Month: October 2022

The author of 《Study of zero-field splitting in Ni(II) complexes with near octahedral geometry》 were Lomjansky, Dominik; Rajnak, Cyril; Titis, Jan; Moncol, Jan; Boca, Roman. And the article was published in Inorganica Chimica Acta in 2019. HPLC of Formula: 1134-35-6 The author mentioned the following in the article:

Four novel Ni(II) complexes, [Ni(dppmO,O)2(NCS)2] (1), [Ni(dppmO,O)3][NiCl4] (2), [Ni(dmbpy)(H2O)2Br2] (3) and [Ni(dppmO,O)3][NiCl4]·[Ni(dppm)Cl2] (4) (dppm = bis(diphenylphosphino)methane, dppmO,O = bis(diphenylphosphanoxido)methane, dmbpy = 4,4′-dimethyl-2,2′-bipyridine), were synthesized and structurally and magnetically characterized. 1 And 3 are pseudooctahedral, while 2 and 4 are unique due to the existence of hexa- or tetracoordination in two/three independent Ni(II) atoms. For hexacoordinated systems the magnetic data confirm small magnetic anisotropy expressed through the axial zero-field splitting parameter D/hc = -4.5 to +4.4 cm-1. For [NiCl4]2- tetrahedral units (in complexes 2 and 4) the magnetic anisotropy is substantially larger. Exptl. findings were confirmed by ab initio calculations and forwarded to magnetostructural D-correlations. In the experimental materials used by the author, we found 4,4′-Dimethyl-2,2′-bipyridine(cas: 1134-35-6HPLC of Formula: 1134-35-6)

4,4′-Dimethyl-2,2′-bipyridine(cas: 1134-35-6) is used as a chemical Intermediate. It can be used for the determination of ferrous and cyanide compounds.HPLC of Formula: 1134-35-6 Furthermore, 4,4′-Dimethyl-2,2′-bipyridine is used in the synthesis of a series of o-phenanthroline-substituted ruthenium(II) complexes.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

The author of 《A nickel pyridine-selenolate complex for the photocatalytic evolution of hydrogen from aqueous solutions》 were Xie, An; Tao, Yun-Wen; Peng, Cheng; Luo, Geng-Geng. And the article was published in Inorganic Chemistry Communications in 2019. Quality Control of 4,4′-Dimethyl-2,2′-bipyridine The author mentioned the following in the article:

A nickel pyridine-selenolate complex, [Ni(4,4′-dmbpy)(2-pySe)2] (1, where 4,4′-dmbpy = 4,4′-dimethyl-2,2′-bipyridine, and 2-pySe = pyridine-2-selenolate), was synthesized, and studied for photocatalytic production of H2 from aqueous solution Electrochem. studies show that the nickel complex 1 can efficiently electrocatalyze H2 evolution from weakly acidic solutions Under visible-light irradiation (λ > 420 nm), the complex 1 displays impressive H2 evolution activity with a TON of 1340 (based on a catalyst) in a noble-metal-free system, which contains fluorescein (Fl) as photosensitizer and triethylamine (TEA) as sacrificial electron donor in acetonitrile-water solution It should be noted that complex 1 is the rare example of nickel pyridine-selenolate complex as mol. photocatalyst for water reduction After reading the article, we found that the author used 4,4′-Dimethyl-2,2′-bipyridine(cas: 1134-35-6Quality Control of 4,4′-Dimethyl-2,2′-bipyridine)

4,4′-Dimethyl-2,2′-bipyridine(cas: 1134-35-6) is used as a chemical Intermediate. It can be used for the determination of ferrous and cyanide compounds.Quality Control of 4,4′-Dimethyl-2,2′-bipyridine Furthermore, 4,4′-Dimethyl-2,2′-bipyridine is used in the synthesis of a series of o-phenanthroline-substituted ruthenium(II) complexes.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

The author of 《Safety and Efficacy of NC120 for Improving Lipid Profile: A Double Blind Randomized Controlled Trial.》 were Nafrialdi, Nafrialdi; Hudyono, Johannes; Suyatna, Frans D; Setiawati, Arini. And the article was published in Acta medica Indonesiana in 2019. Recommanded Product: Picolinic acid The author mentioned the following in the article:

BACKGROUND: the use of statin to lower blood cholesterol is often associated with bothersome adverse effects such as myopathy and liver dysfunction. NC120 is herbal lipid lowering drug containing red yeast rice (RYR) extract, guggulipid, and chromium picolinate, and expected to have better safety profile. The aim of this study was to evaluate the efficacy and safety profiles of NC120 in lowering blood lipid. METHODS: this was a double blind randomized clinical trial comparing NC120 with placebo in subjects with hypercholesterolemia. Two capsules of NC120 or placebo were administered twice a day for 28 days. Blood total-cholesterol, LDL-cholesterol, and triglyceride were measured on day-0, day-7, and day-28. Unpaired t-test was used to compare study parameter between groups, and one-way ANOVA was used to compare within group. RESULTS: 25 subjects received NC120 and 24 subjects received placebo. Significant decrease of total cholesterol and LDL-cholesterol were observed since day-7 in NC120 group, while the changes in placebo group were not significant at all time of observation. No significant decrease of triglyceride was observed in NC120 group and in placebo group. Side effects were minor and comparable between the two groups. CONCLUSION: NC120 is effective in reducing total cholesterol and LDL-cholesterol, but not triglyceride. This drug shows a good safety profile, and thus can be considered for patients who can not tolerate statin drugs. The experimental process involved the reaction of Picolinic acid(cas: 98-98-6Recommanded Product: Picolinic acid)

Picolinic acid(cas: 98-98-6) is used as a chelate for alkaline earth metals. Used to prepare picolinato ligated transition metal complexes. In synthetic organic chemistry, has been used as a substrate in the Mitsunobu reaction and in the Hammick reaction.Recommanded Product: Picolinic acid

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

The author of 《Perrhenate-ions adsorption by N-substituted chitosan derivatives》 were Melchakova, O. V.; Pestov, A. V.; Pechishcheva, N. V.; Shunyaev, K. Yu.. And the article was published in Russian Chemical Bulletin in 2019. SDS of cas: 103-74-2 The author mentioned the following in the article:

A comparative study of the sorption properties of N-(2-carboxyethyl)chitosan (CEC), N-(2-sulfoethyl)chitosan (SEC), N-(2,3-dihydroxy)propyl chitosan (HPC) and N-2-(2-pyridyl)ethyl chitosan (PEC) with respect to perrhenate ions in an acidic medium was carried out. From the anal. of the adsorption isotherms and the perrhenate ion adsorption degrees as functions of pH, the efficiency of adsorbents decreases in the sequence PEC > SEC > HPC > CEC. The studied chitosan derivatives are characterized by a higher rate of sorption of perrhenate ions in comparison with known com. anionites. In the case of PEC, accompanying ions have the least effect on the sorption. After reading the article, we found that the author used 2-(2-Hydroxyethyl)pyridine(cas: 103-74-2SDS of cas: 103-74-2)

2-(2-Hydroxyethyl)pyridine(cas: 103-74-2) belongs to pyridine. Pyridine derivatives lend themselves to many roles in the spirited field of supramolecular chemistry – whether as the ligand backbone of metal-organic polymers or presiding over the key electronic stations of nanodevices. In biochemistry, pyridine-containing cofactors are necessary nutrients on which our lives depend. SDS of cas: 103-74-2

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

《Cs2CO3 Catalyzed Intramolecular Aminocarbonylation of Alkynes: Synthesis of 3-Amino-1H-inden-1-ones from N-tert-Butyl-2-(1-alkynyl)benzaldimines》 was published in Advanced Synthesis & Catalysis in 2020. These research results belong to Guo, Zhen; Liu, Tao; Liang, Xiujuan; Wu, Yuting; Yao, Tuanli. Recommanded Product: 2-Bromonicotinaldehyde The article mentions the following:

Synthesis of a wide variety of 3-amino-1H-inden-1-ones I [R1 = H, 5-F, 6-Cl, etc.; R2 = Ph, 2-MeC6H4, 4-CO2EtC6H4, etc.] from N-tert-butyl-2-(1-alkynyl)benzaldimines via intramol. aminocarbonylation of alkynes using Cs2CO3 as catalyst and air as oxidant was developed. This highly atom-efficient, transition-metal-free reaction proceeded under thermal conditions. The reaction proceeded through an unprecedented 5-exo-dig cyclization of N-tert-butyl-2-(1-alkynyl)benzaldimines and thermal rearrangement of 3-methylene-2λ2-isoindolin-1-ols was proposed.2-Bromonicotinaldehyde(cas: 128071-75-0Recommanded Product: 2-Bromonicotinaldehyde) was used in this study.

2-Bromonicotinaldehyde(cas: 128071-75-0) belongs to pyridine. Pyridine is widely used in the precursor to agrochemicals and pharmaceuticals. Also, it is used as an important reagent and organic solvent.Recommanded Product: 2-Bromonicotinaldehyde

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

《Fragment-based discovery of a new class of inhibitors targeting mycobacterial tRNA modification》 was published in Nucleic Acids Research in 2020. These research results belong to Thomas, Sherine E.; Whitehouse, Andrew J.; Brown, Karen; Burbaud, Sophie; Belardinelli, Juan M.; Sangen, Jasper; Lahiri, Ramanuj; Libardo, Mark Daben J.; Gupta, Pooja; Malhotra, Sony; Boshoff, Helena I. M.; Jackson, Mary; Abell, Chris; Coyne, Anthony G.; Blundell, Tom L.; Floto, Rodrigo Andres; Mendes, Vitor. Formula: C6H7Br2N The article mentions the following:

Translational frameshift errors are often deleterious to the synthesis of functional proteins and could therefore be promoted therapeutically to kill bacteria. TrmD (tRNA-(N(1)G37) methyltransferase) is an essential tRNA modification enzyme in bacteria that prevents +1 errors in the reading frame during protein translation and represents an attractive potential target for the development of new antibiotics. Here, we describe the application of a structure-guided fragment-based drug discovery approach to the design of a new class of inhibitors against TrmD in Mycobacterium abscessus. Fragment library screening, followed by structure-guided chem. elaboration of hits, led to the rapid development of drug-like mols. with potent in vitro TrmD inhibitory activity. Several of these compounds exhibit activity against planktonic M. abscessus and M. tuberculosis as well as against intracellular M. abscessus and M. leprae, indicating their potential as the basis for a novel class of broad-spectrum mycobacterial drugs. In addition to this study using 2-(Bromomethyl)pyridine hydrobromide, there are many other studies that have used 2-(Bromomethyl)pyridine hydrobromide(cas: 31106-82-8Formula: C6H7Br2N) was used in this study.

2-(Bromomethyl)pyridine hydrobromide(cas: 31106-82-8) belongs to pyridine. Pyridine is widely used in the precursor to agrochemicals and pharmaceuticals. Also, it is used as an important reagent and organic solvent.Formula: C6H7Br2N

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

《In Situ Ring-Closing Strategy for Direct Synthesis of N-Heterocyclic Carbene Nickel Complexes and Their Application in Coupling of Allylic Alcohols with Aryl Boronic Acids》 was published in Advanced Synthesis & Catalysis in 2020. These research results belong to Wang, Yu-Bin; Liu, Bin-Yuan; Bu, Qingqing; Dai, Bin; Liu, Ning. Synthetic Route of C5H3Br2N The article mentions the following:

An in situ ring-closing strategy was developed for the synthesis of N-heterocyclic carbene nickel complexes, e.g., I. The process was carried out in air, and did not require solvent purification The resulting nickel complexes were investigated as catalysts for the coupling of allylic alcs. RCH=CHCH(OH)R1 (R = H, Me, phenyl; R1 = Me, Ph, thiophen-3-yl, etc.) with aryl boronic acids R2B(OH)2 (R2 = 4-methoxyphenyl, thiophen-3-yl, naphthalen-2-yl, etc.). A wide range of allylic substrates and aryl acids proved to be applicable to this catalytic system. Control experiments suggest that the Ni(0) may be the true active species in the coupling reactions. The results came from multiple reactions, including the reaction of 2,6-Dibromopyridine(cas: 626-05-1Synthetic Route of C5H3Br2N)

2,6-Dibromopyridine(cas: 626-05-1) belongs to pyridine. In industry and in the lab, pyridine is used as a reaction solvent, particularly when its basicity is useful, and as a starting material for synthesizing some herbicides, fungicides, and antiseptics.Synthetic Route of C5H3Br2N

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

《Iridium(III)-Catalyzed Tandem Annulation of Pyridine-Substituted Anilines and α-Cl Ketones for Obtaining 2-Arylindoles》 was published in Journal of Organic Chemistry in 2020. These research results belong to Cui, Xin-Feng; Qiao, Xin; Wang, He-Song; Huang, Guo-Sheng. Recommanded Product: 3510-66-5 The article mentions the following:

A facile and expeditious protocol for the synthesis of 2-arylindole compounds from readily available N-(2-pyridyl)anilines and com. available α-Cl ketones through iridium-catalyzed C-H activation and cyclization is reported here. As a complementary approach to the conventional strategies for indole synthesis, the transformation exhibits powerful reactivity, tolerates a large number of functional groups, and proceeds with good to excellent yields under mild conditions, providing a straightforward method to obtain structurally diverse and valuable indole scaffolds. Furthermore, the reaction could be easily scaled up to gram scale. In the part of experimental materials, we found many familiar compounds, such as 2-Bromo-5-methylpyridine(cas: 3510-66-5Recommanded Product: 3510-66-5)

2-Bromo-5-methylpyridine(cas: 3510-66-5) belongs to pyridine. In industry and in the lab, pyridine is used as a reaction solvent, particularly when its basicity is useful, and as a starting material for synthesizing some herbicides, fungicides, and antiseptics.Recommanded Product: 3510-66-5

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

《Asymmetric Synthesis of Multifunctionalized 2,3-Benzodiazepines by a One-pot N-Heterocyclic Carbene/Chiral Palladium Sequential Catalysis》 was published in Journal of Organic Chemistry in 2020. These research results belong to Ding, Ya-Li; Zhao, Yun-Long; Niu, Shuang-Shuo; Wu, Pei; Cheng, Ying. Computed Properties of C6H4BrNO The article mentions the following:

The first example of the construction of chiral 2,3-benzodiazepine compounds which are of biol. and pharmaceutical relevance by asym. catalysis is reported. Catalyzed by a thiazolium derived carbene and a palladium-chiral bidentate phosphine complex in sequence, one-pot reaction between 1-(2-(2-nitrovinyl)aryl)allyl esters with azodicarboxylates took place efficiently at ambient temperature to produce 4-nitro-1-vinyl-1H-2,3-benzodiazepine-2,3-dicarboxylates I (R = Me, Et, iPr; Z = C, N; X, Y = H, Me, Cl, etc.) in good to excellent yields with an enantiomeric ratio up to 95 : 5. In the part of experimental materials, we found many familiar compounds, such as 2-Bromonicotinaldehyde(cas: 128071-75-0Computed Properties of C6H4BrNO)

2-Bromonicotinaldehyde(cas: 128071-75-0) belongs to pyridine. Pyridine’s structure is isoelectronic with that of benzene, but its properties are quite different. Pyridine is completely miscible with water, whereas benzene is only slightly soluble. Like all hydrocarbons, benzene is neutral (in the acid–base sense), but because of its nitrogen atom, pyridine is a weak base.Computed Properties of C6H4BrNO

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

《Tryptophan metabolite concentrations in depressed patients before and after electroconvulsive therapy》 was published in Brain, Behavior, and Immunity in 2020. These research results belong to Ryan, Karen M.; Allers, Kelly A.; McLoughlin, Declan M.; Harkin, Andrew. Recommanded Product: Picolinic acid The article mentions the following:

Tryptophan and kynurenine pathway (KP) metabolites are implicated in the pathophysiol. of depression. We aimed to investigate their plasma concentrations in medicated patients with depression (n = 94) compared to age- and sex-matched healthy controls (n = 57), and in patients with depression after electroconvulsive therapy (ECT) in a real-world clin. setting, taking account of co-variables including ECT modality and heterogenous psychopathol. Depression severity was assessed using the Hamilton Depression Rating Scale (HAM-D24). Tryptophan (TRP) and kynurenine (KYN) metabolite concentrations [anthranilic acid (AA), 3-hydroxyanthranilic acid (3HAA), picolinic acid (PA), kynurenic acid (KYNA), and xanthurenic acid (XA)] and KYNA/KYN and KYNA/quinolinic acid (QUIN) ratios were lower in patients compared to controls. For the total group there was no significant change in KP metabolites post-ECT or correlations with mood ratings. However, improvements in mood score were correlated with increased KYN, 3-hydroxykynurenine (3HK), 3HAA, QUIN, and KYN/TRP in a subgroup of unipolar depressed patients. Addnl., in remitters baseline KYN, 3HK, and QUIN were associated with baseline HAM-D24 scores, and changes in 3HK and 3HAA concentrations post-ECT correlated with improvement in mood. KYN, KYNA, AA, 3HK, XA, PA, and QUIN were increased in a smaller 3-mo follow-up group (n = 19) compared to pre-ECT concentrations Overall, the results indicate that ECT mobilizes the KP, where a moderate association between selected metabolites and treatment response in unipolar depressed patients is evident. In the experiment, the researchers used Picolinic acid(cas: 98-98-6Recommanded Product: Picolinic acid)

Picolinic acid(cas: 98-98-6) is used in the preparation of 2-Aminodihydro[1,3]thiazines as BACE 2 inhibitors and their preparation and use in the treatment of diabetes.Recommanded Product: Picolinic acid

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem