Month: October 2022

Product Details of 1122-54-9In 2019 ,《One-pot metal-free synthesis of 3-CF3-1,3-oxazinopyridines by reaction of pyridines with CF3CO-acetylenes》 appeared in Molecules. The author of the article were Muzalevskiy, Vasiliy M.; Sizova, Zoia A.; Belyaeva, Kseniya V.; Trofimov, Boris A.; Nenajdenko, Valentine G.. The article conveys some information:

The reaction of pyridines with trifluoroacetylated acetylenes was investigated. It was found that the reaction of various pyridines with two mols. of CF3CO-acetylenes proceeded under mild metal-free conditions. As a result, efficient stereoselective synthesis of 3-arylethynyl-3-trifluoromethyl-1,3-oxazinopyridines was elaborated. Target heterocycles were prepared in up to quant. yields. In the part of experimental materials, we found many familiar compounds, such as 4-Acetylpyridine(cas: 1122-54-9Product Details of 1122-54-9)

4-Acetylpyridine(cas: 1122-54-9) belongs to pyridine. The basicity and metallophilic high donor number of these π-deficient systems has long favored them as ligands in metal catalysis. The last decade saw pyridine assume a stronger role as functional group for directed C–H oxidation/activation.Product Details of 1122-54-9

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Category: pyridine-derivativesIn 2020 ,《Failure of 2-pyridinecarboxylic acid, an inhibitor of 1-aminocyclopropane-1-carboxylate oxidase, as a universal flower care agent to extend the vase lifeof cut carnation flowers》 appeared in Horticulture Journal. The author of the article were Satoh, Shigeru; Makino, Keiko; Shimada, Keita; Nomura, Yoshihiro. The article conveys some information:

The 2-Pyridinecarboxylic acid (2-PCA) acts as an inhibitor of ethylene biosynthesis in Arabidopsis thaliana by binding to the active site of 1-aminocyclopropane-1-carboxylate oxidase. In this study, we examined the action of 2-PCA in comparison with the action of 3-PCA, a recently discovered stimulator of flower opening, in cut flowers of the spray-type carnation cultivars, ‘Light Pink Barbara (LPB)’, ‘Carnet’, ‘Collin’, and ‘Zulia’. With ‘LPB’ flowers, 2-PCA at 0.5-5 mM did not prolong the vase life, whereas 3-PCA at 5 mM did so. With the other three cultivars, 3-PCA generally promoted flower opening of all the cultivars. On the other hand, the action of 2-PCA on flower opening and senescence varied with the carnation cultivar and time of harvest, resulting in a shortened, unchanged or lengthened vase life of the flowers. 2-PCA also caused severe bending of flower stems in all cultivars, which lowered the display value of the flowers. The present results showed that 2-PCA is not likely to be a useful flower care agent in carnation flowers. The experimental part of the paper was very detailed, including the reaction process of Picolinic acid(cas: 98-98-6Category: pyridine-derivatives)

Picolinic acid(cas: 98-98-6) is used as a chelate for alkaline earth metals. Used to prepare picolinato ligated transition metal complexes. In synthetic organic chemistry, has been used as a substrate in the Mitsunobu reaction and in the Hammick reaction.Category: pyridine-derivatives

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

SDS of cas: 94928-86-6In 2019 ,《Aroylchlorination of 1,6-Dienes via a Photoredox Catalytic Atom-Transfer Radical Cyclization Process》 appeared in Organic Letters. The author of the article were Zhao, Quan-Sheng; Xu, Guo-Qiang; Liang, Hui; Wang, Zhu-Yin; Xu, Peng-Fei. The article conveys some information:

A method using aroyl chlorides as atom-transfer radical cyclization agents in a novel visible-light photocatalytic aroylchlorination reaction is developed. The overall transformation involves the formation of two new C-C bonds and one new C-Cl bond in a one-pot process. The advantages of this reaction include high atom/step/redox economy, mild conditions, operational simplicity, and broad substrate scopes. The experimental part of the paper was very detailed, including the reaction process of fac-Tris(2-phenylpyridine)iridium(cas: 94928-86-6SDS of cas: 94928-86-6)

fac-Tris(2-phenylpyridine)iridium(cas: 94928-86-6) belongs to pyridine. Pyridine and pyridine-derived structures are privileged pharmacophores in medicinal chemistry and an essential functionality for organic chemists. As the prototypical π-deficient heterocycle, pyridine illustrates distinctive chemistry as both substrate and reagent. SDS of cas: 94928-86-6

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Recommanded Product: Methyl 5-bromopicolinateIn 2012 ,《Synthesis of Highly Oxidized Quinolizidine via Reduction of Acylpyridinium Cations, and Total Syntheses of Quinolizidines 207I and 1-epi-207I》 appeared in Organic Letters. The author of the article were Tsukano, Chihiro; Oimura, Atsuko; Enkhtaivan, Iderbat; Takemoto, Yoshiji. The article conveys some information:

A new strategy for synthesizing quinolizidine skeletons by reductive cyclization via acylpyridinium cations was developed. Several functional groups, including carbonyl, silyl, and acetal, were tolerated under mild reaction conditions. For example, reacting the acylpyridinium cations derived from I (R = Me, Ph, Br, CF3) with Ghosez’s reagent and Hantzch ester in the presence of 4Å mol. sieves gave quinolizidines II. The reaction was successfully extended to a one-pot synthesis of a bicyclic compound, and the synthetic strategy was applied to concise total syntheses of quinolizidines 207I and 1-epi-207I, without protecting groups. The experimental part of the paper was very detailed, including the reaction process of Methyl 5-bromopicolinate(cas: 29682-15-3Recommanded Product: Methyl 5-bromopicolinate)

Methyl 5-bromopicolinate(cas: 29682-15-3) belongs to pyridine. Pyridine and pyridine-derived structures are privileged pharmacophores in medicinal chemistry and an essential functionality for organic chemists. As the prototypical π-deficient heterocycle, pyridine illustrates distinctive chemistry as both substrate and reagent. Recommanded Product: Methyl 5-bromopicolinate

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Name: fac-Tris(2-phenylpyridine)iridiumIn 2021 ,《A Roadmap Towards Visible Light Mediated Electron Transfer Chemistry with Iridium(III) Complexes》 appeared in ChemPhotoChem. The author of the article were Bevernaegie, Robin; Wehlin, Sara A. M.; Elias, Benjamin; Troian-Gautier, Ludovic. The article conveys some information:

A review. Photo-induced electron transfer chem. between mols. is a central theme in several fields including biol., physics and chem. Specifically, in photoredox catalysis, greater use has been made of iridium(III) complexes as they exhibit ground- and excited-state redox potentials that span a very large range. Unfortunately, most of these complexes suffer from limited visible light absorption properties. This concept article highlights recent developments in the synthesis of iridium(III) complexes with increased visible light absorption properties and their use as candidates for visible light driven redox catalysis. Fundamental tools are provided to enable the independent tuning of the HOMO and LUMO energy levels. Recent examples are given with the hope that this concept article will foster further developments of iridium(III)-based sensitizers for visible light driven reactivity. The experimental process involved the reaction of fac-Tris(2-phenylpyridine)iridium(cas: 94928-86-6Name: fac-Tris(2-phenylpyridine)iridium)

fac-Tris(2-phenylpyridine)iridium(cas: 94928-86-6) belongs to pyridine. Pyridine and pyridine-derived structures are privileged pharmacophores in medicinal chemistry and an essential functionality for organic chemists. As the prototypical π-deficient heterocycle, pyridine illustrates distinctive chemistry as both substrate and reagent. Name: fac-Tris(2-phenylpyridine)iridium

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

SDS of cas: 128071-75-0In 2018 ,《Zincation and Magnesiation of Functionalized Silylated Cyanohydrins Using TMP-Bases》 was published in Synthesis. The article was written by Castello-Mico, Alicia; Knochel, Paul. The article contains the following contents:

Polyfunctional silylated cyanohydrins are readily magnesiated or zincated with TMPMgCl·LiCl or TMP2Zn·2MgCl2·2LiCl leading to the corresponding metalated derivatives These Mg- or Zn-derivatives react with various electrophiles such as benzylic bromides, allylic bromides, acid chlorides, aldehydes, NCCO2Et, or MeSO2SMe. Subsequently, TBAF-deprotection provides the corresponding keto or 1,2-diketo derivatives2-Bromonicotinaldehyde(cas: 128071-75-0SDS of cas: 128071-75-0) was used in this study.

2-Bromonicotinaldehyde(cas: 128071-75-0) belongs to pyridine. Pyridines, quinolines, and isoquinolines have found a function in almost all aspects of organic chemistry. Pyridine has found use as a solvent, base, ligand, functional group, and molecular scaffold. As structural elements, these moieties are potent electron-deficient groups, metal-directing functionalities, fluorophores, and medicinally important pharmacophores. SDS of cas: 128071-75-0

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

《Electrocatalytic dechlorination of chloropicolinic acid mixtures by using palladium-modified metal cathodes in aqueous solutions》 was written by Ma, Hongxing; Xu, Yinghua; Ding, Xufen; Liu, Qi; Ma, Chun-An. Formula: C6H2Cl3NO2 And the article was included in Electrochimica Acta on August 20 ,2016. The article conveys some information:

In China, chloropicolinic acid (ClPA) mixtures comprising 3,5,6-trichloropicolinic acid, 3,6-dichloropicolinic acid (3,6-D), 3-ClPA, and 6-ClPA are discharged as organic wastes at a rate of ∼300 tons per yr. The authors developed an aqueous phase electrocatalytic hydrogenation (ECH) system based on Pd catalyst to dechlorinate the ClPA mixtures into picolinic acid (PA) at room temperature Firstly, the authors evaluated the influence of cathode support and Pd loading on the catalytic performance of cathodes, as well as the effects of operating parameters on the intermediate product selectivity and dechlorination efficiency of the ECH process with 3,6-D as the target compound Secondly, the authors analyzed the ECH dechlorination mechanism of 3,6-D with regard to the surface condition of cathode and catholyte pH, and the rate-limiting step of the dechlorination process is also discussed. Finally, the authors assessed the practicability of the ECH system to dechlorinate the ClPA mixtures into PA by using a plate-and-frame cell. Pd/Ni foam cathodes with Pd loading of 2.25-3.6 mg cm-2 exhibited the optimum ECH dechlorination performance, and the basic aqueous solution and high 3,6-D concentration favored the ECH process. The ClPA mixtures with 47 g L-1 concentration (the total concentration of ClPAs was ∼250 mM) can be selectively dechlorinated into PA with 99% yield, 76.3% current efficiency, and 2.47 kW h kg-1 PA specific elec. energy consumption at a c.d. of 208 A m-2 in a 1.25 M NaOH aqueous solution In addition to this study using 3,5,6-Trichloropicolinic acid, there are many other studies that have used 3,5,6-Trichloropicolinic acid(cas: 40360-44-9Formula: C6H2Cl3NO2) was used in this study.

3,5,6-Trichloropicolinic acid(cas: 40360-44-9) belongs to pyridine. Pyridine-based materials are valued for their optical and physical properties as well as their medical potential. Additionally, pyridine-based natural products continue to be discovered and studied for their properties and to understand their biosynthesis.Formula: C6H2Cl3NO2

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

《Rational design, synthesis and testing of novel tricyclic topoisomerase inhibitors for the treatment of bacterial infections part 1》 was written by Kirk, R.; Ratcliffe, A.; Noonan, G.; Uosis-Martin, M.; Lyth, D.; Bardell-Cox, O.; Massam, J.; Schofield, P.; Hindley, S.; Jones, D. R.; Maclean, J.; Smith, A.; Savage, V.; Mohmed, S.; Charrier, C.; Salisbury, A-M.; Moyo, E.; Metzger, R.; Chalam-Judge, N.; Cheung, J.; Stokes, N. R.; Best, S.; Craighead, M.; Armer, R.; Huxley, A.. Recommanded Product: 6-Bromopyridin-3-amineThis research focused ontricyclic topoisomerase inhibitor bacterial infection treatment. The article conveys some information:

The alarming reduction in drug effectiveness against bacterial infections has created an urgent need for the development of new antibacterial agents that circumvent bacterial resistance mechanisms. We report here a series of DNA gyrase and topoisomerase IV inhibitors that demonstrate potent activity against a range of Gram-pos. and selected Gram-neg. organisms, including clin.-relevant and drug-resistant strains. In part 1, we present a detailed structure activity relationship (SAR) anal. that led to the discovery of our previously disclosed compound, REDX05931, which has a min. inhibitory concentration (MIC) of 0.06 μg mL-1 against fluoroquinolone-resistant Staphylococcus aureus. Although in vitro hERG and CYP inhibition precluded further development, it validates a rational design approach to address this urgent unmet medical need and provides a scaffold for further optimization, which is presented in part 2. The experimental part of the paper was very detailed, including the reaction process of 6-Bromopyridin-3-amine(cas: 13534-97-9Recommanded Product: 6-Bromopyridin-3-amine)

6-Bromopyridin-3-amine(cas: 13534-97-9) belongs to anime. Amines characteristically form salts with acids; a hydrogen ion, H+, adds to the nitrogen. With the strong mineral acids (e.g., H2SO4, HNO3, and HCl), the reaction is vigorous. Salt formation is instantly reversed by strong bases such as NaOH. Neutral electrophiles (compounds attracted to regions of negative charge) also react with amines; alkyl halides (R′X) and analogous alkylating agents are important examples of electrophilic reagents.Recommanded Product: 6-Bromopyridin-3-amine

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

《Selective C-H trifluoromethoxylation of (hetero)arenes as limiting reagent》 was written by Deng, Zhijie; Zhao, Mingxin; Wang, Feng; Tang, Pingping. Reference of 4-CyanopyridineThis research focused ontrifluoromethoxylated compound preparation regioselective; arene heteroarene trifluoromethyl arylsulfonate trifluoromethoxylation. The article conveys some information:

A general late-stage C-H trifluoromethoxylation of arenes and heteroarenes RH (R = 4-methoxypyridin-2-yl, 4-t-butylphenyl, 3-acetylbenzothien-2-yl, etc.) as limiting reagent with trifluoromethoxide anion was described. The reaction is mediated by silver salts under mild reaction conditions, exhibiting broad substrate scope and wide functional-group compatibility. In addition, ortho-position selective C-H trifluoromethoxylation of pyridines is observed The method is not only applicable to the gram-scale synthesis of trifluoromethoxylated products ROCF3 but also allows efficient late-stage C-H trifluoromethoxylation of marketed small-mol. drugs, common pharmacophores and natural products. In the experimental materials used by the author, we found 4-Cyanopyridine(cas: 100-48-1Reference of 4-Cyanopyridine)

4-Cyanopyridine(cas: 100-48-1) belongs to pyridine. Pyridine-based materials are valued for their optical and physical properties as well as their medical potential. Additionally, pyridine-based natural products continue to be discovered and studied for their properties and to understand their biosynthesis.Reference of 4-Cyanopyridine

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Safety of 2-Oxo-5-phenyl-1,2-dihydropyridine-3-carboxylic acidOn March 31, 1995, Monge, A.; Martinez-Merino, V.; Simon, M. A.; Sanmartin, C. published an article in Arzneimittel-Forschung. The article was 《New 5H-[1,3]thiazolo[3,2-a]pyrido[3,2-e]pyrimidin-5-one derivatives as diuretics》. The article mentions the following:

A series of new 5H-[1,3]thiazolo[3,2-a]pyrido[3.2-3]pyrimidin-5-ones 3-substituted and/or 8,9-hydrogenated was prepared and tested for their diuretic, natriuretic and kaliuretic activities on male Wistar rats at a dosage of 25 mg/kg or less. Diuretic and saliuretic activities were strongly influenced by substituents in 3-position. Quant. structure-activity relationships show that electron withdrawn substituents in 3-position enhance both diuretic and saliuretic activities at 25 mg/kg. Global anal. of the variations introduced on pyridine, pyrimidine and thiazole rings of this tricyclic system showed an increases of diuretic and natriuretic activities when the formal charge on N9a and C9b increases. Potassium ion excretion also increases, although not as drastically a in the earlier cases. Regression equations were calculated by partial least squares method (PLS) and validated by the cross-validation (leave-one-out) technique. The results came from multiple reactions, including the reaction of 2-Oxo-5-phenyl-1,2-dihydropyridine-3-carboxylic acid(cas: 10177-08-9Safety of 2-Oxo-5-phenyl-1,2-dihydropyridine-3-carboxylic acid)

2-Oxo-5-phenyl-1,2-dihydropyridine-3-carboxylic acid(cas: 10177-08-9) belongs to pyridine derivatives. The ring atoms in the pyridine molecule are sp2-hybridized. The nitrogen is involved in the π-bonding aromatic system using its unhybridized p orbital. Safety of 2-Oxo-5-phenyl-1,2-dihydropyridine-3-carboxylic acidThe lone pair is in an sp2 orbital, projecting outward from the ring in the same plane as the σ bonds.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem