Month: October 2022

Li, Lei; Yu, Jiancheng; Xie, Chengyi; Wang, Chenlu; Guan, Pengfei; Hu, Jun Jack; Tang, Keqi published their research in Analyst (Cambridge, United Kingdom) in 2021. The article was titled 《A TIMS-TOF mass spectrometry study of disaccharides from in situ ESI derivatization with 3-pyridinylboronate》.Application In Synthesis of Pyridin-3-ylboronic acid The article contains the following contents:

3-Pyridinylboronate, a zwitterionic boronic acid, displayed effective in situ ESI for reversible covalent tagging of saccharides in both cation and anion modes. The ion mobilities of thus-generated ions were examined with the Bruker TIMS-TOF fleX instrument. Nine disaccharides were examined using this method. They have identical mass-to-charge ratios, differing only in monomer compositions, regio-linkages, and anomeric configurations (α or β). The IMS separations of the disaccharides from this method were compared with those from sodium adducts reported in the literature. The differentiation effects of this method on the disaccharide isomers were increased on average by an order of magnitude. Using this method, all the pairs of disaccharides selected from nine isomers were completely identified by comparing the mobility spectra of single-tagged and double-tagged ions. The experimental process involved the reaction of Pyridin-3-ylboronic acid(cas: 1692-25-7Application In Synthesis of Pyridin-3-ylboronic acid)

Pyridin-3-ylboronic acid(cas: 1692-25-7) belongs to pyridine. Pyridine is very deactivated towards electrophilic substitution with respect to benzene. For this reason classical formylation, using methods such as the Gattermann or Vilsmeier reactions, are not generally successful. Application In Synthesis of Pyridin-3-ylboronic acid

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Ji, Wen-Zhe; Shi, Hao-Nan; Wei, Ping; Hao, Wen-Juan; Tu, Shu-Jiang; Jiang, Bo published their research in Advanced Synthesis & Catalysis in 2021. The article was titled 《Photocatalytic Annulation-Carbohalogenation of 1,7-Enynes for Atom-Economic Synthesis of Functionalized 3,4-dihydronaphthalen-1(2H)-ones》.Reference of fac-Tris(2-phenylpyridine)iridium The article contains the following contents:

A general and efficient photocatalytic annulation-carbohalogenation of 1,7-enynes with a wide variety of alkyl halides were reported, which resulted in atom-economic synthesis of functionalized 3,4-dihydronaphthalen-1(2H)-ones with good yields and high stereoselectivity under the mild and oxidant-free conditions. The reaction demonstrated remarkable compatibility regarding alkyl halides as a bifunctional reagents, such as ethyl-2-bromo-2,2-difluoroacetate, ethyl-2,2-difluoro-2-iodoacetate, perfluorobutyl iodide, bromotrichloromethane, and diethyl-2-bromomalonate, and which provided wide substrate scope, high functional group tolerance, and 100% atom utilization.fac-Tris(2-phenylpyridine)iridium(cas: 94928-86-6Reference of fac-Tris(2-phenylpyridine)iridium) was used in this study.

fac-Tris(2-phenylpyridine)iridium(cas: 94928-86-6) belongs to pyridine. Pyridine is very deactivated towards electrophilic substitution with respect to benzene. For this reason classical formylation, using methods such as the Gattermann or Vilsmeier reactions, are not generally successful. Reference of fac-Tris(2-phenylpyridine)iridium

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Kanao, Eisuke; Tsuchiya, Yuko; Tanaka, Kei; Masuda, Yusuke; Tanigawa, Tetsuya; Naito, Toyohiro; Sano, Tomoharu; Kubo, Takuya; Otsuka, Koji published an article in 2021. The article was titled 《Poly(ethylene glycol) Hydrogels with a Boronic Acid Monomer via Molecular Imprinting for Selective Removal of Quinic Acid Gamma-Lactone in Coffee》, and you may find the article in ACS Applied Polymer Materials.HPLC of Formula: 1692-25-7 The information in the text is summarized as follows:

We developed molecularly imprinted polymers (MIPs) with a poly(ethylene glycol) (PEG)-based cross-linker and boronic acids in functional monomers, which selectively form a complex with a diol structure for selective removal of lactones from a coffee beverage. We synthesized a boronic acid monomer, 1-allylpyridinium-3-boronic acid, which has lower pKa and stronger binding strength to saccharides than commonly used boronic acids. Then, we prepared the MIPs with the monomer and succeeded in selective adsorption for a type of lactones, quinic acid gamma-lactone (QAGL). Furthermore, the high hydrophilicity of PEG and the mol. imprinting effect prevented an un-specific adsorption of other components in coffee. Finally, we achieved in removal of QAGL in coffee with high yield and at high speed by using the MIP-based microsphere as a separation medium in solid-phase extraction This study provides a simple method for better-tasting freshly brewed coffee. In the part of experimental materials, we found many familiar compounds, such as Pyridin-3-ylboronic acid(cas: 1692-25-7HPLC of Formula: 1692-25-7)

Pyridin-3-ylboronic acid(cas: 1692-25-7) belongs to pyridine. Pyridine derivatives lend themselves to many roles in the spirited field of supramolecular chemistry – whether as the ligand backbone of metal-organic polymers or presiding over the key electronic stations of nanodevices. In biochemistry, pyridine-containing cofactors are necessary nutrients on which our lives depend. HPLC of Formula: 1692-25-7

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

In 2022,Zhang, Boaiqi; Liu, Fuyang; Nie, Chenyi; Hou, Yanghui; Tong, Meiping published an article in Journal of Hazardous Materials. The title of the article was 《Photocatalytic degradation of paracetamol and bisphenol A by chitosan supported covalent organic framework thin film with visible light irradiation》.Electric Literature of C5H7N3 The author mentioned the following in the article:

Covalent Organic Frameworks (COFs) have attracted extensive attention for the photocatalytic degradation of emerging organic contaminants. The difficulty in separation and recovery after use yet would hinder the practical application of COFs in powder form. In present study, COFs in film form were fabricated via using chitosan as the film-substrate to support COFs (CSCF). We found that CSCF could effectively degrade two types of emerging organic contaminants under visible light irradiation Particularly, CSCF could effectively degrade 99.8% of paracetamol (PCT) and 94.0% of bisphenol A (BPA) within 180 min under visible light irradiation ·O2- and h+ played dominant roles during the photocatalytic degradation process. Hydroxylation and cleavage were the main degradation processes. CSCF exhibited good photocatalytic degradation performance in a broad range of ionic strengths, in the presence of common coexisting ions including Cl-, NO3- and SO42-, in a wide range of pH (5-11), and in real water samples including tap water, river water and lake water. Moreover, CSCF could be easily collected after use and exhibited excellent degradation performance in five successive cycles. CSCF has potential applications to treat water with either PCT or BPA contamination. This study provided a new insight into the practical application of COFs. In the experiment, the researchers used many compounds, for example, 2,6-Diaminopyridine(cas: 141-86-6Electric Literature of C5H7N3)

2,6-Diaminopyridine(cas: 141-86-6) belongs to pyridine. Pyridine and its simple derivatives are stable and relatively unreactive liquids, with strong penetrating odours that are unpleasant.Electric Literature of C5H7N3

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

In 2022,Chen, Guangbo; An, Yun; Liu, Shengwen; Sun, Fanfei; Qi, Haoyuan; Wu, Haofei; He, Yanghua; Liu, Pan; Shi, Run; Zhang, Jian; Kuc, Agnieszka; Kaiser, Ute; Zhang, Tierui; Heine, Thomas; Wu, Gang; Feng, Xinliang published an article in Energy & Environmental Science. The title of the article was 《Highly accessible and dense surface single metal FeN4 active sites for promoting the oxygen reduction reaction》.Recommanded Product: 141-86-6 The author mentioned the following in the article:

Single iron atom and nitrogen-codoped carbon (Fe-N-C) electrocatalysts, which have great potential to catalyze the kinetically sluggish oxygen reduction reaction (ORR), have been recognized as the most promising alternatives to the precious metal platinum. Unfortunately, the ORR properties of the existing Fe-N-C catalysts are significantly hampered by the inferior accessibility and intrinsic activity of FeN4 moieties. Here, we constructed densely exposed surface FeN4 moieties on a hierarchically porous carbon (sur-FeN4-HPC) by Fe ion anchoring and a subsequent pyrolysis strategy using the nitrogen-doped hierarchically porous carbon (NHPC) as the scaffold. The high surface area of the NHPC with abundant surface Fe anchoring sites enabled the successful fabrication of densely accessible FeN4 active moieties (34.7 x 1019 sites g-1) on sur-FeN4-HPC. First-principles calculations further suggested that the edge effect could regulate the electronic structure of the single Fe site, hence promoting the intrinsic ORR activity of the FeN4 moiety. As a result, the sur-FeN4-HPC electrocatalyst exhibited excellent ORR activity in acidic media with a high half-wave potential of 0.83 V (vs. the reversible hydrogen electrode). We further examined sur-FeN4-HPC as a cathode catalyst in proton exchange membrane fuel cells (PEMFCs). The membrane electrode assembly delivered a high c.d. of 24.2 mA cm-2 at 0.9 ViR-free (internal resistance-compensated voltage) under 1.0 bar O2 and a maximum peak power d. of 0.412 W cm-2 under 1.0 bar air. Importantly, the catalyst demonstrated promising durability during 30 000 voltage cycles under harsh H2 and air conditions. The PEMFC performance of sur-FeN4-HPC outperforms those of the previously reported Fe-N-C electrocatalysts. The engineering of highly accessible and dense surface FeN4 sites on sur-FeN4-HPC offers a fruitful pathway for designing high-performance electrocatalysts for different electrochem. processes. In the experiment, the researchers used many compounds, for example, 2,6-Diaminopyridine(cas: 141-86-6Recommanded Product: 141-86-6)

2,6-Diaminopyridine(cas: 141-86-6) belongs to pyridine. Pyridine and its simple derivatives are stable and relatively unreactive liquids, with strong penetrating odours that are unpleasant.Recommanded Product: 141-86-6

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

In 2022,Sayin, Koray; Rezaeivala, Majid; Erkan, Sultan; Guney, Elif published an article in Journal of Molecular Structure. The title of the article was 《Determination of structural, spectral, computational and OLED properties of Ex2.2Box2+ Cyclophane and its derivatives: Experimental and computational study》.Formula: C7H5N The author mentioned the following in the article:

Ex2.2Box2+ Cyclophane was synthesized and spectral characterization of this compound was completed by using 1H, 13CNMR, and ESI-MS spectroscopy. Furthermore, this compound and its seven derivatives were investigated by computational analyses. Initially, they were optimized at B3LYP/6-31G(d) level in the gas phase and water; then, IR and NMR spectra were analyzed. Especially, exptl. and computational results were compared with each other in Ex2.2Box2+ Cyclophane. Computational spectral results were presented due to the good harmony between exptl. and computational results. These compounds chem. reactivity and electron mobility were investigated using a contour plot of frontier MO and mol. electrostatic potential map. Finally, the OLED properties were examined, and it was found that three of the compounds were suitable candidates for OLED applications. In the part of experimental materials, we found many familiar compounds, such as 4-Ethynylpyridine(cas: 2510-22-7Formula: C7H5N)

4-Ethynylpyridine(cas: 2510-22-7) belongs to pyridine. When pyridine is adsorbed on oxide surfaces or in porous materials, the following species are commonly observed: (i) pyridine coordinated to Lewis acid sites, (ii) pyridine H-bonded to weakly acidic hydroxyls, and (iii) protonated pyridine. At high coverage, physisorbed pyridine and protonated dimers can also be observed.Formula: C7H5N

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Quality Control of 6-Bromopyridin-3-amineIn 2010 ,《Catalytic Chain-Breaking Pyridinol Antioxidants》 appeared in Journal of Organic Chemistry. The author of the article were Kumar, Sangit; Johansson, Henrik; Kanda, Takahiro; Engman, Lars; Muller, Thomas; Bergenudd, Helena; Jonsson, Mats; Pedulli, Gian Franco; Amorati, Riccardo; Valgimigli, Luca. The article conveys some information:

The synthesis of 3-pyridinols carrying alkyltelluro, alkylseleno, and alkylthio groups is described together with a detailed kinetic, thermodn., and mechanistic study of their antioxidant activity. When assayed for their capacity to inhibit azo-initiated peroxidation of linoleic acid in a water/chlorobenzene two-phase system, tellurium-containing 3-pyridinols were readily regenerable by N-acetylcysteine contained in the aqueous phase. The best inhibitors quenched peroxyl radicals more efficiently than α-tocopherol, and the duration of inhibition was limited only by the availability of the thiol reducing agent. In homogeneous phase, inhibition of styrene autoxidation absolute rate constants kinh for quenching of peroxyl radical were as large as 1 × 107 M-1/s-1, thus outperforming the best phenolic antioxidants including α-tocopherol. Tellurium-containing 3-pyridinols could be quant. regenerated in homogeneous phase by N-tert-butoxycarbonyl cysteine Me ester, a lipid-soluble analog of N-acetylcysteine. In the presence of an excess of the thiol, a catalytic mode of action was observed, similar to the one in the two-phase system. Overall, compounds bearing the alkyltelluro moiety ortho to the OH group were much more effective antioxidants than the corresponding para isomers. The origin of the high reactivity of these compounds was explored using pulse-radiolysis thermodn. measurements, and a mechanism for their unusual antioxidant activity was proposed. The tellurium-containing 3-pyridinols were also found to catalyze reduction of hydrogen peroxide in the presence of thiol reducing agents, thereby acting as multifunctional (preventive and chain-breaking) catalytic antioxidants. In the experiment, the researchers used 6-Bromopyridin-3-amine(cas: 13534-97-9Quality Control of 6-Bromopyridin-3-amine)

6-Bromopyridin-3-amine(cas: 13534-97-9) belongs to anime. The methylamines occur in small amounts in some plants. Many polyfunctional amines (i.e., those having other functional groups in the molecule) occur as alkaloids in plants—for example, mescaline, 2-(3,4,5-trimethoxyphenyl)ethylamine; the cyclic amines nicotine, atropine, morphine, and cocaine; and the quaternary salt choline, N-(2-hydroxyethyl)trimethylammonium chloride, which is present in nerve synapses and in plant and animal cells.Quality Control of 6-Bromopyridin-3-amine

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Quality Control of Picolinic acidIn 2019 ,《Detection of Purine Metabolite Uric Acid with Picolinic-Acid-Functionalized Metal-Organic Frameworks》 appeared in ACS Applied Materials & Interfaces. The author of the article were Qu, Shumei; Li, Zheng; Jia, Qiong. The article conveys some information:

Uric acid (UA) is a purine metabolite closely related to the metabolic function of human. Fluorescence anal. is a very effective method because of high selectivity and sensitivity but still remains a great challenge for direct UA detection. In this work, a fluorescent sensor based on postfunctionalized metal organic framework (UiO-PSM) was designed focusing on the direct detection of UA. UiO-PSM was synthesized from a zirconium-based MOF (UiO-66-NH2) and 2-picolinic acid (PA) through an amidation reaction. Because UA could quench the fluorescence of UiO-PSM through coordination, hydrogen bonding, and π-π interactions, the sensor could detect UA directly. UiO-PSM exhibited the advantages of short reaction time, high selectivity, high sensitivity, and wide linear range for UA detection. This work provided a novel method for UA detection and had potential application value in clin. diagnosis. The experimental part of the paper was very detailed, including the reaction process of Picolinic acid(cas: 98-98-6Quality Control of Picolinic acid)

Picolinic acid(cas: 98-98-6) is used as a chelate for alkaline earth metals. Used to prepare picolinato ligated transition metal complexes. In synthetic organic chemistry, has been used as a substrate in the Mitsunobu reaction and in the Hammick reaction.Quality Control of Picolinic acid

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Product Details of 1122-54-9In 2021 ,《3H-Pyrazolo[4,3-f]quinoline-Based Kinase Inhibitors Inhibit the Proliferation of Acute Myeloid Leukemia Cells In Vivo》 appeared in Journal of Medicinal Chemistry. The author of the article were Dayal, Neetu; Reznickova, Eva; Hernandez, Delmis E.; Perina, Miroslav; Torregrosa-Allen, Sandra; Elzey, Bennett D.; Skerlova, Jana; Ajani, Haresh; Djukic, Stefan; Vojackova, Veronika; Lepsik, Martin; Rezacova, Pavlina; Krystof, Vladimir; Jorda, Radek; Sintim, Herman O.. The article conveys some information:

Herein, various 3H-pyrazolo[4,3-f]quinoline-containing compounds e.g., I were rapidly assembled via the Doebner-Povarov multicomponent reaction from the readily available 5-aminoindazoles, ketones and aldehydes in good yields. The most active compounds potently inhibit the recombinant FLT3 kinase and its mutant forms with nanomolar IC50 values. Docking studies with the FLT3 kinase showed a type I binding mode, where the 3H-pyrazolo group interacts with Cys694 in the hinge region. The compounds blocked the proliferation of AML cell lines harboring oncogenic FLT3-ITD mutations with remarkable IC50 values, which were comparable to the approved FLT3 inhibitor quizartinib. The compounds also inhibited the growth of leukemia in a mouse-disseminated AML model, and hence, the novel 3H-pyrazolo[4,3-f]quinoline-containing kinase inhibitors are potential lead compounds to develop into anticancer agents, especially for kinase-driven cancers. The results came from multiple reactions, including the reaction of 4-Acetylpyridine(cas: 1122-54-9Product Details of 1122-54-9)

4-Acetylpyridine(cas: 1122-54-9) belongs to pyridine. The basicity and metallophilic high donor number of these π-deficient systems has long favored them as ligands in metal catalysis. The last decade saw pyridine assume a stronger role as functional group for directed C–H oxidation/activation.Product Details of 1122-54-9

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

HPLC of Formula: 1122-54-9In 2020 ,《Synthesis of selective bioactive pyridylpyridones: in silico studies and biological evaluations》 appeared in Asian Journal of Chemistry. The author of the article were Ramasamy, Suresh; Ponnuchamy, Singanan; Ponnusamy, Sivakumar. The article conveys some information:

Twenty three substituted pyridylpyridones I (X = CH, N; Y = N, CH; R = H, 2,5-F2, 4-Cl, 4-OMe, etc.) were designed and performed for mol. docking studies against α-amylase enzyme. Exptl. biol. applications were studied for the top three hit compounds (X = N, Y = CH, R = 2-Cl; X = CH, Y = N, R = H; X = CH, Y = N, R = 2,5-F2). The DFT calculations were executed for the hit compounds In addition, mol. electrostatic potential mapping was also executed for addnl. support. The experimental part of the paper was very detailed, including the reaction process of 4-Acetylpyridine(cas: 1122-54-9HPLC of Formula: 1122-54-9)

4-Acetylpyridine(cas: 1122-54-9) belongs to pyridine. Pyridine and pyridine-derived structures are privileged pharmacophores in medicinal chemistry and an essential functionality for organic chemists. As the prototypical π-deficient heterocycle, pyridine illustrates distinctive chemistry as both substrate and reagent. HPLC of Formula: 1122-54-9

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem