Month: October 2022

In 2017,Yasue, Risa; Miyauchi, Masaru; Yoshida, Kazuhiro published 《Planar Chiral Cyclic (Amino)(ferrocenyl)carbene as Ligand for Transition Metals》.Advanced Synthesis & Catalysis published the findings.Reference of 2-(Bromomethyl)pyridine hydrobromide The information in the text is summarized as follows:

Planar chiral ferrocene-fused iminium salts were synthesized in enantiomerically pure form. The novel planar chiral cyclic (amino)(ferrocenyl)carbene successfully generated from such salt was subjected to carbene trapping experiments with sulfur and copper chloride. The utility of the carbene as a chiral ligand for transition metals was preliminarily demonstrated in the copper-catalyzed enantioselective β-boration of an α,β-unsaturated ester. After reading the article, we found that the author used 2-(Bromomethyl)pyridine hydrobromide(cas: 31106-82-8Reference of 2-(Bromomethyl)pyridine hydrobromide)

2-(Bromomethyl)pyridine hydrobromide(cas: 31106-82-8) belongs to pyridine. Pyridine derivatives lend themselves to many roles in the spirited field of supramolecular chemistry – whether as the ligand backbone of metal-organic polymers or presiding over the key electronic stations of nanodevices. In biochemistry, pyridine-containing cofactors are necessary nutrients on which our lives depend. Reference of 2-(Bromomethyl)pyridine hydrobromide

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

In 2019,Bioorganic Chemistry included an article by Benchekroun, Mohamed; Pachon-Angona, Irene; Luzet, Vincent; Martin, Helene; Oset-Gasque, Maria-Jesus; Marco-Contelles, Jose; Ismaili, Lhassane. SDS of cas: 128071-75-0. The article was titled 《Synthesis, antioxidant and Aβ anti-aggregation properties of new ferulic, caffeic and lipoic acid derivatives obtained by the Ugi four-component reaction》. The information in the text is summarized as follows:

We report herein the synthesis antioxidant and Aβ anti-aggregation capacity of (E)-N-benzyl-N-[2-(benzylamino)-2-oxoethyl]-3-(aryl)acrylamides and related (R)-N-benzyl-N-(2-(benzylamino)-2-oxoethyl)-5-(1,2-dithiolan-3-yl)pentanamides 1-12. These compounds have been obtained, via Ugi four-component reaction, from modest to good yields. Their antioxidant anal., using the DPPH and ORAC assays, allowed us to identify compounds 8 and 9, as potent antioxidant agents, showing also strong Aβ1-40 self-aggregation inhibition, two biol. properties of interest in pathologies linked to the oxidative stress, such as Alzheimer’s disease. In the experimental materials used by the author, we found 2-Bromonicotinaldehyde(cas: 128071-75-0SDS of cas: 128071-75-0)

2-Bromonicotinaldehyde(cas: 128071-75-0) belongs to pyridine. In industry and in the lab, pyridine is used as a reaction solvent, particularly when its basicity is useful, and as a starting material for synthesizing some herbicides, fungicides, and antiseptics.SDS of cas: 128071-75-0

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

In 2019,ACS Applied Materials & Interfaces included an article by Yu, Ziwei; Zhang, Jiaxin; Liu, Shihao; Zhang, Letian; Zhao, Yi; Zhao, Hongyu; Xie, Wenfa. Electric Literature of C5H3Br2N. The article was titled 《High-Efficiency Blue Phosphorescent Organic Light-Emitting Devices with Low Efficiency Roll-Off at Ultrahigh Luminance by the Reduction of Triplet-Polaron Quenching》. The information in the text is summarized as follows:

High-performance phosphorescent organic light-emitting devices (PhOLEDs) at high luminance are still a remaining problem that needs to be solved, especially blue PhOLEDs. (5-(5-9H-Carbazol-9-yl)pyridin-2-yl)-8-(9H-carbazol-9-yl)-5H-pyrido[3,2-b]indole (p2PCB2CZ) with excellent characteristics as a host is designed to realize a novel host-guest system without hole trapping effect in blue PhOLEDs. The device in which p2PCB2CZ and FIrpic is used as host and guest, resp., is proposed to improve the performances of blue PhOLEDs at high luminance, especially at ultrahigh luminance (>30000 cd/m2). The maximum external quantum efficiency (EQE) of this type of blue PhOLEDs is 19.2%, while the maximum EQE of the reference blue PhOLEDs is 18.7%. Nevertheless, the p2PCB2CZ-based devices exhibit significant advantages at high luminance, because its EQE still attains to 10.8% even when the luminance increases to 30000 cd/m2, which is 1.67 times that of the reference device. From measurements based on steady-state and time-resolved spectroscopies, the reduction of triplet-polaron quenching in p2PCB2CZ-based devices is the main reason for improving the performances of blue PhOLEDs at high luminance. In the experimental materials used by the author, we found 2,5-Dibromopyridine(cas: 624-28-2Electric Literature of C5H3Br2N)

2,5-Dibromopyridine(cas: 624-28-2) belongs to pyridine. Pyridine’s structure is isoelectronic with that of benzene, but its properties are quite different. Pyridine is completely miscible with water, whereas benzene is only slightly soluble. Like all hydrocarbons, benzene is neutral (in the acid–base sense), but because of its nitrogen atom, pyridine is a weak base.Electric Literature of C5H3Br2N

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

In 2019,Journal of Organic Chemistry included an article by Zhang, Yu-Fang; Duan, Wen-Di; Chen, Jingjing; Hu, Youhong. Safety of 4-Ethynylpyridine. The article was titled 《Base-Promoted Cascade Reactions of 3-(1-Alkynyl)chromones with Pyridinium Ylides to Chromeno[2,3-d]azepine Derivatives》. The information in the text is summarized as follows:

A base-promoted cascade reaction of 3-(1-alkynyl)chromones with pyridinium ylides has been developed to afford a novel chromeno[2,3-d]azepine scaffold in an efficient and economic manner. This tandem process involves multiple reactions including a Michael addition/deprotonation/alkyne-allene isomerization/cyclization and the subsequent 1,2-addition under mild conditions without a transition metal catalyst. In the part of experimental materials, we found many familiar compounds, such as 4-Ethynylpyridine(cas: 2510-22-7Safety of 4-Ethynylpyridine)

4-Ethynylpyridine(cas: 2510-22-7) belongs to pyridine. Pyridines are often used as catalysts or reagents; particular notice has been paid recently to how pyridine coordinates to metal centers enabling a wide range of valuable reactions. Safety of 4-Ethynylpyridine

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

The author of 《Synthesis of Functionalized Spirocyclic Indolines by Visible Light-Induced One-Pot Sequential Difluoromethylative Dearomatization, Hydroxylation, and Substitution Reactions》 were Wang, Qiang; Qu, Yi; Liu, Yuxiu; Song, Haibin; Wang, Qingmin. And the article was published in Advanced Synthesis & Catalysis in 2019. Name: fac-Tris(2-phenylpyridine)iridium The author mentioned the following in the article:

Herein an one-pot protocol for visible light-induced synthesis of functionalized spirocyclic indolines I [R = P(O)Ph2, 2-pyrrolyl, 3-indolyl, etc.; R1 = H, 5-F, 6-Me, etc.] was described under mild conditions by means of a process involving sequential difluoromethylative dearomatization, hydroxylation and substitution reactions of indole derivatives The transformation proceeded via a hydroxylated “”acetal pool”” intermediate that could react with various nucleophiles. Several of the phosphine-oxide and indole-substituted products showed good fungicidal activity, suggesting that this protocol might be useful in the agrochem. field. The results came from multiple reactions, including the reaction of fac-Tris(2-phenylpyridine)iridium(cas: 94928-86-6Name: fac-Tris(2-phenylpyridine)iridium)

fac-Tris(2-phenylpyridine)iridium(cas: 94928-86-6) belongs to pyridine. Pyridine is very deactivated towards electrophilic substitution with respect to benzene. For this reason classical formylation, using methods such as the Gattermann or Vilsmeier reactions, are not generally successful. Name: fac-Tris(2-phenylpyridine)iridium

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

The author of 《Visible-Light-Mediated Stereoselective 1,2-Iodoalkylation of Alkynes》 were Liu, Jie-Jie; Lan, Ling; Gao, Yu-Ting; Liu, Qi; Cheng, Liang; Wang, Dong; Liu, Li. And the article was published in Advanced Synthesis & Catalysis in 2019. Formula: C7H5N The author mentioned the following in the article:

A visible-light-mediated and photocatalyst/initiator-free addition to alkynes to afford iodo-substituted alkenyl derivatives I [R1 = n-Pr, Ph, 3-pyridyl, etc.; R = H, Me, n-Pr, etc.] and e.g. II were developed. An atom transfer radical addition mechanistic afforded a broad scope of valuable compounds I and e.g. II with high E/Z-selectivities, which were versatile intermediates for the synthesis of various tri- and tetra- substituted alkenes. In the part of experimental materials, we found many familiar compounds, such as 4-Ethynylpyridine(cas: 2510-22-7Formula: C7H5N)

4-Ethynylpyridine(cas: 2510-22-7) belongs to pyridine. Pyridine is a relatively complex molecule and exhibits a number of different bands in IR spectra. Among others, the bands characterizing the ν8a and ν19b modes have been found to be sensitive to the coordination or protonation of the molecule. Note that the band that is diagnostic for the PyH+ ion at about 1545 cm− 1 (ν19b mode) does not overlap with any of the other bands.Formula: C7H5N

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

The author of 《Smart Responsive Luminescent Aptamer-Functionalized Covalent Organic Framework Hydrogel for High-Resolution Visualization and Security Protection of Latent Fingerprints》 were Hai, Jun; Wang, Hao; Sun, Panpan; Li, Tianrong; Lu, Siyu; Zhao, Yang; Wang, Baodui. And the article was published in ACS Applied Materials & Interfaces in 2019. Synthetic Route of C12H13N3 The author mentioned the following in the article:

Covalent organic frameworks (COFs) have been proposed as alternative candidates for “”smart”” materials due to its ordered π-columnar structures. However, it remains a challenge to develop external-stimuli-responsive luminescent COFs for confidential information protection. Here we have designed and synthesized a water-dispersible and smart responsive luminescent CM-cellulose (CMC)-COF-LZU1 hydrogel with encapsulated 5-(Dimethylamino)-N,N-bis (pyridin-2-ylmethyl) naphthalene-1-sulfonamide (DPYNS), named CMC-COF-LZU1⊃DPYNS, for LFP imaging and encryption. We show that the fluorescence of CMC-COF-LZU1⊃DPYNS is reversibly switchable upon addition of Cu2+/H2O. This effect endows potential applications of tunable luminescent COFs based hydrogel as an invisible security probe for imaging, record, storage, and security of latent fingerprint information. It is shown that the latent fingerprint information incubated by the CMC-COF-LZU1⊃DPYNS hydrogel is invisible in the presence of Cu2+, but three levels of fingerprint features with high-resolution patterns can be readable upon addition of H2O under UV light. The design strategy provides a promising platform for the development of smart responsive luminescent COFs and their detection and protection of valuable LFP information. The results came from multiple reactions, including the reaction of Bis(pyridin-2-ylmethyl)amine(cas: 1539-42-0Synthetic Route of C12H13N3)

Bis(pyridin-2-ylmethyl)amine(cas: 1539-42-0) is a secondary amine with two picolyl substituents. As a tridentate ligand this compound provides three nitrogen donors that affords good selectivity for Zn2+ over biologically relevant metals such as Na+, K+, Mg2+ and Ca2+, and leaves coordination sites free for anion binding. Synthetic Route of C12H13N3

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

The author of 《MIL-101 supported highly active single-site metal catalysts for tricomponent coupling》 were Sun, Weng-Jie; Gao, En-Qing. And the article was published in Applied Catalysis, A: General in 2019. Application In Synthesis of 4-Ethynylpyridine The author mentioned the following in the article:

Metal-organic frameworks with regular pore structures provide powerful platforms for the design of single-site metal catalysts for chem. transformation. In this paper, we develop a facile, stable and recyclable MOF-supported Cu(II) catalyst, MIL-101-SO3Cu. It shows extremely high activity for the A3 coupling of alkynes, aldehydes and amines. The turnover frequency can reach 6.8 × 105 h-1 under neat conditions, which is the highest so far reported for the reaction. The high activity is because the specific structure of the MIL-101-SO3 support enables a single-site dispersion and an unhindered open environment for the metal ion. MIL-101-SO3Cu also exhibits high activity for the one-pot cascade reactions combining A3 coupling and 5-endo-dig cyclization. In the experiment, the researchers used many compounds, for example, 4-Ethynylpyridine(cas: 2510-22-7Application In Synthesis of 4-Ethynylpyridine)

4-Ethynylpyridine(cas: 2510-22-7) belongs to pyridine. Pyridine is a relatively complex molecule and exhibits a number of different bands in IR spectra. Among others, the bands characterizing the ν8a and ν19b modes have been found to be sensitive to the coordination or protonation of the molecule. Note that the band that is diagnostic for the PyH+ ion at about 1545 cm− 1 (ν19b mode) does not overlap with any of the other bands.Application In Synthesis of 4-Ethynylpyridine

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

The author of 《Validation of Phosphodiesterase-10 as a Novel Target for Pulmonary Arterial Hypertension via Highly Selective and Subnanomolar Inhibitors》 were Huang, Yi-You; Yu, Yan-Fa; Zhang, Chen; Chen, Yiping; Zhou, Qian; Li, Zhuoming; Zhou, Sihang; Li, Zhe; Guo, Lei; Wu, Deyan; Wu, Yinuo; Luo, Hai-Bin. And the article was published in Journal of Medicinal Chemistry in 2019. Recommanded Product: 103-74-2 The author mentioned the following in the article:

Pulmonary arterial hypertension (PAH) causes pathol. increase in pulmonary vascular resistance, leading to right-heart failure and eventual death. Previously, phosphodiesterase-10 (PDE10) was reported to be a promising target for PAH based on the studies with a nonselective PDE inhibitor papaverine, but little progress has been made to confirm the practical application of PDE10 inhibitors. To validate whether PAH is ameliorated by PDE10 inhibition rather than other PDE isoforms, here we report an integrated strategy to discover highly selective PDE10 inhibitors as chem. probes. Structural optimization resulted in a PDE10 inhibitor 2b with subnanomolar affinity and good selectivity of >45 000-fold against other PDEs. The cocrystal structure of the PDE10-2b complex revealed an important H-bond interaction between 2b and Tyr693. Finally, compound 2b significantly decreased the arterial pressure in PAH rats and thus validated the potential of PDE10 as a novel anti-PAH target. These findings suggest that PDE10 inhibition may be a viable treatment option for PAH. In the part of experimental materials, we found many familiar compounds, such as 2-(2-Hydroxyethyl)pyridine(cas: 103-74-2Recommanded Product: 103-74-2)

2-(2-Hydroxyethyl)pyridine(cas: 103-74-2) belongs to pyridine. Pyridine derivatives lend themselves to many roles in the spirited field of supramolecular chemistry – whether as the ligand backbone of metal-organic polymers or presiding over the key electronic stations of nanodevices. In biochemistry, pyridine-containing cofactors are necessary nutrients on which our lives depend. Recommanded Product: 103-74-2

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

《Heterocycles 45.Synthesis, characterization and biological evaluation of 3-indolyl-1-pyridyl-2-propenones as anticancer agents》 was published in Farmacia (Bucharest, Romania) in 2020. These research results belong to Kamga, Justin; Leonte, Denisa; Ambassa, Pantaleon; Mbaveng, Armelle T.; Fotso, Ghislain W.; Coman, Fana-Maria; Ngadjui, Bonaventure T.; Kuete, Victor; Zaharia, Valentin; Ngameni, Bathelemy. Category: pyridine-derivatives The article mentions the following:

A series of seven indolyl pyridyl propenones I [R = H, Me, Et, etc.; Ar = 3-pyridyl, 4-pyridyl] were synthesized via Claisen-Schmidt condensation with 68.8-91.8% yields. All the synthesized compounds I were purified and characterized by m.ps., IR, 1H NMR, 13C NMR and HRMS. The cytotoxicity of the synthesized indolyl pyridyl propenones I and doxorubicin, used as pos. control, was determined in a panel of nine human cancer cell lines including both sensitive and drug-resistant phenotypes, as well as in normal AML12 hepatocytes. Compounds I [R = Et, allyl; Ar = 4-pyridyl] and [R = Me; Ar = 3-pyridyl] displayed half maximal inhibitory concentration (IC50) values below 100μM in all tested cancer cell lines meanwhile, other compounds displayed selective activities. The experimental process involved the reaction of 4-Acetylpyridine(cas: 1122-54-9Category: pyridine-derivatives)

4-Acetylpyridine(cas: 1122-54-9) belongs to pyridine. Pyridine and its simple derivatives are stable and relatively unreactive liquids, with strong penetrating odours that are unpleasant.Category: pyridine-derivatives

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem