Month: October 2022

Guo, Zhifen’s team published research in Applied Organometallic Chemistry in 2020 | CAS: 2510-22-7

4-Ethynylpyridine(cas: 2510-22-7) belongs to pyridine. Pyridine is a relatively complex molecule and exhibits a number of different bands in IR spectra. Among others, the bands characterizing the ν8a and ν19b modes have been found to be sensitive to the coordination or protonation of the molecule. Note that the band that is diagnostic for the PyH+ ion at about 1545 cm− 1 (ν19b mode) does not overlap with any of the other bands.Recommanded Product: 4-Ethynylpyridine

《Construction of visible-light-responsive metal-organic framework with pillared structure for dye degradation and Cr(VI) reduction》 was written by Guo, Zhifen; Zhao, Hongmei; Liu, Xin; Liang, Xiao; Wei, Hongxia; Mei, Yingchun; Xing, Hongzhu. Recommanded Product: 4-Ethynylpyridine And the article was included in Applied Organometallic Chemistry in 2020. The article conveys some information:

A water-stable mixed-linker metal-organic framework (MOF) was rationally synthesized using a controllable pillared-layer method. The prepared Co(II)-MOF shows wide-range absorption in the visible light region due to the incorporation of highly conjugated anthracene-based bipyridine ligand. Experiments suggest that the MOF is highly efficient for the photoreduction of toxic Cr(VI) ions in water under visible light. Important issues affecting photocatalytic performance, such as the influence of pH and the control of electron-hole separation by scavenger, were carefully examined Beyond Cr(VI) ions, we also explored the photocatalytic degradation performance of the MOF using a persistent azo dye as a model substrate, where H2O2-involved advanced oxidation process was applied. Control experiments suggest that the introduction of environmentally benign H2O2 significantly enhances the degradation performance due to the generation of reactive hydroxyl radicals. The study not only demonstrates the great feasibility of the preparation of a new MOF photocatalyst through a controllable pillared-layer method, but also reveals that rational functionalization of ligand in the MOF is convenient for achieving desirable applications. The experimental part of the paper was very detailed, including the reaction process of 4-Ethynylpyridine(cas: 2510-22-7Recommanded Product: 4-Ethynylpyridine)

4-Ethynylpyridine(cas: 2510-22-7) belongs to pyridine. Pyridine is a relatively complex molecule and exhibits a number of different bands in IR spectra. Among others, the bands characterizing the ν8a and ν19b modes have been found to be sensitive to the coordination or protonation of the molecule. Note that the band that is diagnostic for the PyH+ ion at about 1545 cm− 1 (ν19b mode) does not overlap with any of the other bands.Recommanded Product: 4-Ethynylpyridine

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Takashima, Chinami’s team published research in Chemical Physics Letters in 2021 | CAS: 94928-86-6

fac-Tris(2-phenylpyridine)iridium(cas: 94928-86-6) belongs to pyridine. Pyridines form stable salts with strong acids. Pyridine itself is often used to neutralize acid formed in a reaction and as a basic solvent. Safety of fac-Tris(2-phenylpyridine)iridium

Takashima, Chinami; Seino, Junji; Nakai, Hiromi published an article in 2021. The article was titled 《Database-assisted local unitary transformation method for two-electron integrals in two-component relativistic calculations》, and you may find the article in Chemical Physics Letters.Safety of fac-Tris(2-phenylpyridine)iridium The information in the text is summarized as follows:

This letter presents an efficient algorithm for local unitary transformation based on the spin-free infinite-order two-component relativistic method for the two-electron interaction, which is assisted by one-center relativistic two-electron integral (TEI) database. The database stores a set of TEIs, one for each element-basis set combination. The algorithm is numerically assessed for hydrogen halide chains, (HX)n (X = Cl and At), Aun, Ir(ppy)3, Pt3(C7H7)2(HCN)3, and PtCl2(NH3)2. The computational cost (time and memory size) at the Hartree-Fock level is lower than that of the conventional method, especially for small and medium-sized mols.fac-Tris(2-phenylpyridine)iridium(cas: 94928-86-6Safety of fac-Tris(2-phenylpyridine)iridium) was used in this study.

fac-Tris(2-phenylpyridine)iridium(cas: 94928-86-6) belongs to pyridine. Pyridines form stable salts with strong acids. Pyridine itself is often used to neutralize acid formed in a reaction and as a basic solvent. Safety of fac-Tris(2-phenylpyridine)iridium

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Youssef, Heba’s team published research in Chemistry – A European Journal in 2021 | CAS: 1122-54-9

4-Acetylpyridine(cas: 1122-54-9) belongs to pyridine. Pyridine is a relatively complex molecule and exhibits a number of different bands in IR spectra. Among others, the bands characterizing the ν8a and ν19b modes have been found to be sensitive to the coordination or protonation of the molecule. Note that the band that is diagnostic for the PyH+ ion at about 1545 cm− 1 (ν19b mode) does not overlap with any of the other bands.Related Products of 1122-54-9

Youssef, Heba; Sedykh, Alexander E.; Becker, Jonathan; Schafer, Thomas; Taydakov, Ilya V.; Li, Huanrong R.; Mueller-Buschbaum, Klaus published an article in 2021. The article was titled 《Variable Luminescence and Chromaticity of Homoleptic Frameworks of the Lanthanides together with Pyridylpyrazolates》, and you may find the article in Chemistry – A European Journal.Related Products of 1122-54-9 The information in the text is summarized as follows:

Homoleptic, 3D coordination polymers of the formula 33∞[Ln(3-PyPz)3] and 3∞[Ln(4-PyPz)3], (3-PyPz)- = 3-(3-pyridyl)pyrazolate anion, (4-PyPz)- = 3-(4-pyridyl)pyrazolate anion, both C8H6N3-, Ln = Sm, Eu, Gd, Tb, Dy, were obtained as highly luminescent frameworks by reaction of the lanthanide metals (Ln) with the aromatic heterocyclic amine ligands 3-PyPzH and 4-PyPzH. The compounds form 2 isotypic series of 3D coordination polymers and exhibit fair thermal stability up to 360°. The luminescence properties of all 10 compounds were determined in the solid state, with an antenna effect through ligand-metal energy transfer leading to high efficiency of the luminescence displayed by good quantum yields of up to 74%. The emission is mainly based on ion-specific lanthanide-dependent intra 4f-4f transitions for Tb3+: green, Dy3+: yellow, Sm3+: orange-red, Eu3+: red. For the Gd3+-containing compounds, the yellow emission of ligand triplet-based phosphorescence is observed at room temperature and 77 K. Codoping of the Gd-containing frameworks with Eu3+ and Tb3+ allow further shifting of the chromaticity towards white light emission. The experimental part of the paper was very detailed, including the reaction process of 4-Acetylpyridine(cas: 1122-54-9Related Products of 1122-54-9)

4-Acetylpyridine(cas: 1122-54-9) belongs to pyridine. Pyridine is a relatively complex molecule and exhibits a number of different bands in IR spectra. Among others, the bands characterizing the ν8a and ν19b modes have been found to be sensitive to the coordination or protonation of the molecule. Note that the band that is diagnostic for the PyH+ ion at about 1545 cm− 1 (ν19b mode) does not overlap with any of the other bands.Related Products of 1122-54-9

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Oh, Sangmi’s team published research in ACS Medicinal Chemistry Letters in 2021 | CAS: 197958-29-5

2-Pyridinylboronic acid(cas: 197958-29-5) belongs to pyridine. Pyridine derivatives lend themselves to many roles in the spirited field of supramolecular chemistry – whether as the ligand backbone of metal-organic polymers or presiding over the key electronic stations of nanodevices. In biochemistry, pyridine-containing cofactors are necessary nutrients on which our lives depend. COA of Formula: C5H6BNO2

Oh, Sangmi; Kwon, Do Yoon; Choi, Inhee; Kim, Young Mi; Lee, Ji Young; Ryu, Jiyoung; Jeong, Hangyeol; Kim, Myung Jin; Song, Rita published an article in 2021. The article was titled 《Identification of Piperidine-3-carboxamide Derivatives Inducing Senescence-like Phenotype with Antimelanoma Activities》, and you may find the article in ACS Medicinal Chemistry Letters.COA of Formula: C5H6BNO2 The information in the text is summarized as follows:

This study evaluated the potential use of senescence-inducing small mols. in the treatment of melanoma. We screened com. available small-mol. libraries with high-throughput screening and high-content screening image-based technol. Our findings showed an initial hit with the embedded N-arylpiperidine-3-carboxamide scaffold induced senescence-like phenotypic changes in human melanoma A375 cells without serious cytotoxicity against normal cells. A focused library containing diversely modified analogs were constructed and examined to evaluate the structure-activity relationship of N-arylpiperidine-3-carboxamide derivatives starting from hit 1. This work identified a novel compound with remarkable antiproliferative activity in vitro and demonstrated the key structural moieties within. In the part of experimental materials, we found many familiar compounds, such as 2-Pyridinylboronic acid(cas: 197958-29-5COA of Formula: C5H6BNO2)

2-Pyridinylboronic acid(cas: 197958-29-5) belongs to pyridine. Pyridine derivatives lend themselves to many roles in the spirited field of supramolecular chemistry – whether as the ligand backbone of metal-organic polymers or presiding over the key electronic stations of nanodevices. In biochemistry, pyridine-containing cofactors are necessary nutrients on which our lives depend. COA of Formula: C5H6BNO2

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Shi, Zhaojiang’s team published research in Organic Chemistry Frontiers in 2022 | CAS: 197958-29-5

2-Pyridinylboronic acid(cas: 197958-29-5) belongs to pyridine. Pyridine is very deactivated towards electrophilic substitution with respect to benzene. For this reason classical formylation, using methods such as the Gattermann or Vilsmeier reactions, are not generally successful. SDS of cas: 197958-29-5

In 2022,Shi, Zhaojiang; Lu, Hao-Kuan; Li, Nan; Yuan, Yaofeng; Li, Zhen; Ye, Ke-Yin published an article in Organic Chemistry Frontiers. The title of the article was 《Electrochemical oxidative dearomatization of 2-arylthiophenes》.SDS of cas: 197958-29-5 The author mentioned the following in the article:

A green and sustainable electrochem. oxidative dearomatization of 2-arylthiophenes was reported. The variation of substitution patterns afforded easy access to both C2/C3 and C2/C5 difunctionalized dearomative dihydrothiophenes such as I [R = Ph, 3-FC6H4, 2-pyridyl, etc.; R1 = OAc, OC(O)Et]. The synthetic utility of the resulting dihydrothiophenes was further demonstrated by the concise synthesis of a pyridazinone analog with interesting vasodilator activity. The results came from multiple reactions, including the reaction of 2-Pyridinylboronic acid(cas: 197958-29-5SDS of cas: 197958-29-5)

2-Pyridinylboronic acid(cas: 197958-29-5) belongs to pyridine. Pyridine is very deactivated towards electrophilic substitution with respect to benzene. For this reason classical formylation, using methods such as the Gattermann or Vilsmeier reactions, are not generally successful. SDS of cas: 197958-29-5

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Covington,JohnnyB.’s team published research in Journal of Organic Chemistry in 1980-04-11 | 73018-09-4

Journal of Organic Chemistry published new progress about Self-association. 73018-09-4 belongs to class pyridine-derivatives, and the molecular formula is C5H4ClNO, COA of Formula: C5H4ClNO.

Beak, Peter; Covington, Johnny B.; Smith, Stanley G.; White, J. Matthew; Zeigler, John M. published the artcile< Displacement of protomeric equilibriums by self-association: hydroxypyridine-pyridone and mercaptopyridine-thiopyridone isomer pairs>, COA of Formula: C5H4ClNO, the main research area is tautomerism pyridinol pyridinethiol association; solvent effect association pyridinol.

Self-association and protomeric equilibrium constants are reported for 2-hydroxypyridine-2-pyridone, 4-hydroxypyridine-4-pyridone and 2-mercaptopyridine-2-thiopyridone isomer pairs in different solvents. These results provide quant. evidence for significant differences in the positions of protomeric equilibrium for self-associated and monomeric species. The 2-substituted isomers are associated as well-known dimers while the 4-substituted systems form oligomers. In polar and H-bonding solvents self-association is substantially reduced. Sterically hindered 2- and 4-pyridones are less associated than unhindered systems. These results imply that determinations and interpretations of protomeric equilibrium should take into account the possible dominance of self-association

Journal of Organic Chemistry published new progress about Self-association. 73018-09-4 belongs to class pyridine-derivatives, and the molecular formula is C5H4ClNO, COA of Formula: C5H4ClNO.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Ladduwahetty, Tammy’s team published research in Journal of Medicinal Chemistry in 2022-07-28 | 870997-85-6

Journal of Medicinal Chemistry published new progress about Molecular docking. 870997-85-6 belongs to class pyridine-derivatives, and the molecular formula is C6H5BrN2O2, Quality Control of 870997-85-6.

Ladduwahetty, Tammy; Lee, Matthew R.; Maillard, Michel C.; Cachope, Roger; Todd, Daniel; Barnes, Michael; Beaumont, Vahri; Chauhan, Alka; Gallati, Caroline; Haughan, Alan F.; Kempf, Georg; Luckhurst, Christopher A.; Matthews, Kim; McAllister, George; Mitchell, Philip; Patel, Hiral; Rose, Mark; Saville-Stones, Elizabeth; Steinbacher, Stefan; Stott, Andrew J.; Thatcher, Emma; Tierney, Jason; Urbonas, Liudvikas; Munoz-Sanjuan, Ignacio; Dominguez, Celia published the artcile< Identification of a Potent, Selective, and Brain-Penetrant Rho Kinase Inhibitor and its Activity in a Mouse Model of Huntington's Disease>, Quality Control of 870997-85-6, the main research area is piperazine analog preparation Rho kinase inhibitor SAR docking pharmacokinetics.

The Rho kinase (ROCK) pathway is implicated in the pathogenesis of several conditions, including neurol. diseases. In Huntington’s disease (HD), ROCK is implicated in mutant huntingtin (HTT) aggregation and neurotoxicity, and members of the ROCK pathway are increased in HD mouse models and patients. To validate this mode of action as a potential treatment for HD, a potent, selective, central nervous system (CNS)-penetrant ROCK inhibitor was sought. Identifying a compound that could be dosed orally in mice with selectivity against other AGC kinases, including protein kinase G (PKG), whose inhibition could potentially activate the ROCK pathway, was paramount for the program. The optimization of published ligands to identify a novel series of ROCK inhibitors based on a piperazine core was demonstrated. Morphing of the early series developed inhouse by scaffold hopping enabled the identification of a compound exhibiting high potency and desired selectivity and demonstrating a robust pharmacodynamic (PD) effect by the inhibition of ROCK-mediated substrate (MYPT1) phosphorylation after oral dosing.

Journal of Medicinal Chemistry published new progress about Molecular docking. 870997-85-6 belongs to class pyridine-derivatives, and the molecular formula is C6H5BrN2O2, Quality Control of 870997-85-6.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Gurgul, Ilona’s team published research in Metallomics in 2020 | 366-18-7

Metallomics published new progress about Cytotoxicity. 366-18-7 belongs to class pyridine-derivatives, and the molecular formula is C10H8N2, Synthetic Route of 366-18-7.

Gurgul, Ilona; Mazuryk, Olga; Lomzik, Michal; Gros, Philippe C.; Rutkowska-Zbik, Dorota; Brindell, Malgorzata published the artcile< Unexplored features of Ru(II) polypyridyl complexes - towards combined cytotoxic and antimetastatic activity>, Synthetic Route of 366-18-7, the main research area is cytotoxicity antimetastatic polypyridyl Ru II.

Therefore, scientists have to concentrate their efforts on designing compounds affecting not only the primary tumor, but also efficiently inhibiting metastasis. Herein, we report two families of Ru(II) polypyridyl complexes bearing 2,2′-bipyridine substituted by a semicarbazone 2-formylopyridine moiety as one of the ligands and 4,4′-di-tert-butyl-2,2′-dipyridyl or 4,7-diphenyl-1,10-phenanthroline as auxiliary ligands. These complexes strengthen cells’ adherent properties and inhibit the activity of metalloproteinases (MMPs) in vitro, which is relevant in anti-metastatic treatment. The in vitro studies were performed on human lung adenocarcinoma (A549) and human pancreatic cancer (PANC-1) cells, which have a well-documented invasive potential. The induced alteration of the tumor cells’ adhesion properties correlated with the high cytotoxic effect exerted by the complexes and their excellent cellular uptake. It was also proved that both complexes directly inhibit M-MP2 and M-MP9 enzyme activities, which are essential for the development of tumor metastasis. The results of this study indicate that the biol. properties of polypyridyl Ru(II) complexes extend beyond the standard cytotoxic activity and represent an important step towards designing new anti-metastatic agents.

Metallomics published new progress about Cytotoxicity. 366-18-7 belongs to class pyridine-derivatives, and the molecular formula is C10H8N2, Synthetic Route of 366-18-7.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Robinson, Donovan J’s team published research in Organic Letters in 2022-05-20 | 93-60-7

Organic Letters published new progress about Aromatic esters Role: RCT (Reactant), RACT (Reactant or Reagent). 93-60-7 belongs to class pyridine-derivatives, and the molecular formula is C7H7NO2, Name: 3-(Methoxycarbonyl)pyridine.

Robinson, Donovan J.; Ortiz, Kacey G.; O’Hare, Nathan P.; Karimov, Rashad R. published the artcile< Dearomatization of Heteroarenium Salts with ArBpin Reagents. Application to the Total Synthesis of a Nuphar Alkaloid>, Name: 3-(Methoxycarbonyl)pyridine, the main research area is carbonylpyridinium triflate arylboron pinacol ester rhodium catalyst enantioselective dearomatization; aryl dihydropyridinecarboxylate preparation; Nuphar alkaloid preparation.

Rhodium-catalyzed enantioselective addition of aryl and heteroaryl boron pinacol esters to pyridinium and quinolinium salts were developed for the synthesis of enantioenriched dihydroheteroarenes. The methodol. was enabled the synthesis of 2-heteroaryl-substituted dihydropyridines in high yield and ee, which provided efficient synthetic access to a nuphar alkaloid.

Organic Letters published new progress about Aromatic esters Role: RCT (Reactant), RACT (Reactant or Reagent). 93-60-7 belongs to class pyridine-derivatives, and the molecular formula is C7H7NO2, Name: 3-(Methoxycarbonyl)pyridine.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Anson, Francesca’s team published research in JACS Au in 2021-08-23 | 2127-03-9

JACS Au published new progress about Apoptosis. 2127-03-9 belongs to class pyridine-derivatives, and the molecular formula is C10H8N2S2, Recommanded Product: 1,2-Di(pyridin-2-yl)disulfane.

Anson, Francesca; Thayumanavan, S.; Hardy, Jeanne A. published the artcile< Exogenous Introduction of Initiator and Executioner Caspases Results in Different Apoptotic Outcomes>, Recommanded Product: 1,2-Di(pyridin-2-yl)disulfane, the main research area is initiator executioner caspase apoptosis.

The balance of pro-apoptotic and pro-survival proteins defines a cell′s fate. These processes are controlled through an interdependent and finely tuned protein network that enables survival or leads to apoptotic cell death. The caspase family of proteases is central to this apoptotic network, with initiator and executioner caspases, and their interaction partners, regulating and executing apoptosis. In this work, we interrogate and modulate this network by exogenously introducing specific initiator or executioner caspase proteins. Each caspase is exogenously introduced using redox-responsive polymeric nanogels. Although caspase-3 might be expected to be the most effective due to the centrality of its role in apoptosis and its heightened catalytic efficiency relative to other family members, we observed that caspase-7 and caspase-9 are the most effective at inducing apoptotic cell death. By critically analyzing the introduced activity of the delivered caspase, the pattern of substrate cleavage, as well as the ability to activate endogenous caspases, we conclude that the efficacy of each caspase correlated with the levels of pro-survival factors that both directly and indirectly impact the introduced caspase. These findings lay the groundwork for developing methods for exogenous introduction of caspases as a therapeutic option that can be tuned to the apoptotic balance in a proliferating cell.

JACS Au published new progress about Apoptosis. 2127-03-9 belongs to class pyridine-derivatives, and the molecular formula is C10H8N2S2, Recommanded Product: 1,2-Di(pyridin-2-yl)disulfane.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem