Month: October 2022

Category: pyridine-derivativesOn October 20, 2003 ,《Coordination Properties of New Bis(1,4,7-triazacyclononane) Ligands: A Highly Active Dizinc Complex in Phosphate Diester Hydrolysis》 was published in Inorganic Chemistry. The article was written by Arca, Massimiliano; Bencini, Andrea; Berni, Emanuela; Caltagirone, Claudia; Devillanova, Francesco A.; Isaia, Francesco; Garau, Alessandra; Giorgi, Claudia; Lippolis, Vito; Perra, Alessandro; Tei, Lorenzo; Valtancoli, Barbara. The article contains the following contents:

The synthesis and characterization of three new bis([9]aneN3) ligands, containing resp. 2,2′-bipyridine (L1), 1,10-phenanthroline (L2), and quinoxaline (L3) moieties linking the two macrocyclic units, are reported. Proton binding and Cu(II), Zn(II), Cd(II), and Pb(II) coordination with L1-L3 were studied by potentiometric titrations and, for L1 and L2, by spectrophotometric UV-visible measurements in aqueous solutions All ligands can give stable mono- and dinuclear complexes. In the case of L1, trinuclear Cu(II) complexes are also formed. The stability constants and structural features of the formed complexes are strongly affected by the different architecture and binding properties of the spacers bridging the two [9]aneN3 units. In the case of the L1 and L2 mononuclear complexes, the metal is coordinated by the three donors of one [9]aneN3 moiety; in the [ML2]2+ complexes, however, the phenanthroline nitrogens are also involved in metal binding. Finally, in the [ML3]2+ complexes both macrocyclic units, at a short distance from each other, can be involved in metal coordination, giving rise to sandwich complexes. In the binuclear complexes each metal ion is generally coordinated by one [9]aneN3 unit. In L1, however, the dipyridine nitrogens can also act as a potential binding site for metals. The dinuclear complexes show a marked tendency to form mono-, di-, and, in some cases, trihydroxo species in aqueous solutions The resulting M-OH functions may behave as nucleophiles in hydrolytic reactions. The hydrolysis rate of bis(p-nitrophenyl)phosphate (BNPP) was measured in aqueous solution at 308.1 K in the presence of the L2 and L3 dinuclear Zn(II) complexes. Both the L2 complexes [Zn2L2(OH)2]2+ and [Zn2L2(OH)3]+ and the L3 complex [Zn2L3(OH)3]+ promote BNPP hydrolysis. The [Zn2L3(OH)3]+ complex is ∼2 orders of magnitude more active than the L2 complexes, due both to the short distance between the metal centers in [Zn2L3(OH)3]+, which could allow a bridging interaction of the phosphate ester, and to the simultaneous presence of single-metal bound nucleophilic Zn-OH functions. These structural features are substantially corroborated by semiempirical PM3 calculations carried out on the mono-, di-, and trihydroxo species of the L3 dizinc complex. In addition to this study using 4,4′-Bis(chloromethyl)-2,2′-bipyridine, there are many other studies that have used 4,4′-Bis(chloromethyl)-2,2′-bipyridine(cas: 138219-98-4Category: pyridine-derivatives) was used in this study.

4,4′-Bis(chloromethyl)-2,2′-bipyridine(cas: 138219-98-4) belongs to pyridine derivatives. Several pyridine derivatives play important roles in biological systems. While its biosynthesis is not fully understood, nicotinic acid (vitamin B3) occurs in some bacteria, fungi, and mammals. Category: pyridine-derivatives

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Bakke, Jan M.; Ranes, Eli; Riha, Jaroslav; Svensen, Harald published an article on February 28 ,1999. The article was titled 《The synthesis of β-nitropyridine compounds》, and you may find the article in Acta Chemica Scandinavica.HPLC of Formula: 59290-82-3 The information in the text is summarized as follows:

Pyridine and a number of substituted pyridines have been nitrated by reaction with N2O5 followed by reaction with an aqueous solution of SO2xH2O or NaHSO3. The dependence of the yields on the pH of the aqueous reaction medium, on the concentration of SO2xH2O-HSO3-, on addition of methanol to the aqueous phase, and on the reaction temperature were investigated. The yields obtained with NaHSO3 were: 3-nitropyridine 77%, 2-methyl-5-nitropyridine 36%, 3-methyl-5-nitropyridine 24%, 3-acetyl-5-nitropyridine 18%, 5-nitropyridine-3-carboxylic acid 15%, 3-chloro-5-nitropyridine 11%, 4-methyl-3-nitropyridine 39%, 4-acetyl-3-nitropyridine 67%, 4-cyano-3-nitropyridine 45%, 4-phenyl-3-nitropyridine 68%, 4-formyl-3-nitropyridine 62% (from reaction in liquid SO2), 3-nitropyridine-4-carboxylic acid 48%, Me 3-nitropyridine-4-carboxylate 75%, 2,3-dimethyl-5-nitropyridine 37%, 2,4-dimethyl-5-nitropyridine 64%, 3-nitroquinoline 10% and 4-nitroisoquinoline 42%. The experimental part of the paper was very detailed, including the reaction process of 3-Nitroisonicotinic acid(cas: 59290-82-3HPLC of Formula: 59290-82-3)

3-Nitroisonicotinic acid(cas: 59290-82-3) belongs to pyridine. Pyridine, its benzo and pyridine-based compounds play diverse roles in organic chemistry. As ligands, solvents, and catalysts they facilitate reactions; thus descriptions of these new ligands and their applications abound each year.HPLC of Formula: 59290-82-3

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Chatterjee, Tanmay; Sarma, Monima; Das, Samar K. published their research in Tetrahedron Letters on December 29 ,2010. The article was titled 《Donor-acceptor amphiphilic 2,2′-bipyridine chromophores: synthesis, linear optical, and thermal properties》.Related Products of 138219-98-4 The article contains the following contents:

Two sym. and one unsym. push-pull amphiphilic 2,2′-bipyridine chromophores were synthesized through Horner-Wadsworth-Emmons and Knoevenagel reaction mechanized synthetic protocols and characterized by spectroscopy. The linear optical properties and thermal stability of the synthesized chromophores were studied. In the experiment, the researchers used 4,4′-Bis(chloromethyl)-2,2′-bipyridine(cas: 138219-98-4Related Products of 138219-98-4)

4,4′-Bis(chloromethyl)-2,2′-bipyridine(cas: 138219-98-4) belongs to pyridine derivatives. Several pyridine derivatives play important roles in biological systems. While its biosynthesis is not fully understood, nicotinic acid (vitamin B3) occurs in some bacteria, fungi, and mammals. Related Products of 138219-98-4

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

In 2017,Chen, Fu-Min; Huang, Fei-Dong; Yao, Xue-Yi; Li, Tian; Liu, Feng-Shou published 《Direct C-H heteroarylation by an acenaphthyl-based α-diimine palladium complex: improvement of the reaction efficiency for bi(hetero)aryls under aerobic conditions》.Organic Chemistry Frontiers published the findings.Reference of 5-Bromo-2-chloropyridine The information in the text is summarized as follows:

A bulky acenaphthyl skeleton-based α-diimine palladium complex with ortho-tert-Bu on N-aryl moieties was designed, synthesized and characterized. The developed palladium complex was applied for direct C-H arylation under aerobic reaction conditions. A range of heteroaryls, such as thiazoles, thiophenes, furans, imidazopyridines, indolizines, isoxazoles, imidazoles, triazoles, pyrazoles, indoles, pyrroles and pyrazolidinones, were used, while various coupling partners of heteroaryl bromides with wide functional groups were compatible. Upon using 0.05-0.1 mol% of a precatalyst, more than 90 examples of cross-coupling products were afforded in good to excellent yields, demonstrating that this phosphine-free catalytic system scaffold enables a general access to biheteroaryls. After reading the article, we found that the author used 5-Bromo-2-chloropyridine(cas: 53939-30-3Reference of 5-Bromo-2-chloropyridine)

5-Bromo-2-chloropyridine(cas: 53939-30-3) belongs to pyridine. Pyridine is very deactivated towards electrophilic substitution with respect to benzene. For this reason classical formylation, using methods such as the Gattermann or Vilsmeier reactions, are not generally successful. Reference of 5-Bromo-2-chloropyridine

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

In 2018,Kirlikovali, Kent O.; Cho, Eunho; Downard, Tyler J.; Grigoryan, Lilit; Han, Zheng; Hong, Sooji; Jung, Dahee; Quintana, Jason C.; Reynoso, Vanessa; Ro, Sooihk; Shen, Yi; Swartz, Kevin; Ter Sahakyan, Elizabeth; Wixtrom, Alex I.; Yoshida, Brandon; Rheingold, Arnold L.; Spokoyny, Alexander M. published 《Buchwald-Hartwig amination using Pd(I) dimer precatalysts supported by biaryl phosphine ligands》.Dalton Transactions published the findings.Related Products of 53939-30-3 The information in the text is summarized as follows:

The synthesis of air-stable Pd(I) dimer complexes featuring biaryl phosphine ligands was reported. Catalytic experiments suggested that these complexes were competent precatalysts that mediated cross-coupling amination reaction between aryl halides with both aliphatic and aromatic amine nucleophiles. An expansion of the air-stable precatalyst toolbox for Pd-catalyzed cross-coupling transformations were represented. The results came from multiple reactions, including the reaction of 5-Bromo-2-chloropyridine(cas: 53939-30-3Related Products of 53939-30-3)

5-Bromo-2-chloropyridine(cas: 53939-30-3) belongs to pyridine. Pyridine is widely used in the precursor to agrochemicals and pharmaceuticals. Also, it is used as an important reagent and organic solvent.Related Products of 53939-30-3

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

In 2018,Mikhailine, Alexandre A.; Grasa Mannino, Gabriela A.; Colacot, Thomas J. published 《Catalyst-Directed Chemoselective Double Amination of Bromo-chloro(hetero)arenes: A Synthetic Route toward Advanced Amino-aniline Intermediates》.Organic Letters published the findings.COA of Formula: C5H3BrClN The information in the text is summarized as follows:

A chemoselective sequential one-pot coupling protocol was developed for preparing several amino-anilines in high yield as building blocks for active pharmaceutical ingredients (APIs). Site (Cl vs Br on electrophile) and nucleophile (amine vs imine) selectivity is dictated by the catalyst employed. A Pd-crotyl(t-BuXPhos) precatalyst selectively coupled the Ar-Br of the polyhaloarene with benzophenone imine, even in the presence of a secondary amine, while Pd-based RuPhos or (BINAP)Pd(allyl)Cl coupled the Ar-Cl site with secondary amines. In the experimental materials used by the author, we found 5-Bromo-2-chloropyridine(cas: 53939-30-3COA of Formula: C5H3BrClN)

5-Bromo-2-chloropyridine(cas: 53939-30-3) belongs to pyridine. In industry and in the lab, pyridine is used as a reaction solvent, particularly when its basicity is useful, and as a starting material for synthesizing some herbicides, fungicides, and antiseptics.COA of Formula: C5H3BrClN

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

In 2019,Journal of Medicinal Chemistry included an article by Zhao, Chao; Huang, Dane; Li, Ruyue; Xu, Yida; Su, Shimin; Gu, Qiong; Xu, Jun. Recommanded Product: 2510-22-7. The article was titled 《Identifying Novel Anti-Osteoporosis Leads with a Chemotype-Assembly Approach》. The information in the text is summarized as follows:

In this paper, we applied a chemotype-assembly approach for ligand-based drug discovery (LBDD) to discover novel anti-osteoporosis leads. With this new approach, we identified 12 chemotypes and derived 18 major chemotype assembly rules from 245 known anti-osteoporosis compounds Then, we selected 19 compounds from an inhouse compound library using chemotype-assembly approach for anti-osteoporosis assays, which resulted in 13 hits. Based on structural features in these 13 compounds, we synthesized 50 possible anti-osteoporosis compounds from the anti-osteoporosis chemotypes by means of click chem. techniques and discovered a compound (10a, IC50 = 2 nM) with nanomolar activity. Compound 10a was then proved to be an anti-osteoporosis lead since it can prevent bone loss in vivo. After reading the article, we found that the author used 4-Ethynylpyridine(cas: 2510-22-7Recommanded Product: 2510-22-7)

4-Ethynylpyridine(cas: 2510-22-7) belongs to pyridine. In industry and in the lab, pyridine is used as a reaction solvent, particularly when its basicity is useful, and as a starting material for synthesizing some herbicides, fungicides, and antiseptics.Recommanded Product: 2510-22-7

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

In 2019,Advanced Synthesis & Catalysis included an article by Li, Lixin; Ma, Yan-Na; Tang, Mi; Guo, Jing; Yang, Zhen; Yan, Yizhe; Ma, Xiantao; Tang, Lin. Electric Literature of C33H24IrN3. The article was titled 《Photoredox-Catalyzed Oxydifluoroalkylation of Styrenes for Access to Difluorinated Ketones with DMSO as an Oxidant》. The information in the text is summarized as follows:

By taking advantage of DMSO (DMSO) as an oxidant, the photoredox-catalyzed alkene oxydifluoroalkylation for formal C(sp3)-CF2R and C(sp2)=O formation is disclosed for the first time. This difunctionalization reaction employs readily available styrenes as the substrates and bromodifluoro compounds as the difluoroalkylating reagents, which can afford the difluorinated ketones in acceptable yields with excellent regioselectivity. Experiments indicate that fac-Ir(ppy)3-catalyzed oxydifluoroalkylation can proceed smoothly under base-free conditions in the presence of AgTFA. In the experiment, the researchers used fac-Tris(2-phenylpyridine)iridium(cas: 94928-86-6Electric Literature of C33H24IrN3)

fac-Tris(2-phenylpyridine)iridium(cas: 94928-86-6) belongs to pyridine. In industry and in the lab, pyridine is used as a reaction solvent, particularly when its basicity is useful, and as a starting material for synthesizing some herbicides, fungicides, and antiseptics.Electric Literature of C33H24IrN3

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

In 2019,Chemistry of Materials included an article by Meier, Christian B.; Clowes, Rob; Berardo, Enrico; Jelfs, Kim E.; Zwijnenburg, Martijn A.; Sprick, Reiner Sebastian; Cooper, Andrew I.. Recommanded Product: 2,5-Dibromopyridine. The article was titled 《Structurally diverse covalent triazine-based framework materials for photocatalytic hydrogen evolution from water》. The information in the text is summarized as follows:

A structurally diverse family of 39 covalent triazine-based framework materials (CTFs) are synthesized by Suzuki-Miyaura polycondensation and tested as hydrogen evolution photocatalysts using a high-throughput workflow. The two best-performing CTFs are based on benzonitrile and dibenzo[b,d]thiophene sulfone linkers, resp., with catalytic activities that are among the highest for this material class. The activities of the different CTFs are rationalized in terms of four variables: the predicted electron affinity, the predicted ionization potential, the optical gap, and the dispersibility of the CTFs particles in solution, as measured by optical transmittance. The electron affinity and dispersibility in solution are found to be the best predictors of photocatalytic hydrogen evolution activity. The results came from multiple reactions, including the reaction of 2,5-Dibromopyridine(cas: 624-28-2Recommanded Product: 2,5-Dibromopyridine)

2,5-Dibromopyridine(cas: 624-28-2) belongs to pyridine. Pyridine is very deactivated towards electrophilic substitution with respect to benzene. For this reason classical formylation, using methods such as the Gattermann or Vilsmeier reactions, are not generally successful. Recommanded Product: 2,5-Dibromopyridine

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

The author of 《Mechanochemistry, an Easy Technique to Boost the Synthesis of CuI Pyrazine Coordination Polymers》 were Cappuccino, Chiara; Farinella, Francesco; Braga, Dario; Maini, Lucia. And the article was published in Crystal Growth & Design in 2019. SDS of cas: 100-48-1 The author mentioned the following in the article:

Depending on the exptl. conditions, the solid-state reactions of CuI with pyrazine (pyz) yield three distinct coordination polymers (CPs): a double chain polymer [Cu2I2(pyz)]n (yellow powder) and a single strand [CuI(pyz)]n (red powder) and its new isomeric compound [(CuI)2(pyz)2]n (orange powder), which present dimers of CuI bridged by the pyrazine ligands. The conversions among the three CPs were studied: by heating to 110°, [CuI(pyz)]n or [(CuI)2(pyz)2]n convert into [Cu2I2(pyz)]n, which reverts to the starting compounds upon kneading or grinding in the presence of pyrazine. The orange isomer [(CuI)2(pyz)2]n is obtained only when the solid-state reaction is performed with neat grinding or by direct melting of the pyrazine; it is unstable in the presence of solvent or vapor, and it readily transforms into the red isomer. The structure of [(CuI)2(pyz)2]n was determined by x-ray powder diffraction. [Cu2I2(pyz)]n reacts also with 4-cyanopyrazine to yield the mixed ligand compound [(CuI)(4CN-py)2 py]n, which, when heated, decomposes into [Cu2I2(pyz)]n and [(CuI)4(4CN-py)5]n. In the experiment, the researchers used 4-Cyanopyridine(cas: 100-48-1SDS of cas: 100-48-1)

4-Cyanopyridine(cas: 100-48-1) belongs to pyridine. Pyridine is a relatively complex molecule and exhibits a number of different bands in IR spectra. Among others, the bands characterizing the ν8a and ν19b modes have been found to be sensitive to the coordination or protonation of the molecule. Note that the band that is diagnostic for the PyH+ ion at about 1545 cm− 1 (ν19b mode) does not overlap with any of the other bands.SDS of cas: 100-48-1

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem