Month: October 2022

At 25 °C pyridine has a viscosity of 0.88 mPa/s and thermal conductivity of 0.166 W·m−1·K−1. 31181-90-5, formula is C6H4BrNO, Name is 5-Bromopicolinaldehyde. The enthalpy of vaporization is 35.09 kJ·mol−1 at the boiling point and normal pressure.The enthalpy of fusion is 8.28 kJ·mol−1 at the melting point. COA of Formula: C6H4BrNO.

Kern, Felix;Wanner, Klaus T. research published 《 Screening oxime libraries by means of mass spectrometry (MS) binding assays: Identification of new highly potent inhibitors to optimized inhibitors γ-aminobutyric acid transporter 1》, the research content is summarized as follows. Generation and screening of oxime libraries by competitive MS Binding Assays represents a powerful tool for the identification of new compounds, with affinity to mGAT1, the most abundant plasma membrane bound GABA transporter in the CNS. By screening a guvacine derived oxime library, new potent inhibitors of mGAT1 had been revealed. Oxime libraries generated by reaction of a large excess of a rac-nipecotic acid derivative displaying a hydroxylamine functionality in which various aldehydes under suitable conditions, were examined for new potent inhibitors of mGAT1. The pK_i values obtained of the best hits were compared with those of related compounds displaying a guvacine instead of a nipecotic acid subunit as hydrophilic moiety. Amongst the new compounds one of the most affine ligands of mGAT1 known so far (pK_i = 8.55 ± 0.04) was found.

COA of Formula: C6H4BrNO, 5-Bromopyridine-2-carbaldehyde is a useful research compound. Its molecular formula is C6H4BrNO and its molecular weight is 186.01 g/mol. The purity is usually 95%.

5-Bromopyridine-2-carbaldehyde is a water soluble organic molecule that has been shown to inhibit the mitochondrial respiratory chain. It is a structural analog of the natural substrate for mitochondrial cytochrome c oxidase, 5-aminolevulinic acid. This compound has been shown to be selective against cancer cells and has anti-viral properties. The photophysical properties of 5-bromopyridine-2-carbaldehyde have been studied extensively. The fluorescence quantum yield of this molecule in aqueous solution is 0.06%., 31181-90-5.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Pyridine is a basic heterocyclic organic compound with the chemical formula C5H5N. It is structurally related to benzene, with one methine group (=CH−) replaced by a nitrogen atom. 766-11-0, formula is C5H3BrFN, Name is 5-Bromo-2-fluoropyridine. It is a highly flammable, weakly alkaline, water-miscible liquid with a distinctive, unpleasant fish-like smell. Application of C5H3BrFN.

Kerchner, Hilary A.;Montgomery, John research published 《 Synthesis of Secondary and Tertiary Alkylboranes via Formal Hydroboration of Terminal and 1,1-Disubstituted Alkenes》, the research content is summarized as follows. Cu-catalyzed functionalization of terminal or 1,1-disubstituted alkenes with bis(pinacolato)diboron and MeOH provides formal hydroboration products with exceptional regiocontrol favoring the branched isomer. Pairing this procedure with photocatalytic cross-couplings using Ir and Ni cocatalysis provides an effective, highly regioselective procedure for the hydroarylation of terminal alkenes.

766-11-0, 5-Bromo-2-fluoropyridine is a useful research compound. Its molecular formula is C5H3BrFN and its molecular weight is 175.99 g/mol. The purity is usually 95%.
5-Bromo-2-fluoropyridine is a boronic acid that has been shown to react with iodides and form 5-bromo-2-fluoroiodobenzene. The reaction of 5-bromo-2-fluoropyridine with benzene gives the same product as the reaction with 1,3,5-trioxane. The UV absorption of 5-bromo-2-fluoropyridine is found at 230 nm and 260 nm. It also has an absorption band in the infrared region at 1625 cm−1. Vibrational progressions have been observed for this molecule, which are due to dipole moments and electron density distributions in the molecule.
5-bromo-2-fluoropyridine is used in the synthesis of heteroaromatic and aniline derivatives of piperidines as potent ligands used for vesicular acetylcholine transport. , Application of C5H3BrFN

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

At 25 °C pyridine has a viscosity of 0.88 mPa/s and thermal conductivity of 0.166 W·m−1·K−1. 1603-41-4, formula is C6H8N2, Name is 2-Amino-5-methylpyridine. The enthalpy of vaporization is 35.09 kJ·mol−1 at the boiling point and normal pressure.The enthalpy of fusion is 8.28 kJ·mol−1 at the melting point. Category: pyridine-derivatives.

Kavitha, Natte;Alivelu, Munagala research published 《 The Computational Study, 3D-QSAR, and Molecular Docking Study of 2-Amino 5-Methyl Pyridine》, the research content is summarized as follows. The indeed optimized structure of the 2-Amino 5-Me Pyridine (2A5MP) and its min. energies were analyzed by using B3LYP functional with B3LYP/6-311++G (d, p) basis set. The first hyperpolarizability (β), polarizability (α), and dipole moment (μ) of the compound were computed and the results were reported. The Mulliken charges, at. polarizability tensor (APT) charges and HOMO-LUMO energy difference were calculated This energy difference illustrates the properties of optical polarizability, chem. hardness/softness, and kinetic stability/reactivity of a mol. NBO anal. was executed to know the transfer of electrons within the mol. and mol. electrostatic potential (MEP) anal. was also performed. The docking procedure was accomplished between 2- amino 5-Me pyridine and rigid protein receptors. Druglikeness principles are based on the rules of Lipinski and Veber appraise that the title mol. had the ideal physicochem. and pharmacokinetic properties to be a good drug candidate orally. The docking studies were carried out and analyzed in order to understand the binding mode of the titled compound and it was found to have a binding energy of -3.32 kcal/mol.

1603-41-4, 2-Amino-5-methylpyridine, also known as 2-Amino-5-methylpyridine, is a useful research compound. Its molecular formula is C6H8N2 and its molecular weight is 108.14 g/mol. The purity is usually 95%.
2-Amino-5-methylpyridine is a chemical compound that belongs to the group of methyl ketones. It has a nitrogen atom and an oxygen atom in its structure, which allows it to form hydrogen bonds with other molecules. 2-Amino-5-methylpyridine can be obtained by reacting hydrochloric acid and xanthone in the presence of a base. The compound is highly reactive and has been shown to have antiinflammatory properties. This can be attributed to its ability to inhibit prostaglandin synthesis. 2-Amino-5-methylpyridine also has fluorescence properties that are sensitive to pH changes and can be used as a probe for metal ions. 2-Amino-5-methylpyridine is an organic compound that contains a methyl group, two nitrogen atoms, and one oxygen atom in its chemical structure. This molecule can form hydrogen bonds with other molecules due to its nitrogen atoms and oxygen atom,, Category: pyridine-derivatives

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

The critical parameters of pyridine are pressure 6.70 MPa, temperature 620 K and volume 229 cm3·mol−1. 1603-41-4, formula is C6H8N2, Name is 2-Amino-5-methylpyridine. In the temperature range 340–426 °C its vapor pressure p can be described with the Antoine equation.. Application In Synthesis of 1603-41-4.

Karteek, S. Durga;Reddy, A. Gopi;Tej, M. Bhuvan;Rao, M. V. Basaveswara research published 《 Synthesis and Docking Study of Novel Pyranocoumarin Derivatives》, the research content is summarized as follows. A new series of fused tricyclic coumarin derivatives I [R¹ = H, Me, Ph, etc.; R² = H, Me, Et] were designed, synthesized by a simple and convenient method, starting from 4-hydroxycoumarin and virtually screened by mol. docking on the target protein 3FRZ (PDB ID: 3FRZ), a HCV RNA-dependent RNA polymerase, for potency against hepatitis C virus (HCV). Efficient binding to the target protein was found for most of the synthesized compds I.

Application In Synthesis of 1603-41-4, 2-Amino-5-methylpyridine, also known as 2-Amino-5-methylpyridine, is a useful research compound. Its molecular formula is C6H8N2 and its molecular weight is 108.14 g/mol. The purity is usually 95%.
2-Amino-5-methylpyridine is a chemical compound that belongs to the group of methyl ketones. It has a nitrogen atom and an oxygen atom in its structure, which allows it to form hydrogen bonds with other molecules. 2-Amino-5-methylpyridine can be obtained by reacting hydrochloric acid and xanthone in the presence of a base. The compound is highly reactive and has been shown to have antiinflammatory properties. This can be attributed to its ability to inhibit prostaglandin synthesis. 2-Amino-5-methylpyridine also has fluorescence properties that are sensitive to pH changes and can be used as a probe for metal ions. 2-Amino-5-methylpyridine is an organic compound that contains a methyl group, two nitrogen atoms, and one oxygen atom in its chemical structure. This molecule can form hydrogen bonds with other molecules due to its nitrogen atoms and oxygen atom,, 1603-41-4.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Pyridine is a basic heterocyclic organic compound with the chemical formula C5H5N. It is structurally related to benzene, with one methine group (=CH−) replaced by a nitrogen atom. 1603-41-4, formula is C6H8N2, Name is 2-Amino-5-methylpyridine. It is a highly flammable, weakly alkaline, water-miscible liquid with a distinctive, unpleasant fish-like smell. Product Details of C6H8N2.

Kargar, Hadi;Fallah-Mehrjardi, Mehdi;Behjatmanesh-Ardakani, Reza;Torabi, Vajiheh;Munawar, Khurram Shahzad;Ashfaq, Muhammad;Tahir, Muhammad Nawaz research published 《 Sonication-assisted synthesis of new Schiff bases derived from 3-ethoxysalicylaldehyde: Crystal structure determination, Hirshfeld surface analysis, theoretical calculations and spectroscopic studies》, the research content is summarized as follows. A rapid and efficient preparation of a new series of the Schiff bases (Pn) by the reaction of 2-aminopyridine derivatives with 3-ethoxysalicylaldehyde under ultrasonic irradiation is reported. Sono-chem. synthesis is the safest and greener method for the preparation of Schiff bases in the shorter period of time with higher yield as compared to traditional methods. The synthesized compounds have been characterized by ¹H NMR spectroscopic technique and elemental analyses. Furthermore, the crystal structures of two compounds (P0 and P6) were determined by single crystal X-ray diffraction studies. Hirshfeld surface anal. showed that H…H interat. contact is the most significant contributor in crystal packing of both compounds with percentage contribution of 53.7% and 57.7% for P0 and P6, resp. Theor. calculations of the synthesized compounds were carried out by DFT using B3LYP method with the help of Def2-TZVP basis set, indicating that the results of calculation are in accordance with the exptl. findings.

Product Details of C6H8N2, 2-Amino-5-methylpyridine, also known as 2-Amino-5-methylpyridine, is a useful research compound. Its molecular formula is C6H8N2 and its molecular weight is 108.14 g/mol. The purity is usually 95%.
2-Amino-5-methylpyridine is a chemical compound that belongs to the group of methyl ketones. It has a nitrogen atom and an oxygen atom in its structure, which allows it to form hydrogen bonds with other molecules. 2-Amino-5-methylpyridine can be obtained by reacting hydrochloric acid and xanthone in the presence of a base. The compound is highly reactive and has been shown to have antiinflammatory properties. This can be attributed to its ability to inhibit prostaglandin synthesis. 2-Amino-5-methylpyridine also has fluorescence properties that are sensitive to pH changes and can be used as a probe for metal ions. 2-Amino-5-methylpyridine is an organic compound that contains a methyl group, two nitrogen atoms, and one oxygen atom in its chemical structure. This molecule can form hydrogen bonds with other molecules due to its nitrogen atoms and oxygen atom,, 1603-41-4.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem