Month: October 2022

Fiore, Gina L.; Goguen, Brenda N.; Klinkenberg, Jessica L.; Payne, Sarah J.; Demas, J. N.; Fraser, Cassandra L. published an article in Inorganic Chemistry. The title of the article was 《Ruthenium Tris(bipyridine) Complexes with Sulfur Substituents: Model Studies for PEG Coupling》.Recommanded Product: 138219-98-4 The author mentioned the following in the article:

Ruthenium polypyridyl complexes are incorporated into polymers for sensing and light emitting materials applications. Coupling reactions between metal complexes and polymers are one route to polymeric metal complexes. In an effort to increase conjugation efficiency, tune materials properties, and introduce a responsive crosslink, ruthenium tris(bipyridine) derivatives with sulfur substituents were synthesized and compared to oxygen analogs. Difunctional thiols, thioesters, thioethers, and disulfides, as well as hexafunctional nonpolymeric model systems, were explored. Upon exposure to oxygen, the thiol derivative was readily oxidized. These studies guided Ru(bpy)3 PEG coupling reactions with disulfide and thioether linkages, which proceeded to ∼80% and ∼60% yield, resp. The luminescence properties of the Ru PEG derivatives and model systems were investigated. The emission spectra and lifetimes for all complexes in CH3CN under an inert atm. are comparable to [Ru(bpy)3]Cl2. Lifetime data for nonpolymeric analogs fit to a single exponential decay indicating heterogeneity, suggesting sample homogeneity, whereas data for polymers fit to a multiexponential decay. In contrast to certain [Ru(bpy)3]2+/thiol mixtures, no intramol. quenching by the sulfide is observed for [Ru(bpy)2{bpy(CH2SH)2}](PF6)2. Emission spectra red shift and multiexponential decay are noted for the oxidized Ru thiol product. The rates of oxygen quenching are slower for Ru PEG derivatives than those for nonpolymeric analogs, which may be attributed to shielding effects of the polymer chain. In the experiment, the researchers used 4,4′-Bis(chloromethyl)-2,2′-bipyridine(cas: 138219-98-4Recommanded Product: 138219-98-4)

4,4′-Bis(chloromethyl)-2,2′-bipyridine(cas: 138219-98-4) belongs to pyridine derivatives. The ring atoms in the pyridine molecule are sp2-hybridized. The nitrogen is involved in the π-bonding aromatic system using its unhybridized p orbital. Recommanded Product: 138219-98-4 Pyridine has a conjugated system of six π electrons that are delocalized over the ring.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

In 2020,Dalton Transactions included an article by Busto, Natalia; Carrion, M. Carmen; Montanaro, Sonia; Diaz de Grenu, Borja; Biver, Tarita; Jalon, Felix A.; Manzano, Blanca R.; Garcia, Begona. Category: pyridine-derivatives. The article was titled 《Targeting G-quadruplex structures with Zn(II) terpyridine derivatives: a SAR study》. The information in the text is summarized as follows:

Based on the ability of terpyridines to react with G-quadruplex DNA (G4) structures along with the interest aroused by Zn as an essential metal center in many biol. processes, the authors synthesized and characterized six Zn chloride or nitrate complexes containing terpyridine ligands with different 4′-substituents. The authors have studied their interaction with G4 and their cytotoxicity. The exptl. results revealed that the leaving group exerts a strong influence on the cytotoxicity, since the complexes bearing chloride were more cytotoxic than their nitrate analogs and an effect of the terpyridine ligand was also observed The thermal stabilization profiles showed that the greatest stabilization of hybrid G4, Tel22, was observed for the Zn complexes bearing the terpyridine ligand that contained one or two methylated 4-(imidazol-1-yl)phenyl substituents, 3Cl and 3(L)2, resp., probably due to their extra pos. charge. Stability and aquation studies for these complexes were carried out and no ligand release was detected. Complexes 3Cl and 3(L)2 were successfully internalized by SW480 cells and they seemed to be localized mainly in the nucleolus. The highest cytotoxicity, G4 selectivity and G4 affinity determined by fluorescence and ITC experiments, and subcellular localization quantified by ICP-MS measurements, rendered 3Cl a very interesting complex from a biol. standpoint. The experimental process involved the reaction of 4′-(4-Pyridyl)-2,2′:6′,2”-terpyridine(cas: 112881-51-3Category: pyridine-derivatives)

4′-(4-Pyridyl)-2,2′:6′,2”-terpyridine(cas: 112881-51-3) belongs to pyridine derivatives. The ring atoms in the pyridine molecule are sp2-hybridized. The nitrogen is involved in the π-bonding aromatic system using its unhybridized p orbital. Category: pyridine-derivativesThe lone pair is in an sp2 orbital, projecting outward from the ring in the same plane as the σ bonds.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Zheng, Yanping; Tan, Yan; Zhou, Wanli; Hao, Xiangrong; Liu, Xuekun; Peng, Jun published their research in Inorganic Chemistry on August 16 ,2021. The article was titled 《Three Polyoxovanadates-Based Organic-Inorganic Hybrids: Structural Variation, Bifunctional Electrocatalytic Activities, and Computational Studies》.COA of Formula: C20H14N4 The article contains the following contents:

Three bimetallic organic-inorganic hybrids based on the [V2O6]2- building unit, [Cu(pty)(V2O6)]·H2O (1), [Cu(pty)(V2O6)] (2), [Cu(tpy)(V2O6)] (3), (pty = 4′-(4”-pyridyl)-2,2′:6′,2”-terpyridine, tpy = 2,2′:6′,2”-terpyridine), were synthesized via a one-pot method. Hybrid 1 has a 1D straight chain architecture with [V2O6]2- clusters and Cu-pty complexes; hybrids 2 and 3 possess a 2D sheet structure including 10-membered rings assembled from four [Cu(pty)]2+ motifs and six [V2O6]2- clusters in 2, and two [Cu(tpy)]2+ units and eight [V2O6]2- clusters in 3. Noteworthy, hybrids 1-3 can be employed as bifunctional electrocatalysts for electroreduction of nitrite and electrooxidation of ascorbic acid. Addnl., theor. calculations including the mol. electrostatic potential and the frontier MO were performed to estimate the electronic structure of hybrids 1-3. The natural bond orbital anal. was also calculated to interpret the electron charge distribution. The experimental part of the paper was very detailed, including the reaction process of 4′-(4-Pyridyl)-2,2′:6′,2”-terpyridine(cas: 112881-51-3COA of Formula: C20H14N4)

4′-(4-Pyridyl)-2,2′:6′,2”-terpyridine(cas: 112881-51-3) belongs to pyridine derivatives. The ring atoms in the pyridine molecule are sp2-hybridized. The nitrogen is involved in the π-bonding aromatic system using its unhybridized p orbital. COA of Formula: C20H14N4The lone pair is in an sp2 orbital, projecting outward from the ring in the same plane as the σ bonds.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

In 2017,Wang, Hong; Wang, Guanghui; Li, Pengfei published 《Iridium-catalyzed intermolecular directed dehydrogenative ortho C-H silylation》.Organic Chemistry Frontiers published the findings.Computed Properties of C7H9NO The information in the text is summarized as follows:

An efficient method for iridium-catalyzed direct silylation of C(sp2)-H and C(sp3)-H bonds using HSiMe(OSiMe3)2 as the silylating reagent is described. The reaction is amenable to various directing groups under simple and mild conditions leading to the mono- and regioselective synthesis of versatile organosilane compounds2-(2-Hydroxyethyl)pyridine(cas: 103-74-2Computed Properties of C7H9NO) was used in this study.

2-(2-Hydroxyethyl)pyridine(cas: 103-74-2) belongs to pyridine. Pyridine is a relatively complex molecule and exhibits a number of different bands in IR spectra. Among others, the bands characterizing the ν8a and ν19b modes have been found to be sensitive to the coordination or protonation of the molecule. Note that the band that is diagnostic for the PyH+ ion at about 1545 cm− 1 (ν19b mode) does not overlap with any of the other bands.Computed Properties of C7H9NO

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

In 2019,Materials Today: Proceedings included an article by Mazur, D.; Pariiska, O.; Kurys, Y.. Synthetic Route of C5H7N3. The article was titled 《Co-N-C electrocatalysts derived from nitrogen containing conjugated polymers for hydrogen evolution》. The information in the text is summarized as follows:

New Co-N-C electrocatalysts for hydrogen evolution reaction (HER) were successfully prepared via heat treatment of a series of nitrogen containing conjugated polymers – N-CP (poly-m-phenylenediamine, poly-8-aminoquinoline, poly-2,6-diaminopyridine, poly-5-aminoindole) with carbon black and Co(NO3)2. For the first time, we demonstrated influence of the N-CP type, like a nitrogen precursor, on activity toward HER of Co-N-C composites in acidic media, which may be related, in particular, to the differences in the mol. structure of polymers. It was found, that the best HER performance inherent to an electrocatalyst obtained based on poly-5-aminoindole (overpotential at 5 mA/cm2 ∼ 177 mV, Tafel slope – 132 mV/dec). According to obtained exptl. data, it was assumed that the hydrogen evolution on Co-N-C catalysts takes place by the Volmer-Heyrovsky mechanism and the Volmer step is rate-limiting. The experimental part of the paper was very detailed, including the reaction process of 2,6-Diaminopyridine(cas: 141-86-6Synthetic Route of C5H7N3)

2,6-Diaminopyridine(cas: 141-86-6) belongs to pyridine. Pyridine and its simple derivatives are stable and relatively unreactive liquids, with strong penetrating odours that are unpleasant.Synthetic Route of C5H7N3

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

The author of 《Bioreducible Zinc(II)-Dipicolylamine Functionalized Hyaluronic Acid Mediates Safe siRNA Delivery and Effective Glioblastoma RNAi Therapy》 were Zheng, Meng; Yang, Zhipeng; Chen, Shizhu; Wu, Haigang; Liu, Yang; Wright, Amanda; Lu, Jeng-Wei; Xia, Xue; Lee, Albert; Zhang, Jinchao; Yin, Huijun; Wang, Yingze; Ruan, Weimin; Liang, Xing-Jie. And the article was published in ACS Applied Bio Materials in 2019. Application In Synthesis of Bis(pyridin-2-ylmethyl)amine The author mentioned the following in the article:

RNA interference (RNAi) is an emerging therapeutic modality for tumors. However, lack of a safe and efficient small interfering RNA (siRNA) delivery system limits its clin. application. Here, we report a bioreducible and less-cationic siRNA delivery carrier by conjugating Zn(II)-dipicolylamine complexes (Zn-DPA) onto hyaluronic acid (HA) via a redox-sensitive disulfide (-SS-) linker. Such polymer conjugates can formulate stable siRNA nanomedicines via coordination between zinc ions of DPA and the anionic phosphate of siRNA. After the conjugates are taken up by cells, intracellular reduction stimulus subsequently triggers the release of siRNAs and elucidates the desired RNAi effect. Our studies showed the formulated siRNA nanomedicines can be efficiently delivered into tumor cells/tissues and mediates less cytotoxicities both in vitro and in vivo. More importantly, when applied in a xenograft glioblastoma tumor model, this siRNA nanomedicine demonstrated significantly enhanced antitumor ability comparing to naked siRNA. This work demonstrates that such bioreducible Zn-DPA-functionalized HA conjugates without using cationic material as a siRNA carrier represents a promising direction for RNAi-based cancer therapy.Bis(pyridin-2-ylmethyl)amine(cas: 1539-42-0Application In Synthesis of Bis(pyridin-2-ylmethyl)amine) was used in this study.

Bis(pyridin-2-ylmethyl)amine(cas: 1539-42-0) is a secondary amine with two picolyl substituents. As a tridentate ligand this compound provides three nitrogen donors that affords good selectivity for Zn2+ over biologically relevant metals such as Na+, K+, Mg2+ and Ca2+, and leaves coordination sites free for anion binding. Application In Synthesis of Bis(pyridin-2-ylmethyl)amine

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

The author of 《Metal Catalyzed Synthesis of Dihydropyridobenzodiazepines》 were Maddess, Matthew L.; Li, Chaomin. And the article was published in Organometallics in 2019. Quality Control of 2-Bromonicotinaldehyde The author mentioned the following in the article:

A versatile synthesis of dihydropyridobenzodiazepines that proceeds via a palladium-catalyzed C-N coupling and catalytic hydrogenation cascade is reported. The intermediate 2-anilinonicotinaldehydes may be efficiently protected to ultimately afford N6 differentiated dihydropyridobenzodiazepines, which facilitates further elaboration. The experimental process involved the reaction of 2-Bromonicotinaldehyde(cas: 128071-75-0Quality Control of 2-Bromonicotinaldehyde)

2-Bromonicotinaldehyde(cas: 128071-75-0) belongs to pyridine. Pyridine is a relatively complex molecule and exhibits a number of different bands in IR spectra. Among others, the bands characterizing the ν8a and ν19b modes have been found to be sensitive to the coordination or protonation of the molecule. Note that the band that is diagnostic for the PyH+ ion at about 1545 cm− 1 (ν19b mode) does not overlap with any of the other bands.Quality Control of 2-Bromonicotinaldehyde

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

The author of 《A nitrogen and phosphorus enriched pyridine bridged inorganic-organic hybrid material for supercapacitor application》 were Dhiman, Nisha; Mohanty, Paritosh. And the article was published in New Journal of Chemistry in 2019. Safety of 2,6-Diaminopyridine The author mentioned the following in the article:

A new class of N- and P-enriched pyridine bridged inorganic-organic hybrid material is synthesized via the condensation of phosphonitrilic chloride trimer and 2,6-diaminopyridine at 140°C for 18 h. It was used as the active electrode material for supercapacitor application. The role of mass loading on the overall performance of the HPHM supercapacitor electrode has been investigated. Specific capacitances of 243 and 107 F g-1 are estimated from cyclic voltammetry and galvanostatic charge-discharge measurements at a scan rate of 1 mV s-1 and c.d. of 0.5 A g-1, resp. The high retention of 81% of the initial Csp value is observed after 2000 cycles at a c.d. of 5 A g-1. A fabricated solid-state sym. supercapacitor device made with the optimal mass loading shows power and energy densities of 244 W kg-1 and 14.4 W h kg-1, resp., and it could light up a green LED display (23 in total) for up to 50 s upon charging for 5 s at 3 V. After reading the article, we found that the author used 2,6-Diaminopyridine(cas: 141-86-6Safety of 2,6-Diaminopyridine)

2,6-Diaminopyridine(cas: 141-86-6) belongs to pyridine. Pyridine and its simple derivatives are stable and relatively unreactive liquids, with strong penetrating odours that are unpleasant.Safety of 2,6-Diaminopyridine

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

《Phenotypic Discovery of an Antivirulence Agent against Vibrio vulnificus via Modulation of Quorum-Sensing Regulator SmcR》 was published in ACS Infectious Diseases in 2020. These research results belong to Kim, Seung Min; Park, Jongmin; Kim, Myun Soo; Song, Heebum; Jo, Ala; Park, Hankum; Kim, Tae Sung; Choi, Sang Ho; Park, Seung Bum. Formula: C5H3Br2N The article mentions the following:

An antivirulence agent against Vibrio vulnificus named quoromycin (QM, I) was discovered by a phenotype-based elastase inhibitor screening. Using the fluorescence difference in two-dimensional gel electrophoresis (FITGE) approach, SmcR, a quorum-sensing master regulator and homolog of LuxR, was identified as the target protein of QM. We confirmed that the direct binding of QM to SmcR inhibits the quorum-sensing signaling pathway by controlling the DNA-binding affinity of SmcR and thus effectively alleviates the virulence of V. vulnificus in vitro and in vivo. I can be regarded as a novel antivirulence agent for the treatment of V. vulnificus infection. In the part of experimental materials, we found many familiar compounds, such as 2,5-Dibromopyridine(cas: 624-28-2Formula: C5H3Br2N)

2,5-Dibromopyridine(cas: 624-28-2) belongs to pyridine. In industry and in the lab, pyridine is used as a reaction solvent, particularly when its basicity is useful, and as a starting material for synthesizing some herbicides, fungicides, and antiseptics.Formula: C5H3Br2N

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

《Artificial Iron Proteins: Modeling the Active Sites in Non-Heme Dioxygenases》 was published in Inorganic Chemistry in 2020. These research results belong to Miller, Kelsey R.; Paretsky, Jonathan D.; Follmer, Alec H.; Heinisch, Tillmann; Mittra, Kaustuv; Gul, Sheraz; Kim, In-Sik; Fuller, Franklin D.; Batyuk, Alexander; Sutherlin, Kyle D.; Brewster, Aaron S.; Bhowmick, Asmit; Sauter, Nicholas K.; Kern, Jan; Yano, Junko; Green, Michael T.; Ward, Thomas R.; Borovik, A. S.. Name: Bis(pyridin-2-ylmethyl)amine The article mentions the following:

An important class of non-heme dioxygenases contains a conserved Fe binding site that consists of a 2-His-1-carboxylate facial triad. Results from structural biol. show that, in the resting state, these proteins are six-coordinate with aqua ligands occupying the remaining three coordination sites. We have utilized biotin-streptavidin (Sav) technol. to design new artificial Fe proteins (ArMs) that have many of the same structural features found within active sites of these non-heme dioxygenases. An Sav variant was isolated that contains the S112E mutation, which installed a carboxylate side chain in the appropriate position to bind to a synthetic FeII complex confined within Sav. Structural studies using X-ray diffraction (XRD) methods revealed a facial triad binding site that is composed of two N donors from the biotinylated ligand and the monodentate coordination of the carboxylate from S112E. Two aqua ligands complete the primary coordination sphere of the FeII center with both involved in hydrogen bond networks within Sav. The corresponding FeIII protein was also prepared and structurally characterized to show a six-coordinate complex with two exogenous acetato ligands. The FeIII protein was further shown to bind an exogenous azido ligand through replacement of one acetato ligand. Spectroscopic studies of the ArMs in solution support the results found by XRD. Biol. O2 activation is often accomplished with dioxygenases that contain non-heme iron centers with a common 2-His-1-carboxylate endogenous binding site for iron. We have engineered an artificial protein to model this site using biotin-streptavidin technol. Structural and spectroscopic studies support formation of an Fe(II) artificial protein with features similar to those in the native proteins, including hydrogen bonds within the secondary coordination sphere. This work highlights the utility of embedding metal complexes with protein hosts.Bis(pyridin-2-ylmethyl)amine(cas: 1539-42-0Name: Bis(pyridin-2-ylmethyl)amine) was used in this study.

Bis(pyridin-2-ylmethyl)amine(cas: 1539-42-0) is a secondary amine with two picolyl substituents. As a tridentate ligand this compound provides three nitrogen donors that affords good selectivity for Zn2+ over biologically relevant metals such as Na+, K+, Mg2+ and Ca2+, and leaves coordination sites free for anion binding. Name: Bis(pyridin-2-ylmethyl)amine

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem