Month: October 2022

《Fluoroalkyl sulfides as photoredox-active coupling reagents for alkene difunctionalization》 was written by Kosobokov, Mikhail D.; Zubkov, Mikhail O.; Levin, Vitalij V.; Kokorekin, Vladimir A.; Dilman, Alexander D.. Electric Literature of C33H24IrN3 And the article was included in Chemical Communications (Cambridge, United Kingdom) in 2020. The article conveys some information:

A visible-light-promoted fluoroalkylation-thiolation of alkenes is described. A 4-tetrafluoropyridinylthio fragment serves as a photoredox-active group in the initiation step and undergoes a radical group transfer, which is important for the reaction efficiency. In the primary products, the pyridinylthio substituent may be further functionalized via radical processes or an aromatic substitution reaction. The experimental process involved the reaction of fac-Tris(2-phenylpyridine)iridium(cas: 94928-86-6Electric Literature of C33H24IrN3)

fac-Tris(2-phenylpyridine)iridium(cas: 94928-86-6) belongs to pyridine. Pyridine is very deactivated towards electrophilic substitution with respect to benzene. For this reason classical formylation, using methods such as the Gattermann or Vilsmeier reactions, are not generally successful. Electric Literature of C33H24IrN3

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Li, Zheng; Xu, Yanqi; Xu, Huandi; Cui, Mengyuan; Liu, Tianguang; Ren, Xiangyu; Sun, Jianfei; Deng, Dawei; Gu, Yueqing; Wang, Peng published their research in Spectrochimica Acta, Part A: Molecular and Biomolecular Spectroscopy in 2021. The article was titled 《A dicyanomethylene-4H-pyran-based fluorescence probe with high selectivity and sensitivity for detecting copper (II) and its bioimaging in living cells and tissue》.Computed Properties of C6H5NO2 The article contains the following contents:

Copper (Cu) plays a significant role in the process of oxygenic photosynthesis in living systems. The detection of copper ion (Cu2+) is valuable and meaningful for further studying the functions of Cu2+ under physiol. and pathol. conditions. A novel fluorescence probe DCM-Cu (I) based on the near-IR (NIR) fluorophore dicyanomethylene-4H-pyran (DCM) was designed for Cu2+ detection. The probe DCM-Cu possessed characteristic of “”turn-on”” fluorescent signal in the presence of Cu2+ through the enhanced ICT process. It exhibited satisfactory sensitivity and selectivity toward Cu2+. A good linear correlation was observed between the concentrations of Cu2+ and the fluorescence intensities at 700 nm. The detection limit (LOD) of DCM-Cu toward Cu2+ is 2.54 × 10-8 M. Importantly, DCM-Cu was successfully applied in the detection of Cu2+ in living MCF-7 cells and tumor tissue with low cytotoxicity. Therefore, this probe would have the potential to monitor cellular Cu2+ in the living system and be applied to the diagnosis of related diseases. In addition to this study using Picolinic acid, there are many other studies that have used Picolinic acid(cas: 98-98-6Computed Properties of C6H5NO2) was used in this study.

Picolinic acid(cas: 98-98-6) is used in the preparation of 2-Aminodihydro[1,3]thiazines as BACE 2 inhibitors and their preparation and use in the treatment of diabetes.Computed Properties of C6H5NO2

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

《A binding hotspot in Trypanosoma cruzi histidyl-tRNA synthetase revealed by fragment-based crystallographic cocktail screens》 was written by Koh, Cho Yeow; Kallur Siddaramaiah, Latha; Ranade, Ranae M.; Nguyen, Jasmine; Jian, Tengyue; Zhang, Zhongsheng; Gillespie, J. Robert; Buckner, Frederick S.; Verlinde, Christophe L. M. J.; Fan, Erkang; Hol, Wim G. J.. Category: pyridine-derivativesThis research focused onTrypanosoma histidyl tRNA synthetase crystal structure inhibitor Chagas antiparasitics; fragment-based crystallographic cocktail screening; inhibitor of histidyl-tRNA synthetase; reactive fragment; structure-guided drug discovery; trypanosomiasis. The article conveys some information:

American trypanosomiasis, commonly known as Chagas disease, is a neglected tropical disease caused by the protozoan parasite Trypanosoma cruzi. The chronic form of the infection often causes debilitating morbidity and mortality. However, the current treatment for the disease is typically inadequate owing to drug toxicity and poor efficacy, necessitating a continual effort to discover and develop new antiparasitic therapeutic agents. The structure of T. cruzi histidyl-tRNA synthetase (HisRS), a validated drug target, has previously been reported. Based on this structure and those of human cytosolic HisRS, opportunities for the development of specific inhibitors were identified. Here, efforts are reported to identify small mols. that bind to T. cruzi HisRS through fragment-based crystallog. screening in order to arrive at chem. starting points for the development of specific inhibitors. T. cruzi HisRS was soaked into 68 different cocktails from the Medical Structural Genomics of Pathogenic Protozoa (MSGPP) fragment library and diffraction data were collected to identify bound fragments after soaking. A total of 15 fragments were identified, all bound to the same site on the protein, revealing a fragment-binding hotspot adjacent to the ATP-binding pocket. On the basis of the initial hits, the design of reactive fragments targeting the hotspot which would be simultaneously covalently linked to a cysteine residue present only in trypanosomatid HisRS was initiated. Inhibition of T. cruzi HisRS was observed with the resultant reactive fragments and the anticipated binding mode was confirmed crystallog. These results form a platform for the development of future generations of selective inhibitors for trypanosomatid HisRS.6-Bromopyridin-3-amine(cas: 13534-97-9Category: pyridine-derivatives) was used in this study.

6-Bromopyridin-3-amine(cas: 13534-97-9) belongs to anime. The reaction of alkyl halides, R―X, where X is a halogen, or analogous reagents with ammonia (or amines) is useful with certain compounds. Not all alkyl halides are effective reagents; the reaction is sluggish with secondary alkyl groups and fails with tertiary ones. Its usefulness is largely confined to primary alkyl halides (those having two hydrogen atoms on the reacting site).Category: pyridine-derivatives

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

《Zirconium bistriazolylpyridine phosphonate materials for efficient, selective An(III)/Ln(III) separations》 was written by Veliscek-Carolan, Jessica; Rawal, Aditya. Electric Literature of C5H3Br2NThis research focused onzirconium triazolylpyridinephosphonate complex preparation porosity adsorption surface structure. The article conveys some information:

Direct synthesis of ZrCl4 and bistriazolylpyridine phosphonate has produced novel sorbent materials that, for the first time, demonstrate selective extraction of Am(III) in the presence of excess Eu(III). Further, the high ligand content of these materials affords them high extraction efficiencies. In the part of experimental materials, we found many familiar compounds, such as 2,6-Dibromopyridine(cas: 626-05-1Electric Literature of C5H3Br2N)

2,6-Dibromopyridine(cas: 626-05-1) belongs to pyridine. Pyridine-based materials are valued for their optical and physical properties as well as their medical potential. Additionally, pyridine-based natural products continue to be discovered and studied for their properties and to understand their biosynthesis.Electric Literature of C5H3Br2N

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Application In Synthesis of 4′-(4-Pyridyl)-2,2′:6′,2”-terpyridineOn November 20, 2021 ,《Coordination-driven self-assembly of nanoZnO hybrids with tripodal zinc terpyridyl-viologen complex multilayers and their photochromic properties》 appeared in Colloids and Surfaces, A: Physicochemical and Engineering Aspects. The author of the article were Xian, Yu; Ma, Dong-Mei; Liu, Jian-Hong; Qian, Dong-Jin. The article conveys some information:

Viologen (VIO) functionalized nanomaterials and supramol. systems have attracted much attention because of their well reversible redox properties, unique photo-/electrochromic and radical-rich features that resulting in potential applications in the fields of coloration and memory devices, energy conversion and biomimetic chem. Here, a tripodal terpyridyl-viologen (TPyVIO) multidentate ligand was newly synthesized, which was then used as a linker, together with Zn2+ ion as a connector, to construct Zn-TPyVIO multilayers on the surfaces of nanoZnO particles to produce nanoZnO@(Zn-TPyVIO)n hybrids by a layer-by-layer (LBL) technique. Luminescent emission of nanoZnO semiconductors was largely quenched in the nanoZnO@(Zn-TPyVIO)n hybrids, attributed to a quick electron transfer from the conduction band of excited nanoZnO particles to viologens; this electron transfer process resulted in the formation of colored monovalent viologen radical cations. Reversible redox couple was recorded for the glass carbon electrode modified by the nanohybrids, with the cationic and anionic potentials at approx. – 0.78– 0.84 and – 0.63–0.73 mV (vs Hg/Hg2Cl2), resp. Finally, it was revealed that the nanoZnO@(Zn-TPyVIO)n hybrids displayed well photochromic behaviors under light radiation. The experimental part of the paper was very detailed, including the reaction process of 4′-(4-Pyridyl)-2,2′:6′,2”-terpyridine(cas: 112881-51-3Application In Synthesis of 4′-(4-Pyridyl)-2,2′:6′,2”-terpyridine)

4′-(4-Pyridyl)-2,2′:6′,2”-terpyridine(cas: 112881-51-3) belongs to pyridine derivatives. Several pyridine derivatives play important roles in biological systems. While its biosynthesis is not fully understood, nicotinic acid (vitamin B3) occurs in some bacteria, fungi, and mammals. Application In Synthesis of 4′-(4-Pyridyl)-2,2′:6′,2”-terpyridine

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

《Study Protocol for a Randomized Controlled Trial Evaluating the Effectof Chromium Picolinate Supplementation on Gene Expression of TumorNecrosis Factor-α and DNA Damage in Metabolic Syndrome Patients.》 was written by Mozaffari-Khosravi, Hassan; Jambarsan, Sara; Karimpour, Fazad; Hosseini, Seyyed Ebrahim; Kour, Behrooz Ebrahimzadeh. Application In Synthesis of Picolinic acid And the article was included in Saudi journal of kidney diseases and transplantation in 2021. The article conveys some information:

Metabolic syndrome (MS) is caused by environmental factors as well as genetic. Human studies of efficacy of chromium for glucose and lipid metabolism and insulin function is not still definitive. Furthermore, the effect of chromium supplementation on the expression of inflammatory genes in patients with MS has not been studied. We will assess effects of chromium picolinate supplementation on gene expression of tumor necrosis factor-α (TNF-α) and DNA damage in MS patients. In this triple-blind randomized placebo-controlled clinical trial, 48 MS patients will be randomly assigned into two groups to receive daily 400 μg chromium picolinate supplement or placebo for 12 weeks. The outcome measures include of change in fasting blood sugar, glycosylated hemoglobin A1C, inflammatory biomarkers, lipid profile, blood pressure, gene expression of TNF-α, and 8-hydroxy-deoxyguanosine concentration as DNA damage biomarker, will be quantified at baseline and end of intervention. This protocol was approved by Institutional Research Ethics Committee School of Public Health Shahid Sadoughi University of Medical Sciences (Approval ID: IR.SSU.SPH.REC.1399.141). In addition to this study using Picolinic acid, there are many other studies that have used Picolinic acid(cas: 98-98-6Application In Synthesis of Picolinic acid) was used in this study.

Picolinic acid(cas: 98-98-6) is used in the preparation of 2-Aminodihydro[1,3]thiazines as BACE 2 inhibitors and their preparation and use in the treatment of diabetes.Application In Synthesis of Picolinic acid

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Related Products of 98-98-6In 2021 ,《Concentration effects on optical properties, DFT, crystal characterization and α-glucosidase activity studies: Novel Zn(II) complex》 appeared in Spectrochimica Acta, Part A: Molecular and Biomolecular Spectroscopy. The author of the article were Dege, Necmi; Ozge, Ozgen; Avci, Davut; Basoglu, Adil; Sonmez, Fatih; Yaman, Mavise; Tamer, Omer; Atalay, Yusuf; Zengin Kurt, Belma. The article conveys some information:

A novel Zn(II) complex of 6-ClpicH and picH was synthesized and its structure was determined by XRD technique. The detailed exptl. optical susceptibility and band gap, refractive index, linear polarizability, optical and elec. conductivity parameters in various concentrations were studied by the UV-visible spectroscopic data. The optical band gap, refractive index (n), linear optical susceptibility (χ(1)), third-order nonlinear optical susceptibility (χ(3)), second- and third-order nonlinear optical (β and γ) parameters were examined by using DFT/M06-L and ωB97XD/6-311++G(d,p) levels. The IC50 value of Zn(II) complex against α-glucosidase was also obtained at 0.44 mM. The exptl. band gap of the Zn(II) complex at 13, 33, 44 and 94μM concentrations in ethanol are 4.38, 4.37, 4.35 and 4.28 eV, resp. The third-order NLO susceptibility χ(3) parameter at 94μM concentration corresponding to the photon energies of 4.6 and 5.7 eV in the UV-visible region were observed at 206.6 x 10-13 and 294.3 x 10-13 esu, resp. Besides, the theor. χ(3) values were obtained at 50.58 x 10-13 and 20.37 x 10-13 esu by using M06-L level. Zn(II) complex could be an effective third-order NLO candidate material. In brief, the detailed theor. and exptl. structural, spectral and optical properties of the Zn(II) complex were presented comparatively. In addition to this study using Picolinic acid, there are many other studies that have used Picolinic acid(cas: 98-98-6Related Products of 98-98-6) was used in this study.

Picolinic acid(cas: 98-98-6) is used as a chelate for alkaline earth metals. Used to prepare picolinato ligated transition metal complexes. In synthetic organic chemistry, has been used as a substrate in the Mitsunobu reaction and in the Hammick reaction.Related Products of 98-98-6

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Product Details of 1539-42-0In 2020 ,《A 4,5-quinolimide-based fluorescent sensor for sequential detection of Cu2+ and cysteine in water and living cells with application in a memorized device》 appeared in Spectrochimica Acta, Part A: Molecular and Biomolecular Spectroscopy. The author of the article were Zhang, Yu; Li, Lan; Wang, Jinping; Jia, Lihua; Yang, Rui; Guo, Xiangfeng. The article conveys some information:

A new 4,5-quinolimide-based fluorescent sensor BNC was synthesized and characterized. BNC showed single selectivity for Cu2+via the “”turn-off”” fluorescence among various common metal ions. After forming a 1:1 stoichiometric complex with Cu2+, the detection limit (LOD) of BNC for Cu2+ is 0.44μM. Subsequently, the in situ generated BNC-Cu2+ complex had been used for sensing Cys with the LOD of 1.5μM through the displacement strategy, resulting in the revivable emission of BNC. According to the “”off-on-off”” fluorescence cycle of BNC generated by the alternate addition of Cu2+ and Cys, a reversible memorized device with “”read-write-read-erase”” behavior was constructed at the mol. level. Furthermore, the recoveries of Cu2+ in lake water with BNC were at 95.0-105%. And sequential fluorescence imagings of BNC for Cu2+ and Cys were successfully applied in living yeast cells.Bis(pyridin-2-ylmethyl)amine(cas: 1539-42-0Product Details of 1539-42-0) was used in this study.

Bis(pyridin-2-ylmethyl)amine(cas: 1539-42-0) is a secondary amine with two picolyl substituents. The compound is a tridentate ligand in coordination chemistry and commonly used to produce Zn-based chemosensors/probes, such as Zinpry.Product Details of 1539-42-0

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

《Synthesis and structural study of tris(2,6-diaminopyridinium) bis(oxalato)dioxidovanadate(V) 2.5-hydrate》 was written by Sehimi, Hiba; Akitsu, Takashiro; Zid, Mohamed Faouzi. Application In Synthesis of 2,6-DiaminopyridineThis research focused ontrisdiaminopyridinium bis oxalatodioxidovanadatehydrate crystal structure; 2,6-di­amino­pyridine; bis­(oxalato) complexes; crystal structure; dioxovanadate(V); vanadium. The article conveys some information:

Crystals of the title compound, (C5H8N3)3[VO2(C2O4)2]·2.5H2O, a mononuclear VV complex, were obtained by slow evaporation at room temperature of an aqueous solution containing vanadium pentoxide, oxalic acid and 2,6-diaminopyridine. The asym. unit contains one bis(oxalato)dioxovanadate(V) anionic complex, three 2,6-diaminopyridinium cations and two and a half uncoordinated water mols. The mononuclear vanadium(V) anions are connected to the organic cations and water mols. through a strong N-H···O and O-H···O hydrogen-bond network, consolidated by π-π stacking interactions, to form a three-dimensional structure. In the experiment, the researchers used many compounds, for example, 2,6-Diaminopyridine(cas: 141-86-6Application In Synthesis of 2,6-Diaminopyridine)

2,6-Diaminopyridine(cas: 141-86-6) belongs to pyridine. Pyridine and its simple derivatives are stable and relatively unreactive liquids, with strong penetrating odours that are unpleasant.Application In Synthesis of 2,6-Diaminopyridine

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

The author of 《Impact of Pyridyl Moieties on the Inhibitory Properties of Prominent Acyclic Metal Chelators Against Metallo-β-Lactamase-Producing Enterobacteriaceae: Investigating the Molecular Basis of Acyclic Metal Chelators’ Activity》 were Sosibo, Sphelele C.; Somboro, Anou M.; Amoako, Daniel G.; Osei Sekyere, John; Bester, Linda A.; Ngila, Jane C.; Sun, Darren D.; Kumalo, Hezekiel M.. And the article was published in Microbial Drug Resistance (New Rochelle, NY, United States) in 2019. Computed Properties of C12H13N3 The author mentioned the following in the article:

Carbapenem-resistant Enterobacteriaceae (CREs)-mediated infections remain a huge public health concern. CREs produce enzymes such as metallo-β-lactamases (MBLs), which inactivate β-lactam antibiotics. Hence, developing efficient mols. capable of inhibiting these enzymes remains a way forward to overcoming this phenomenon. In this study, we demonstrate that pyridyl moieties favor the inhibitory activity of cyclic metal-chelating agents through in vitro screening, mol. modeling, and docking assays. Di-(2-picolyl) amine and tris-(2-picolyl) amine exhibited great efficacy against different types of MBLs and strong binding affinity for NDM-1, whereas 2-picolyl amine did not show activity at a concentration of 64 mg/L in combination with meropenem; it further showed the lowest binding affinity from computational mol. anal., commensurating with the in vitro screening assays. The findings revealed that the pyridyl group plays a vital role in the inhibitory activity of the tested mols. against CREs and should be exploited as potential MBL inhibitors. After reading the article, we found that the author used Bis(pyridin-2-ylmethyl)amine(cas: 1539-42-0Computed Properties of C12H13N3)

Bis(pyridin-2-ylmethyl)amine(cas: 1539-42-0) is a secondary amine with two picolyl substituents. As a tridentate ligand this compound provides three nitrogen donors that affords good selectivity for Zn2+ over biologically relevant metals such as Na+, K+, Mg2+ and Ca2+, and leaves coordination sites free for anion binding. Computed Properties of C12H13N3

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem