Month: October 2022

The author of 《Copper-Catalyzed C-4 Carboxylation of 1-Naphthylamide Derivatives with CBr4/MeOH》 were Sahoo, Tapan; Sen, Chiranjit; Singh, Harshvardhan; Suresh, E.; Ghosh, Subhash Chandra. And the article was published in Advanced Synthesis & Catalysis in 2019. Recommanded Product: Picolinic acid The author mentioned the following in the article:

A copper catalyzed C-4 carboxylation reaction of 1-naphthylamide derivatives using carbon tetra bromide and methanol was reported to get corresponding ester derivatives e.g., I. Picolinamide and its derivatives were used as a bidentate directing group for the distal C4-H functionalization. Various substituted naphthylamide derivatives, and anilides were employed for the carboxylation and proceeds in good yields under mild condition. From the outcome of exptl. results, it was proposed that C4-H carboxylation reaction of 1-naphthylamides might proceed through a single electron transfer pathway. In the experimental materials used by the author, we found Picolinic acid(cas: 98-98-6Recommanded Product: Picolinic acid)

Picolinic acid(cas: 98-98-6) is used in the preparation of 2-Aminodihydro[1,3]thiazines as BACE 2 inhibitors and their preparation and use in the treatment of diabetes.Recommanded Product: Picolinic acid

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

《Synthesis of 2-Arylpyridines and 2-Arylbipyridines via Photoredox-Induced Meerwein Arylation with in Situ Diazotization of Anilines》 was published in Journal of Organic Chemistry in 2020. These research results belong to Hagui, Wided; Soule, Jean-Francois. Computed Properties of C7H7NO The article mentions the following:

Herein a sustainable method for the preparation of 2-arylpyridines through C-H arylation of pyridines using in situ formed diazonium salts (from com. available aromatic amines) in the presence of a photoredox catalyst under blue light-emitting diode (LED) irradiation The reaction is tolerant to a wide range of functional groups (e.g., halogen, nitrile, formyl, acetyl, ester). Applications to the C-H bond arylation of bipyridine ligands is also presented. The experimental part of the paper was very detailed, including the reaction process of 4-Acetylpyridine(cas: 1122-54-9Computed Properties of C7H7NO)

4-Acetylpyridine(cas: 1122-54-9) belongs to pyridine. In industry and in the lab, pyridine is used as a reaction solvent, particularly when its basicity is useful, and as a starting material for synthesizing some herbicides, fungicides, and antiseptics.Computed Properties of C7H7NO

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

《Water-soluble copper(II) complexes with 4,5-dichloro-isothiazole-3-carboxylic acid and heterocyclic N-donor ligands: Synthesis, crystal structures, cytotoxicity, and DNA binding study》 was published in Inorganica Chimica Acta in 2020. These research results belong to Eremina, Julia A.; Lider, Elizaveta V.; Sukhikh, Taisiya S.; Klyushova, Lyubov S.; Perepechaeva, Maria L.; Sheven’, Dmitriy G.; Berezin, Alexey S.; Grishanova, Alevtina Y.; Potkin, Vladimir I.. Product Details of 1134-35-6 The article mentions the following:

Mixed-ligand copper(II) complexes based on 1,10-phenanthroline and related compounds are of interest to scientists due to their promising anticancer properties. In this study, four new water-soluble copper(II) complexes [Cu(dmbipy)L2], [Cu(phen)(H2O)L2], [Cu(dmphen)L2] and [Cu2(bipy)2L4], where HL – 4,5-dichloro-isothiazole-3-carboxylic acid, bipy = 2,2′-bipyridine, dmbipy = 2,2′-bi-4-picoline, phen = 1,10-phenanthroline, dmphen = 4,7-dimethyl-1,10-phenanthroline are reported. All complexes have been characterized by elemental and powder x-ray diffraction anal., EPR and IR-spectroscopy. Mol. structures of the reported complexes have been determined by single crystal x-ray diffraction. Copper(II) ion, HL and heterocyclic N-donor ligands have been found to form 1:2:1 complexes that possess square bipyramid or square pyramidal geometry. The UV-vis spectroscopy and mass spectrometry have been applied to show the behavior of the compounds in solution All complexes have been screened in vitro for their cytotoxic activity against Hep-2 and MCF-7 cell lines. They exhibit significant dose-dependent cytotoxic effect and [Cu(dmphen)L2] is the most cytotoxic (IC50 = 0.97 ± 0.03μM when compared to IC50 = 9.2 ± 0.5μM for control, cisplatin – Hep-2 cell line). The investigation of DNA binding ability by UV-vis titration technique indicates that complexes obtained exhibit moderate binding affinity toward calf thymus DNA. Effect of [Cu(dmbipy)L2] and [Cu(dmphen)L2] on activity of drug-metabolizing enzymes cytochromes P 450 has also been investigated. The addition of complexes to the hepatic microsomes of 3-MC or PB-treated rat, lead to a dose-dependent decrease of CYP’s activities. The data obtained indicate that [Cu(dmphen)L2] and [Cu(phen)(H2O)L2] can be potential anticancer agents. The experimental process involved the reaction of 4,4′-Dimethyl-2,2′-bipyridine(cas: 1134-35-6Product Details of 1134-35-6)

4,4′-Dimethyl-2,2′-bipyridine(cas: 1134-35-6) is used as a chemical Intermediate. It can be used for the determination of ferrous and cyanide compounds.Product Details of 1134-35-6 Furthermore, 4,4′-Dimethyl-2,2′-bipyridine is used in the synthesis of a series of o-phenanthroline-substituted ruthenium(II) complexes.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

《Regioisomeric monopyridine-functionalized triarylethene: small AIEgens with isomeric effect and an efficient platform for the selective and sensitive detection of Pd2+ and Fe3+》 was written by Mukherjee, Atasi; Chakravarty, Manab. Application of 1692-25-7 And the article was included in New Journal of Chemistry in 2020. The article conveys some information:

Previously, pyridine-functionalized tetraarylethenes have been established as potential AIEgens (aggregation-induced emission-active fluorogens) for numerous applications, whereas monopyridyl-linked triarylethene has been reported as a non-AIEgen. In this study, we afforded AIE-active monopyridine-functionalized unsym. substituted triarylethene in which naphthyl, biphenyl, and 4-phenylpyridine rotors were attached to an alkene stator. Moreover, two regioisomeric pyridyl compounds were synthesized to study the isomeric effect on AIE properties. Both regioisomeric compounds were found to be AIE-active with slight variation. The reasons behind the AIE properties of these compounds were substantiated by SEM studies, lifetime measurements, and mol. packing studies in a single crystal. The relatively large number of non-covalent interactions in the 4-pyridyl isomer were slightly unfavorable for the emission of fluorescence in the aggregate state; however, these interactions were beneficial for the emission of strong fluorescence in the solid state. Both compounds were individually utilized for the naked eye detection and identification of Fe3+ and Pd2+ based on the extent of fluorescence quenching in the solution state (~10-9 M detection limit) and the solid state (10-3 M for Pd2+ and 10-2 M for Fe3+). The quenching mechanism was found to involve the static and dynamic complexation of pyridyl N-atom with the metal ion. This fact was further proved by 1H NMR titration In the part of experimental materials, we found many familiar compounds, such as Pyridin-3-ylboronic acid(cas: 1692-25-7Application of 1692-25-7)

Pyridin-3-ylboronic acid(cas: 1692-25-7) belongs to pyridine. Pyridine is very deactivated towards electrophilic substitution with respect to benzene. For this reason classical formylation, using methods such as the Gattermann or Vilsmeier reactions, are not generally successful. Application of 1692-25-7

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

《Heteroleptic copper(II) complexes with 2-bromo-5-methylpyridine: Structures, features of non-covalent interactions and magnetic behavior》 was written by Adonin, Sergey A.; Novikov, Alexander S.; Chernova, Katerina V.; Vinnik, Denis A.; Taskaev, Sergey V.; Korolkov, Ilya V.; Ilyina, Ekaterina V.; Pavlov, Alexander A.; Novikov, Valentin V.; Sokolov, Maxim N.; Fedin, Vladimir P.. Reference of 2-Bromo-5-methylpyridine And the article was included in Inorganica Chimica Acta in 2020. The article conveys some information:

Isostructural [Cu(2-Br-5-MePy)2X2] (2-Br-5-MePy = 2-bromo-5-methylpyridine, X = Cl 1, Br 2) were prepared and structurally characterized. Magnetic measurements reveal that both complexes demonstrate paramagnetic behavior. The results came from multiple reactions, including the reaction of 2-Bromo-5-methylpyridine(cas: 3510-66-5Reference of 2-Bromo-5-methylpyridine)

2-Bromo-5-methylpyridine(cas: 3510-66-5) belongs to pyridine. Pyridines form stable salts with strong acids. Pyridine itself is often used to neutralize acid formed in a reaction and as a basic solvent. Reference of 2-Bromo-5-methylpyridine

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Heydari, Somayyeh; Habibi, Davood; Reza Faraji, Ali; Keypour, Hassan; Mahmoudabadi, Masoumeh published their research in Inorganica Chimica Acta in 2021. The article was titled 《An overview on the progress and development on the palladium catalyzed direct cyanation》.Formula: C5H6BNO2 The article contains the following contents:

The simultaneous use of the new Pd nano-catalyst as well as the three types of the N-arylsulfonyl cyanamides 4-ClC6H4N(CN)S(O)2C6H4(4-X) (X = CH3, Br, NO2) as potent reagents for the in situ generation of the pos. CN ion for the direct cyanation of phenylboronic acids ArB(OH)2 [Ar = 4-ClC6H4, pyridin-3-yl, 2-(dihydroxyboranyl)phenyl, etc.] in acetonitrile at reflux conditions has been described. The experimental part of the paper was very detailed, including the reaction process of Pyridin-3-ylboronic acid(cas: 1692-25-7Formula: C5H6BNO2)

Pyridin-3-ylboronic acid(cas: 1692-25-7) belongs to pyridine. In industry and in the lab, pyridine is used as a reaction solvent, particularly when its basicity is useful, and as a starting material for synthesizing some herbicides, fungicides, and antiseptics.Formula: C5H6BNO2

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Ge, Yanning; Zhang, Dehua; Zhang, Xiaoyan; Liu, Yang; Du, Longfei; Wang, Yingying published their research in Journal of Chemical Research in 2021. The article was titled 《A new perimidine-based fluorescent turn-on chemosensor for selective detection of Cu2+ ions》.Safety of 2-(Bromomethyl)pyridine hydrobromide The article contains the following contents:

Two new mols. based on 2-(2-alkoxy-1-naphthyl)-2,3-dihydro-1h-perimidine are synthesized. The binding properties are investigated by fluorescence spectroscopy showing that one of the products (2a) can selectively bind Cu2+ with fluorescence enhancement. In the experiment, the researchers used 2-(Bromomethyl)pyridine hydrobromide(cas: 31106-82-8Safety of 2-(Bromomethyl)pyridine hydrobromide)

2-(Bromomethyl)pyridine hydrobromide(cas: 31106-82-8) belongs to pyridine. Pyridines are often used as catalysts or reagents; particular notice has been paid recently to how pyridine coordinates to metal centers enabling a wide range of valuable reactions. Safety of 2-(Bromomethyl)pyridine hydrobromide

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Zhang, Ya-Qi; Hou, Lin; Bi, Hao-Xue; Fang, Xiao-Xue; Ma, Yuan-Yuan; Han, Zhan-Gang published an article in 2021. The article was titled 《Organic moiety-regulated Photocatalytic Performance of Phosphomolybdate hybrids for hexavalent chromium reduction》, and you may find the article in Chemistry – An Asian Journal.Formula: C12H12N2 The information in the text is summarized as follows:

Visible-light-driven photocatalytic Cr(VI) reduction is a promising pathway to moderate environmental pollution, in which the development of photocatalysts is pivotal. Herein, three hourglass-type phosphomolybdate-based hybrids with the formula of: (H2bpe)3[Zn(H2PO4)][Zn(bpe)(H2O)2]H{Zn[P4Mo6O31H6]2}·6H2O (1) Na6[H2bz]2[ZnNa4(H2O)5]{Zn [P4Mo6O31H3]2}·2H2O (2) and (H2mbpy) {[Zn(mbpy)(H2O)]2[Zn(H2O)]2}{Zn[P4Mo6O31H6]2}·10H2O (3) (bpe = trans-1,2-bi(4-pyridyl)-ethylene; bz = 4,4′-diaminobiphenyl; mbpy = 4,4′-dimethyl-2,2′bipyridine) were synthesized under the guidance of the functional organic moiety modification strategy. Structural anal. showed that hybrids 1-3 have similar 2D layer-like spatial arrangements constructed by {Zn[P4Mo6]2} clusters and organic components with different conjugated degree. With excellent redox properties and wide visible-light absorption capacities, hybrids 1-3 display favorable photocatalytic activity for Cr(VI) reduction with 79%, 70% and 64% reduction rates, which are superior to that of only inorganic {Zn[P4Mo6]2} itself (21%). The investigation of organic components on photocatalytic performance of hybrids 1-3 suggested that the organic counter cations (bpe, bz and mbpy) can effectively affect the visible-light absorption, as well as the recombination of photogenerated carriers stemmed from {Zn[P4Mo6]2} clusters, further promoting their photocatalytic performances towards Cr(VI) reduction This work provides an exptl. basis for the design of functionalized photocatalysts via the modification of organic species. In the part of experimental materials, we found many familiar compounds, such as 4,4′-Dimethyl-2,2′-bipyridine(cas: 1134-35-6Formula: C12H12N2)

4,4′-Dimethyl-2,2′-bipyridine(cas: 1134-35-6) is used as a chemical Intermediate. It can be used for the determination of ferrous and cyanide compounds.Formula: C12H12N2 Furthermore, 4,4′-Dimethyl-2,2′-bipyridine is used in the synthesis of a series of o-phenanthroline-substituted ruthenium(II) complexes.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

In 2022,Jayabharathi, J.; Thilagavathy, S.; Thanikachalam, V.; Anudeebhana, J. published an article in Materials Today Chemistry. The title of the article was 《Multifunctional zig-zag-shaped D-π-A-π-D emitters with high conjugation extent for blue FOLEDs and host for PHOLEDs》.SDS of cas: 624-28-2 The author mentioned the following in the article:

We have synthesized zig-zag shaped, meta- and para-linked D-π-A-π-D blue emitters, m-BTPAPy and p-BTPAPy based on a non-sym. connection strategy of two identical π-conjugated groups. The phenanthrimidazole moiety coupled to pyridine via naphthyl spacer by para- and meta-linking modes. Both m-BTPAPy (Td/Tg, °C: 564/281) and p-BTPAPy (Td/Tg, °C: 502/246) exhibit excellent thermal stability and can form a stable amorphous film. Changing the connection strategy from para to meta mode, m-BTPAPy shows deep blue emission with CIE (0.15, 0.07). The highly twisted m-BTPAPy exhibit higher Photoluminescence quantum yield (PLQY)s/f of 0.98/0.85 than p-BTPAPy (0.95/0.80) owing to the suppression of intermol. stacking. The non-doped blue device (BOLEDs) with multifunctional m-BTPAPy/p-BTPAPy show external quantum efficiency (EQE) of 7.12/5.12% with small roll-off efficiency of 1.68/2.14%, power efficiency (PE) of 5.92/5.42 lm/W, the luminance of 58675/76234 cd/m2, and current efficiency (CE) of 6.12/5.86 cd/A. The non-doped device using m-BTPAPy/p-BTPAPy as both emitting and electron-transporting material exhibit luminance of 40671/49539 cd/m2, CE of 5.01/5.08 cd/A, PE of 4.68/4.76 lm/W, EQE of 6.12/4.81%, roll-off efficiency of 1.63/1.87%, and CIE (0.15, 0.10)/(0.15, 0.11). These bipolar materials with high triplet energy were employed as hosts in green and red PhOLEDs. The green (m-BTPAPy: Ir(ppy)3)/red device (m-BTPAPy: Ir(MDQ)2(acac)) exhibit maximum EQE of 29.85/20.09%, luminance of 79523/42412 cd/m2, CE of 78.62/27.56 cd/A, and PE of 72.36/23.86 lm/W, and CIE (0.33, 0.60)/(0.65,0.33). The experimental process involved the reaction of 2,5-Dibromopyridine(cas: 624-28-2SDS of cas: 624-28-2)

2,5-Dibromopyridine(cas: 624-28-2) belongs to pyridine. Pyridine derivatives lend themselves to many roles in the spirited field of supramolecular chemistry – whether as the ligand backbone of metal-organic polymers or presiding over the key electronic stations of nanodevices. In biochemistry, pyridine-containing cofactors are necessary nutrients on which our lives depend. SDS of cas: 624-28-2

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Category: pyridine-derivativesIn 2019 ,《Electrochemical and electronic properties of a series of substituted polypyridine ligands and their Co(II) complexes》 appeared in Inorganica Chimica Acta. The author of the article were Ferreira, Hendrik; Conradie, Marrigje M.; Conradie, Jeanet. The article conveys some information:

DFT calculations show that, due to Jahn-Teller distortion, the d7 [Co(N,N)3]2+ complexes, with S = 1/2 (N,N = bipyridine or substituted bipyridine ligand) have two longer axial and four shorter equatorial Co-N bonds (elongation Jahn-Teller), while [Co(terpyridine)2]2+ with S = 1/2, instead has two shorter central (axial) Co-N bonds and four longer distal Co-N bonds (compression Jahn-Teller), since in the latter, the distal Co-N bonds are more flexible than the Co-N axial bonds in the rigid structure of the tridentate terpyridine ligand. The same trend is observed for the related high spin S = 3/2 Co(II) complexes, though less pronounced. The cyclic voltammograms of [Co(terpyridine)2]2+ and a series of the [Co(N,N)3]2+ complexes show at least three chem. as well as electrochem. reversible redox couples, namely CoIII/II, CoII/I and a ligand based reduction of the polypyridine-Co(I) complex. The reduction of the uncoordinated free polypyridine ligand is more than 0.5 V more neg. than the reduction of the coordinated ligand in the polypyridine-Co(I) complex. The experimental part of the paper was very detailed, including the reaction process of 4,4′-Dimethyl-2,2′-bipyridine(cas: 1134-35-6Category: pyridine-derivatives)

4,4′-Dimethyl-2,2′-bipyridine(cas: 1134-35-6) is used in the synthesis of a series of o-phenanthroline-substituted ruthenium(II) complexes.Category: pyridine-derivatives Furthermore, 4,4′-Dimethyl-2,2′-bipyridine is used as a chemical Intermediate. It can be used for the determination of ferrous and cyanide compounds.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem