Month: October 2022

In 2018,Dyes and Pigments included an article by Yan, Zhengquan; Wei, Gang; Guang, Shanyi; Xu, Manman; Ren, Xia; Wu, Rongliang; Zhao, Gang; Ke, Fuyou; Xu, Hongyao. Formula: C6H7Br2N. The article was titled 《A multidentate ligand chromophore with rhodamine-triazole-pyridine units and its acting mechanism for dual-mode visual sensing trace Sn2+》. The information in the text is summarized as follows:

A multidentate ligand chromophore, combining rhodamine, triazole, and pyridine units, was identified and developed for the 1st time. Using triazole and pyridine rings as coordinating functional recognition groups, it was expected to selectively recognize Sn2+ to form some stable 5-member or 6-member rings with nitrogen and oxygen atoms. Under the optimized conditions, the ligand chromophore could selectively react with trace Sn2+ in CH3CN/H2O (99/1, volume/volume), accompanying with obvious changes in fluorescent spectrum, UV-visible spectrum and visual color. For fluorescent anal., a turn-on fluorescence at 587 nm was found and increased linearly at 1.2-6.2 × 10-7 mol L-1 Sn2+ from colorless to orange. For UV-visible one, a new absorption peak at 560 nm emerged with a linear range of 2.0-11.0 × 10-7 mol L-1 Sn2+ from colorless to pink. The action mechanism between the ligand chromophore and Sn2+ was confirmed basing on UV-visible titration, 1H NMR titration, Job’s plot, binding constants and theor. calculation In addition to this study using 2-(Bromomethyl)pyridine hydrobromide, there are many other studies that have used 2-(Bromomethyl)pyridine hydrobromide(cas: 31106-82-8Formula: C6H7Br2N) was used in this study.

2-(Bromomethyl)pyridine hydrobromide(cas: 31106-82-8) belongs to pyridine. When pyridine is adsorbed on oxide surfaces or in porous materials, the following species are commonly observed: (i) pyridine coordinated to Lewis acid sites, (ii) pyridine H-bonded to weakly acidic hydroxyls, and (iii) protonated pyridine. At high coverage, physisorbed pyridine and protonated dimers can also be observed.Formula: C6H7Br2N

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

In 2019,ChemSusChem included an article by Gholinejad, Mohammad; Oftadeh, Erfan; Shojafar, Mohammad; Sansano, Jose M.; Lipshutz, Bruce H.. Synthetic Route of C6H7Br2N. The article was titled 《Synergistic Effects of ppm Levels of Palladium on Natural Clinochlore for Reduction of Nitroarenes》. The information in the text is summarized as follows:

The modified naturally occurring clay clinochlore with ppm amounts of palladium that leads to a new and very effective reagent for the reduction of numerous aromatic nitro species RNO2 (R = H3CC(O)NHC6H4, naphthalen-1-yl, pyridin-2-yl, etc.) has been augmented. When palladium nanoparticles are supported on pyridyltriazole-modified clinochlore, iron within clinochlore acts synergistically with palladium to catalyze the reduction of a wide variety of nitroarenes at room temperature in aqueous media. Based on E-factor calculations, the catalyst system is found to be in line with green chem. standards and can be recycled up to five times. In the experiment, the researchers used 2-(Bromomethyl)pyridine hydrobromide(cas: 31106-82-8Synthetic Route of C6H7Br2N)

2-(Bromomethyl)pyridine hydrobromide(cas: 31106-82-8) belongs to pyridine. In industry and in the lab, pyridine is used as a reaction solvent, particularly when its basicity is useful, and as a starting material for synthesizing some herbicides, fungicides, and antiseptics.Synthetic Route of C6H7Br2N

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

In 2019,Organic Letters included an article by Cheng, Yuan-Yuan; Lei, Tao; Su, Longlong; Fan, Xiuwei; Chen, Bin; Tung, Chen-Ho; Wu, Li-Zhu. Safety of fac-Tris(2-phenylpyridine)iridium. The article was titled 《Visible Light Irradiation of Acyl Oxime Esters and Styrenes Efficiently Constructs β-Carbonyl Imides by a Scission and Four-Component Reassembly Process》. The information in the text is summarized as follows:

Acyl radical triggered difunctionalizations of aryl olefins have been realized using oxime ester as the acyl precursor for the first time. Irradiation of fac-Ir(ppy)3 and oxime ester by visible light caused scission into three components, which recombined with olefins to yield significant β-carbonyl imides, e.g., I showing good functional group tolerance and high atom economy. Control experiments as well as spectroscopic and electrochem. studies revealed the efficient intermol. reorganization of oxime ester into styrene with the aid of solvent exchange. After reading the article, we found that the author used fac-Tris(2-phenylpyridine)iridium(cas: 94928-86-6Safety of fac-Tris(2-phenylpyridine)iridium)

fac-Tris(2-phenylpyridine)iridium(cas: 94928-86-6) belongs to pyridine. Pyridines are often used as catalysts or reagents; particular notice has been paid recently to how pyridine coordinates to metal centers enabling a wide range of valuable reactions. Safety of fac-Tris(2-phenylpyridine)iridium

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

The author of 《Mitochondria-localized iridium(III) complexes with anthraquinone groups as effective photosensitizers for photodynamic therapy under hypoxia》 were Guo, Song; Han, Meiping; Chen, Ruizhe; Zhuang, Yanling; Zou, Liang; Liu, Shujuan; Huang, Wei; Zhao, Qiang. And the article was published in Science China: Chemistry in 2019. Electric Literature of C5H3Br2N The author mentioned the following in the article:

Photodynamic therapy (PDT) is a potential way for the tumor treatment. However, it notably suffers the limitation of hypoxia in solid tumors. Thus, it is significant to develop effective photosensitizers which can exhibit excellent therapeutic performance under both normoxia and hypoxia. Herein, we reported four ionic iridium(III) complexes (Ir1-Ir4) with anthraquinone groups which can regulate their excited state energy levels effectively. Among them, the energy gap of Ir1 was between 1.63 and 2.21 eV, which can match well with that of O2, and the HOMO energy of Ir1 is less than -5.51 eV. Compared with Ir2-Ir4, the luminescent quantum efficiency of Ir1 was the highest. Particularly, Ir1 can specifically target the mitochondria of the tumor cells. Meanwhile, Ir1 showed high singlet oxygen quantum yields (φΔ) in both solutions and living cells with low cytotoxicity. The results of PDT experiments revealed that Ir1, as a photosensitizer, exhibited excellent therapeutic effect not only in normoxia but also in hypoxia condition. We believe that this work is meaningful for developing excellent PDT agents based on cyclometalated Ir(III) complexes via rational ligand modification. In the experiment, the researchers used many compounds, for example, 2,5-Dibromopyridine(cas: 624-28-2Electric Literature of C5H3Br2N)

2,5-Dibromopyridine(cas: 624-28-2) belongs to pyridine. Pyridine is a relatively complex molecule and exhibits a number of different bands in IR spectra. Among others, the bands characterizing the ν8a and ν19b modes have been found to be sensitive to the coordination or protonation of the molecule. Note that the band that is diagnostic for the PyH+ ion at about 1545 cm− 1 (ν19b mode) does not overlap with any of the other bands.Electric Literature of C5H3Br2N

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

The author of 《Efficient Passivation with Lead Pyridine-2-Carboxylic for High-Performance and Stable Perovskite Solar Cells》 were Fu, Sheng; Li, Xiaodong; Wan, Li; Wu, Yulei; Zhang, Wenxiao; Wang, Yueming; Bao, Qinye; Fang, Junfeng. And the article was published in Advanced Energy Materials in 2019. Product Details of 98-98-6 The author mentioned the following in the article:

Stability has become the main obstacle for the commercialization of perovskite solar cells (PSCs) despite the impressive power conversion efficiency (PCE). Poor crystallization and ion migration of perovskite are the major origins of its degradation under working condition. Here, high-performance PSCs incorporated with pyridine-2-carboxylic lead salt (PbPyA2) are fabricated. The pyridine and carboxyl groups on PbPyA2 can not only control crystallization but also passivate grain boundaries (GBs), which result in the high-quality perovskite film with larger grains and fewer defects. In addition, the strong interaction among the hydrophobic PbPyA2 mols. and perovskite GBs acts as barriers to ion migration and component volatilization when exposed to external stresses. Consequently, superior optoelectronic perovskite films with improved thermal and moisture stability are obtained. The resulting device shows a champion efficiency of 19.96% with negligible hysteresis. Furthermore, thermal (90°C) and moisture (RH 40-60%) stability are improved threefold, maintaining 80% of initial efficiency after aging for 480 h. More importantly, the doped device exhibits extraordinary improvement of operational stability and remains 93% of initial efficiency under maximum power point (MPP) tracking for 540 h. The experimental part of the paper was very detailed, including the reaction process of Picolinic acid(cas: 98-98-6Product Details of 98-98-6)

Picolinic acid(cas: 98-98-6) is used in the preparation of 2-Aminodihydro[1,3]thiazines as BACE 2 inhibitors and their preparation and use in the treatment of diabetes.Product Details of 98-98-6

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

The author of 《Xantphos as a Branch-Selective Ligand for the Acyclic sec-Alkyl Negishi Cross-Coupling of Heteroaryl Halides》 were Cherney, Alan H.; Hedley, Simon J.; Mennen, Steven M.; Tedrow, Jason S.. And the article was published in Organometallics in 2019. Computed Properties of C5H5BrN2 The author mentioned the following in the article:

We present the application of the common bidentate phosphine ligand Xantphos toward the highly selective Negishi cross-coupling of heteroaryl halides and acyclic sec-alkyl organozinc reagents to prepare pharmaceutically relevant motifs. Branched-to-linear ratios of >100:1 can be achieved for several substrates relevant to the pharmaceutical industry, and tolerance of certain acidic protons is exhibited. A high-throughput experimentation approach was taken to rapidly compare Xantphos Pd G3 to other selective Negishi coupling catalysts, leading to sep. reactivity profiles for each methodol. The utility of Xantphos Pd G3 was demonstrated through the scale-up and isolation of a complex pyridine building block. In the experimental materials used by the author, we found 6-Bromopyridin-3-amine(cas: 13534-97-9Computed Properties of C5H5BrN2)

6-Bromopyridin-3-amine(cas: 13534-97-9) belongs to anime. To avoid the problem of multiple alkylation, methods have been devised for “blocking” substitution so that only one alkyl group is introduced. The Gabriel synthesis is one such method; it utilizes phthalimide, C6H4(CO)2NH, whose one acidic hydrogen atom has been removed upon the addition of a base such as KOH to form a salt.Computed Properties of C5H5BrN2

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

《Cationic Iridium Complexes with 3,4,5-Triphenyl-4H-1,2,4-Triazole Type Cyclometalating Ligands: Synthesis, Characterizations, and Their Use in Light-Emitting Electrochemical Cells》 was published in Inorganic Chemistry in 2020. These research results belong to Meng, Xianwen; Chen, Mengzhen; Bai, Rubing; He, Lei. Quality Control of 4,4′-Dimethyl-2,2′-bipyridine The article mentions the following:

Cationic Ir complexes that show blue-shifted emission and high phosphorescent efficiency were pursued for their optoelectronic applications. Five cationic Ir complexes with 3,4,5-triphenyl-4H-1,2,4-triazole (tPhTAZ) type cyclometalating ligands (C^N) and 2,2′-bipyridine or 2-(pyridin-2-yl)-1H-benzo[d]imidazole type ancillary ligands (N^N) were designed and synthesized. Their structures were confirmed by x-ray crystallog., and their photophys. and electrochem. properties were comprehensively characterized. In solution and thin films, the complexes afford efficient yellow to blue-green emission. The highest occupied MOs (HOMOs) of these complexes are delocalized over the C^N ligand and the Ir ion, and compared with the conventional 2-phenylpyridine (Hppy) ligand, the tPhTAZ ligand largely shifts the emission of the complex toward blue by over 40 nm through stabilizing the HOMO. Also, the peripheral Ph rings in tPhTAZ provide steric hindrance to the complexes, which suppresses phosphorescence concentration-quenching of the complexes, leading to high luminescent efficiencies in neat films. Theor. calculations showed that the emission of the complexes originates from either the charge-transfer state (Ir/C^N → N^N) or the C^N/N^N-centered 3π-π* state, depending on the local surrounding of the complex. The complexes exhibit good electrochem. stability with reversible oxidation and reduction processes in solution Solid-state light emitting electrochem. cells (LECs) using the complexes afford yellow to blue-green emission, with peak current efficiencies of up to 34.7 cd A-1 and maximum brightness of up to 256 cd m-2 at 3.0 V, which are among the highest for LECs based on cationic Ir complexes reported so far, indicating the great potential for the use of tPhTAZ-type C^N ligands in construction of cationic Ir complexes for LEC applications. tPhTAZ-type cyclometalating ligands (tPhTAZ is 3,4,5-triphenyl-4H-1,2,4-triazole) blue-shift the emission and suppress phosphorescence-concentration quenching for cationic Ir complexes, leading to highly efficient blue-green to yellow light-emitting electrochem. cells (LECs) with efficiencies of up to 34.7 cd A-1. In the experiment, the researchers used many compounds, for example, 4,4′-Dimethyl-2,2′-bipyridine(cas: 1134-35-6Quality Control of 4,4′-Dimethyl-2,2′-bipyridine)

4,4′-Dimethyl-2,2′-bipyridine(cas: 1134-35-6) is used as a chemical Intermediate. It can be used for the determination of ferrous and cyanide compounds.Quality Control of 4,4′-Dimethyl-2,2′-bipyridine Furthermore, 4,4′-Dimethyl-2,2′-bipyridine is used in the synthesis of a series of o-phenanthroline-substituted ruthenium(II) complexes.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

《Diversity-Oriented Enzymatic Synthesis of Cyclopropane Building Blocks》 was published in ACS Catalysis in 2020. These research results belong to Wittmann, Bruce J.; Knight, Anders M.; Hofstra, Julie L.; Reisman, Sarah E.; Jennifer Kan, S. B.; Arnold, Frances H.. Electric Literature of C5H3BrClN The article mentions the following:

While biocatalysis is increasingly incorporated into drug development pipelines, it is less commonly used in the early stages of drug discovery. By engineering a protein to produce a chiral motif with a derivatizable functional handle, biocatalysts can be used to help generate diverse building blocks for drug discovery. Here we show the engineering of two variants of Rhodothermus marinus nitric oxide dioxygenase (RmaNOD) to catalyze the formation of cis- and trans-diastereomers of a pinacolboronate-substituted cyclopropane which can be readily derivatized to generate diverse stereopure cyclopropane building blocks. After reading the article, we found that the author used 5-Bromo-2-chloropyridine(cas: 53939-30-3Electric Literature of C5H3BrClN)

5-Bromo-2-chloropyridine(cas: 53939-30-3) belongs to pyridine. Pyridine is very deactivated towards electrophilic substitution with respect to benzene. For this reason classical formylation, using methods such as the Gattermann or Vilsmeier reactions, are not generally successful. Electric Literature of C5H3BrClN

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

《Discrimination of Pd0 and Pd2+ in solution and in live cells by novel light-up fluorescent probe with AIE and ESIPT characteristics》 was written by Wang, Qiang; Chen, Qingqing; Li, Chunbin; Lai, Qingfang; Zou, Fenglan; Liang, Feng; Jiang, Guoyu; Wang, Jianguo. Related Products of 1692-25-7 And the article was included in Microchemical Journal in 2020. The article conveys some information:

A novel and simple light-up fluorescent probe (PASPy-al) with a D-π-A structure based on AIE as well as ESIPT processes was designed for highly selective discrimination of Pd2+ and Pd0. PASPy-al displayed a large Stokes shift (95 nm), a high light-up ratio (116 fold) and a low limit of detection (LOD: 96 nM) toward Pd0. Moreover, the practical applications of PASPy-al for detection of Pd0 in environmental, human urine and pharmaceutical samples were realized, indicating the unique advantages of designing anti-ACQ fluorescent probes based on AIE and ESIPT mechanism. Fluorescence imaging of Pd0 in live cells was realized by using PASPy-al. Furthermore, imaging of Pd0 generation in live cells was also realized by in situ reduction of Pd2+ to Pd0 in the presence of reducing agent like CO, indicating the potential ability of this probe for further fluorescent imaging of cellular reducing agent. The easy preparation of probe PASPy-al plus their excellent parameters would make it a simple to handle probe for detection of Pd0 both in practical samples and in live cells. In the experiment, the researchers used many compounds, for example, Pyridin-3-ylboronic acid(cas: 1692-25-7Related Products of 1692-25-7)

Pyridin-3-ylboronic acid(cas: 1692-25-7) belongs to pyridine. When pyridine is adsorbed on oxide surfaces or in porous materials, the following species are commonly observed: (i) pyridine coordinated to Lewis acid sites, (ii) pyridine H-bonded to weakly acidic hydroxyls, and (iii) protonated pyridine. At high coverage, physisorbed pyridine and protonated dimers can also be observed.Related Products of 1692-25-7

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Paymode, Dinesh J.; Chang, Le; Chen, Dan; Wang, Binglin; Kashinath, Komirishetty; Gopalsamuthiram, Vijayagopal; McQuade, D. Tyler; Vasudevan, N.; Ahmad, Saeed; Snead, David R. published their research in Organic Letters in 2021. The article was titled 《Application of Vinamidinium Salt Chemistry for a Palladium Free Synthesis of Anti-Malarial MMV048: A “”Bottom-Up”” Approach》.Product Details of 624-28-2 The article contains the following contents:

MMV390048 is a clin. compound under investigation for antimalarial activity. A new synthetic route was developed which couples two aromatic fragments while forming the central pyridine ring over two steps. This sequence takes advantage of raw materials used in the existing etoricoxib supply chain and eliminates the need for palladium catalysts, which were projected to be major cost-drivers. In the experimental materials used by the author, we found 2,5-Dibromopyridine(cas: 624-28-2Product Details of 624-28-2)

2,5-Dibromopyridine(cas: 624-28-2) belongs to pyridine. Pyridines are often used as catalysts or reagents; particular notice has been paid recently to how pyridine coordinates to metal centers enabling a wide range of valuable reactions. Product Details of 624-28-2

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem