Frimurer, Thomas M.; Rosenkilde, Mette M.; Gloriam, David E.. The article conveys some information:

Chemokine receptors are involved in trafficking of leukocytes and represent targets for autoimmune conditions, inflammatory diseases, viral infections, and cancer. We recently published CCR1, CCR8, and CCR5 agonists and pos. modulators based on a three metal-ion chelator series: 2,2′-bipyridine, 1,10-phenanthroline, and 2,2′;6′,2”-terpyridine. Here, we have performed an in-depth structure-activity relationship study and tested eight new optimized analogs. Using d. functional theory calculations we demonstrate that the chelator zinc affinities depend on how electron-donating and -withdrawing substituents modulate the partial charges of chelating nitrogens. The zinc affinity was found to constitute the major factor for receptor potency, although the activity of some chelators deviate suggesting favorable or unfavorable interactions. Hydrophobic and halogen substituents are generally better accommodated in the receptors than polar groups. The new analog brominated terpyridine (29) resulted in the highest chelator potencies observed so far CCR1 (EC50: 0.49 μM) and CCR8 (EC50: 0.28 μM). Furthermore, we identified the first selective CCR5 agonist chelator, meta dithiomethylated bipyridine (23). The structure-activity relationships contribute to small-mol. drug development, and the novel chelators constitute valuable tools for studies of structural mechanisms for chemokine receptor activation. The results came from multiple reactions, including the reaction of 4,4′-Bis(chloromethyl)-2,2′-bipyridine(cas: 138219-98-4HPLC of Formula: 138219-98-4)

4,4′-Bis(chloromethyl)-2,2′-bipyridine(cas: 138219-98-4) belongs to pyridine derivatives. The ring atoms in the pyridine molecule are sp2-hybridized. The nitrogen is involved in the π-bonding aromatic system using its unhybridized p orbital. HPLC of Formula: 138219-98-4 Pyridine has a conjugated system of six π electrons that are delocalized over the ring.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

In 2018,Fang, Xiangqing; Xu, Jiajia; Qi, Wu; Yang, Liguo; Ya, Li published 《Crystal structure of catena-poly[(μ2-dicyanamido-κ2N:N’)-(μ2-2-(pyridin-2-yl)ethan-1-olato-κ3N,O:O’)copper(II)], C9H8CuN4O》.Zeitschrift fuer Kristallographie – New Crystal Structures published the findings.Formula: C7H9NO The information in the text is summarized as follows:

C9H8CuN4O, triclinic, P1̅ (number 2), a = 7.6740(6) Å, b = 8.6401(8) Å, c = 8.8869(9) Å, α = 109.201(2)°, β = 106.629(1)°, γ = 105.410(1)°, V = 489.21(8) Å3, Z = 2, Rgt(F) = 0.0406, wRref(F2) = 0.0993, T = 298(2) K. After reading the article, we found that the author used 2-(2-Hydroxyethyl)pyridine(cas: 103-74-2Formula: C7H9NO)

2-(2-Hydroxyethyl)pyridine(cas: 103-74-2) belongs to pyridine. Pyridine is very deactivated towards electrophilic substitution with respect to benzene. For this reason classical formylation, using methods such as the Gattermann or Vilsmeier reactions, are not generally successful. Formula: C7H9NO

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

In 2019,Chemical Communications (Cambridge, United Kingdom) included an article by Ragupathi, Ayyakkannu; Sagadevan, Arunachalam; Charpe, Vaibhav Pramod; Lin, Chun-Cheng; Hwu, Jih-Ru; Hwang, Kuo Chu. Reference of 4-Ethynylpyridine. The article was titled 《Visible-light-driven copper-catalyzed aerobic oxidative cascade cyclization of N-tosylhydrazones and terminal alkynes: regioselective synthesis of 3-arylcoumarins》. The information in the text is summarized as follows:

Regioselective green synthesis of 3-arylcoumarins I [R1 = H, 6-Me, 6-Br, etc.; R2 = H, 3-MeOC6H4, 4-Py, etc.; R3 = H, Me, Ph] as sustainable process was carried out via visible-light-driven copper catalyzed aerobic oxidative cascade cyclization of N-tosylhydrazones with terminal alkynes. This operationally simple methodol. was successfully proceeded well to afford biol. active compounds, such as monoamine oxidase B inhibitor I [R1 = 6-Me; R2 = 3-MeOC6H4; R3 = H] and horseradish peroxidase inhibitor I [R1 = 6-OH; R2 = 2-HOC6H4; R3 = H] in satisfactory yields under mild conditions. In the experiment, the researchers used many compounds, for example, 4-Ethynylpyridine(cas: 2510-22-7Reference of 4-Ethynylpyridine)

4-Ethynylpyridine(cas: 2510-22-7) belongs to pyridine. In industry and in the lab, pyridine is used as a reaction solvent, particularly when its basicity is useful, and as a starting material for synthesizing some herbicides, fungicides, and antiseptics.Reference of 4-Ethynylpyridine

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

In 2019,Chemical Communications (Cambridge, United Kingdom) included an article by Sanchez, Monica L. K.; Wu, Chang-Hao; Adams, Michael W. W.; Dyer, R. Brian. Reference of 4,4′-Dimethyl-2,2′-bipyridine. The article was titled 《Optimizing electron transfer from CdSe QDs to hydrogenase for photocatalytic H2 production》. The information in the text is summarized as follows:

A series of viologen related redox mediators of varying reduction potential has been characterized and their utility as electron shuttles between CdSe quantum dots and hydrogenase enzyme has been demonstrated. Tuning the mediator LUMO energy optimizes the performance of this hybrid photocatalytic system by balancing electron transfer rates of the shuttle. In the experimental materials used by the author, we found 4,4′-Dimethyl-2,2′-bipyridine(cas: 1134-35-6Reference of 4,4′-Dimethyl-2,2′-bipyridine)

4,4′-Dimethyl-2,2′-bipyridine(cas: 1134-35-6) is used as a chemical Intermediate. It can be used for the determination of ferrous and cyanide compounds.Reference of 4,4′-Dimethyl-2,2′-bipyridine Furthermore, 4,4′-Dimethyl-2,2′-bipyridine is used in the synthesis of a series of o-phenanthroline-substituted ruthenium(II) complexes.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

《Superstructural diversity in salt-cocrystals: higher-order hydrogen-bonded assemblies formed using U-shaped dications and with assistance of π–π stacking》 was published in Chemical Communications (Cambridge, United Kingdom) in 2020. These research results belong to Yelgaonkar, Shweta P.; Kiani, Daniyal; Baltrusaitis, Jonas; MacGillivray, Leonard R.. COA of Formula: C7H5N The article mentions the following:

Salt cocrystals with components that assemble by hydrogen bonds and aromatic anion-mol. stacks (π–π stacks) are reported. U-shaped bipyridines and an isocoumarin carboxylic acid self-assemble to form 5-, 6-, and 10-component aggregates with components in double and quadruple face-to-face stacks. DFT calculations support the π–π stacks to help stabilize the salt cocrystals. The experimental part of the paper was very detailed, including the reaction process of 4-Ethynylpyridine(cas: 2510-22-7COA of Formula: C7H5N)

4-Ethynylpyridine(cas: 2510-22-7) belongs to pyridine. Pyridine’s structure is isoelectronic with that of benzene, but its properties are quite different. Pyridine is completely miscible with water, whereas benzene is only slightly soluble. Like all hydrocarbons, benzene is neutral (in the acid–base sense), but because of its nitrogen atom, pyridine is a weak base.COA of Formula: C7H5N

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Margonis, Caroline M.; Ho, Marissa; Travis, Benjamin D.; Brennessel, William W.; McNamara, William R. published an article in 2021. The article was titled 《Iron polypyridyl complex adsorbed on carbon surfaces for hydrogen generation》, and you may find the article in Chemical Communications (Cambridge, United Kingdom).Product Details of 1539-42-0 The information in the text is summarized as follows:

A series of homogeneous Fe(III) complexes were recently reported that are active for electrocatalytic hydrogen generation. Herein we report a naphthalene-terminated Fe(III) complex for use in the functionalization of glassy carbon surfaces for electrocatalytic hydrogen generation with retention of catalytic activity. In the part of experimental materials, we found many familiar compounds, such as Bis(pyridin-2-ylmethyl)amine(cas: 1539-42-0Product Details of 1539-42-0)

Bis(pyridin-2-ylmethyl)amine(cas: 1539-42-0) is a secondary amine with two picolyl substituents. As a tridentate ligand this compound provides three nitrogen donors that affords good selectivity for Zn2+ over biologically relevant metals such as Na+, K+, Mg2+ and Ca2+, and leaves coordination sites free for anion binding. Product Details of 1539-42-0

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Synthetic Route of C5H6BNO2In 2020 ,《Synthesis and characterization of high affinity fluorogenic α-synuclein probes》 was published in Chemical Communications (Cambridge, United Kingdom). The article was written by Lengyel-Zhand, Zsofia; Ferrie, John J.; Janssen, Bieneke; Hsieh, Chia-Ju; Graham, Thomas; Xu, Kui-ying; Haney, Conor M.; Lee, Virginia M.-Y.; Trojanowski, John Q.; Petersson, E. James; Mach, Robert H.. The article contains the following contents:

Fluorescent small mols. are powerful tools for imaging α-synuclein pathol. in vitro and in vivo. In this work, we explore benzofuranone as a potential scaffold for the design of fluorescent α-synuclein probes. These compounds have high affinity for α-synuclein, show fluorescent turn-on upon binding to fibrils, and display different binding to Lewy bodies, Lewy neurites and glial cytoplasmic inclusion pathologies in post-mortem brain tissue. These studies not only reveal the potential of benzofuranone compounds as α-synuclein specific fluorescent probes, but also have implications for the ways in which α-synucleinopathies are conformationally different and display distinct small mol. binding sites. The experimental process involved the reaction of Pyridin-3-ylboronic acid(cas: 1692-25-7Synthetic Route of C5H6BNO2)

Pyridin-3-ylboronic acid(cas: 1692-25-7) belongs to pyridine. Pyridines, quinolines, and isoquinolines have found a function in almost all aspects of organic chemistry. Pyridine has found use as a solvent, base, ligand, functional group, and molecular scaffold. As structural elements, these moieties are potent electron-deficient groups, metal-directing functionalities, fluorophores, and medicinally important pharmacophores. Synthetic Route of C5H6BNO2

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

《Synthesis, characterization and introduction of a new ion-coordinating ruthenium sensitizer dye in quasi-solid state TiO2 solar cells》 was published in Journal of Photochemistry and Photobiology, A: Chemistry in 2011. These research results belong to White, Ryan C.; Benedetti, Joao E.; Goncalves, Agnaldo D.; Romao, Wanderson; Vaz, Boniek G.; Eberlin, Marcos N.; Correia, Carlos R. D.; De Paoli, Marco A.; Nogueira, Ana F.. Application of 138219-98-4 The article mentions the following:

A new ion-coordinating heteroleptic ruthenium(II) dye was synthesized by attaching two crown ether moieties in the 4,4′ positions of one of the bipyridine ligands. This new dye (named as RC730) was characterized by UV-Vis spectroscopy, CHN elemental anal., NMR and electrospray ionization Fourier transform-ion cyclotron resonance mass spectrometry (ESI FT-ICR MS). In order to investigate the properties of these ion-coordinating species, dye-sensitized solar cells were assembled with a gel polymer electrolyte based on two different cations: lithium and sodium. The devices were characterized by J-V curves under 100 mW cm-2, incident photon to current conversion efficiency spectra (IPCE) and photovoltage decay transients under open-circuit conditions. The solar cells based on the new heteroleptic dye provided higher photocurrent and photovoltage when lithium was used in the electrolyte instead of sodium cations, reaching overall conversion efficiencies up to 2%. This behavior might be related to the ability of the ion-coordinating RC730 dye to trap Li ions, minimizing the conduction band edge shift. When the polymer electrolyte based on lithium is used, the IPCE spectra show a maximum efficiency of 31% at the maximum absorption peak of the RC730 dye (ca. 530 nm). After reading the article, we found that the author used 4,4′-Bis(chloromethyl)-2,2′-bipyridine(cas: 138219-98-4Application of 138219-98-4)

4,4′-Bis(chloromethyl)-2,2′-bipyridine(cas: 138219-98-4) belongs to pyridine derivatives. The ring atoms in the pyridine molecule are sp2-hybridized. The nitrogen is involved in the π-bonding aromatic system using its unhybridized p orbital. Application of 138219-98-4 Pyridine has a conjugated system of six π electrons that are delocalized over the ring.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

In 2017,Satpathi, Bishnupada; Wagulde, Siddhant V.; Ramasastry, S. S. V. published 《An enantioselective organocatalytic intramolecular Morita-Baylis-Hillman (IMBH) reaction of dienones, and elaboration of the IMBH adducts to fluorenones》.Chemical Communications (Cambridge, United Kingdom) published the findings.Recommanded Product: 128071-75-0 The information in the text is summarized as follows:

An enantioselective organocatalytic intramol. Morita-Baylis-Hillman (IMBH) reaction of dienones is reported for the first time. This has been achieved by incorporating entropy and synergy considerations during the substrate design. The reaction conditions are thoroughly verified for an efficient synthesis of highly functionalized cyclopenta-fused arenes and heteroarenes in excellent yields and enantioselectivities. The synthetic utility of the IMBH-adducts has been demonstrated by transforming them into 3,4-disubstituted fluorenones in a serendipitous manner. In the experiment, the researchers used 2-Bromonicotinaldehyde(cas: 128071-75-0Recommanded Product: 128071-75-0)

2-Bromonicotinaldehyde(cas: 128071-75-0) belongs to pyridine. Pyridine is very deactivated towards electrophilic substitution with respect to benzene. For this reason classical formylation, using methods such as the Gattermann or Vilsmeier reactions, are not generally successful. Recommanded Product: 128071-75-0

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem