Month: October 2022

Safety of 4,4′-Dimethyl-2,2′-bipyridineIn 2021 ,《Supramolecular photocatalysts fixed on the inside of the polypyrrole layer in dye sensitized molecular photocathodes: application to photocatalytic CO2 reduction coupled with water oxidation》 appeared in Chemical Science. The author of the article were Kuttassery, Fazalurahman; Kumagai, Hiromu; Kamata, Ryutaro; Ebato, Yusuke; Higashi, Masanobu; Suzuki, Hajime; Abe, Ryu; Ishitani, Osamu. The article conveys some information:

The development of systems for photocatalytic CO2 reduction with water as a reductant and solar light as an energy source is one of the most important milestones on the way to artificial photosynthesis. Although such reduction can be performed using dye-sensitized mol. photocathodes comprising metal complexes as redox photosensitizers and catalyst units fixed on a p-type semiconductor electrode, the performance of the corresponding photoelectrochem. cells remains low, e.g., their highest incident photon-to-current conversion efficiency (IPCE) equals 1.2%. Herein, we report a novel dye-sensitized mol. photocathode for photocatalytic CO2 reduction in water featuring a polypyrrole layer, [Ru(diimine)3]2+ as a redox photosensitizer unit, and Ru(diimine)(CO)2Cl2 as the catalyst unit and reveal that the incorporation of the polypyrrole network significantly improves reactivity and durability relative to those of previously reported dye-sensitized mol. photocathodes. The irradiation of the novel photocathode with visible light under low applied bias stably induces the photocatalytic reduction of CO2 to CO and HCOOH with high faradaic efficiency and selectivity (even in aqueous solution), and the highest IPCE is determined as 4.7%. The novel photocathode is coupled with n-type semiconductor photoanodes (CoOx/BiVO4 and RhOx/TaON) to construct full cells that photocatalytically reduce CO2 using water as the reductant upon visible light irradiation as the only energy input at zero bias. The artificial Z-scheme photoelectrochem. cell with the dye-sensitized mol. photocathode achieves the highest energy conversion efficiency of 8.3 × 10-2% under the irradiation of both electrodes with visible light, while a solar to chem. conversion efficiency of 4.2 × 10-2% is achieved for a tandem-type cell using a solar light simulator (AM 1.5, 100 mW cm-2). In the experiment, the researchers used 4,4′-Dimethyl-2,2′-bipyridine(cas: 1134-35-6Safety of 4,4′-Dimethyl-2,2′-bipyridine)

4,4′-Dimethyl-2,2′-bipyridine(cas: 1134-35-6) is used in the synthesis of a series of o-phenanthroline-substituted ruthenium(II) complexes.Safety of 4,4′-Dimethyl-2,2′-bipyridine Furthermore, 4,4′-Dimethyl-2,2′-bipyridine is used as a chemical Intermediate. It can be used for the determination of ferrous and cyanide compounds.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Application In Synthesis of 4-AcetylpyridineIn 2021 ,《Palladium(II)-catalyzed three-component tandem reactions: synthesis of multiply substituted quinolines》 appeared in Organic Chemistry Frontiers. The author of the article were Zhang, Yetong; Chen, Lepeng; Shao, Yinlin; Zhang, Fangjun; Chen, Zhongyan; Lv, Ningning; Chen, Jiuxi; Li, Renhao. The article conveys some information:

The three-component tandem reaction of 2-aminobenzonitriles, arylboronic acids and ketones allowing the synthesis of polysubstituted quinolines I [R1 = H, 7-Me, 6-F, etc.; R2 = Me, Ph, 2-thienyl, etc.; R3 = Ph, 2-naphthyl, 3-thienyl, etc.; R4 = H, Et, Br, etc.; R2R4 = CH2CH2CH2; CH2(CH2)2CH2, etc.] was reported. This strategy presented a practical, efficient, one-pot procedure that delivered functional quinolines in moderate to good yields with high functional group tolerance. To enrich the synthetic applications in accessing diverse quinolines, a new method for the introduction of halogen substituents into target products was developed as well, which showed potential for further synthetic elaborations.4-Acetylpyridine(cas: 1122-54-9Application In Synthesis of 4-Acetylpyridine) was used in this study.

4-Acetylpyridine(cas: 1122-54-9) belongs to pyridine. Pyridine derivatives lend themselves to many roles in the spirited field of supramolecular chemistry – whether as the ligand backbone of metal-organic polymers or presiding over the key electronic stations of nanodevices. In biochemistry, pyridine-containing cofactors are necessary nutrients on which our lives depend. Application In Synthesis of 4-Acetylpyridine

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Safety of 4-CyanopyridineIn 2021 ,《Nickelocene as an Air- and Moisture-Tolerant Precatalyst in the Regioselective Synthesis of Multisubstituted Pyridines》 appeared in Journal of Organic Chemistry. The author of the article were Cho, Il Young; Kim, Woo Gyum; Jeon, Ji Hwan; Lee, Jeong Woo; Seo, Jeong Kon; Seo, Jongcheol; Hong, Sung You. The article conveys some information:

Herein, operationally simple nickel(0) catalysis to access substituted pyridines I [R = Me, Ph, 2-furyl, etc.; R1 = Me, Ph, trimethylsilyl, etc.; R2 = H, Me, Ph, etc.; Z = CH2, O, C(CO2Et)2, N-Ts] from various nitriles and 1,6-diynes without the aid of air-free techniques was reported. The Ni-Xantphos-based catalytic manifold was tolerant to air, moisture and heat while promoting the [2 + 2 + 2] cycloaddition reactions with high reaction yields and broad substrate scope. In addition, the steric effect but also the frontier MO interactions could played a critical role in determining the regiochem. outcome of nickel-catalyzed [2 + 2 + 2] cycloaddition for the synthesis of compounds I.4-Cyanopyridine(cas: 100-48-1Safety of 4-Cyanopyridine) was used in this study.

4-Cyanopyridine(cas: 100-48-1) belongs to pyridine. The basicity and metallophilic high donor number of these π-deficient systems has long favored them as ligands in metal catalysis. The last decade saw pyridine assume a stronger role as functional group for directed C–H oxidation/activation.Safety of 4-Cyanopyridine

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Computed Properties of C6H4N2In 2020 ,《Pyridine-Diketopyrrolopyrrole-Based Novel Metal-Free Visible-Light Organophotoredox Catalyst for Atom-Transfer Radical Polymerization》 appeared in Journal of Physical Chemistry A. The author of the article were Yang, Long; Huang, Yujie; Peng, Yuting; Liu, Fei; Zhang, Qingchun; He, Huichao; Wang, Jun; Jiang, Long; Zhou, Yong. The article conveys some information:

In the field of electronics, organocatalysts are in high demand for use in the synthesis of clean polymers using solar radiation rather than potentially contaminating metals. Combining theor. design, simulation, and experiments, this work presents a novel, pyridine-diketopyrrolopyrrole (P-DPP)-based metal-free visible-light organophotoredox catalyst (P-DPP). It is effective in the photocontrolled organocatalytic atom-transfer radical polymerization (O-ATRP) of Me methacrylate (MMA) and styrene. The use of this catalyst and white light-emitting diode (LED) irradiation produces polymers with a crosslinked feature. In O-ATRP, the P-DPP catalyst has an oxidative quenching catalytic mechanism with an excited-state reductive potential of -1.8 V, fluorescence lifetime of 7.5 ns, and radical-cation oxidative potential of 0.45 V. Through mol. simulation, we found that the adjacent pyridine group is key to reducing the alkyl halide initiator and generating radicals, while the diketopyrrolopyrrole core stabilizes the triplet state of the catalyst through intramol. charge transfer. The findings related to this novel photoredox catalyst will aid in the search for much more effective organophotoredox catalysts for use in controlled radical polymerization They will also be of value in the fields of polymer chem. and physics and in various applications. The experimental process involved the reaction of 4-Cyanopyridine(cas: 100-48-1Computed Properties of C6H4N2)

4-Cyanopyridine(cas: 100-48-1) belongs to pyridine. The basicity and metallophilic high donor number of these π-deficient systems has long favored them as ligands in metal catalysis. The last decade saw pyridine assume a stronger role as functional group for directed C–H oxidation/activation.Computed Properties of C6H4N2

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Synthetic Route of C7H7NOIn 2020 ,《Synthesis, antioxidant and antimicrobial properties of novel pyridyl-carbonyl thiazoles as dendrodoine analogs》 appeared in Turkish Journal of Chemistry. The author of the article were Sahin, Zafer; Biltekin, Sevde Nur; Yurttas, Leyla; Demirayak, Seref. The article conveys some information:

Marine compound dendrodoine was first obtained from tunicate species (Dendrodo grossularia), it has a five-membered ring, namely, it is a heterocycle thiadiazole, which is found rarely in natural sources. Following its biol. activities, novel analogs have been investigated recently. Synthesis of the analogs I (R1 = 2-pyridyl, 3-pyridyl, 4-pyridyl; R2 = pyrrolidin-1-yl, piperidin-1-yl, azepan-1-yl, etc.) for this study is realized with uncommon thiazole closure, including methylene-carbonyl condensation. As an alkaloid derivative, antioxidant properties were evaluated with DPPH and FRAP assays and antimicrobial effect with microdilution method. Among the series, few compds showed higher antioxidant activity than those having 3 or 4-pyridyl substituents. There is lesser activity for 2-pyridyl activity for 2-pyridyl containing group, which may be a result of intramol. interactions. No activity was observed against gram-neg. bacteria at 250μg/mL. Compound I (R1 = 2-pyridyl, 4-pyridyl; R2 = hexamethylamine) showed activity at 64μg/mL against S. aureus and I (R1 = 2-pyridyl; R2 = hexamethylamine) showed activity at 16μg/mL against S. epidermidis gram-pos. bacteria. Chloramphenicol showed activity against all microorganisms at 8-16μg/mL. Sixteen original dendrodoine analogs have been defined by close/higher activity compared to dendrodoine analogs and Trolox. The experimental process involved the reaction of 4-Acetylpyridine(cas: 1122-54-9Synthetic Route of C7H7NO)

4-Acetylpyridine(cas: 1122-54-9) belongs to pyridine. Pyridine and pyridine-derived structures are privileged pharmacophores in medicinal chemistry and an essential functionality for organic chemists. As the prototypical π-deficient heterocycle, pyridine illustrates distinctive chemistry as both substrate and reagent. Synthetic Route of C7H7NO

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Recommanded Product: 1539-42-0In 2020 ,《Synthesis, characterization and photoinduced CO-release by manganese(I) complexes》 appeared in New Journal of Chemistry. The author of the article were Amorim, Andre L.; Guerreiro, Ana; Glitz, Vinicius A.; Coimbra, Daniel F.; Bortoluzzi, Adailton J.; Caramori, Giovanni F.; Braga, Antonio L.; Neves, Ademir; Bernardes, Goncalo J. L.; Peralta, Rosely A.. The article conveys some information:

Herein, authors report the CO-releasing activity of three new photoCORMs, two with nonbonding pyridine moieties and one with a benzyl group. Compounds [MnBr(CO)3(bpa-κ2)] (2, where bpa = N-benzyl(2-pyridylmethyl)amine); [MnBr(CO)3(pmpea-κ2)] (3, where pmpea = N-(2-pyridylmethyl)-N’-(2-pyridylethyl)amine) and [MnBr(CO)3(bpea-κ2)] (4, where bpea = N-bis(2-pyridylethyl)amine) were synthesized and characterized by common spectroscopic techniques (UV-Vis and IR). D. functional theory studies were also performed to provide new insights into the M-C bond and to assume the orbitals involved in the absorption transitions. Their CO-releasing activities were measured both in organic and in physiol. media and compared to that of a previously published compound [Mn(CO)3(dpa-κ3)]Br (1, where dpa = N-bis(2-pyridylmethyl)amine). An increase in the number of members of the chelate from five to six influenced the release of CO, affecting both the binding mode of the ligand and the CO-release process and affecting their potential use as CO-release carriers and therapeutic agents. The experimental part of the paper was very detailed, including the reaction process of Bis(pyridin-2-ylmethyl)amine(cas: 1539-42-0Recommanded Product: 1539-42-0)

Bis(pyridin-2-ylmethyl)amine(cas: 1539-42-0) is a secondary amine with two picolyl substituents. The compound is a tridentate ligand in coordination chemistry and commonly used to produce Zn-based chemosensors/probes, such as Zinpry.Recommanded Product: 1539-42-0

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Safety of 2,5-DibromopyridineIn 2020 ,《Color-tunable white-light of binary tris-β-diketonate-(Dy3+, Gd3+x) complexes’ blend under single wavelength excitation》 appeared in Inorganic Chemistry Communications. The author of the article were Shi, Qi; Liu, Jiaxiang; Wang, Jia; Yang, Xiaohui; Zhang, Xingmei; Li, Shuna; Sun, Ping; Chen, Jin; Li, Beibei; Lu, Xingqiang. The article conveys some information:

Based on the Dy3+-centered yellow-light and the ligands-based blue-light of the iso-structural two complexes [Ln(acac)3(5-Br-2,2′-bpy)] (Ln3+ = Dy3+ (2) or Gd3+ (3); Hacac = acetylacetone, 5-Br-2,2′-bpy = 5-bromo-2,2′-bipyridine), resp., the stoichiometric fluorescence titrations of their tris-β-diketonate-(Dy3+, Gd3+x)-mixed complex, show that it is capable of the smooth color-tuning (yellow- to white- and to blue-light) under single wavelength excitation. Moreover, through the dichromatic integration, the binary tris-β-diketonate-(Dy3+, Gd3+x) complex exhibits the straightforward white-light in solid-state. In the part of experimental materials, we found many familiar compounds, such as 2,5-Dibromopyridine(cas: 624-28-2Safety of 2,5-Dibromopyridine)

2,5-Dibromopyridine(cas: 624-28-2) belongs to pyridine. Pyridine and pyridine-derived structures are privileged pharmacophores in medicinal chemistry and an essential functionality for organic chemists. As the prototypical π-deficient heterocycle, pyridine illustrates distinctive chemistry as both substrate and reagent. Safety of 2,5-Dibromopyridine

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Formula: C12H12N2In 2019 ,《Synthesis, structures and spectroscopy of three new lanthanide β-diketonate complexes with 4,4′-dimethyl-2,2′-bipyridine. Near-infrared electroluminescence of ytterbium(III) complex in OLED》 appeared in Inorganica Chimica Acta. The author of the article were Santos, Hudson P.; Gomes, Emmanuel S.; dos Santos, Moliria V.; D’Oliveira, Kaique A.; Cuin, Alexandre; Martins, Jefferson S.; Quirino, Welber G.; Marques, Lippy F.. The article conveys some information:

Three new lanthanide(III) β-diketonate complexes [Ln(btfa)3(4,4′-dmbpy)] (Ln = Yb(III), Gd(III) and Nd(III); btfa = anionic 4,4,4-trifluoro-1-phenyl-1,3-butanedione and 4,4′-dmbpy = 4,4′-dimethyl-2,2′-bipyridine) were synthesized and their characterization, including elemental anal., FTIR spectroscopy and thermal anal. (TG/DTA), is reported. The crystal description based on powder x-ray diffraction reveals that Gd(III) and Yb(III) compounds are isostructural and that lanthanide ion is eight-coordinated by oxygen and nitrogen atoms to give new tris- β-diketonates [Ln(btfa)3(4,4′-dmbpy)]. The cell parameters of Nd(III) complex are close to Gd(III) and Yb(III) ones. Phosphorescence data of Gd(III) complex shows that the triplet states (T1) of the ligands have higher energy than the emitting states of Yb(III) and Nd(III), indicating the possibility of intramol. energy transfer to these metal ions, which exhibit near-IR (NIR) emission. The authors used the Yb(III) complex as an emitting layer (EML) in a near IR organic light emitting diode (NIR-OLED) with the structure: CuPc(15 nm)/XD-03(40 nm)/Yb(60 nm)/BCP(15 nm)/Alq3(10 nm)/Al(120 nm). OLEDs exhibit both visible electroluminescence and a NIR electroluminescence at 980 nm from the 2F5/2 → 2F7/2 transition of the Yb(III). The experimental process involved the reaction of 4,4′-Dimethyl-2,2′-bipyridine(cas: 1134-35-6Formula: C12H12N2)

4,4′-Dimethyl-2,2′-bipyridine(cas: 1134-35-6) is used in the synthesis of a series of o-phenanthroline-substituted ruthenium(II) complexes.Formula: C12H12N2 Furthermore, 4,4′-Dimethyl-2,2′-bipyridine is used as a chemical Intermediate. It can be used for the determination of ferrous and cyanide compounds.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

COA of Formula: C5H6BNO2In 2020 ,《Reactivity of Boronic Acids toward Catechols in Aqueous Solution》 appeared in Journal of Organic Chemistry. The author of the article were Suzuki, Yota; Kusuyama, Daisuke; Sugaya, Tomoaki; Iwatsuki, Satoshi; Inamo, Masahiko; Takagi, Hideo D.; Ishihara, Koji. The article conveys some information:

Fundamental information on the reactivities of boronic acids toward catechols in aqueous solution is required in all the fields dealing with boronic acid. However, comprehensive studies on reactivity are often hindered by so-called “”proton ambiguity,”” which makes it impossible for the rate constants of boronic acid and boronate ion to be determined sep. Herein, we set up two reaction systems without proton ambiguity: (1) Alizarin Red S and (2) Tiron with several boronic acids (RB(OH)2) with different pKa’s and performed kinetic and equilibrium studies on the reaction systems. It was shown that the logarithms of the rate constants of RB(OH)2 and its conjugate boronate ion (RB(OH)3-) decreased and increased linearly, resp., with increasing pKa of RB(OH)2 for both systems. Consequently, the reactivities of RB(OH)2 and RB(OH)3- were reversed at high RB(OH)2 pKa. It was also shown that the bulky o-substituents of phenylboronic acids retarded the backward reactions, resulting in enhancement of the formation constants of boronic acid-catechol esters. In the experiment, the researchers used many compounds, for example, Pyridin-3-ylboronic acid(cas: 1692-25-7COA of Formula: C5H6BNO2)

Pyridin-3-ylboronic acid(cas: 1692-25-7) belongs to pyridine. Pyridine and pyridine-derived structures are privileged pharmacophores in medicinal chemistry and an essential functionality for organic chemists. As the prototypical π-deficient heterocycle, pyridine illustrates distinctive chemistry as both substrate and reagent. COA of Formula: C5H6BNO2

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Related Products of 103-74-2In 2017 ,《Semisynthesis of (-)-Rutamarin Derivatives and Their Inhibitory Activity on Epstein-Barr Virus Lytic Replication》 was published in Journal of Natural Products. The article was written by Lin, Yongsheng; Wang, Qian; Gu, Qiong; Zhang, Hongao; Jiang, Cheng; Hu, Jiayuan; Wang, Yan; Yan, Yuan; Xu, Jun. The article contains the following contents:

(+)-Rutamarin inhibits EBV lytic DNA replication with an IC50 of 7.0 μM. (-)-Chalepin, a (-)-rutamarin derivative, was isolated from the whole plant of Ruta graveolens and used as a precursor of (-)-rutamarin. Altogether, 28 (-)-rutamarin derivatives were synthesized starting from (-)-chalepin. Of these, 16 compounds were found to be more potent against EBV lytic DNA replication than (-)-chalepin. Three compounds exhibited IC50 values of 1.5, 0.32, and 0.83 μM and showed selectivity index values (SI) of 801, 211, and >120, resp. Thus, these 3 compounds are considered promising leads for further laboratory investigation. The experimental process involved the reaction of 2-(2-Hydroxyethyl)pyridine(cas: 103-74-2Related Products of 103-74-2)

2-(2-Hydroxyethyl)pyridine(cas: 103-74-2) belongs to pyridine. Pyridine and pyridine-derived structures are privileged pharmacophores in medicinal chemistry and an essential functionality for organic chemists. As the prototypical π-deficient heterocycle, pyridine illustrates distinctive chemistry as both substrate and reagent. Related Products of 103-74-2

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem