Month: October 2022

《Synthesis of Diethynyltriptycene-Linked Dipyridyl Ligands》 was written by Kodanko, Jeremy J.; Morys, Anna J.; Lippard, Stephen J.. Recommanded Product: 29682-15-3This research focused ontriptycene pyridylethynyl preparation dinucleating ligand; pyridine bromo dual Sonogashira coupling diethynyltriptycene. The article conveys some information:

An efficient route to a new family of dinucleating ligands has been developed. A convergent strategy to these ligands involved dual Sonogashira cross-coupling of 2,3-diethynyltriptycene with a variety of functionally diverse 5-bromopyridines. The resultant ligands were accessed in four steps and 40-50% overall yields from 1,2,4,5-tetrabromobenzene. Synthesis of an imidazole and a quinoline derivative by this method is also described. The results came from multiple reactions, including the reaction of Methyl 5-bromopicolinate(cas: 29682-15-3Recommanded Product: 29682-15-3)

Methyl 5-bromopicolinate(cas: 29682-15-3) belongs to pyridine. Pyridine-based materials are valued for their optical and physical properties as well as their medical potential. Additionally, pyridine-based natural products continue to be discovered and studied for their properties and to understand their biosynthesis.Recommanded Product: 29682-15-3

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

《Synthesis of perfluoroalkylated bipyridines – new ligands for oxidation reactions under fluorous triphasic conditions》 was written by Quici, Silvio; Cavazzini, Marco; Ceragioli, Silvia; Montanari, Fernando; Pozzi, Gianluca. Application In Synthesis of 4,4′-Bis(chloromethyl)-2,2′-bipyridine And the article was included in Tetrahedron Letters on April 30 ,1999. The article conveys some information:

Fluorous soluble bipyridines bearing two perfluoroalkylated side chains in the 6,6′- or 4,4′-positions have been prepared in good yields via etherification of 6,6′-bis(chloromethyl)-2,2′-bipyridine or C-alkylation of 4,4′-dimethyl-2,2′-bipyridine. The new ligands L exhibit amphiphilic behavior with respect to certain fluorous-organic biphasic systems. Nevertheless, their ruthenium complexes (RuLn)X generated in situ are efficient catalysts for the epoxidation of trans-stilbene in a fluorous triphasic system CH2Cl2/H2O/C8F18 in the presence of NaIO4. The fluorous phase, where (RuLn)X is trapped, can be used up to four times without major loss of catalytic activity. In addition to this study using 4,4′-Bis(chloromethyl)-2,2′-bipyridine, there are many other studies that have used 4,4′-Bis(chloromethyl)-2,2′-bipyridine(cas: 138219-98-4Application In Synthesis of 4,4′-Bis(chloromethyl)-2,2′-bipyridine) was used in this study.

4,4′-Bis(chloromethyl)-2,2′-bipyridine(cas: 138219-98-4) belongs to pyridine derivatives. The ring atoms in the pyridine molecule are sp2-hybridized. The nitrogen is involved in the π-bonding aromatic system using its unhybridized p orbital. Application In Synthesis of 4,4′-Bis(chloromethyl)-2,2′-bipyridine Pyridine has a conjugated system of six π electrons that are delocalized over the ring.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

HPLC of Formula: 116383-98-3On May 7, 1999 ,《Selective palladium-catalyzed carbonylations of dichloroquinoline and simple dichloropyridines》 appeared in Tetrahedron Letters. The author of the article were Najiba, Douja; Carpentier, Jean-Francois; Castanet, Yves; Biot, Christophe; Brocard, Jacques; Mortreux, Andre. The article conveys some information:

Dichloroquinoline and some dichloropyridines undergo selective alkoxycarbonylation in the presence of carbon monoxide, an alc. and PdCl2(PPh3)2 as a catalyst, affording chloro-monoester and/or diesters in good yields under selected reaction conditions. In addition to this study using Methyl 3-chloropicolinate, there are many other studies that have used Methyl 3-chloropicolinate(cas: 116383-98-3HPLC of Formula: 116383-98-3) was used in this study.

Methyl 3-chloropicolinate(cas: 116383-98-3) belongs to pyridine. Pyridine, its benzo and pyridine-based compounds play diverse roles in organic chemistry. As ligands, solvents, and catalysts they facilitate reactions; thus descriptions of these new ligands and their applications abound each year.HPLC of Formula: 116383-98-3

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Computed Properties of C12H10Cl2N2On November 24, 2010 ,《Convenient synthesis of functionalized 4,4′-disubstituted-2,2′-bipyridine with extended π-system for dye-sensitized solar cell applications》 appeared in Tetrahedron Letters. The author of the article were Klein, Cedric; Baranoff, Etienne; Nazeeruddin, Khaja Md.; Graetzel, Michael. The article conveys some information:

Exploration of new ruthenium-based sensitizers for dye-sensitized solar cell (DSC) applications required an easy access to multifunctionalized ligands for efficient screening of sensitizers’ properties. Based on the Horner-Wadsworth-Emmons reaction, a convenient synthetic route for the extension of the π-system on 4,4′-disubstituted-2,2′-bipyridines was used to develop a novel series of functionalized 2,2′-bipyridine ligands, e.g., I (R = CO2C6H13, CO2C8C17, OC6H13, OC8H17), with either electron-withdrawing or donating end-capping groups. The experimental part of the paper was very detailed, including the reaction process of 4,4′-Bis(chloromethyl)-2,2′-bipyridine(cas: 138219-98-4Computed Properties of C12H10Cl2N2)

4,4′-Bis(chloromethyl)-2,2′-bipyridine(cas: 138219-98-4) belongs to pyridine derivatives. Several pyridine derivatives play important roles in biological systems. While its biosynthesis is not fully understood, nicotinic acid (vitamin B3) occurs in some bacteria, fungi, and mammals. Computed Properties of C12H10Cl2N2

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Gawinecki, Ryszard; Rasala, Danuta; Obrzut, Jan; Tamasik, Piotr published their research in Chemica Scripta on December 31 ,1985. The article was titled 《The ortho effect in pyridines. VI. Singlet → singlet π → π* excited state of 2- and 4-substituted 3-nitropyridines》.Application In Synthesis of 3-Nitroisonicotinic acid The article contains the following contents:

The UV absorption spectra in ethanol were measured for o-substituted nitrobenzenes, 2-substituted-3-nitropyridines and 4-substituted-3-nitropyridines. Based on bathochromic shift of the ICT band and its intensity, the ortho effect is discussed in the singlet→singlet π→π* excited state of investigated compounds In the experiment, the researchers used 3-Nitroisonicotinic acid(cas: 59290-82-3Application In Synthesis of 3-Nitroisonicotinic acid)

3-Nitroisonicotinic acid(cas: 59290-82-3) belongs to pyridine. Pyridine, its benzo and pyridine-based compounds play diverse roles in organic chemistry. As ligands, solvents, and catalysts they facilitate reactions; thus descriptions of these new ligands and their applications abound each year.Application In Synthesis of 3-Nitroisonicotinic acid

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

The author of 《Hydrogen bond-induced abrupt spin crossover behaviour in 1-D cobalt(II) complexes – the key role of solvate water molecules》 were Zenno, Hikaru; Kobayashi, Fumiya; Nakamura, Masaaki; Sekine, Yoshihiro; Lindoy, Leonard F.; Hayami, Shinya. And the article was published in Dalton Transactions in 2021. Reference of 4′-(4-Pyridyl)-2,2′:6′,2”-terpyridine The author mentioned the following in the article:

The magnetic properties and structural aspects of the 1-D cobalt(II) complexes, [Co(pyterpy)Cl2]·2H2O (1·2H2O; pyterpy = 4′-(4”’-pyridyl)-2,2′:6′,2”-terpyridine) and [Co(pyethyterpy)Cl2]·2H2O (2·2H2O; pyethyterpy = 4′-((4”’-pyridyl)ethynyl)-2,2′:6′,2”-terpyridine) are reported. In each complex the central cobalt(II) ion displays an octahedral coordination environment composed of three nitrogen donors from the terpyridine moiety, a nitrogen donor from a pyridyl group and two chloride ligands which occupy the axial sites. 1·2H2O exhibits abrupt spin-crossover (SCO) behavior (T1/2↓ = 218 K; T1/2↑ = 227 K) along with a thermal hysteresis loop, while 2·2H2O and the dehydrated species 1 and 2 exhibit high-spin (HS) states at 2-300 K as well as field-induced single-mol. magnet (SMM) behavior attributed to the presence of magnetic anisotropic HS cobalt(II) species (S = 3/2). 1·2H2O exhibited reversible desorption/resorption of its two water mols., revealing reversible switching between SCO and SMM behavior triggered by the dehydration/rehydration processes. Single crystal x-ray structural analyses revealed that 1·2H2O crystalizes in the orthorhombic space group Pcca while 2 and 2·2H2O crystallize in the monoclinic space group P2/n. Each of the 1-D chains formed by 1·2H2O in the solid state are bridged by hydrogen bonds between water mols. and chloride groups to form a 2-D layered structure. The water mols. bridging 1-D chains in 1·2H2O interact with the chloride ligands occupying the axial positions, complementing the effect of Jahn-Teller distortion and contributing to the abrupt SCO behavior and associated stabilization of the LS state. In the experiment, the researchers used many compounds, for example, 4′-(4-Pyridyl)-2,2′:6′,2”-terpyridine(cas: 112881-51-3Reference of 4′-(4-Pyridyl)-2,2′:6′,2”-terpyridine)

4′-(4-Pyridyl)-2,2′:6′,2”-terpyridine(cas: 112881-51-3) belongs to pyridine derivatives. The ring atoms in the pyridine molecule are sp2-hybridized. The nitrogen is involved in the π-bonding aromatic system using its unhybridized p orbital. Reference of 4′-(4-Pyridyl)-2,2′:6′,2”-terpyridineThe lone pair is in an sp2 orbital, projecting outward from the ring in the same plane as the σ bonds.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Zurwerra, Didier; Quetglas, Vincent; Kloer, Daniel P.; Renold, Peter; Pitterna, Thomas published an article in Organic Letters. The title of the article was 《Synthesis and Stability of Boratriazaroles》.Synthetic Route of C6H7BClNO2 The author mentioned the following in the article:

We describe the synthesis and stability anal. of novel boratriazaroles that can be viewed as bioisosteres of imidazoles or pyrazoles. These heterocycles could conveniently be obtained by condensing a boronic acid and amidrazone 1 in various solvents. A detailed stability anal. of selected compounds at different pH values as a function of time led to the identification of steric hindrance around the boron atom as a key element for stabilization. In addition to this study using (6-Chloro-5-methylpyridin-3-yl)boronic acid, there are many other studies that have used (6-Chloro-5-methylpyridin-3-yl)boronic acid(cas: 1003043-40-0Synthetic Route of C6H7BClNO2) was used in this study.

(6-Chloro-5-methylpyridin-3-yl)boronic acid(cas: 1003043-40-0) belongs to pyridine. Pyridine, its benzo and pyridine-based compounds play diverse roles in organic chemistry. As ligands, solvents, and catalysts they facilitate reactions; thus descriptions of these new ligands and their applications abound each year.Synthetic Route of C6H7BClNO2

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

In 2009,Butcher, Ken J.; Hurst, Jenny published 《Aromatic amines as nucleophiles in the Bargellini reaction》.Tetrahedron Letters published the findings.Related Products of 13534-97-9 The information in the text is summarized as follows:

Aromatic amines can be employed in the Bargellini condensation with piperidinone and CHCl3 in the presence of NaOH to generate useful intermediates. Rapid, practical access to functionalized, privileged structures may have utility in the synthesis of drug-like mols. An improved synthesis of carfentanil analogs illustrates this point. In the experiment, the researchers used many compounds, for example, 6-Bromopyridin-3-amine(cas: 13534-97-9Related Products of 13534-97-9)

6-Bromopyridin-3-amine(cas: 13534-97-9) belongs to anime. Amine, any member of a family of nitrogen-containing organic compounds that is derived, either in principle or in practice, from ammonia (NH3). Naturally occurring amines include the alkaloids, which are present in certain plants; the catecholamine neurotransmitters (i.e., dopamine, epinephrine, and norepinephrine); and a local chemical mediator, histamine, that occurs in most animal tissues.Related Products of 13534-97-9

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

In 2013,Sharma, Sushila; Kumar, Manoranjan; Kumar, Vishal; Kumar, Neeraj published 《Vasicine catalyzed direct C-H arylation of unactivated arenes: organocatalytic application of an abundant alkaloid》.Tetrahedron Letters published the findings.Application of 13534-97-9 The information in the text is summarized as follows:

Vasicine, a quinazoline alkaloid isolated from Adhatoda vasica, has been employed as an organocatalyst for direct C-H arylation of unactivated arenes with aryl iodides/bromides without the assistance of any transition metal catalyst. A number of sensitive functional groups such as Me, methoxy, O-benzyl, acetyl, and amino were well tolerated under present reaction conditions. Mechanistic investigation supported the involvement of radical intermediates.6-Bromopyridin-3-amine(cas: 13534-97-9Application of 13534-97-9) was used in this study.

6-Bromopyridin-3-amine(cas: 13534-97-9) belongs to anime. To avoid the problem of multiple alkylation, methods have been devised for “blocking” substitution so that only one alkyl group is introduced. The Gabriel synthesis is one such method; it utilizes phthalimide, C6H4(CO)2NH, whose one acidic hydrogen atom has been removed upon the addition of a base such as KOH to form a salt.Application of 13534-97-9

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

In 2013,Oberli, Matthias A.; Buchwald, Stephen L. published 《A General Method for Suzuki-Miyaura Coupling Reactions Using Lithium Triisopropyl Borates [Erratum to document cited in CA157:409485]》.Organic Letters published the findings.Electric Literature of C5H5BrN2 The information in the text is summarized as follows:

An NIH grant acknowledgment was omitted from the published article; the omitted acknowledgment is given. In the experiment, the researchers used many compounds, for example, 6-Bromopyridin-3-amine(cas: 13534-97-9Electric Literature of C5H5BrN2)

6-Bromopyridin-3-amine(cas: 13534-97-9) belongs to anime. The methylamines occur in small amounts in some plants. Many polyfunctional amines (i.e., those having other functional groups in the molecule) occur as alkaloids in plants—for example, mescaline, 2-(3,4,5-trimethoxyphenyl)ethylamine; the cyclic amines nicotine, atropine, morphine, and cocaine; and the quaternary salt choline, N-(2-hydroxyethyl)trimethylammonium chloride, which is present in nerve synapses and in plant and animal cells.Electric Literature of C5H5BrN2

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem