Month: October 2022

Electric Literature of C12H12N2In 2021 ,《A straightforward synthesis of neutral hexacoordinated silicon(IV) complexes with SiN6 skeleton》 was published in Inorganica Chimica Acta. The article was written by Cruz-Lopez, Juan F.; Palacios-Chavez, Jesus A.; Guajardo-Garcia, Joel A.; Gonzalez-Garcia, Andres; Baez, Jose E.; Lopez, Jorge A.; Orozco-Castellanos, Luis M.; Gonzalez-Garcia, Gerardo. The article contains the following contents:

Three neutral hexacoordinate silicon(IV) complexes with SiN6 skeleton were obtained via one-pot synthesis by using tetra(thiocyanato-N)silane, Si(NCS)4 with an equimolar amount of 2,2′-bipyridyl (bipy), 4,4′-dimethyl-2,2′-dipyridyl (dmp) and 1,10-phenanthroline (phen) resp. The complexes obtained; (bipy)Si(NCS)4 (1), (dmp)Si(NCS)4 (2), and (phen)Si(NCS)4 (3) belong to a family of neutral hexacoordinate silicon(IV) with SiN6 coordinating framework, which has been less studied both by single-crystal x-ray diffraction and 29Si NMR spectroscopies. All the complexes were characterized by single-crystal x-ray diffraction, solution 1H, 13C{H}, 29Si, solid-state 29Si CP/MAS NMR spectroscopies, and elemental anal. was used to confirm the structures. Comparison of the 29Si chem. shieldings of the complexes 1-3 in the solution and solid-state indicated that all complexes maintain the hexacoordination at silicon atom in DMSO-D6 solution This works demonstrated the synthetic potential of Si(NCS)4 for the synthesis of new neutral hexacoordinate silicon complexes with SiN6 skeleton via one-pot synthesis. The experimental process involved the reaction of 4,4′-Dimethyl-2,2′-bipyridine(cas: 1134-35-6Electric Literature of C12H12N2)

4,4′-Dimethyl-2,2′-bipyridine(cas: 1134-35-6) is used in the synthesis of a series of o-phenanthroline-substituted ruthenium(II) complexes.Electric Literature of C12H12N2 Furthermore, 4,4′-Dimethyl-2,2′-bipyridine is used as a chemical Intermediate. It can be used for the determination of ferrous and cyanide compounds.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

《Transition-metal-free direct nucleophilic substitution of carboranyllithium and 2-halopyridines》 was written by Lu, Ju-You; Zhao, Bo; Du, Yongmei; Yang, Jianxin; Lu, Jian. Electric Literature of C6H6BrNThis research focused ontransition metal free nucleophilic substitution carboranyl lithium halopyridine; pyridinyl carborane preparation. The article conveys some information:

A practical and efficient C(cage)-heteroarylation of carborane is presented, via direct nucleophilic substitution of carboranyllithium with 2-halopyridines. This reaction does not need the aid of any transition metal and utilizes readily available carboranyllithium nucleophiles, thereby avoiding transmetalation of carboranyllithium. The process exhibits a broad scope, and a vast array of 2-halopyridines have proven to be suitable substrates. The method serves as a complement to C(cage)-arylation reactions and may find wide applications in materials science and medicinal and coordination chem. The experimental part of the paper was very detailed, including the reaction process of 2-Bromo-5-methylpyridine(cas: 3510-66-5Electric Literature of C6H6BrN)

2-Bromo-5-methylpyridine(cas: 3510-66-5) belongs to pyridine. Pyridine-based materials are valued for their optical and physical properties as well as their medical potential. Additionally, pyridine-based natural products continue to be discovered and studied for their properties and to understand their biosynthesis.Electric Literature of C6H6BrN

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

《Zn(II) and Cd(II) monomer, dimer and polymer compounds coordinated by benzoic acid and 4-acetylpyridine: Synthesis and crystal structures》 was written by Moreno-Gomez, Laura; Sanchez-Ferez, Francisco; Calvet, Teresa; Font-Bardia, Merce; Pons, Josefina. SDS of cas: 1122-54-9This research focused onzinc cadmium benzoate acetylpyridine complex preparation fluorescence; crystal structure zinc cadmium benzoate acetylpyridine. The article conveys some information:

Reaction of MO (MO = Metal oxide, M = Zn(II) or Cd(II)) with benzoic acid (HBz) in H2O/MeOH mixture as solvent yields two benzoate compounds: [Zn(μ-Bz)2]n (1) and [Cd(Bz)2(H2O)3] (2). In addition, the reaction between M(MeCO2)2 (M = Zn(II) or Cd(II)) with HBz and 4-acetylpyridine (4-Acpy) in a 1:2:4 M ratio and in MeOH solution, leads to the formation of [Zn(μ-Bz)2(4-Acpy)]2 (3) and [Cd(μ-Bz)2(4-Acpy)2]2 (4). These four compounds have been fully characterized by anal. and spectroscopic techniques. Besides, their crystal structures have been elucidated revealing a 1D coordination polymer (1), a monomer (2), a paddle-wheel (3) and a dimer (4). In 1, the Zn(II) ion is four-coordinated in a tetrahedral geometry while in 3 is penta-coordinated in a square-pyramidal geometry. By contrast, compounds 2 and 4 exhibit seven-coordinated Cd(II) ions in a pentagonal-bipyramidal geometry. In these set of compounds, the benzoate ligand presents different coordination modes such as bidentate bridged (μ2-η1:η1) (1 and 3), chelate (μ1-η2) (2) and both bridged and chelate (μ2-η2:η1) (4). Besides, their extended structures have been analyzed. Finally, the UV-Vis and fluorescence spectra of all the compounds have been recorded as well as their quantum yields calculated4-Acetylpyridine(cas: 1122-54-9SDS of cas: 1122-54-9) was used in this study.

4-Acetylpyridine(cas: 1122-54-9) belongs to pyridine. Pyridine-based materials are valued for their optical and physical properties as well as their medical potential. Additionally, pyridine-based natural products continue to be discovered and studied for their properties and to understand their biosynthesis.SDS of cas: 1122-54-9

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Formula: C6H2Cl3NO2On May 1, 2008 ,《Degradation of picloram by the electro-Fenton process》 appeared in Journal of Hazardous Materials. The author of the article were Oezcan, Ali; Sahin, Yuecel; Koparal, A. Savas; Oturan, Mehmet A.. The article conveys some information:

The degradation of the picloram, a widely used herbicide, was undertaken by the electrochem. advanced oxidation process, namely electro-Fenton in aqueous solution This process generates catalytically OH radicals that are strong oxidizing reagents for the oxidation of organic substances. Degradation kinetics of picloram was investigated. Kinetic results evidence a pseudo first-order degradation, with a rate constant of reaction between picloram and OH radicals of (2.73 ± 0.08) × 109 M-1 s-1. The effect of applied current and catalyst concentration on the degradation and mineralization of picloram was also investigated. The optimum applied current and catalyst concentration values for the degradation of picloram was determined as 300 mA and 0.2 mM Fe3+, resp. Mineralization of picloram was followed by the total organic carbon (TOC) anal. At the end of 8 h of electrolysis, 95% of the initial TOC was removed. Several degradation products were identified by using HPLC, LC-MS, GC-MS, and IC anal. The identified byproducts allowed to propose a mineralization pathway for the picloram degradation In the experiment, the researchers used many compounds, for example, 3,5,6-Trichloropicolinic acid(cas: 40360-44-9Formula: C6H2Cl3NO2)

3,5,6-Trichloropicolinic acid(cas: 40360-44-9) belongs to pyridine. Pyridine, its benzo and pyridine-based compounds play diverse roles in organic chemistry. As ligands, solvents, and catalysts they facilitate reactions; thus descriptions of these new ligands and their applications abound each year.Formula: C6H2Cl3NO2

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

SDS of cas: 828918-24-7On June 7, 2019, Sattar, Moh.; Patidar, Krishna; Thorat, Raviraj Ananda; Kumar, Sangit published an article in Journal of Organic Chemistry. The article was 《Copper-Mediated Selective Mono- and Sequential Organochalcogenation of C-H Bonds: Synthesis of Hybrid Unsymmetrical Aryl Ferrocene Chalcogenides》. The article mentions the following:

A 8-aminoquinoline directed Cu/1,10-phenanthroline-mediated selective mono-organothiolation of C-H bond in ferroceneamide was developed using aryl/alkyl-disulfide substrates. The sequential ferrocene C-H organochalcogenation (chalcogen = S, Se, and Te) also was established for the synthesis of novel hybrid unsym. aryl chalcogenides with the aid of a catalytic amount of Cu(OAc)2 under ambient reaction conditions. The developed protocol exhibits a broad functional group tolerance to allow alkyl, aryl, hetero-aryl, bromo, chloro, and nitro containing diorgano dichalcogenides as a coupling partner. Further, the 8-aminoquinoline directing group is easily removed to afford the aldehyde functionality after C-H organochalcogenation. A mechanistic understanding of the Cu-mediated selective mono-organothiolation reaction suggests that rigid bi-coordinated 1,10-phenanthroline ligand and freshly generated Cu(II) from Cu(I) in the less polar solvent MeCN seem crucial for the selective mono-C-H functionalization of ferroceneamide. In the experiment, the researchers used many compounds, for example, 2,6-Bis((R)-4-isopropyl-5,5-diphenyl-4,5-dihydrooxazol-2-yl)pyridine(cas: 828918-24-7SDS of cas: 828918-24-7)

2,6-Bis((R)-4-isopropyl-5,5-diphenyl-4,5-dihydrooxazol-2-yl)pyridine(cas: 828918-24-7) belongs to pyridine derivatives. The ring atoms in the pyridine molecule are sp2-hybridized. The nitrogen is involved in the π-bonding aromatic system using its unhybridized p orbital. SDS of cas: 828918-24-7 Pyridine has a conjugated system of six π electrons that are delocalized over the ring.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Reference of 2,6-Bis((R)-4-isopropyl-5,5-diphenyl-4,5-dihydrooxazol-2-yl)pyridineOn June 3, 2016, Suneja, Arun; Bisai, Vishnumaya; Singh, Vinod K. published an article in Journal of Organic Chemistry. The article was 《Asymmetric Syntheses of Medicinally Important Isoindolinones (S)-PD 172938, (R)-JM 1232, and Related Structures》. The article mentions the following:

A unified approach for the asym. syntheses of medicinally important isoindolinones (S)-PD 172938 and (R)-JM 1232 has been accomplished via a Cu(I)-PYBOX-diPh catalyzed highly enantioselective (up to 99% ee) alkynylation/lactamization sequence in a one-pot fashion. The overall sequence involves one C-C and two C-N bond forming events in one pot starting from inexpensive starting material in ambient reaction conditions. The results came from multiple reactions, including the reaction of 2,6-Bis((R)-4-isopropyl-5,5-diphenyl-4,5-dihydrooxazol-2-yl)pyridine(cas: 828918-24-7Reference of 2,6-Bis((R)-4-isopropyl-5,5-diphenyl-4,5-dihydrooxazol-2-yl)pyridine)

2,6-Bis((R)-4-isopropyl-5,5-diphenyl-4,5-dihydrooxazol-2-yl)pyridine(cas: 828918-24-7) belongs to pyridine derivatives. The ring atoms in the pyridine molecule are sp2-hybridized. The nitrogen is involved in the π-bonding aromatic system using its unhybridized p orbital. Reference of 2,6-Bis((R)-4-isopropyl-5,5-diphenyl-4,5-dihydrooxazol-2-yl)pyridineThe lone pair is in an sp2 orbital, projecting outward from the ring in the same plane as the σ bonds.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Albaneze-Walker, Jennifer; Bazaral, Charles; Leavey, Tanya; Dormer, Peter G.; Murry, Jerry A. published an article in Organic Letters. The title of the article was 《Improved Carbonylation of Heterocyclic Chlorides and Electronically Challenging Aryl Bromides》.HPLC of Formula: 116383-98-3 The author mentioned the following in the article:

Optimized conditions are described that effect the carbonylation of diverse heterocyclic chlorides to yield the desired alkyl esters. In addition, bromoanilines and bromoanisoles, which normally are poor substrates under standard carbonylation protocols, were efficiently converted to the desired products under these new conditions. The nature of the metal bidentate ligand complex was found to be critical Specifically, a correlation between ligand bite angle and catalytic efficiency is documented. In the part of experimental materials, we found many familiar compounds, such as Methyl 3-chloropicolinate(cas: 116383-98-3HPLC of Formula: 116383-98-3)

Methyl 3-chloropicolinate(cas: 116383-98-3) belongs to pyridine. Pyridine, its benzo and pyridine-based compounds play diverse roles in organic chemistry. As ligands, solvents, and catalysts they facilitate reactions; thus descriptions of these new ligands and their applications abound each year.HPLC of Formula: 116383-98-3

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Liu, Zhida; Ning, Liangmin; Wang, Kaiyuan; Feng, Lixi; Gu, Wen; Liu, Xin published their research in Journal of Molecular Structure on December 5 ,2020. The article was titled 《A new imidazole-functionalized 3D-cobalt metal-organic framework as a high efficiency heterogeneous catalyst for Knoevenagel condensation reaction of furfural》.Reference of 4′-(4-Pyridyl)-2,2′:6′,2”-terpyridine The article contains the following contents:

A new 3D Co(II) based metal-organic framework [Co(pytpy)(AIP)·H2O]n (I) (C2/c)(pytpy = 4′-(4-pyridyl)-4,2′:6′,4″”-terpyridine, AIP = 5-aminoisophthalic acid) by solvothermal method was synthesized. Its crystal structure was determined with single-crystal X-ray diffraction (SC-XRD) techniques. And then Imidazole groups were introduced into I by Schiff base post-synthetic reaction to make a Lewis base sites rich MOF-based catalyst. The post-synthetic MOF-based catalyst showed an excellent performance in Knoevenagel Condensation Reaction of furfural. Moreover, the catalytic performance for others homologues of furfural RCHO [R = [5-(hydroxymethyl)furan-2-yl], 4-fluorophenyl, Pr, etc.] and malononitrile was also tested. In the experiment, the researchers used 4′-(4-Pyridyl)-2,2′:6′,2”-terpyridine(cas: 112881-51-3Reference of 4′-(4-Pyridyl)-2,2′:6′,2”-terpyridine)

4′-(4-Pyridyl)-2,2′:6′,2”-terpyridine(cas: 112881-51-3) belongs to pyridine derivatives. The ring atoms in the pyridine molecule are sp2-hybridized. The nitrogen is involved in the π-bonding aromatic system using its unhybridized p orbital. Reference of 4′-(4-Pyridyl)-2,2′:6′,2”-terpyridine Pyridine has a conjugated system of six π electrons that are delocalized over the ring.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Venkateshwarlu, Rapolu; Nath Singh, Shambhu; Siddaiah, Vidavalur; Ramamohan, Hindupur; Dandela, Rambabu; Pal, Manojit published their research in Tetrahedron Letters on December 26 ,2019. The article was titled 《Ultrasound assisted one-pot synthesis of 1,2-diaryl azaindoles via Pd/C-Cu catalysis: Identification of potential cytotoxic agents》.Related Products of 39856-58-1 The article contains the following contents:

Ultrasound assisted one-pot and direct access to 1,2-diaryl substituted azaindole derivatives I [W = CH, N; X = CH, N; Y = CH, N; Z = CH, N; Ar1 = Ph, 4-ClC6H4, 4-MeC6H4; Ar2 = 4-CNC6H4, 4-MeOC6H4, 4-Me(SO2)C6H4, etc.] was achieved via the sequential N-arylation followed by coupling-cyclization under Pd/C-Cu catalysis. The methodol. involved initial C-N bond forming reaction (step 1) between an appropriate o-bromo substituted amino pyridine and iodoarene followed by C-C and C-N bond formation (step 2) between the resulting N-aryl substituted intermediate and a terminal alkyne in the same pot. A variety of azaindoles were prepared by using this method. These compounds were assessed for their cytotoxic properties against two different metastatic breast cancer cell lines e.g. MDA-MB-231 and MCF-7. Compounds I [W = Y = Z = CH, X = N, Ar1 = 4-MeC6H4, Ar2 = 4-MeOC6H4], I [W = Y = Z = CH, X = N, Ar1 = Ph, Ar2 = 4-MeOC6H4] and I [W = Y = Z = CH, X = N, Ar1 = 4-ClC6H4, Ar2 = 3,5-di-MeOC6H3] showed promising growth inhibition of these cell lines and SIRT1 inhibition in vitro. The results came from multiple reactions, including the reaction of 2-Bromopyridin-3-amine(cas: 39856-58-1Related Products of 39856-58-1)

2-Bromopyridin-3-amine(cas: 39856-58-1) belongs to anime. Reaction with nitrous acid (HNO2), which functions as an acylating agent that is a source of the nitrosyl group (―NO), converts aliphatic primary amines to nitrogen and mixtures of alkenes and alcohols corresponding to the alkyl group in a complex process. This reaction has been used for analytical determination of primary amino groups in a procedure known as the Van Slyke method.Related Products of 39856-58-1

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

In 2013,Aik, WeiShen; Demetriades, Marina; Hamdan, Muhammad K. K.; Bagg, Eleanor. A. L.; Yeoh, Kar Kheng; Lejeune, Clarisse; Zhang, Zhihong; McDonough, Michael A.; Schofield, Christopher J. published 《Structural Basis for Inhibition of the Fat Mass and Obesity Associated Protein (FTO)》.Journal of Medicinal Chemistry published the findings.Reference of Methyl 5-bromopicolinate The information in the text is summarized as follows:

The fat mass and obesity associated protein (FTO) is a potential target for anti-obesity medicines. FTO is a 2-oxoglutarate (2OG)-dependent N-Me nucleic acid demethylase that acts on substrates including 3-methylthymidine, 3-methyluracil, and 6-methyladenine. To identify FTO inhibitors, we screened a set of 2OG analogs and related compounds using differential scanning fluorometry- and liquid chromatog.-based assays. The results revealed sets of both cyclic and acyclic 2OG analogs that are FTO inhibitors. Identified inhibitors include small mols. that have been used in clin. studies for the inhibition of other 2OG oxygenases. Crystallog. analyses reveal inhibition by 2OG cosubstrate or primary substrate competitors as well as compounds that bind across both cosubstrate and primary substrate binding sites. The results will aid the development of more potent and selective FTO inhibitors.Methyl 5-bromopicolinate(cas: 29682-15-3Reference of Methyl 5-bromopicolinate) was used in this study.

Methyl 5-bromopicolinate(cas: 29682-15-3) belongs to pyridine. Pyridine is very deactivated towards electrophilic substitution with respect to benzene. For this reason classical formylation, using methods such as the Gattermann or Vilsmeier reactions, are not generally successful. Reference of Methyl 5-bromopicolinate

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem