Month: October 2022

Product Details of 1692-25-7In 2021 ,《Supramolecular Engineering Strategy to Construct BODIPY-Based White Light Emission Materials》 was published in Chemistry – An Asian Journal. The article was written by Li, Fang-Zhou; Zhou, Liang-Liang; Kuang, Gui-Chao. The article contains the following contents:

Two kinds of 4,4-difluoro-4-bora-3a,4a-diaza-s-indacene (BODIPY) dyads BDP-OH containing 4-hydroxystyrene groups and BDP-PY bearing pyridinyl units were prepared In addition, a naphthalene derivative NAP-PY modified by pyridinyl moieties substituent was made. The above three dyads could be used to construct white-light emission (WLE) material by a supramol. engineering strategy due to their three primary colors of blue, green and red. The supramol. correlations between the hydroxyl group of BDP-OH and the pyridinyl groups of NAP-PY and BDP-PY were confirmed by 1H NMR titration, 2D NOESY and FTIR. A fluorescence monitor application was carried out based on the realization of WLE. This work might be useful for designing other WLE supramol. systems and image display. In the experiment, the researchers used many compounds, for example, Pyridin-3-ylboronic acid(cas: 1692-25-7Product Details of 1692-25-7)

Pyridin-3-ylboronic acid(cas: 1692-25-7) belongs to pyridine. Pyridines, quinolines, and isoquinolines have found a function in almost all aspects of organic chemistry. Pyridine has found use as a solvent, base, ligand, functional group, and molecular scaffold. As structural elements, these moieties are potent electron-deficient groups, metal-directing functionalities, fluorophores, and medicinally important pharmacophores. Product Details of 1692-25-7

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

《Photoredox Catalytic Trifluoromethylation and Perfluoroalkylation of Arenes Using Trifluoroacetic and Related Carboxylic Acids》 was written by Yin, Dehang; Su, Dengquan; Jin, Jian. Safety of Methyl 6-oxo-1-phenyl-1,6-dihydropyridine-3-carboxylate And the article was included in Cell Reports Physical Science on August 26 ,2020. The article conveys some information:

Here, a mild and practical method that allows for the direct C-H trifluoromethylation, perfluoroalkylation, and chlorodifluoromethylation of (hetero)arenes such as mesitylene, 1-tosyl-1H-pyrrole, N-(thiophen-3-yl)acetamide, etc. using TFA and the related carboxylic acids RC(O)OH (R = CF3, C5F11, CF2Cl, etc.) was reported. A diverse array of arenes and heteroarenes was successfully transformed into valued fluoroalkylated compounds e.g., I. The combination of photoredox catalysis and a bis(4-chlorophenyl) sulfoxide provides a platform for the facile generation of fluoroalkyl radicals from the corresponding fluoroalkyl carboxylic acids under mild conditions. After reading the article, we found that the author used Methyl 6-oxo-1-phenyl-1,6-dihydropyridine-3-carboxylate(cas: 77837-09-3Safety of Methyl 6-oxo-1-phenyl-1,6-dihydropyridine-3-carboxylate)

Methyl 6-oxo-1-phenyl-1,6-dihydropyridine-3-carboxylate(cas: 77837-09-3) belongs to pyridine derivatives. The ring atoms in the pyridine molecule are sp2-hybridized. The nitrogen is involved in the π-bonding aromatic system using its unhybridized p orbital. Safety of Methyl 6-oxo-1-phenyl-1,6-dihydropyridine-3-carboxylate Pyridine has a conjugated system of six π electrons that are delocalized over the ring.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

《Surface-Enhanced Counter Electrode Materials for the Fabrication of Ultradurable Electrochromic Devices》 was written by Ahmad, Rana; DiPalo, Vittoria-Ann; Bell, Mackenzie; Ebralidze, Iraklii I.; Zenkina, Olena V.; Easton, E. Bradley. Quality Control of 4′-(4-Pyridyl)-2,2′:6′,2”-terpyridine And the article was included in ACS Applied Energy Materials on April 25 ,2022. The article conveys some information:

Electrochromic devices (ECDs) and especially electrochromic supercapacitors, where the real-time state of charge is indicated by the color, have a wide range of applications. However, to meet modern challenges, these devices should demonstrate exceptional charge-discharge durability. In this work, we demonstrate that electrochem. cycling stability of ECDs based on a monolayer of 4′-(4-pyridyl)-2,2′:6′,2′′-terpyridine-iron(II) complex that was covalently linked to the working electrode (WE) can be drastically enhanced by a proper design of the counter electrode (CE). Enhancing the surface area of the flat indium tin oxide (ITO) CE by a layer of screen-printed ITO nanoparticles results in an ECD that upon continuous spectro-electrochem. switching for 600 cycles demonstrates negligible deterioration of the change in optical d. The enhanced surface area of the CE significantly diminishes the electrode and gel electrolyte degradation and allows us to gain fundamental insight into the pathway of degradation of the electrochromic mols. at the WE. During prolonged cycling (20,000 and 50,000 cycles), the overall total resistance of ECDs remains fairly unchanged, while the capacitance decreases due to a loss of the pseudocapacitive component associated with electrochromic mols. XPS suggests that this loss is likely due to the cleavage of the linkage C-N+ bond followed by the dissolution of the entire metal complex mol. into the electrolyte. In the experiment, the researchers used 4′-(4-Pyridyl)-2,2′:6′,2”-terpyridine(cas: 112881-51-3Quality Control of 4′-(4-Pyridyl)-2,2′:6′,2”-terpyridine)

4′-(4-Pyridyl)-2,2′:6′,2”-terpyridine(cas: 112881-51-3) belongs to pyridine derivatives. The ring atoms in the pyridine molecule are sp2-hybridized. The nitrogen is involved in the π-bonding aromatic system using its unhybridized p orbital. Quality Control of 4′-(4-Pyridyl)-2,2′:6′,2”-terpyridineThe lone pair is in an sp2 orbital, projecting outward from the ring in the same plane as the σ bonds.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

《Synthesis, DFT calculations and molecular docking study of mixed ligand metal complexes containing 4,4′-dimethyl-2,2′-bipyridyl as α-glucosidase inhibitors》 was written by Avci, Davut; Alturk, Sumeyye; Sonmez, Fatih; Tamer, Omer; Basoglu, Adil; Atalay, Yusuf; Kurt, Belma Zengin. HPLC of Formula: 1134-35-6This research focused ontransition metal dimethylbipyridyl methylpyridinecarboxylato complex preparation DFT glucosidase inhibitor. The article conveys some information:

Novel mixed ligand metal complexes including 4,4′-dimethyl-2,2′-bipyridyl (dmdpy) and 6-methylpyridine-2-carboxylic acid (6-mpaH) {[VO(6-mpa)(dmdpy)]·SO3, (1), [Fe(6-mpa)(dmdpy)(NO3)2]·NO3, (2), Ni(6-mpa)(dmdpy)Cl2, (3), [Zn(6-mpa)(dmdpy)Cl2]·H2O, (4), Cd(6-mpa)2(dmdpy), (5), [Hg(6-mpa)(dmdpy)(NO3)2]·H2O, (6)} were synthesized as potential α-glucosidase inhibitors. Their structural characterizations, vibrational and electronic spectral behaviors were investigated by elemental anal., LC-MS/MS, FTIR and UV-visible spectroscopic techniques. The inhibitory activities of these complexes against α-glucosidase (from Saccharomyces cerevisiae, EC No: 3.2.1.20) were determined The synthesized complexes 1-6 exhibited α-glucosidase inhibitory activity with the IC50 values ranging from 0.4699 to >600μM. Besides, d. functional theory (DFT) calculations in the mode of hybrid HSEh1PBE method with 6-311G(d,p) and LanL2DZ basis sets for optimal complex geometries were fulfilled to obtain the vibrational frequencies and electronic spectral behaviors as well as substantial contributions to the electronic transitions. Also, the mol. docking study was performed to examine protein-ligand interactions between the synthesized complexes (1-6) and target protein (the template structure S. cerevisiae isomaltase (PDBID: 3A4A)). In the experimental materials used by the author, we found 4,4′-Dimethyl-2,2′-bipyridine(cas: 1134-35-6HPLC of Formula: 1134-35-6)

4,4′-Dimethyl-2,2′-bipyridine(cas: 1134-35-6) is used in the synthesis of a series of o-phenanthroline-substituted ruthenium(II) complexes.HPLC of Formula: 1134-35-6 Furthermore, 4,4′-Dimethyl-2,2′-bipyridine is used as a chemical Intermediate. It can be used for the determination of ferrous and cyanide compounds.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

《Unravelling the structural-electronic impact of arylamine electron-donating antennas on the performances of efficient ruthenium sensitizers for dye-sensitized solar cells》 was written by Chen, Wang-Chao; Kong, Fan-Tai; Ghadari, Rahim; Li, Zhao-Qian; Guo, Fu-Ling; Liu, Xue-Peng; Huang, Yang; Yu, Ting; Hayat, Tasawar; Dai, Song-Yuan. Recommanded Product: 138219-98-4 And the article was included in Journal of Power Sources on April 1 ,2017. The article conveys some information:

We report a systematic research to understand the structural-electronic impact of the arylamine electron-donating antennas on the performances of the ruthenium complexes for dye-sensitized solar cells. Three ruthenium complexes functionalized with different arylamine electron-donating antennas (N,N-diethyl-aniline in RC-31, julolidine in RC-32 and N,N-dibenzyl-aniline in RC-36) are designed and synthesized. The photoelec. properties of RC dyes exhibit apparent discrepancy, which are ascribed to different structural nature and electronic delocalization ability of these arylamine electron-donating system. In conjunction with TiO2 microspheres photoanode and a typical coadsorbent DPA, the devices sensitized by RC-36 achieve the best conversion efficiency of 10.23%. The UV-Vis absorption, electrochem. measurement, incident photon-to-current conversion efficiency and transient absorption spectra confirm that the excellent performance of RC-36 is induced by synergistically structural-electronic impacts from enhanced absorption capacity and well-tuned electronic characteristics. These observations provide valuable insights into the mol. engineering methodol. based on fine tuning structural-electronic impact of electron-donating antenna in efficient ruthenium sensitizers. The experimental part of the paper was very detailed, including the reaction process of 4,4′-Bis(chloromethyl)-2,2′-bipyridine(cas: 138219-98-4Recommanded Product: 138219-98-4)

4,4′-Bis(chloromethyl)-2,2′-bipyridine(cas: 138219-98-4) belongs to pyridine derivatives. The ring atoms in the pyridine molecule are sp2-hybridized. The nitrogen is involved in the π-bonding aromatic system using its unhybridized p orbital. Recommanded Product: 138219-98-4 Pyridine has a conjugated system of six π electrons that are delocalized over the ring.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

《Visible-Light-Induced Intermolecular Dearomative Cyclization of Furans: Synthesis of 1-Oxaspiro[4.4]nona-3,6-dien-2-one》 was written by Dong, Wuheng; Yuan, Yao; Gao, Xiaoshuang; Keranmu, Miladili; Li, Wanfang; Xie, Xiaomin; Zhang, Zhaoguo. Recommanded Product: fac-Tris(2-phenylpyridine)iridiumThis research focused onvisible light intermol dearomative cyclization furan iridium catalyst alkyne; spirolactone preparation. The article conveys some information:

A fac-Ir(ppy)3-catalyzed intermol. dearomative cyclization of 2-bromo-2-((5-bromofuran-2-yl)methyl)malonate and alkynes affording substituted spirolactones, e.g. I, in yields of 19-91% via a 5-exo-dig radical cyclization under visible light is presented. This method provides a new access to the synthesis of spirocycle skeletons applying water as an external oxygen source under mild reaction conditions. In the experiment, the researchers used fac-Tris(2-phenylpyridine)iridium(cas: 94928-86-6Recommanded Product: fac-Tris(2-phenylpyridine)iridium)

fac-Tris(2-phenylpyridine)iridium(cas: 94928-86-6) belongs to pyridine. Pyridine-based materials are valued for their optical and physical properties as well as their medical potential. Additionally, pyridine-based natural products continue to be discovered and studied for their properties and to understand their biosynthesis.Recommanded Product: fac-Tris(2-phenylpyridine)iridium

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Arnold, Eric P.; Mondal, Prolay K.; Schmitt, Daniel C. published an article on January 13 ,2020. The article was titled 《Oxidative Cyclization Approach to Benzimidazole Libraries》, and you may find the article in ACS Combinatorial Science.Reference of 4-Amino-2-picoline The information in the text is summarized as follows:

An efficient approach to the parallel synthesis of benzimidazoles from anilines is described. Library approaches to vary the N1 and C2 vectors of benzimidazoles are well established; however, C4-C7 variation has traditionally relied on 1,2-dianiline building blocks, providing limited chem. space coverage. We have developed an amidine formation/oxidative cyclization sequence that enables anilines as a diversity set for benzimidazole C4-C7 SAR generation in parallel format. The amidine annulation was achieved using PIDA or Cu-mediated oxidation to access both N-H and N-alkyl benzimidazoles. This library protocol has now been utilized for analog production in four medicinal chem. projects. Addnl., the synthesis of aza-benzimidazoles from aminopyridines was achieved via an analogous sequence. After reading the article, we found that the author used 4-Amino-2-picoline(cas: 18437-58-6Reference of 4-Amino-2-picoline)

4-Amino-2-picoline(cas: 18437-58-6) belongs to anime. Reaction with nitrous acid (HNO2), which functions as an acylating agent that is a source of the nitrosyl group (―NO), converts aliphatic primary amines to nitrogen and mixtures of alkenes and alcohols corresponding to the alkyl group in a complex process. This reaction has been used for analytical determination of primary amino groups in a procedure known as the Van Slyke method.Reference of 4-Amino-2-picoline

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

In 2015,Jornet-Molla, Veronica; Romero, Francisco M. published 《Synthesis of rigid ethynyl-bridged polytopic picolinate ligands for MOF applications》.Tetrahedron Letters published the findings.Safety of Methyl 5-bromopicolinate The information in the text is summarized as follows:

Segmented homopolytopic ligands that consist of a rigid central arylene platform, ethynylene spacers, and terminal chelating picolinate subunits have been synthesized in good yields in a two-step procedure involving a Sonogashira-type cross coupling reaction between the ester Me 5-bromopyridine-2-carboxylate and several arylacetylenes, followed by hydrolysis of the resulting Me picolinates [e.g., Me 5-bromopyridine-2-carboxylate + 1,4-diethynylbenzene followed by hydrolysis afforded ligand I]. A similar strategy has been employed for the preparation of heteroditopic ligands containing picolinate and a second non-chelating pyridine or benzoate unit. The compounds are potential candidates for organic linkers in metal-organic frameworks (MOFs). The results came from multiple reactions, including the reaction of Methyl 5-bromopicolinate(cas: 29682-15-3Safety of Methyl 5-bromopicolinate)

Methyl 5-bromopicolinate(cas: 29682-15-3) belongs to pyridine. Pyridine is very deactivated towards electrophilic substitution with respect to benzene. For this reason classical formylation, using methods such as the Gattermann or Vilsmeier reactions, are not generally successful. Safety of Methyl 5-bromopicolinate

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

In 2016,McKinney, David C.; Eyermann, Charles J.; Gu, Rong-Fang; Hu, Jun; Kazmirski, Steven L.; Lahiri, Sushmita D.; McKenzie, Andrew R.; Shapiro, Adam B.; Breault, Gloria published 《Antibacterial FabH Inhibitors with Mode of Action Validated in Haemophilus influenzae by in Vitro Resistance Mutation Mapping》.ACS Infectious Diseases published the findings.Synthetic Route of C5H3BrClN The information in the text is summarized as follows:

Fatty acid biosynthesis is essential to bacterial growth in Gram-neg. pathogens. Several small mols. identified through a combination of high-throughput and fragment screening were cocrystd. with FabH (β-ketoacyl-acyl carrier protein synthase III) from Escherichia coli and Streptococcus pneumoniae. Structure-based drug design was used to merge several scaffolds to provide a new class of inhibitors. After optimization for Gram-neg. enzyme inhibitory potency, several compounds demonstrated antimicrobial activity against an efflux-neg. strain of Haemophilus influenzae. Mutants resistant to these compounds had mutations in the FabH gene near the catalytic triad, validating FabH as a target for antimicrobial drug discovery.5-Bromo-2-chloropyridine(cas: 53939-30-3Synthetic Route of C5H3BrClN) was used in this study.

5-Bromo-2-chloropyridine(cas: 53939-30-3) belongs to pyridine. Pyridine is very deactivated towards electrophilic substitution with respect to benzene. For this reason classical formylation, using methods such as the Gattermann or Vilsmeier reactions, are not generally successful. Synthetic Route of C5H3BrClN

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

In 2017,Ma, Xiantao; Yu, Lei; Su, Chenliang; Yang, Yaqi; Li, Huan; Xu, Qing published 《Efficient Generation of C-S Bonds via a By-Product-Promoted Selective Coupling of Alcohols, Organic Halides, and Thiourea》.Advanced Synthesis & Catalysis published the findings.Recommanded Product: 53939-30-3 The information in the text is summarized as follows:

A metal- and base-free three-component coupling of alcs., heteroaryl halides, and thiourea has been developed for direct and selective synthesis of heteroaryl thioethers. This method can be easily scaled up to the gram scale and extended to dialkyl thioethers, heteroaryl selenides, benzothiazoles, and some antimycobacterially-active thioethers. Mechanistic studies revealed that a byproduct-promoted in situ C-O activation of alcs. to more reactive alkyl halides and slow release of the thiol and alkyl halide intermediates are the key to the high selectivity and success of the reaction. The results came from multiple reactions, including the reaction of 5-Bromo-2-chloropyridine(cas: 53939-30-3Recommanded Product: 53939-30-3)

5-Bromo-2-chloropyridine(cas: 53939-30-3) belongs to pyridine. Pyridine is widely used in the precursor to agrochemicals and pharmaceuticals. Also, it is used as an important reagent and organic solvent.Recommanded Product: 53939-30-3

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem