October 2022 | Page 41 of 299 | Pyridine-derivatives

Maronna, Astrid et al. published their research in Chemistry – A European Journal in 2013 |CAS: 75449-26-2

The Article related to bisguanidine biphenyl binaphthyl bipyridyl backbone protonation proton sponge, crystal structure protonated biaryl bisguanidine group 10 metal complex, dft optimized geometry protonated biaryl bisguanidine, fluorescence bipyridyl bisguanidine, heck catalyst palladium bipyridyl bisguanidine allyl complex, spin density nickel biaryl bisguanidine and other aspects.SDS of cas: 75449-26-2

Maronna, Astrid; Huebner, Olaf; Enders, Markus; Kaifer, Elisabeth; Himmel, Hans-Joerg published an article in 2013, the title of the article was Bisguanidines with Biphenyl, Binaphthyl, and Bipyridyl Cores: Proton-Sponge Properties and Coordination Chemistry.SDS of cas: 75449-26-2 And the article contains the following content:

Herein, the authors report on the synthesis, protonation, and coordination chem. of chelating guanidine ligands with biphenyl, binaphthyl, and bipyridyl backbones. The ligands are proton sponges, and this protonation was studied exptl. and by using quantum-chem. calculations Group 10 metal (Ni, Pd, and Pt) complexes with different metal/ligand ratios were synthesized. In the case of the bipyridyl systems, coordination occurs exclusively at the pyridine N atoms, as opposed to protonation. The spin-d. distribution and the magnetism were evaluated for paramagnetic NiII complexes with the aid of paramagnetic NMR spectroscopic studies in alliance with quantum-chem. calculations and magnetic (SQUID) measurements. Through direct delocalization from the singly occupied MOs (SOMOs), a significant amount of spin d. is placed on the guanidinyl groups, and spin polarization also transports spin d. onto the aromatic backbone. The experimental process involved the reaction of [2,2′-Bipyridine]-3,3′-diamine(cas: 75449-26-2).SDS of cas: 75449-26-2

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Stoessel, Philipp et al. published their patent in 2015 |CAS: 39919-70-5

The Article related to nitrogen heterocyclic compound preparation povarov cyclization cycloalkene aldehyde amine, heterocyclic polycyclic aromatic nitrogen preparation component organic electronic device, organic semiconductor nitrogen heterocycle host hole electron transporter, metallacyclic complex iridium platinum nitrogen heterocycle preparation electroluminescence and other aspects.Reference of 6-(tert-Butyl)pyridin-3-amine

On January 8, 2015, Stoessel, Philipp; Joosten, Dominik; Koenen, Nils published a patent.Reference of 6-(tert-Butyl)pyridin-3-amine The title of the patent was Polycyclic nitrogen heterocyclic compounds as semiconducting materials for components of organic electronic devices. And the patent contained the following:

Polycyclic nitrogen heterocycles I (1, X = methyne, N; E = bivalent group, forming 5- or 6-membered condensed ring; Y = O, S, 1,2-ethenediyl, imino, borylene, silylene CO, alkenylidene, SO, SO2, 1,2-ethanediyl, phosphinidene, phosphinylidene; R = H, D, halo, amino, CN, NO2, OH, CO2H, carbamoyl, silyl, boryl, acyl, phosphinyl, sulfinyl, sulfonyl, sulfo, C1-20 alkyl, alkoxy, alkylthio, alkenyl, alkynyl; R1 = R or R1-R1 = bond) and their cyclometalated platinum and iridium complexes [M(L)n(L1)m] (2, M = Ir, Pd, Pt, Os, Re; L1 = auxiliary ligand), useful as organic semiconducting materials for manufacturing of charge-transporting and charge-injecting layers in organic semiconductor devices, preferably, in organic light-emitting devices (OLEDs) and featuring glass transition temperature at least 110°, were prepared by heterocyclization of aromatic aldehydes with aromatic amines and alkenes with optional subsequent cyclometalation and complexation with protonated ligands HpL1. In an example, Povarov reaction of 500 mmol of aniline with 550 mmol of benzaldehyde and 1 mol of norbornene in 1300 mL of CH2Cl2 catalyzed with 100 mmol of BF3·OEt2 for 40 h at reflux with subsequent oxidation by 5 mol of MnO2 for 16 h at reflux in 1000 mL of 1,2-dichlorobenzene under water separation gave the invented compound (1a, shown as I, E = CH:CHCH:CH, X = CH, Y = CH2, R = R1 = H) with 56% yield. The present invention relates to compounds having polycyclic structural units and to electronic devices, in particular organic electroluminescent devices, containing said compounds The experimental process involved the reaction of 6-(tert-Butyl)pyridin-3-amine(cas: 39919-70-5).Reference of 6-(tert-Butyl)pyridin-3-amine

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Ding, Tao et al. published their research in CrystEngComm in 2017 |CAS: 1431292-15-7

The Article related to zinc manganese cadmium pyridineisophthalate imidazolebiphenyl complex preparation thermal stability, crystal structure zinc manganese cadmium pyridineisophthalate imidazolebiphenyl complex, photoluminescence zinc manganese cadmium pyridineisophthalate imidazolebiphenyl complex, gas adsorption zinc manganese cadmium pyridineisophthalate imidazolebiphenyl complex and other aspects.Safety of 5,5′-(Pyridine-2,5-diyl)diisophthalic acid

Ding, Tao; Wang, Xiao-Xian; Zhang, Meng; Ou, Si-Meng; Hu, Tian-Ju published an article in 2017, the title of the article was Four new coordination polymers based on a pyridinetetracarboxylate ligand: syntheses, structures and high CO2/CH4 separation.Safety of 5,5′-(Pyridine-2,5-diyl)diisophthalic acid And the article contains the following content:

Four new coordination polymers, [Zn(TPTA)0.5(BIBP)] (1), [Mn(TPTA)0.5(BIBP)0.5(DMF)] (2), [Zn1.5(TPTA)]·DMF·H2O (3), and [Cd1.5(TPTA)]·DMF·2H2O (4) (H4TPTA = 5,5′-(pyridine-2,5-diyl)diisophthalic acid, BIBP = 4,4′-bis(imidazol-1-yl)biphenyl), have been synthesized under solvothermal conditions and fully characterized. Single-crystal X-ray diffraction anal. revealed that complex 1 is a three-dimensional (3D) 3-fold interpenetrating architecture with (4·64·8)2(42·62·82) topol. Complex 2 possesses a 3D 2-fold interpenetrating framework based on binuclear Mn2 units with (412·63) topol. Both complexes 3 and 4 exhibit trinuclear 3D non-interpenetrating (4,8)-connected networks with (46)2(412·612·84) topol. The fluorescence properties of 1, 3 and 4 have been also measured. Importantly, gas adsorption studies for 1-4 show highly selective adsorption of CO2 over CH4. The experimental process involved the reaction of 5,5′-(Pyridine-2,5-diyl)diisophthalic acid(cas: 1431292-15-7).Safety of 5,5′-(Pyridine-2,5-diyl)diisophthalic acid

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Adam, Geo et al. published their patent in 2003 |CAS: 98488-99-4

The Article related to alzheimer disease, anti-alzheimer agents, antipsychotics, biological memory retention defect, cognition enhancers, cognitive disorders, drug delivery systems, homo sapiens, human, metabotropic glutamate receptors role: bsu (biological study, unclassified), biol (biological study) (antagonists), nervous system agents, nervous system disease, psychosis, schizophrenia and other aspects.Application In Synthesis of 4-Bromo-5-ethyl-2-methylpyridine

On August 14, 2003, Adam, Geo; Goetschi, Erwin; Wichmann, Juergen; Woltering, Thomas Johannes published a patent.Application In Synthesis of 4-Bromo-5-ethyl-2-methylpyridine The title of the patent was Preparation of dihydrobenzodiazepin-2-ones as metabotropic glutamate receptor antagonists for the treatment of neurological disorders. And the patent contained the following:

This invention relates to dihydrobenzo[b][1,4]diazepin-2-ones (shown as I; variables defined below; e.g. 7,8-dichloro-4-[3-(pyridin-3-yl)phenyl]-1,3-dihydrobenzo[b][1,4]diazepin-2-one). The invention further relates to medicaments containing these compounds, a process for their preparation as well as their use for preparation of medicaments for the treatment or prevention of acute and/or chronic neurol. disorders, e.g. Alzheimer’s disease. Three examples of pharmaceutical compositions containing I are included. Ki values for 50 examples of I as metabotropic glutamate receptor antagonists are tabulated, e.g. 0.00135 μM for 7,8-dichloro-4-(3-pyridin-3-ylphenyl)-1,3-dihydrobenzo[b][1,4]diazepin-2-one. More than 400 example preparations of I and many example preparations of intermediates are included. For example, 7,8-dichloro-4-[3-(pyridin-3-yl)phenyl]-1,3-dihydrobenzo[b][1,4]diazepin-2-one (310 mg) was prepared from 4,5-dichlorophenylenediamine (0.97 mmol) and 3-oxo-3-[3-(pyridin-3-yl)phenyl]propionic acid tert-Bu ester (0.97 mmol) by refluxing in xylene. For I: X is a single bond or an ethynediyl group; and wherein in case X is a single bond, R1 is H, cyano, halogen, lower alkyl, lower alkoxy, fluoro-lower alkyl, fluoro-lower alkoxy, pyrrol-1-yl, or Ph, which is (un)substituted by one or two substituents halogen, lower alkyl or fluoro-lower alkyl; or in case X is an ethynediyl group, R1 is Ph, which is (un)substituted by one or two substituents halogen, lower alkyl or fluoro-lower alkyl. R2 is H, lower alkyl, lower alkenyl lower alkoxy, halogen, -NR’R”, pyrrolidin-1-yl, piperidin-1-yl, morpholin-4-yl, fluoro-lower alkyl, fluoro-lower alkoxy, or lower alkoxy(ethoxy)m; m = 1-4; R’ is H, lower alkyl or C3-C6-cycloalkyl; R” is H, lower alkyl or C3-C6-cycloalkyl; Y is -CH= or =N-; R3 is a six-membered aromatic heterocycle containing 1 to 3-N atoms or a pyridine N-oxide, which rings are (un)substituted by one or two substituents halogen, fluoro-lower alkyl, fluoro-lower alkoxy, cyano, amino, lower alkylamino, lower alkoxy-lower alkylamino, lower hydroxy-lower alkylamino, -(CH2)n-C(O)-OR”, -(CH2)n-C(O)-NR’R”, -(CH2)n-SO2-NR’R”, -(CH2)n-C(NH2):NR”, hydroxy, lower alkoxy, lower alkylthio, C3-C6-cycloalkyl and lower alkyl, which is (un)substituted by fluoro, -NR’R”, hydroxy, lower alkoxy, pyrrolidin-1-yl, azetidin-1-yl, cyano or carbamoyloxy; n = 0-4. The experimental process involved the reaction of 4-Bromo-5-ethyl-2-methylpyridine(cas: 98488-99-4).Application In Synthesis of 4-Bromo-5-ethyl-2-methylpyridine

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Kumar, Sandeep team published research in New Journal of Chemistry in 2021 | 1603-41-4

1603-41-4, 2-Amino-5-methylpyridine, also known as 2-Amino-5-methylpyridine, is a useful research compound. Its molecular formula is C6H8N2 and its molecular weight is 108.14 g/mol. The purity is usually 95%.
2-Amino-5-methylpyridine is a chemical compound that belongs to the group of methyl ketones. It has a nitrogen atom and an oxygen atom in its structure, which allows it to form hydrogen bonds with other molecules. 2-Amino-5-methylpyridine can be obtained by reacting hydrochloric acid and xanthone in the presence of a base. The compound is highly reactive and has been shown to have antiinflammatory properties. This can be attributed to its ability to inhibit prostaglandin synthesis. 2-Amino-5-methylpyridine also has fluorescence properties that are sensitive to pH changes and can be used as a probe for metal ions. 2-Amino-5-methylpyridine is an organic compound that contains a methyl group, two nitrogen atoms, and one oxygen atom in its chemical structure. This molecule can form hydrogen bonds with other molecules due to its nitrogen atoms and oxygen atom,, Recommanded Product: 2-Amino-5-methylpyridine

Pyridine is colorless, but older or impure samples can appear yellow. 1603-41-4, formula is C6H8N2, Name is 2-Amino-5-methylpyridine. The pyridine ring occurs in many important compounds, including agrochemicals, pharmaceuticals, and vitamins. Historically, pyridine was produced from coal tar. Recommanded Product: 2-Amino-5-methylpyridine.

Kumar, Sandeep;Kumar, Sumit;Maity, Jyotirmoy;Kumar, Banty;Bali Mehta, Shilpika;Prasad, Ashok K. research published 《 Synthesis and photophysical properties of 5-(3”-alkyl/aryl-amino-1”-azaindolizin-2”-yl)-2′-deoxyuridines》, the research content is summarized as follows. The Groebke-Blackburn-Bienayame (GBB) reaction has been used for the efficient synthesis of novel fluorescent 5-azaindolizino-2′-deoxyuridines starting from com. available thymidine following two strategies. Thus, thymidine was converted to diacetylthymidine, which on potassium persulfate oxidation afforded 3′,5′-di-O-acetyl-5-formyl-2′-deoxyuridine. In strategy A, diacetylated 5-formyldeoxyuridine was reacted with a variety of 2-aminopyridines and alkyl/aryl isocyanides under optimized GBB reaction conditions followed by deacetylation of the resulting GBB products to afford 5-azaindolizino-2′-deoxyuridines in 83 to 95% overall yields. In strategy B, diacetylated 5-formyldeoxyuridine was first deacetylated, which on GBB reaction under standardized conditions with 2-aminopyridines and alkyl/aryl isocyanides afforded the desired 5-azaindolizino-2′-deoxyuridines in 21 to 23% overall yields, which clearly indicates that strategy A is far more efficient than strategy B. The emission spectra of the synthesized 5-azaindolizino-2′-deoxyuridines exhibited a strong band around 360 nm (excitation at 239 nm) in fluorescence studies. Photophys. studies of these nucleosides showed a high level of fluorescence with Stokes shift in the range 59-126 nm, which indicated their potential for the study of the local structure and dynamics of nucleic acids involving them.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Kumar, Gadde Sathish team published research in Angewandte Chemie, International Edition in 2020 | 5315-25-3

COA of Formula: C6H6BrN, 2-Bromo-6-methylpyridine (2BMPy) is a bromopyridine derivative. It is formed when 2-chloro-6-methylpyridine is heated with bromotrimethylsilane. Its synthesis from various methods have been reported.
2-Bromo-6-methylpyridine is a building block in the preparation of nitrogen containing heterocyclic compounds.
2-Bromo-6-methylpyridine is an organic compound that belongs to the group of pyridinium halides. It is soluble in common solvents such as water, ethanol, and acetone. 2BMPy has been shown to act as a glutamate receptor antagonist and has been used in the study of glutamate receptors, including their subtypes. This chemical has also been shown to have antioxidant properties and can be used in the prevention of atherosclerosis., 5315-25-3.

Pyridine is a basic heterocyclic organic compound with the chemical formula C5H5N. It is structurally related to benzene, with one methine group (=CH−) replaced by a nitrogen atom. 5315-25-3, formula is C6H6BrN, Name is 2-Bromo-6-methylpyridine. It is a highly flammable, weakly alkaline, water-miscible liquid with a distinctive, unpleasant fish-like smell. COA of Formula: C6H6BrN.

Kumar, Gadde Sathish;Peshkov, Anatoly;Brzozowska, Aleksandra;Nikolaienko, Pavlo;Zhu, Chen;Rueping, Magnus research published 《 Nickel-Catalyzed Chain-Walking Cross-Electrophile Coupling of Alkyl and Aryl Halides and Olefin Hydroarylation Enabled by Electrochemical Reduction》, the research content is summarized as follows. The first electrochem. approach for nickel-catalyzed cross-electrophile coupling was developed. This method provides a novel route to 1,1-diarylalkane derivatives from simple and readily available alkyl and aryl halides in good yields and excellent regioselectivity under mild conditions. The procedure shows good tolerance for a broad variety of functional groups and both primary and secondary alkyl halides can be used. Furthermore, the reaction was successfully scaled up to the multigram scale, thus indicating potential for industrial application. Mechanistic study suggested the formation of a nickel hydride in the electroreductive chain-walking arylation, which led to the development of a new nickel-catalyzed hydroarylation of styrenes to provide a series of 1,1-diaryl alkanes in good yields under mild reaction conditions.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Kumar, Anuj team published research in Organic Letters in 2021 | 1603-41-4

Application In Synthesis of 1603-41-4, 2-Amino-5-methylpyridine, also known as 2-Amino-5-methylpyridine, is a useful research compound. Its molecular formula is C6H8N2 and its molecular weight is 108.14 g/mol. The purity is usually 95%.
2-Amino-5-methylpyridine is a chemical compound that belongs to the group of methyl ketones. It has a nitrogen atom and an oxygen atom in its structure, which allows it to form hydrogen bonds with other molecules. 2-Amino-5-methylpyridine can be obtained by reacting hydrochloric acid and xanthone in the presence of a base. The compound is highly reactive and has been shown to have antiinflammatory properties. This can be attributed to its ability to inhibit prostaglandin synthesis. 2-Amino-5-methylpyridine also has fluorescence properties that are sensitive to pH changes and can be used as a probe for metal ions. 2-Amino-5-methylpyridine is an organic compound that contains a methyl group, two nitrogen atoms, and one oxygen atom in its chemical structure. This molecule can form hydrogen bonds with other molecules due to its nitrogen atoms and oxygen atom,, 1603-41-4.

The critical parameters of pyridine are pressure 6.70 MPa, temperature 620 K and volume 229 cm3·mol−1. 1603-41-4, formula is C6H8N2, Name is 2-Amino-5-methylpyridine. In the temperature range 340–426 °C its vapor pressure p can be described with the Antoine equation.. Application In Synthesis of 1603-41-4.

Kumar, Anuj;Dhami, Anamika;Fairoosa, Jaleel;Kant, Ruchir;Mohanan, Kishor research published 《 Silver-Catalyzed Direct Synthesis of Trifluoromethylated Enaminopyridines and Isoquinolinones Employing Trifluorodiazoethane》, the research content is summarized as follows. A Ag-catalyzed three-component approach for the N-alkenylation of 2-aminopyridines employing aldehydes and trifluorodiazoethane was reported. Unlike the known reactions of trifluorodiazoethane with imines, which generate Mannich adducts, aziridines or triazolines depending on the substrates and conditions, this reaction, after Mannich addition, proceeded via a carbene formation and 1,2-aryl migration sequence to afford (E)-enaminopyridines. This surprising selectivity, which is effective for a wide range of aldehydes and 2-aminopyridines, was subsequently explored to access trifluoromethylated isoquinolinones.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Kuleshova, Olena team published research in ACS Catalysis in 2021 | 5315-25-3

5315-25-3, 2-Bromo-6-methylpyridine (2BMPy) is a bromopyridine derivative. It is formed when 2-chloro-6-methylpyridine is heated with bromotrimethylsilane. Its synthesis from various methods have been reported.
2-Bromo-6-methylpyridine is a building block in the preparation of nitrogen containing heterocyclic compounds.
2-Bromo-6-methylpyridine is an organic compound that belongs to the group of pyridinium halides. It is soluble in common solvents such as water, ethanol, and acetone. 2BMPy has been shown to act as a glutamate receptor antagonist and has been used in the study of glutamate receptors, including their subtypes. This chemical has also been shown to have antioxidant properties and can be used in the prevention of atherosclerosis., Reference of 5315-25-3

Kuleshova, Olena;Asako, Sobi;Ilies, Laurean research published 《 Ligand-Enabled, Iridium-Catalyzed ortho-Borylation of Fluoroarenes》, the research content is summarized as follows. A terpyridine derivative and an iridium complex catalyze the C-H borylation of a stoichiometric amount of a fluoroarene with high ortho-selectivity and tolerance of functional groups such as bromide, chloride, ester, ketone, amine, and in situ-borylated hydroxyl. Complex drug mols. such as haloperidol can be selectively borylated ortho to the F atom. The terpyridine ligand undergoes rollover cyclometalation to produce an N,N,C-coordinated iridium complex, which may either selectively borylate the fluoroarene by itself or undergo reductive elimination to produce a borylated ligand.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Kuimov, Anatoly D. team published research in Dyes and Pigments in 2020 | 31181-90-5

Safety of 5-Bromopicolinaldehyde, 5-Bromopyridine-2-carbaldehyde is a useful research compound. Its molecular formula is C6H4BrNO and its molecular weight is 186.01 g/mol. The purity is usually 95%.

5-Bromopyridine-2-carbaldehyde is a water soluble organic molecule that has been shown to inhibit the mitochondrial respiratory chain. It is a structural analog of the natural substrate for mitochondrial cytochrome c oxidase, 5-aminolevulinic acid. This compound has been shown to be selective against cancer cells and has anti-viral properties. The photophysical properties of 5-bromopyridine-2-carbaldehyde have been studied extensively. The fluorescence quantum yield of this molecule in aqueous solution is 0.06%., 31181-90-5.

Pyridine is a basic heterocyclic organic compound with the chemical formula C5H5N. It is structurally related to benzene, with one methine group (=CH−) replaced by a nitrogen atom. 31181-90-5, formula is C6H4BrNO, Name is 5-Bromopicolinaldehyde. It is a highly flammable, weakly alkaline, water-miscible liquid with a distinctive, unpleasant fish-like smell. Safety of 5-Bromopicolinaldehyde.

Kuimov, Anatoly D.;Becker, Christina S.;Koskin, Igor P.;Zhaguparov, Daniiar E.;Sonina, Alina A.;Shundrina, Inna K.;Sherin, Peter S.;Kazantsev, Maxim S. research published 《 2-((9H-fluoren-9-ylidene)methyl)pyridine as a new functional block for aggregation induced emissive and stimuli-responsive materials》, the research content is summarized as follows. Highly-emissive mechanofluorochromic (MFC) organic solids changing their emission colors upon exposure to mech. stimuli are highly demanded for various practical applications. In this work we introduced a planarizable by intramol. N···H bond 2-((9H-fluoren-9-ylidene)methyl)pyridine fragment featuring an Aggregation-Induced Emission Enhancement and, particularly, MFC property for its bithiophene derivative A two compounds, 2-((9H-fluoren-9-ylidene)methyl)-5-(5-phenylthiophen-2-yl)pyridine (FTP) and 2-((9H-fluoren-9-ylidene)methyl)-5-([2,2′-bithiophen]-5-yl)pyridine (FTT) were synthesized and fully characterized. In liquid solution both compounds are low emissive, however in the solid state they exhibit the photoluminescence quantum yield of 33% and 13% for FTP and FTT, resp. Remarkably, the powder of FTT demonstrates a self-reversible mechanofluorochromism: the emission spectrum red-shifts after the grinding or pressurization and it recovers during one-day of storage without any treatment. The powder X-ray diffraction and differential scanning calorimetry revealed the reversible phase transition under temperature and mechanic stimuli. Anal. of mol. structure shows that in the gas phase FTT has a planar geometry while in the solid state it loses the flatness due to the crystal environment. Our results speak in favor of the increase of FTT planarity under the pressure to be responsible for the observed mechanofluorochromism.

Safety of 5-Bromopicolinaldehyde, 5-Bromopyridine-2-carbaldehyde is a useful research compound. Its molecular formula is C6H4BrNO and its molecular weight is 186.01 g/mol. The purity is usually 95%.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Kraupner, Nicolas team published research in European Journal of Medicinal Chemistry in 2022 | 16133-25-8

16133-25-8, Pyridine-3-sulfonyl chloride is a useful research compound. Its molecular formula is C5H4ClNO2S and its molecular weight is 177.61 g/mol. The purity is usually 95%.
Pyridine-3-sulfonyl chloride is a reagent used in the synthesis of pyrimidine derivatives with anti-proliferative activity against negative breast cancer cells.
Pyridine-3-sulfonyl chloride is a chemical compound that binds to the active site of cytochrome P450 enzymes. It can be used to study the effects of matrix effect on reaction solution. Pyridine-3-sulfonyl chloride has been shown to have an UV absorption spectrum with a maximum at 280 nm and a p450 activity that is proportional to the concentration of human serum. This compound has been shown to inhibit kinase domain in vitro assays, which may have clinical relevance in the treatment of obesity., Electric Literature of 16133-25-8

Pyridine is a basic heterocyclic organic compound with the chemical formula C5H5N. It is structurally related to benzene, with one methine group (=CH−) replaced by a nitrogen atom. 16133-25-8, formula is C5H4ClNO2S, Name is Pyridine-3-sulfonyl chloride. It is a highly flammable, weakly alkaline, water-miscible liquid with a distinctive, unpleasant fish-like smell. Electric Literature of 16133-25-8.

Kraupner, Nicolas;Dinh, Chau Phi;Wen, Xiaoan;Landry, Valerie;Herledan, Adrien;Leroux, Florence;Bosc, Damien;Charton, Julie;Maillard, Clara;Warenghem, Sandrine;Duplan, Isabelle;Piveteau, Catherine;Hennuyer, Nathalie;Staels, Bart;Deprez, Benoit;Deprez-Poulain, Rebecca research published 《 Identification of indole-based activators of insulin degrading enzyme》, the research content is summarized as follows. Insulin degrading enzyme (IDE) is a zinc metalloprotease that cleaves numerous substrates among which amyloid-β and insulin. It has been linked through genetic studies to the risk of type-2 diabetes (T2D) or Alzheimer’s disease (AD). Pharmacol. activation of IDE is an attractive therapeutic strategy in AD. While IDE inhibition gave paradoxical activity in glucose homeostasis, recent studies, in particular in the liver suggest that IDE activators could be also of interest in diabetes. Here we describe the discovery of an original series of IDE activators by screening and structure-activity relationships. Early cellular studies show that hit I decreases glucose-stimulating insulin secretion. Docking studies revealed it has an unprecedented extended binding to the polyanion-binding site of IDE. These indole-based pharmacol. tools are activators of both Aβ and insulin hydrolysis by IDE and could be helpful to explore the multiple roles of IDE.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem