Month: October 2022

Xie, Dongsheng; Lu, Jun; Xie, Jin; Cui, Junjun; Li, Teng-Fei; Wang, Yan-Chao; Chen, Yuan; Gong, Nian; Li, Xin-Yan; Fu, Lei; Wang, Yong-Xiang published the artcile< Discovery and analgesic evaluation of 8-chloro-1,4-dihydropyrido[2,3-b]pyrazine-2,3-dione as a novel potent D-amino acid oxidase inhibitor>, Recommanded Product: 5-Fluoropyridine-2,3-diamine, the main research area is chlorodihydro pyridopyrazine dione preparation amino acid oxidase inhibitor; 5-Azaquinoxaline-2,3-diones; 8-Chloro-1,4-dihydropyrido[2,3-b]pyrazine-2,3-dione; Analgesic effects; D-amino acid oxidase; DAAO inhibitors.

A series of 5-azaquinoxaline-2,3-dione derivatives were synthesized and evaluated on D-amino acid oxidase (DAAO) inhibition as potential α-hydroxylactam-based inhibitors. The potent inhibitory activities in vitro suggested that 5-nitrogen could significantly enhance the binding affinity by strengthening relevant hydrogen bond interactions. The analgesic effects of intrathecal and systemic injection of 8-chloro-1,4-dihydropyrido[2,3-b]pyrazine-2,3-dione, a representative mol. of 5-azaquinoxaline-2,3-dione, were investigated in rodents. This research not only confirmed the analgesic effect of the DAAO inhibitors but provided a new class of chem. entities with oral application potential for the treatment of chronic pain and morphine analgesic tolerance.

European Journal of Medicinal Chemistry published new progress about Analgesics. 212268-13-8 belongs to class pyridine-derivatives, and the molecular formula is C5H6FN3, Recommanded Product: 5-Fluoropyridine-2,3-diamine.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Matsuo, Kenya; Yoshihara, Kumiko; Nagaoka, Noriyuki; Makita, Yoji; Obika, Hideki; Okihara, Takumi; Matsukawa, Akihiro; Yoshida, Yasuhiro; Van Meerbeek, Bart published the artcile< Rechargeable anti-microbial adhesive formulation containing cetylpyridinium chloride montmorillonite>, Electric Literature of 123-03-5, the main research area is cetylpyridinium chloride montmorillonite antimicrobial adhesive formulation; Adhesive; Antibacterial; Cetylpyridinium chloride (CPC); Montmorillonite; Recharge; S. mutans.

Long-term anti-bacterial effect is a desired ability of any dental material in combating tooth caries as one of the most common and widespread persistent diseases today. Among several cationic quaternary ammonium compounds with antiseptic properties, cetylpyridinium chloride (CPC) is often used in mouthrinses and toothpastes. In this study, we incorporated CPC in a soft phyllosilicate mineral (clay), referred to as montmorillonite (Mont), to enable gradual CPC release with rechargeability. Besides measuring CPC release and recharge, we examined the anti-bacterial effect, cytotoxicity and bonding effectiveness of five exptl. adhesive formulations, prepared by adding 1 and 3 wt% CPC_Mont, 3 wt% Mont (without CPC), and 1 and 3 wt% CPC (without Mont) to the com. adhesive Clearfil S3 Bond ND Quick (C-S3B; Kuraray Noritake). Strong inhibition of Streptococcus mutans biofilm formation by CPC_Mont adhesives was confirmed by optical d. and SEM. CPC release from CPC_Mont adhesives was higher and lasted longer than from CPC adhesives, while CPC_Mont adhesives could also be recharged with CPC upon immersion in 2 wt% CPC. In conclusion, CPC_Mont technol. rendered adhesives anti-bacterial properties with recharge ability, this without reducing its bonding potential, neither increasing its cytotoxicity. Dental caries is one of the most prevalent chronic diseases in the population worldwide and is the major cause of tooth loss. In this study, we developed cetylpyridinium chloride (CPC) loaded montmorillonite (CPC-Mont) with a long-term antibacterial efficacy to prevent caries. CPC is an antibacterial agent approved by FDA, used as an OTC drug and contained in oral hygiene aids. CPC-Mont was incorporated in a dental adhesive to gradually release CPC. CPC_Mont technol. rendered adhesives anti-bacterial properties with rechargeability, this without reducing its bonding potential, neither increasing its cytotoxicity.

Acta Biomaterialia published new progress about Adhesives. 123-03-5 belongs to class pyridine-derivatives, and the molecular formula is C21H38ClN, Electric Literature of 123-03-5.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Donald, James R.; Berrell, Sophie L. published the artcile< Radical cyanomethylation via vinyl azide cascade-fragmentation>, Related Products of 370878-69-6, the main research area is azido alkenol alkyl nucleophile tandem radical photochem cyanomethylation; alkanenitrile preparation.

A novel methodol. for radical cyanomethylation was described. The process was initiated by radical addition to the vinyl azide reagent 3-azido-2-methylbut-3-en-2-ol which triggered a cascade-fragmentation mechanism driven by the loss of dinitrogen and the stabilized 2-hydroxypropyl radical, ultimately effecting cyanomethylation. Cyanomethyl group was efficiently introduced into a range of substrates via trapping of α-carbonyl, heterobenzylic, alkyl, sulfonyl and aryl radicals, generated from a variety of functional groups under both photoredox catalysis and non-catalytic conditions. The value of this approach was exemplified by the late-stage cyanomethylation of pharmaceuticals.

Chemical Science published new progress about Aliphatic nitriles Role: PRP (Properties), RCT (Reactant), SPN (Synthetic Preparation), RACT (Reactant or Reagent), PREP (Preparation). 370878-69-6 belongs to class pyridine-derivatives, and the molecular formula is C33H21F3IrN3, Related Products of 370878-69-6.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Liu, Jin-Biao; Wu, Chun; Chen, Feng; Leung, Chung-Hang; Ma, Dik-Lung published the artcile< A simple iridium(III) dimer as a switch-on luminescent chemosensor for carbon disulfide detection in water samples>, Application of C10H8N2, the main research area is iridium dimer luminescent chemosensor carbon disulfide water; Carbon disulfide; Chemosensor; Iridium(III) dimer; Luminescence.

A series of iridium(III) dimers were synthesized and their ability to interact with diethyldithiocarbamate for CS2 sensing was evaluated. Upon the addition of CS2, diethylamine can capture CS2 to form diethyldithiocarbamate, which could chelate with the iridium(III) dimer to form a diethyldithiocarbamate iridium(III) complex, resulting in a yellow luminescence. Dimer 8 exhibited a maximum 18-fold of luminescence enhancement upon the addition of CS2. The luminescence signal of the detection system could be readily distinguished from the highly fluorescent media using time-resolved emission spectroscopy (TRES). The capability of the system to determine CS2 level in water samples was also demonstrated.

Analytica Chimica Acta published new progress about Environmental analysis. 581-47-5 belongs to class pyridine-derivatives, and the molecular formula is C10H8N2, Application of C10H8N2.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Smil, David; Wong, Jong Fu; Williams, Eleanor P.; Adamson, Roslin J.; Howarth, Alison; McLeod, David A.; Mamai, Ahmed; Kim, Soyoung; Wilson, Brian J.; Kiyota, Taira; Aman, Ahmed; Owen, Julie; Poda, Gennady; Horiuchi, Kurumi Y.; Kuznetsova, Ekaterina; Ma, Haiching; Hamblin, J. Nicole; Cramp, Sue; Roberts, Owen G.; Edwards, Aled M.; Uehling, David; Al-awar, Rima; Bullock, Alex N.; O’Meara, Jeff A.; Isaac, Methvin B. published the artcile< Leveraging an Open Science Drug Discovery Model to Develop CNS-Penetrant ALK2 Inhibitors for the Treatment of Diffuse Intrinsic Pontine Glioma>, Reference of 916791-62-3, the main research area is preparation ALK2 inhibitor diffuse intrinsic pontine glioma.

There are currently no effective chemotherapeutic drugs approved for the treatment of diffuse intrinsic pontine glioma (DIPG), an aggressive pediatric cancer resident in the pons region of the brainstem. Radiation therapy is beneficial but not curative, with the condition being uniformly fatal. Anal. of the genomic landscape surrounding DIPG has revealed that activin receptor-like kinase-2 (ALK2) constitutes a potential target for therapeutic intervention given its dysregulation in the disease. An open science approach has been adopted to develop a series of potent, selective, orally bioavailable, and brain-penetrant ALK2 inhibitors based on the lead compound LDN-214117. Modest structural changes to the C-3, C-4, and C-5 position substituents of the core pyridine ring afforded compounds M4K2009, M4K2117, and M4K2163, each with a superior potency, selectivity, and/or blood-brain barrier (BBB) penetration profile. Robust in vivo pharmacokinetic (PK) properties and tolerability mark these inhibitors as advanced preclin. compounds suitable for further development and evaluation in orthotopic models of DIPG.

Journal of Medicinal Chemistry published new progress about Activin receptor ACVRLK2 Role: BSU (Biological Study, Unclassified), BIOL (Biological Study). 916791-62-3 belongs to class pyridine-derivatives, and the molecular formula is C5H2Cl2FN, Reference of 916791-62-3.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Azum, Naved; Rub, Malik Abdul; Alfaifi, Sulaiman Yahya; Asiri, Abdullah M. published the artcile< Interaction of diphenhydramine hydrochloride with cationic and anionic surfactants: mixed micellization and binding studies>, Product Details of C21H38ClN, the main research area is diphenhydramine hydrochloride cationic anionic surfactant mixed micellization binding study; binding studies; cetylpyridinium chloride; diphenhydramine hydrochloride; mixed micellization; sodium dodecyl sulfate.

The focus of the present work is to evaluate the interactions of an anti-allergic drug (diphenhydramine hydrochloride, DPH) with anionic (sodium dodecyl sulfate, SDS) and cationic (cetylpyridinium chloride, CPC) surfactants in the aqueous medium. The mixed micellization behavior and surface properties of drug-surfactant mixtures have been examined by surface tension measurements. Various theor. approaches were applied to explore the synergistic or non-ideal behavior of the current mixed systems. Furthermore, the binding studies of drug with surfactants have been elaborated by UV-visible spectroscopy. Benesi-Hildebrand (B-H) theory was used to compute stoichiometric ratio, binding constant, and free energy change for the drug-surfactant mixtures The outputs are deliberated taking into consideration the use of surfactants as capable drug delivery agents for DPH and hence advance bioavailability.

Polymers (Basel, Switzerland) published new progress about Absorption spectra. 123-03-5 belongs to class pyridine-derivatives, and the molecular formula is C21H38ClN, Product Details of C21H38ClN.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Hansen, Andreas; Buse, Anna-Sophie; Wilke, Annika; Skudlik, Christoph; John, Swen M.; Brans, Richard published the artcile< Sensitization to 1,3-diphenylguanidine: An underestimated problem in physicians and nurses using surgical gloves>, Related Products of 123-03-5, the main research area is cetylpyridinium chloride diphenylguanidine surgical gloves; 1,3-diphenylguanidine; allergic contact dermatitis; case report; cetylpyridinium chloride; hand eczema; healthcare workers; patch test; surgical gloves.

This article deals about sensitization to 1,3-diphenylguanidine is underestimated problem in physicians and nurses using surgical gloves. A 55-yr-old male anesthesiologist with hand eczema was patch tested in our department in 2016 revealing sensitization to 1,3-diphenylguanidine and cetylpyridinium chloride. Patch testing of glove was done in three of patients and revealed no pos. reaction. Three of patients were able to continue their occupation with markedly improved skin conditions. No follow-up information was available for female surgeon.

Contact Dermatitis published new progress about Allergic contact dermatitis. 123-03-5 belongs to class pyridine-derivatives, and the molecular formula is C21H38ClN, Related Products of 123-03-5.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Vikram, Venugopalarao; Amperayani, Karteek rao; Ummidi, Venkata Ravi Sankar; Parimi, Umadevi published the artcile< Synthesis, Anti-Microbial Activity, and Docking Studies of Novel N-Pyridine Substituted 2-Chlorothieno[2,3-d]pyrimidine Derivatives>, HPLC of Formula: 55279-29-3, the main research area is pyridine substituted chloro thienopyrimidinamine preparation antibacterial antifungal docking; acetyl coenzyme carboxylase inhibitor pyridine substituted chloro thienopyrimidinamine preparation.

A series of novel N-pyridine substituted 2-chloro-thieno[2,3-d]pyrimidin-4-amine derivatives I [Ar = 2-pyridyl, (3-methyl-2-pyridyl), (5-chloro-2-pyridyl), etc.] had been synthesized and characterized by 1H and 13C NMR spectrometry. All the compounds had been docked against acetyl-CoA carboxylase enzyme and also tested for their in vitro antimicrobial activity on Gram-pos. (Micrococcus luteus, staphylococcus aureus) and Gram-neg. bacteria (Salmonella typhi, klebsiella pneumoniae) and anti-fungal activity on aspergillus niger and fusarium oxysporum. All synthesized compounds have demonstrated moderate activity and two products have exhibited good antibacterial and antifungal activity.

Russian Journal of General Chemistry published new progress about Acetyl-coenzyme A carboxylase inhibitors. 55279-29-3 belongs to class pyridine-derivatives, and the molecular formula is C6H6N2O, HPLC of Formula: 55279-29-3.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Cheung, Chi Wai; Shen, Ni; Wang, Shao-Peng; Ullah, Asim; Hu, Xile; Ma, Jun-An published the artcile< Manganese-mediated reductive amidation of esters with nitroarenes>, Electric Literature of 93-60-7, the main research area is aryl amide; ester nitroarene reductive amidation.

A convenient and efficient method to synthesize N-aryl amides RNHC(O)R1 (R = 4-methylphenyl, 2H-1,3-benzodioxol-5-yl, quinolin-6-yl, etc; R1 = n-C6H13, cyclohexyl, 4-chlorophenyl, pyridin-3-yl, etc.) via amidation of esters R1C(O)OR2 (R2 = Et, benzyl, 2H-1,3-benzodioxol-5-ylmethyl, etc.) with nitroarenes RNO2 was reported. In the presence of manganese metal, this amidation proceeded smoothly without the need for addnl. catalysts or ligands. Various esters and nitroarenes are suitable substrates to afford a wide range of N-aryl amides, including bio-active mols. RNHC(O)R1 (R = 2-phenyl-1,3-benzoxazol-5-yl, R1 = Ph; R = 2-phenyl-1,3-benzoxazol-5-yl, R1 = benzyl) and intermediates I (X = H, Cl) to drug mols. e.g., II.

Organic Chemistry Frontiers published new progress about Amidation (reductive). 93-60-7 belongs to class pyridine-derivatives, and the molecular formula is C7H7NO2, Electric Literature of 93-60-7.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Oelschlegel, Manuel; Hua, Shao-An; Schmid, Lucius; Marquetand, Philipp; Baeck, Anna; Borter, Jan-Hendrik; Luecken, Jana; Dechert, Sebastian; Wenger, Oliver S.; Siewert, Inke; Schwarzer, Dirk; Gonzalez, Leticia; Meyer, Franc published the artcile< Luminescent Iridium Complexes with a Sulfurated Bipyridine Ligand: PCET Thermochemistry of the Disulfide Unit and Photophysical Properties>, SDS of cas: 366-18-7, the main research area is crystallog luminescent iridium complex sulfurated bipyridine ligand; PCET thermochem disulfide unit photophys property.

Mol. systems combining light harvesting and charge storage are receiving great attention in the context of, for example, artificial photosynthesis and solar fuel generation. As part of ongoing efforts to develop new concepts for photoinduced proton-coupled electron transfer (PCET) reactivities, we report a cyclometallated iridium(III) complex [1]+ equipped with our previously developed sulfurated bipyridine ligand S-Sbpy. A new one-step synthetic protocol for S-Sbpy is developed, starting from com. available 2,2′-bipyridine, which significantly facilitates the use of this ligand. The iridium complex [Ir(ppy)2(S-Sbpy)](PF6) ([1]PF6) features a two-electron reduction with potential inversion (|E1| > |E2|) at moderate potentials (E1 = -1.17, E2 = -1.08 V vs. Fc+/0 at 253 K), leading to a dithiolate species [1]-. Protonation with weak acids allows for determination of pKa = 23.5 in MeCN for the S-H···S- unit of [1]H. The driving forces for both the H atom and the hydride transfer are calculated to be ∼ 60 kcal mol-1 and verified exptl. by reaction with a suitable H atom and a hydride acceptor, demonstrating the ability of [1]+ to serve as a versatile PCET reagent, albeit with limited thermal stability. In the MeCN solution, an orange emission for [1]PF6 from a triplet-excited state was found. D. functional calculations and ultrafast absorption spectroscopy are used to give insight into the excited-state dynamics of the complex and suggest a significantly stretched S-S bond for the lowest triplet-state T1. The structural responsiveness of the disulfide unit is proposed to open an effective relaxation channel toward the ground state, explaining the unexpectedly short lifetime of [1]+. These insights as well as the quant. ground-state thermochem. data provide valuable information for the use of S-Sbpy-functionalized complexes and their disulfide-/dithiol-directed PCET reactivity.

Inorganic Chemistry published new progress about Attenuated-total-reflectance IR spectroscopy. 366-18-7 belongs to class pyridine-derivatives, and the molecular formula is C10H8N2, SDS of cas: 366-18-7.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem