Month: October 2022

Martell, Mark; Ocheje, Michael U.; Gelfand, Benjamin S.; Rondeau-Gagne, Simon; Welch, Gregory C. published their research in New Journal of Chemistry in 2021. The article was titled 《Sidechain engineering of N-annulated perylene diimide molecules》.Recommanded Product: 2-(Bromomethyl)pyridine hydrobromide The article contains the following contents:

The synthesis and characterization of six new N-annulated perylene diimide (N-PDI) mols. consisting of different alkyl-based heteroatom and waxy infused sidechains is reported. Amino, urea, quaternary Me ammonium, iminopyridine, hexadecyl and pyridine moieties were all appended to the pyrrolic N-position of N-annulated PDI. These N-PDI derivatives have been synthesized using facile SN2 chem. resulting in high yields and without the need for purification via column chromatog. To further demonstrate the functional diversification offered by N-PDI we appended a cyano group to the 6,7-bay positions opposite the N-annulation site and tested utility in organic field effect transistor devices. Complete characterization of these N-PDI derivatives was completed using UV-Vis spectroscopy, cyclic voltammetry and solubility determination to observe how the appended sidechains affect structure-properties relationships. The experimental part of the paper was very detailed, including the reaction process of 2-(Bromomethyl)pyridine hydrobromide(cas: 31106-82-8Recommanded Product: 2-(Bromomethyl)pyridine hydrobromide)

2-(Bromomethyl)pyridine hydrobromide(cas: 31106-82-8) belongs to pyridine. Pyridine is widely used in the precursor to agrochemicals and pharmaceuticals. Also, it is used as an important reagent and organic solvent.Recommanded Product: 2-(Bromomethyl)pyridine hydrobromide

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Wu, Ye-bin; Wu, You-zhi; Wu, Jian; Xu, Dan; Jiang, Hui; Chang, Wen-wu; Ma, Chang-you published their research in Journal of Organic Chemistry in 2021. The article was titled 《Copper-Catalyzed Regioselective Coupling of Tosylhydrazones and 2-Pyridones: A Strategy for the Production of N-Alkylated Compounds》.Synthetic Route of C7H7NO The article contains the following contents:

The highly regioselective N-alkylation reaction of 2-pyridones was achieved through hydrazone chem., especially for substrates with bulky secondary alkyl groups. Herein, a copper-catalyzed regioselective coupling of tosylhydrazones and 2-pyridones/isoquinolinones for the synthesis of N-alkylated compound such as N-alkylated pyridones I [R = CH(Me)(4-MeOC6H4), R1 = H, CN, C(O)OMe; R2 = H, OMe; R3 = H, F, Br] isoquinolinones II [R1 = H, Me; R2 = Ph, 3-O2NC6H4, 2-ClC6H4, etc.] was described. The experimental process involved the reaction of 4-Acetylpyridine(cas: 1122-54-9Synthetic Route of C7H7NO)

4-Acetylpyridine(cas: 1122-54-9) belongs to pyridine. Pyridine is widely used in the precursor to agrochemicals and pharmaceuticals. Also, it is used as an important reagent and organic solvent.Synthetic Route of C7H7NO

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Yadav, Eqvinshi; Khatana, Anil Kumar; Sebastian, Sharol; Gupta, Manoj K. published their research in New Journal of Chemistry in 2021. The article was titled 《DAP derived fatty acid amide organogelators as novel carrier for drug incorporation and pH-responsive release》.Related Products of 141-86-6 The article contains the following contents:

Inflammation is associated with many different class of diseases and NSAIDs (non-steroidal anti-inflammatory drugs) are mostly preferred for long-term use. Although they are safe to use, some serious side effects are associated with these class of compounds; therefore, local drug delivery is an option to minimize the side effects. In this study, we have designed a new gel formulation for topical and transdermal applications of the NSAIDs with enhanced properties. For this purpose, low mol. mass DAP (2,6-diaminopyridine) derived fatty acid amides with varying alkyl chain lengths are synthesized. These fatty acid amides form stable self-assembled aggregates in organic solvents as well as in organic and aqueous solvent mixtures affording organogels and bigels, resp. The min. gelation concentration (MGC) of the organic gel is 0.5% w/v, which behaves as a super gelator. The various functionality present in the DAP-derived fatty acid amide gelators play an important role in the self-aggregation such as pyridine moiety stack through π-π and alkyl chain via van der Waals interactions resulting in the formation of stable organo and bigels network. The prepared organogel emulsions with these fatty acid amides are capable to encapsulate and release the drug mol. ibuprofen at room temperature without altering its structure and activity. Therefore, these analogs can be successfully utilized in pharmaceutical industries as a novel drug delivery carrier.2,6-Diaminopyridine(cas: 141-86-6Related Products of 141-86-6) was used in this study.

2,6-Diaminopyridine(cas: 141-86-6) belongs to pyridine. Pyridine and its simple derivatives are stable and relatively unreactive liquids, with strong penetrating odours that are unpleasant.Related Products of 141-86-6

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Zhou, Su; Li, Rui; Zhang, Zhichao; Gu, Minyang; Zhu, Hongyan; Fang, Jing; Ji, Zhiwen; Xu, Xiaodong; Tang, Liming published an article in 2021. The article was titled 《Analysis of mutagenic components of oxidative hair dyes with the Ames test》, and you may find the article in Human & Experimental Toxicology.Application In Synthesis of 2,6-Diaminopyridine The information in the text is summarized as follows:

Oxidative hair dyes consist of two components (I and II) that are mixed before use. Aromatic amines in component I and their reaction with hydrogen peroxide after mixing them with component II have been of primary concern. In addition, two in vitro genotoxicity assays are still required for the approval of the final products of oxidative hair dyes in China, and the substance in the oxidative hair dye that causes the high rate of pos. results in genotoxicity tests, especially the Ames test, has not been fully elucidated. In this study, we analyzed the formulation of 55 different oxidative hair dyes from 7 color series and performed Ames tests in the strain TA98 with the S9 mix (oxidative hair dyes Number 1-30) and in strain TA97a without the S9 mix (oxidative hair dyes Number 31-55). We found that toluene-2,5-diamine sulfate (2,5-diaminotoluene sulfate, DATS) in component I may be the cause of mutagenicity in TA98, and hydrogen peroxide in component II may be the cause of mutagenicity in TA97a, and their pos. concentrations were consistent with those that we calculated from Ames tests. The results suggest that the pos. results for the oxidative hair dye in the Ames test were inevitable because of the existence of DATS in component I and of hydrogen peroxide in component II. Therefore, we should carry out safety assessments on each raw material and carry out risk assessments on the final products of oxidative hair dyes instead of genotoxicity tests in China. In the experimental materials used by the author, we found 2,6-Diaminopyridine(cas: 141-86-6Application In Synthesis of 2,6-Diaminopyridine)

2,6-Diaminopyridine(cas: 141-86-6) belongs to pyridine. Pyridine and its simple derivatives are stable and relatively unreactive liquids, with strong penetrating odours that are unpleasant.Application In Synthesis of 2,6-Diaminopyridine

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Stevens, Matthew P.; Spray, Emily; Vitorica-Yrezabal, Inigo J.; Singh, Kuldip; Timmermann, Vanessa M.; Sotorrios, Lia; Macgregor, Stuart A.; Ortu, Fabrizio published an article in 2022. The article was titled 《Synthesis, characterisation and reactivity of group 2 complexes with a thiopyridyl scorpionate ligand》, and you may find the article in Dalton Transactions.Computed Properties of C7H5N The information in the text is summarized as follows:

Herein we report the reactivity of the proligand tris(2-pyridylthio)methane (HTptm) with various Alk. Earth (AE) reagents: (1) dialkylmagnesium reagents and (2) AE bis-amides (AE = Mg-Ba). Heteroleptic complexes of general formulas [Mg(Tptm)(R)] (R = Me, Bu) and [AE(Tptm)(NR2)] (AE = Mg-Ba; R = SiMe3) were targeted from the reaction of HTptm with R2Mg or [AE(NR2)2]2. Reaction of the proligand with dialkylmagnesium reagents led to formation of [{Mg(κ3C,N,N-CBu{S-C5H4N}2)(μ-S-C5H4N)}2] (1) and [{Mg(κ3C,N,N-CMe{S-C5H4N}2)(μ-OSiMe3)}2] (2) resp., as a result of a novel transfer of an alkyl group onto the methanide carbon with concomitant C-S bond cleavage. However, reactivity of bis-amide precursors for Mg and Ca did afford the target species [AE(Tptm)(NR2)] (3-AE; AE = Mg-Ca), although these proved susceptible to ligand degradation processes. DFT calculations show that alkyl transfer in the putative [Mg(Tptm)(Bu)] (1m’) system and amide transfer in 3-Ca is a facile process that induces C-S bond cleavage in the Tptm ligand. The complexes 3-Mg and 3-Ca were also tested as catalysts for the hydrophosphination of selected alkenes and alkynes, including the first example of mono-hydrophosphination of 4-ethynylpyridine which was achieved with high conversions and excellent regio- and stereochem. control. The experimental process involved the reaction of 4-Ethynylpyridine(cas: 2510-22-7Computed Properties of C7H5N)

4-Ethynylpyridine(cas: 2510-22-7) belongs to pyridine. Pyridine is widely used in the precursor to agrochemicals and pharmaceuticals. Also, it is used as an important reagent and organic solvent.Computed Properties of C7H5N

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

In 2022,Chen, Yan; Gao, Zhanming; Wang, Lei; Li, Jiansheng; Tang, Yutian; Liu, Chun published an article in ACS Applied Polymer Materials. The title of the article was 《Living Supramolecular Polymerization of Ultrastable Kinetic Species of Ir(III) Complexes in Aqueous Media》.COA of Formula: C6H6BrN The author mentioned the following in the article:

Living supramol. polymerization (LSP) has become a key technol. for the progress of materials science. However, under the influence of hydrophobic interaction, the precise kinetic control of LSP in aqueous media is still challenging. The authors report a strategy to realize the LSP of ultrastable kinetic species that is nearly impossible to assemble spontaneously. Due to the strong hydrophobic interaction, the kinetic species of Ir(III) complex 2 (nanoparticles, 2NP) at 90 and 95% H2O contents can exist stably for >50 days at room temperature By mixing the seeds at an 85% H2O content and the suspension of kinetic species at a 95% H2O content in equal volume, LSP can be carried out at a 90% H2O content, and multicycle LSP at a 90% H2O content can be performed successfully. This LSP strategy broadens the practicality of LSP and is implemented by structurally simple Ir(III) complexes, which provides ideas for broadening the monomer scope of LSP. Time-, temperature-, and concentration-dependent spectroscopic results show that the formation of kinetic species 2NP and thermodn. species 2NS (nanosheets) follows the isodesmic model and the cooperative (nucleation-elongation) model, resp., and 2NP are the off-pathway intermediates of 2NS. This study illustrates an ingenious and precise kinetic control on the LSP in aqueous media. The experimental part of the paper was very detailed, including the reaction process of 2-Bromo-5-methylpyridine(cas: 3510-66-5COA of Formula: C6H6BrN)

2-Bromo-5-methylpyridine(cas: 3510-66-5) belongs to pyridine. Pyridine is very deactivated towards electrophilic substitution with respect to benzene. For this reason classical formylation, using methods such as the Gattermann or Vilsmeier reactions, are not generally successful. COA of Formula: C6H6BrN

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

In 2022,Chen, Yi; Liu, Di; Wang, Rui; Xu, Li; Tan, Jingyao; Shu, Mao; Tian, Lingfeng; Jin, Yuan; Zhang, Xiaoke; Lin, Zhihua published an article in Journal of Organic Chemistry. The title of the article was 《Bronsted Acid-Catalyzed : Synthesis of Phenanthrenes via Phosphomolybdic Acid as a Catalyst》.Formula: C6H4BrNO The author mentioned the following in the article:

Herein, disclosed a synthetic protocol for the synthesis of phenanthrenes such as I [R = H, Me; R1 = H, Me, OMe, etc.; R2 = H, F, OMe, etc.; R3 = H, OTIPS; R4 = H, F, Cl, etc.] through the CCOM with the inexpensive, nontoxic phosphomolybdic acid as a catalyst. The current annulations could realized carbonyl-olefin, carbonyl-alc., and acetal-alc. in situ CCOM reactions and feature mild reaction conditions, simple manipulation and scalability, making this strategy a promising alternative to the Lewis acid-catalyzed COM reaction.2-Bromonicotinaldehyde(cas: 128071-75-0Formula: C6H4BrNO) was used in this study.

2-Bromonicotinaldehyde(cas: 128071-75-0) belongs to pyridine. Pyridine derivatives lend themselves to many roles in the spirited field of supramolecular chemistry – whether as the ligand backbone of metal-organic polymers or presiding over the key electronic stations of nanodevices. In biochemistry, pyridine-containing cofactors are necessary nutrients on which our lives depend. Formula: C6H4BrNO

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Category: pyridine-derivativesIn 2017 ,《Magneto-structural correlations in a family of di-alkoxo bridged chromium dimers》 appeared in Dalton Transactions. The author of the article were Fraser, Hector W. L.; Nichol, Gary S.; Velmurugan, Gunasekaran; Rajaraman, Gopalan; Brechin, Euan K.. The article conveys some information:

A series of di-alkoxo bridged Cr(III) dimers were synthesized using pyridine alc. ligands. The structures fall into four general categories and are of formula: [Cr2(OMe)2(pic)4]·0.5MeOH·0.5Et2O (1), [Cr2(hmp)2(pic)2X2] (X = Cl (2), Br (3)), [Cr2(L)2Cl4(A)2]·2S (L = hmp, A = H2O and S = Et2O (4); L = hmp, A = pyridine and S = pyridine (5); L = hmp, A = 4-picoline and no S (6); L = hep, A = H2O and S = MeCN (7)), and [Cr(hmp)(hmpH)Cl2]·MeCN (8). D.c. (d.c.) magnetic susceptibility measurements show relatively weak antiferromagnetic exchange interactions between the Cr(III) centers with J values <|15| cm-1 in all of the complexes measured. DFT calculations performed on complexes 1-8 reproduce both the sign and strength of the exchange interactions found exptl., and confirm that the magnitude and sign of the J value is strongly dependent upon the orientation of the dihedral angle formed between the bridging Cr2O2 plane and the O-R vector of the bridging group (θ), and the Cr-O-Cr-O dihedral angle (ψ). After reading the article, we found that the author used 2-(2-Hydroxyethyl)pyridine(cas: 103-74-2Category: pyridine-derivatives)

2-(2-Hydroxyethyl)pyridine(cas: 103-74-2) belongs to pyridine. The basicity and metallophilic high donor number of these π-deficient systems has long favored them as ligands in metal catalysis. The last decade saw pyridine assume a stronger role as functional group for directed C–H oxidation/activation.Category: pyridine-derivatives

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Computed Properties of C5H3Br2NIn 2020 ,《Structure-Activity Relationship Study of Novel 6-Aryl-2-benzoyl-pyridines as Tubulin Polymerization Inhibitors with Potent Antiproliferative Properties》 appeared in Journal of Medicinal Chemistry. The author of the article were Chen, Hao; Deng, Shanshan; Wang, Yuxi; Albadari, Najah; Kumar, Gyanendra; Ma, Dejian; Li, Weimin; White, Stephen W.; Miller, Duane D.; Li, Wei. The article conveys some information:

We recently reported the crystal structure of tubulin in complex with a colchicine binding site inhibitor (CBSI), ABI-231, having 2-aryl-4-benzoyl-imidazole (ABI). Based on this and addnl. crystal structures, here we report the structure-activity relationship study of a novel series of pyridine analogs of ABI-231, with compound 4v being the most potent one (average IC50 ∼ 1.8 nM) against a panel of cancer cell lines. We determined the crystal structures of another potent CBSI ABI-274 and 4v in complex with tubulin and confirmed their direct binding at the colchicine site. 4v inhibited tubulin polymerization, strongly suppressed A375 melanoma tumor growth, induced tumor necrosis, disrupted tumor angiogenesis, and led to tumor cell apoptosis in vivo. Collectively, these studies suggest that 4v represents a promising new generation of tubulin inhibitors.2,6-Dibromopyridine(cas: 626-05-1Computed Properties of C5H3Br2N) was used in this study.

2,6-Dibromopyridine(cas: 626-05-1) belongs to pyridine. The basicity and metallophilic high donor number of these π-deficient systems has long favored them as ligands in metal catalysis. The last decade saw pyridine assume a stronger role as functional group for directed C–H oxidation/activation.Computed Properties of C5H3Br2N

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

COA of Formula: C7H7NOIn 2019 ,《Transition-metal-free catalyzed [3+2] cycloadditions/oxidative aromatization reactions for the synthesis of annulated indolizines》 appeared in New Journal of Chemistry. The author of the article were Zhang, Qianwei; Wang, Bin; Ma, Huifang; Ablajan, Keyume. The article conveys some information:

In this study, transition-metal-free catalyzed [3+2] cycloadditions/oxidative aromatization three-component reactions for the successful direct construction of pyrrolo[3,4-a]indolizine-1,3(2H)-diones via pyridinium ylides are reported. This method utilizes readily available pyridines, acetophenones and maleimides as starting materials in the presence of TBAI (N-tetrabutylammonium iodide)/TBHP (tert-Bu hydroperoxide), with a wide substrate scope and moderate to good yields, avoiding the use of metal catalysts and generation of halides. The experimental part of the paper was very detailed, including the reaction process of 4-Acetylpyridine(cas: 1122-54-9COA of Formula: C7H7NO)

4-Acetylpyridine(cas: 1122-54-9) belongs to pyridine. The basicity and metallophilic high donor number of these π-deficient systems has long favored them as ligands in metal catalysis. The last decade saw pyridine assume a stronger role as functional group for directed C–H oxidation/activation.COA of Formula: C7H7NO

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem