Month: October 2022

《Gold-Catalyzed Alkynylative Meyer-Schuster Rearrangement》 was published in Organic Letters in 2020. These research results belong to Banerjee, Somsuvra; Ambegave, Shivhar B.; Mule, Ravindra D.; Senthilkumar, Beeran; Patil, Nitin T.. Formula: C6H4BrNO The article mentions the following:

In the presence of a (methylbenzotriazole)(triphenylphosphine)gold(I) triflate, propargyl alcs. such as BuCCCH(OH)Ph underwent alkynylation and Meyer-Schuster rearrangement reactions with silylethynylbenziodoxolones such as TIPS-EBX to yield (E)-α-alkynyl-α,β-unsaturated ketones such as I. Mass spectroscopic observation of intermediates and control reactions indicate that a gold(III) intermediate is necessary to catalyze the Meyer-Schuster rearrangement, and that an alkynylgold(III) intermediate is formed and mediates the alkynylation reaction. In the experiment, the researchers used many compounds, for example, 2-Bromonicotinaldehyde(cas: 128071-75-0Formula: C6H4BrNO)

2-Bromonicotinaldehyde(cas: 128071-75-0) belongs to pyridine. Pyridine is widely used in the precursor to agrochemicals and pharmaceuticals. Also, it is used as an important reagent and organic solvent.Formula: C6H4BrNO

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

《One-Pot Synthesis of a Linear [4]Catenate Using Orthogonal Metal Templation and Ring-Closing Metathesis》 was published in Inorganic Chemistry in 2020. These research results belong to Colley, Nathan D.; Nosiglia, Mark A.; Li, Lei; Amir, Faheem; Chang, Christy; Greene, Angelique F.; Fisher, Jeremy M.; Li, Ruihan; Li, Xuesong; Barnes, Jonathan C.. SDS of cas: 624-28-2 The article mentions the following:

The efficient synthesis of well-defined, linear oligocatenanes possessing multiple mech. bonds remains a formidable challenge in the field of mech. interlocked mols. Here, a one-pot synthetic strategy is described to prepare a linear [4]catenate using orthogonal metal templation between a macrocycle precursor, composed of terpyridine and phenanthroline ligands spaced by flexible glycol linkers, and a closed phenanthroline-based mol. ring. Implementation of two simultaneous ring-closing metathesis reactions after metal complexation resulted in the formation of three mech. bonds. The linear [4]catenate product was isolated in 55% yield as a mixture of topol. diastereomers. The intermediate metal complexes and corresponding interlocked products (with and without metals) were characterized by NMR, mass spectrometry, gel permeation chromatog., and UV-vis absorption spectroscopy. We envision that this general synthetic strategy may pave the way for the synthesis of higher order linear oligocatenates/catenanes with precise mol. weights and four or more interlocking mol. rings. The experimental part of the paper was very detailed, including the reaction process of 2,5-Dibromopyridine(cas: 624-28-2SDS of cas: 624-28-2)

2,5-Dibromopyridine(cas: 624-28-2) belongs to pyridine. Pyridines are often used as catalysts or reagents; particular notice has been paid recently to how pyridine coordinates to metal centers enabling a wide range of valuable reactions. SDS of cas: 624-28-2

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

《Cu2+-based distance measurements by pulsed EPR provide distance constraints for DNA backbone conformations in solution》 was published in Nucleic Acids Research in 2020. These research results belong to Ghosh, Shreya; Lawless, Matthew J.; Brubaker, Hanna J.; Singewald, Kevin; Kurpiewski, Michael R.; Jen-Jacobson, Linda; Saxena, Sunil. Recommanded Product: 1539-42-0 The article mentions the following:

ESR (EPR) has become an important tool to probe conformational changes in nucleic acids. An array of EPR labels for nucleic acids are available, but they often come at the cost of long tethers, are dependent on the presence of a particular nucleotide or can be placed only at the termini. Site directed incorporation of Cu2+-chelated to a ligand, 2,2’dipicolylamine (DPA) is potentially an attractive strategy for site-specific, nucleotide independent Cu2+-labeling in DNA. To fully understand the potential of this label, we undertook a systematic and detailed anal. of the Cu2+-DPA motif using EPR and mol. dynamics (MD) simulations. We used continuous wave EPR experiments to characterize Cu2+ binding to DPA as well as optimize Cu2+ loading conditions. We performed double electron-electron resonance (DEER) experiments at two frequencies to elucidate orientational selectivity effects. Furthermore, comparison of DEER and MD simulated distance distributions reveal a remarkable agreement in the most probable distances. The results illustrate the efficacy of the Cu2+-DPA in reporting on DNA backbone conformations for sufficiently long base pair separations This labeling strategy can serve as an important tool for probing conformational changes in DNA upon interaction with other macromols. In the experiment, the researchers used Bis(pyridin-2-ylmethyl)amine(cas: 1539-42-0Recommanded Product: 1539-42-0)

Bis(pyridin-2-ylmethyl)amine(cas: 1539-42-0) is a secondary amine with two picolyl substituents. As a tridentate ligand this compound provides three nitrogen donors that affords good selectivity for Zn2+ over biologically relevant metals such as Na+, K+, Mg2+ and Ca2+, and leaves coordination sites free for anion binding. Recommanded Product: 1539-42-0

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

《A cyanobiphenyl-based ratiometric fluorescent sensor for highly selective and sensitive detection of Zn2+》 was published in Inorganica Chimica Acta in 2020. These research results belong to Bie, Fusheng; Cao, Han; Yan, Peng; Cui, Haizhu; Shi, Yijun; Ma, Jie; Liu, Xuejing; Han, Ying. COA of Formula: C12H13N3 The article mentions the following:

A novel fluorescent sensor (BCN, I) based on cyanobiphenyl and di-2-picolylamine (DPA) was designed, synthesized and characterized by the UV-vis absorption, fluorescence spectra and NMR studies. This sensor demonstrated ratiometric response, high selectivity and sensitivity for the detection of Zn2+ without the interference of other metal ions particularly the Cd2+ in HEPES buffer/DMSO solution The Job’s plot, HRMS (high-resolution mass spectroscopy) and single-crystal X-ray diffraction revealed the formation of 1:1 stoichiometry for BCN-Zn2+ complex. The binding constant (Ka) of the complex was determined to be 3.67 x 104 M-1 and the detection limit for Zn2+ was calculated to be 0.77μM. The entire results certificated that BCN can be an advantageous sensor for Zn2+ detection. After reading the article, we found that the author used Bis(pyridin-2-ylmethyl)amine(cas: 1539-42-0COA of Formula: C12H13N3)

Bis(pyridin-2-ylmethyl)amine(cas: 1539-42-0) is a secondary amine with two picolyl substituents. As a tridentate ligand this compound provides three nitrogen donors that affords good selectivity for Zn2+ over biologically relevant metals such as Na+, K+, Mg2+ and Ca2+, and leaves coordination sites free for anion binding. COA of Formula: C12H13N3

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

《Efficient synthesis of dibenzazepine lactams via a sequential Pd-catalyzed amination and aldol condensation reaction》 was published in Tetrahedron Letters in 2020. These research results belong to Song, Ha-Jeong; Yoon, Eunyoung; Heo, Jung-Nyoung. Quality Control of 2-Bromonicotinaldehyde The article mentions the following:

A simple and efficient reaction was developed for the synthesis of dibenzazepine lactam derivatives e.g., I. The core 7-membered azepine ring was formed by a stepwise sequence involving a palladium-catalyzed amination and an aldol condensation. The experimental process involved the reaction of 2-Bromonicotinaldehyde(cas: 128071-75-0Quality Control of 2-Bromonicotinaldehyde)

2-Bromonicotinaldehyde(cas: 128071-75-0) belongs to pyridine. Pyridine is very deactivated towards electrophilic substitution with respect to benzene. For this reason classical formylation, using methods such as the Gattermann or Vilsmeier reactions, are not generally successful. Quality Control of 2-Bromonicotinaldehyde

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

《Zooming in on the hydrated imidazoline ring expansion: Factors influencing the rate of N → N’ aroyl migration in N-aroyl-N-(hetero)aryl ethylenediamines》 was written by Lavit, Kseniya; Reutskaya, Elena; Grintsevich, Sergey; Sapegin, Alexander; Krasavin, Mikhail. Product Details of 197958-29-5 And the article was included in Tetrahedron Letters in 2020. The article conveys some information:

The influence of electronic factors on the rates of N → N’ aroyl migration in N-aroyl-N-(hetero)aryl ethylenediamines was examined Electron-withdrawing substituents on the aroyl group weakly accelerate the reaction (in linear correlation with the Hammett σp constants). Much stronger influence came from the nitrogen-bound aromatic group which gave a strong linear correlation with the Hammett σ-p constants For electron-deficient heteroaromatics and nitroaroms., the migration was nearly instantaneous in basic medium. These findings will significantly impact the planning of mechanistically related transformations of N-(2-aminoethyl) lactams through the hydrated imidazoline ring expansion (HIRE) process. The results came from multiple reactions, including the reaction of 2-Pyridinylboronic acid(cas: 197958-29-5Product Details of 197958-29-5)

2-Pyridinylboronic acid(cas: 197958-29-5) belongs to pyridine. Pyridines form stable salts with strong acids. Pyridine itself is often used to neutralize acid formed in a reaction and as a basic solvent. Product Details of 197958-29-5

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Sonavane, Sachin; Deshmukh, Ganesh; Wakchaure, Satish; Deshmukh, Sharayu published their research in Heterocyclic Letters in 2021. The article was titled 《An improved, practical, reliable and scalable synthesis of 2,5-dibromopyridine》.Product Details of 624-28-2 The article contains the following contents:

A convenient and scalable process for preparation of 2,5-dibromopyridine has been developed. Total yield of 83% has been achieved from 2-aminopyridine. The process is convenient and could be easily scaled up. Byproduct dibromide pyridine is separated and 2-amino-5-bromopyridine is converted by modified Sandmeyer conditions to synthesize 2,5-dibromopyridine from its diazonium salt in presence of bromine instead of conventional copper halide such as CuBr as reagents or catalysts. The experimental part of the paper was very detailed, including the reaction process of 2,5-Dibromopyridine(cas: 624-28-2Product Details of 624-28-2)

2,5-Dibromopyridine(cas: 624-28-2) belongs to pyridine. Pyridine’s structure is isoelectronic with that of benzene, but its properties are quite different. Pyridine is completely miscible with water, whereas benzene is only slightly soluble. Like all hydrocarbons, benzene is neutral (in the acid–base sense), but because of its nitrogen atom, pyridine is a weak base.Product Details of 624-28-2

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Joyce, Justin P.; Portillo, Romeo I.; Nite, Collette M.; Nite, Jacob M.; Nguyen, Michael P.; Rappe, Anthony K.; Shores, Matthew P. published their research in Inorganic Chemistry in 2021. The article was titled 《Electronic Structures of Cr(III) and V(II) Polypyridyl Systems: Undertones in an Isoelectronic Analogy》.Safety of 4,4′-Dimethyl-2,2′-bipyridine The article contains the following contents:

A recently reported description of the photophys. properties of V2+ polypyridyl systems has highlighted several distinctions between isoelectronic, d3, Cr3+, and V2+ tris-homoleptic polypyridyl complexes of 2,2′-bipyridine (bpy) and 1,10-phenanthroline (phen). Here, we combine theory and exptl. data to elucidate the differences in electronic structures. We provide the first crystallog. structures of the V2+ complexes [V(bpy)3](BPh4)2 (V-1B) and [V(phen)3](OTf)2 (V2) and observe pronounced trigonal distortion relative to analogous Cr3+ complexes. We use electronic absorption spectroscopy in tandem with TD-DFT computations to assign metal-ligand charge transfer (MLCT) properties of V-1B and V2 that are unique from the intraligand transitions, 4(3IL), solely observed in Cr3+ analogs. Our newly developed natural transition spin d. (NTρα,β) plots characterize both the Cr3+ and V2+ absorbance properties. A multideterminant approach to DFT assigns the energy of the 2E state of V-1B as stabilized through electron delocalization. We find that the profound differences in excited state lifetimes for Cr3+ and V2+ polypyridyls arise from differences in the characters of their lowest doublet states and pathways for intersystem crossing, both of which stem from trigonal structural distortion and metal-ligand π-covalency. In addition to this study using 4,4′-Dimethyl-2,2′-bipyridine, there are many other studies that have used 4,4′-Dimethyl-2,2′-bipyridine(cas: 1134-35-6Safety of 4,4′-Dimethyl-2,2′-bipyridine) was used in this study.

4,4′-Dimethyl-2,2′-bipyridine(cas: 1134-35-6) is used as a chemical Intermediate. It can be used for the determination of ferrous and cyanide compounds.Safety of 4,4′-Dimethyl-2,2′-bipyridine Furthermore, 4,4′-Dimethyl-2,2′-bipyridine is used in the synthesis of a series of o-phenanthroline-substituted ruthenium(II) complexes.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Ohtsu, Hiroyoshi; Kim, Joonsik; Kanamaru, Tatsuya; Inoue, Daishi; Hashizume, Daisuke; Kawano, Masaki published an article in 2021. The article was titled 《Stepwise Observation of Iodine Diffusion in a Flexible Coordination Network Having Dual Interactive Sites》, and you may find the article in Inorganic Chemistry.Reference of Pyridin-3-ylboronic acid The information in the text is summarized as follows:

We created dual interactive sites in a porous coordination network using a CuI cluster and a rotation-restricted ligand, tetra(3-pyridyl)phenylmethane (3-TPPM). The dual interactive sites of iodide and Cu ions can adsorb I2 via four-step processes including two chemisorption processes. Initially, one I2 mol. was physisorbed in a pore and successively chemisorbed on iodide sites of the pore surface, and then the next I2 mol. was physisorbed and chemisorbed on Cu ions to form a cross-linked network. We revealed the four-step I2 diffusion process by single-crystal X-ray structure determination and spectroscopic kinetic anal. In the experiment, the researchers used many compounds, for example, Pyridin-3-ylboronic acid(cas: 1692-25-7Reference of Pyridin-3-ylboronic acid)

Pyridin-3-ylboronic acid(cas: 1692-25-7) belongs to pyridine. Pyridines form stable salts with strong acids. Pyridine itself is often used to neutralize acid formed in a reaction and as a basic solvent. Reference of Pyridin-3-ylboronic acid

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Hassan, Mirja Mahamudul Md; Hoque, Emdadul Md; Dey, Sayan; Guria, Saikat; Roy, Brindaban; Chattopadhyay, Buddhadeb published an article in 2021. The article was titled 《Iridium-Catalyzed Site-Selective Borylation of 8-Arylquinolines》, and you may find the article in Synthesis.Recommanded Product: 3510-66-5 The information in the text is summarized as follows:

The authors report a convenient method for the highly site-selective borylation of 8-arylquinoline. The reaction proceeds smoothly in the presence of a catalytic amount of [Ir(OMe)(cod)]2 and 2-phenylpyridine derived ligand using bis(pinacolato)diborane as the borylating agent. The reactions occur with high selectivity with many functional groups, providing borylated 8-aryl quinolines with good to excellent yield and excellent selectivity. The borylated compounds formed in this method can be transformed into various important synthons by using known transformations. The experimental process involved the reaction of 2-Bromo-5-methylpyridine(cas: 3510-66-5Recommanded Product: 3510-66-5)

2-Bromo-5-methylpyridine(cas: 3510-66-5) belongs to pyridine. Pyridine is a relatively complex molecule and exhibits a number of different bands in IR spectra. Among others, the bands characterizing the ν8a and ν19b modes have been found to be sensitive to the coordination or protonation of the molecule. Note that the band that is diagnostic for the PyH+ ion at about 1545 cm− 1 (ν19b mode) does not overlap with any of the other bands.Recommanded Product: 3510-66-5

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem