Month: October 2022

In 2002,Organic Syntheses included an article by Smith, Adam P.; Lamba, Jaydeep J. S.; Fraser, Cassandra L.. Application of 138219-98-4. The article was titled 《Efficient synthesis of halomethyl-2,2′-bipyridines: 4,4′-bis(chloromethyl)-2,2′-bipyridine》. The information in the text is summarized as follows:

Silylation of 4,4′-dimethyl-2,2′-bipyridine with LDA followed by chlorotrimethylsilane gave 97% 4,4′-bis(trimethylsilylmethyl)-2,2′-bipyridine, treatment of which with Cl3CCCl3 and CsF in MeCN, gave 91% 4,4′-bis(chloromethyl)-2,2′-bipyridine. Among the 7 other halobipyridines similarly prepared were 98% 5-(chloromethyl)-2,2′-bipyridine 99% 4,4′-bis(bromomethyl)-2,2′-bipyridine. In the experiment, the researchers used 4,4′-Bis(chloromethyl)-2,2′-bipyridine(cas: 138219-98-4Application of 138219-98-4)

4,4′-Bis(chloromethyl)-2,2′-bipyridine(cas: 138219-98-4) belongs to pyridine derivatives. Several pyridine derivatives play important roles in biological systems. While its biosynthesis is not fully understood, nicotinic acid (vitamin B3) occurs in some bacteria, fungi, and mammals. Application of 138219-98-4

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

In 2016,ChemMedChem included an article by Doebelin, Christelle; Patouret, Remi; Garcia-Ordonez, Ruben D.; Chang, Mi Ra; Dharmarajan, Venkatasubramanian; Kuruvilla, Dana S.; Novick, Scott J.; Lin, Li; Cameron, Michael D.; Griffin, Patrick R.; Kamenecka, Theodore M.. Formula: C7H8BrNO. The article was titled 《N-Arylsulfonyl Indolines as Retinoic Acid Receptor-Related Orphan Receptor γ (RORγ) Agonists》. The information in the text is summarized as follows:

The nuclear retinoic acid receptor-related orphan receptor γ (RORγ; NR1F3) is a key regulator of inflammatory gene programs involved in T helper 17 (TH17) cell proliferation. As such, synthetic small-mol. repressors (inverse agonists) targeting RORγ have been extensively studied for their potential as therapeutic agents for various autoimmune diseases. Alternatively, enhancing TH17 cell proliferation through activation (agonism) of RORγ may boost an immune response, thereby offering a potentially new approach in cancer immunotherapy. Herein the authors describe the development of N-arylsulfonyl indolines as RORγ agonists. Structure-activity studies reveal a critical linker region in these mols. as the major determinant for agonism. Hydrogen/deuterium exchange coupled to mass spectrometry (HDX-MS) anal. of RORγ-ligand complexes help rationalize the observed results. In the experiment, the researchers used many compounds, for example, 2-(Bromomethyl)-3-methoxypyridine(cas: 889360-84-3Formula: C7H8BrNO)

2-(Bromomethyl)-3-methoxypyridine(cas: 889360-84-3) belongs to pyridine. Pyridine, its benzo and pyridine-based compounds play diverse roles in organic chemistry. As ligands, solvents, and catalysts they facilitate reactions; thus descriptions of these new ligands and their applications abound each year.Formula: C7H8BrNO

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Koay, Natalie; Tonelli, Devin L.; Truong, Vouy Linh published an article on January 5 ,2011. The article was titled 《Practical and efficient synthesis of N-fused tricyclic indoles》, and you may find the article in Tetrahedron Letters.Formula: C8H9NO3 The information in the text is summarized as follows:

A practical and efficient synthesis of Me 6,7,8,9-tetrahydropyrido[1,2-a]indol-10-ylacetate derivatives is reported. This synthetic approach featured the nucleophilic aromatic substitution of 2-piperidinemethanol derivatives with haloaryl fluorides, and the intramol. Heck coupling as key steps to afford the desired N-fused tricyclic indoles. After reading the article, we found that the author used Methyl 5-methoxypicolinate(cas: 29681-39-8Formula: C8H9NO3)

Methyl 5-methoxypicolinate(cas: 29681-39-8) belongs to pyridine. Pyridine, its benzo and pyridine-based compounds play diverse roles in organic chemistry. As ligands, solvents, and catalysts they facilitate reactions; thus descriptions of these new ligands and their applications abound each year.Formula: C8H9NO3

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

In 2016,Lemouzy, Sebastien; Jean, Marion; Giordano, Laurent; Herault, Damien; Buono, Gerard published 《The Hydroxyalkyl Moiety As a Protecting Group for the Stereospecific Alkylation of Masked Secondary Phosphine-Boranes》.Organic Letters published the findings.Product Details of 31106-82-8 The information in the text is summarized as follows:

The synthesis of functionalized tertiary phosphine-boranes has been developed via a chemodivergent approach from readily accessible (hydroxymethyl) phosphine-boranes under mild conditions. O-Alkylation or decarbonylative P-alkylation product could be exclusively obtained. The P-alkylation reaction was found to proceed in moderate to very good yields and very high enantiospecificity (es >95%) using a variety of alkyl halides as electrophiles. The configurational stability of the sodium phosphido-borane intermediate was also investigated and allowed a deeper understanding of the reaction mechanism, furnishing secondary phosphine-boranes in moderate yield and enantiopurity. In the experimental materials used by the author, we found 2-(Bromomethyl)pyridine hydrobromide(cas: 31106-82-8Product Details of 31106-82-8)

2-(Bromomethyl)pyridine hydrobromide(cas: 31106-82-8) belongs to pyridine. Pyridines form stable salts with strong acids. Pyridine itself is often used to neutralize acid formed in a reaction and as a basic solvent. Product Details of 31106-82-8

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

In 2017,Yamamoto, Yoshihiko; Nishimura, Kei-ichiro; Shibuya, Masatoshi published 《Ruthenium-Catalyzed Cycloisomerization of 1,6-Diynes with Styryl Terminals Leading to Indenylidene Cycloalkanes》.ACS Catalysis published the findings.COA of Formula: C6H4BrNO The information in the text is summarized as follows:

In the presence of a neutral ruthenium catalyst, Cp*RuCl(cod), 1,5,10-enediynes bearing a styryl terminal underwent cycloisomerization to afford exocyclic 1,3-dienes with an indenylidene moiety. The reaction mechanism is proposed on the basis of the results of control experiments and d. functional calculations The transformations of the obtained cyclization products were also investigated to demonstrate the synthetic potential of this method. In addition to this study using 2-Bromonicotinaldehyde, there are many other studies that have used 2-Bromonicotinaldehyde(cas: 128071-75-0COA of Formula: C6H4BrNO) was used in this study.

2-Bromonicotinaldehyde(cas: 128071-75-0) belongs to pyridine. Pyridine is very deactivated towards electrophilic substitution with respect to benzene. For this reason classical formylation, using methods such as the Gattermann or Vilsmeier reactions, are not generally successful. COA of Formula: C6H4BrNO

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

In 2018,ChemistrySelect included an article by Lemouzy, Sebastien; Jean, Marion; Deplante, Fabien; Albalat, Muriel; Herault, Damien; Buono, Gerard. Formula: C6H7Br2N. The article was titled 《Tunable P-Stereogenic P,N-Phosphine Ligands Design: Synthesis and Coordination Chemistry to Palladium》. The information in the text is summarized as follows:

The synthesis of P,N heterobidentate phosphine / palladium complexes was realized from P-stereogenic enantiopure ligands. Five, six or seven membered ring complexes were fully characterized, notably by x-ray diffraction, allowing the study of the chelation to a palladium (II) dichloride unit. The nature of nitrogen coordination site as well as the size of the ring modify the bite-angle at the solid state. In the part of experimental materials, we found many familiar compounds, such as 2-(Bromomethyl)pyridine hydrobromide(cas: 31106-82-8Formula: C6H7Br2N)

2-(Bromomethyl)pyridine hydrobromide(cas: 31106-82-8) belongs to pyridine. When pyridine is adsorbed on oxide surfaces or in porous materials, the following species are commonly observed: (i) pyridine coordinated to Lewis acid sites, (ii) pyridine H-bonded to weakly acidic hydroxyls, and (iii) protonated pyridine. At high coverage, physisorbed pyridine and protonated dimers can also be observed.Formula: C6H7Br2N

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

In 2018,Green Chemistry included an article by Chakrabarti, Kaushik; Mishra, Anju; Panja, Dibyajyoti; Paul, Bhaskar; Kundu, Sabuj. Reference of 2-(2-Hydroxyethyl)pyridine. The article was titled 《Selective synthesis of mono- and di-methylated amines using methanol and sodium azide as C1 and N1 sources》. The information in the text is summarized as follows:

A Ru(II) complex mediated synthesis of various N,N-di-Me and N-monomethyl amines from organic azides using methanol as a methylating agent was reported. This methodol. was successfully applied for a one-pot reaction of bromide derivatives and sodium azide in methanol. Notably, by controlling the reaction time several N-monomethylated and N,N-dimethylated amines were synthesized selectively. The practical applicability of this tandem process was revealed by preparative scale reactions with different organic azides and synthesis of an anti-vertigo drug betahistine. Several kinetic experiments and DFT studies were carried out to understand the mechanism of this transformation. In the experiment, the researchers used many compounds, for example, 2-(2-Hydroxyethyl)pyridine(cas: 103-74-2Reference of 2-(2-Hydroxyethyl)pyridine)

2-(2-Hydroxyethyl)pyridine(cas: 103-74-2) belongs to pyridine. Pyridine derivatives lend themselves to many roles in the spirited field of supramolecular chemistry – whether as the ligand backbone of metal-organic polymers or presiding over the key electronic stations of nanodevices. In biochemistry, pyridine-containing cofactors are necessary nutrients on which our lives depend. Reference of 2-(2-Hydroxyethyl)pyridine

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

In 2019,Green Chemistry included an article by Kucinski, Krzysztof; Hreczycho, Grzegorz. Synthetic Route of C7H7NO. The article was titled 《Lithium triethylborohydride as catalyst for solvent-free hydroboration of aldehydes and ketones》. The information in the text is summarized as follows:

Com. available and inexpensive lithium triethylborohydride (LiHBEt3) acts as an efficient catalyst for the solvent-free hydroboration of a wide range of aldehydes and ketones, which were subsequently transformed to corresponding 1° and 2° alcs. in one-pot procedure at room temperature (rt). In the experiment, the researchers used many compounds, for example, 4-Acetylpyridine(cas: 1122-54-9Synthetic Route of C7H7NO)

4-Acetylpyridine(cas: 1122-54-9) belongs to pyridine. Pyridine is widely used in the precursor to agrochemicals and pharmaceuticals. Also, it is used as an important reagent and organic solvent.Synthetic Route of C7H7NO

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

In 2019,Organic Letters included an article by Nakajima, Kazunari; Zhang, Yulin; Nishibayashi, Yoshiaki. Recommanded Product: 94928-86-6. The article was titled 《Alkylation Reactions of Azodicarboxylate Esters with 4-Alkyl-1,4-Dihydropyridines under Catalyst-Free Conditions》. The information in the text is summarized as follows:

Introduction of alkyl groups on azodicarboxylate esters is an important method to prepare alkyl amine derivatives Herein, we report reactions of 4-alkyl-1,4-dihydropyridines as alkylation reagents with di-tert-Bu azodicarboxylate to prepare alkyl amine derivatives under heating conditions. The alkylation reactions via C-C bond cleavage of the dihydropyridines are achieved in the absence of catalysts and additives. In the experiment, the researchers used fac-Tris(2-phenylpyridine)iridium(cas: 94928-86-6Recommanded Product: 94928-86-6)

fac-Tris(2-phenylpyridine)iridium(cas: 94928-86-6) belongs to pyridine. Pyridine is widely used in the precursor to agrochemicals and pharmaceuticals. Also, it is used as an important reagent and organic solvent.Recommanded Product: 94928-86-6

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

In 2019,Nature Communications included an article by Zhu, Shengqing; Qin, Jian; Wang, Fang; Li, Huan; Chu, Lingling. COA of Formula: C6H4N2. The article was titled 《Photoredox-catalyzed branch-selective pyridylation of alkenes for the expedient synthesis of Triprolidine》. The information in the text is summarized as follows:

A catalytic, branch-selective pyridylation of alkenes via a sulfinate assisted photoredox catalysis was reported. This reaction proceeded through a sequential radical addition/coupling/elimination, by utilizing readily available sodium sulfinates as reusable radical precursors as well as traceless elimination groups. This versatile protocol allows for the installation of important vinylpyridines with complete branched selectivity under mild conditions. Furthermore, this catalytic manifold was successfully applied to the expedient synthesis of Triprolidine. In the experiment, the researchers used 4-Cyanopyridine(cas: 100-48-1COA of Formula: C6H4N2)

4-Cyanopyridine(cas: 100-48-1) belongs to pyridine. In industry and in the lab, pyridine is used as a reaction solvent, particularly when its basicity is useful, and as a starting material for synthesizing some herbicides, fungicides, and antiseptics.COA of Formula: C6H4N2

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem