Month: October 2022

Gao, Xu-Sheng; Dai, Hai-Jie; Tang, Yuerou; Ding, Mei-Juan; Pei, Wen-Bo; Ren, Xiao-Ming published the artcile< Crystal Structures, Photoluminescence, and Magnetism of Two Novel Transition-Metal Complex Cocrystals with Three-Dimensional H-Bonding Organic Framework or Alternating Noncovalent Anionic and Cationic Layers>, Category: pyridine-derivatives, the main research area is copper zinc bipyridine benzenedicarboxylate cocrystal photoluminescence magnetism crystal structure; transition metal complex cocrystal hydrogen bonding organic framework.

Cocrystn. may alter material physicochem. properties; thus, the strategy of forming a cocrystal is generally used to improve the material performance for practical applications. In this study, two transition-metal complex cocrystals [Zn(bpy)3]H0.5BDC·H1.5BDC·0.5bpy·3H2O (1) and [Cu2(BDC)(bpy)4]BDC·bpy·2H2O (2) have been achieved using a hydrothermal reaction, where bpy and H2BDC represent 2,2′-bipyridine and benzene-1,3-dicarboxylic acid, resp. Cocrystals were characterized by microanal., IR spectroscopy, and UV-visible spectroscopy. Cocrystal 1 contains five components and crystallizes in a monoclinic space group P21/n. The H0.5BDC1.5-, H1.5BDC0.5-, and H2O mols. construct three-dimensional H-bonding organic framework; the [Zn(bpy)3]2+ coordination cations and uncoordinated bpy mols. reside in channels, where two coordinated bpy ligands in [Zn(bpy)3]2+ and one uncoordinated bpy adopt sandwich-type alignment via π···π stacking interactions. Cocrystal 2 with four components crystallizes in a triclinic space group P-1 to form alternating layers; the binuclear [Cu2(bpy)4(BDC)]2+ cations and uncoordinated bpy mols. build the cationic layers, and the BDC2- species with disordered lattice water mols. form the anionic layers. Cocrystal 1 shows intense photoluminescence at an ambient condition with a quantum yield of 14.96% and decay time of 0.48 ns, attributed to the π* → π electron transition within phenyl/pyridyl rings, and 2 exhibits magnetic behavior of an almost isolated spin system with rather weak antiferromagnetic coupling in the [Cu2(bpy)4(BDC)]2+ cation.

ACS Omega published new progress about Antiferromagnetic exchange. 366-18-7 belongs to class pyridine-derivatives, and the molecular formula is C10H8N2, Category: pyridine-derivatives.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Dong, Guoqiang; Chen, Wei; Wang, Xia; Yang, Xinglin; Xu, Tianying; Wang, Pei; Zhang, Wannian; Rao, Yu; Miao, Chaoyu; Sheng, Chunquan published the artcile< Small Molecule Inhibitors Simultaneously Targeting Cancer Metabolism and Epigenetics: Discovery of Novel Nicotinamide Phosphoribosyltransferase (NAMPT) and Histone Deacetylase (HDAC) Dual Inhibitors>, Synthetic Route of 56622-54-9, the main research area is preparation NAMPT HDAC dual inhibitor cancer; antitumor preparation nicotinamide phosphoribosyltransferase histone deacetylase inhibitor.

Cancer metabolism and epigenetics are among the most intensely pursued research areas in anticancer drug discovery. Here we report the first small mols. that simultaneously inhibit nicotinamide phosphoribosyltransferase (NAMPT)and histone deacetylase (HDAC), two important targets of cancer metabolism and epigenetics, resp. Through iterative structure-based drug design, chem. synthesis, and biol. assays, a highly potent dual NAMPT and HDAC inhibitor was successfully identified. Compound 35 possessed excellent and balanced activities against both NAMPT (IC50 = 31 nM) and HDAC1 (IC50 = 55 nM). It could effectively induce cell apoptosis and autophagy and ultimately led to cell death. Importantly, compound 35 showed excellent in vivo antitumor efficacy in the HCT116 xenograft model. This proof-of-concept study demonstrates the feasibility of discovering an inhibitor targeting cancer metabolism and epigenetics and provides an efficient strategy for multitarget antitumor drug discovery.

Journal of Medicinal Chemistry published new progress about Antitumor agents. 56622-54-9 belongs to class pyridine-derivatives, and the molecular formula is C7H10N2, Synthetic Route of 56622-54-9.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Wang, Ze-Kun; Lin, Jia-Le; Zhang, Yun-Chang; Yang, Chen-Wu; Zhao, Ya-Kun; Leng, Zheng-Wei; Wang, Hui; Zhang, Dan-Wei; Zhu, Jiang; Li, Zhan-Ting published the artcile< Synthesis and short DNA in situ loading and delivery of 4 nm-aperture flexible organic frameworks>, Related Products of 55279-29-3, the main research area is flexible organic framework short DNA loading delivery synthesis.

Five water-soluble flexible organic frameworks have been synthesized from a pyridinium-derived tetracationic tetraaldehyde and five diacylhydrazines (1 : 2) through the quant. formation of a hydrazone bond in water at ambient temperature Dynamic light scattering experiments reveal that the homogeneous frameworks display hydrodynamic diameters ranging from 68 nm to 167 nm, which can be tuned by changing the concentration of the components. Mol. modeling shows that, when adopting an ideal, extended conformation, the frameworks form an aperture of 4 nm diameter The new flexible frameworks are generally of low cytotoxicity. Fluorescence imaging and flow cytometric anal. demonstrate that the new flexible porous frameworks can quickly include single and double stranded DNA of 21 nucleotides and deliver the included DNA into both normal and cancer cells, with the percentage of delivered cells reaching up to 99.5%.

Materials Chemistry Frontiers published new progress about Bioconcentration. 55279-29-3 belongs to class pyridine-derivatives, and the molecular formula is C6H6N2O, Related Products of 55279-29-3.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Chitti, Surendar; Pulya, Sravani; Nandikolla, Adinarayana; Patel, Tarun Kumar; Banoth, Karan Kumar; Murugesan, Sankaranarayanan; Ghosh, Balaram; Chandra Sekhar Kondapalli, Venkata Gowri published the artcile< Design, synthesis and structure-activity relationship studies of novel spirochromanone hydrochloride analogs as anticancer agents>, Recommanded Product: Pyridin-4-ylmethanamine, the main research area is aminomethylphenyl spirochromanepiperidineone preparation anticancer mol docking SAR cytotoxicity; anticancer; apoptosis; cytotoxicity; molecular docking; spiro-[chromane-2,4′-piperidine]-4-one.

The authors designed and synthesized 18 spirochromanone derivs I [R = isopropylamino, cyclopentylamino, 4-methoxycyclohexylamino etc.]. The compounds I were characterized and evaluated for anticancer activity against human breast cancer (MCF-7) and murine melanoma (B16F10) cell lines. The anticancer activity ranged from 4.34 to 29.31 μm. The most potent compounds, I [R = dimethylamino, benzylamino] were less toxic against the human embryonic kidney (HEK-293) cell line and ∼ two/∼fourfold selective toward MCF-7 than B16F10 in comparison to the reference, BG-45. Compound , I [R = benzylamino] caused 28.6% total apoptosis, leading to significant cytotoxicity, and arrested the G2 phase of the cell cycle in B16F10 cells. A mol. docking study of compound , I [R = benzylamino] exhibited effective binding at the active site of the epidermal growth factor receptor kinase domain. This study highlights the importance of spirochromanones as anticancer agents.

Future Medicinal Chemistry published new progress about Amines Role: RCT (Reactant), RACT (Reactant or Reagent). 3731-53-1 belongs to class pyridine-derivatives, and the molecular formula is C6H8N2, Recommanded Product: Pyridin-4-ylmethanamine.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Hooda, Anjli; Nehra, Kapeesha; Dalal, Anuj; Singh, Sitender; Kumar Saini, Raman; Kumar, Sanjay; Singh, Devender published the artcile< Terbium complexes of an asymmetric β-diketone: Preparation, photophysical and thermal investigation>, Formula: C10H8N2, the main research area is preparation terbium asym beta diketonate substituted bipyridin complex; thermal decomposition terbium asym beta diketonate substituted bipyridin complex; luminescence terbium asym beta diketonate substituted bipyridin complex; emission spectra terbium asym beta diketonate substituted bipyridin complex; band gap terbium asym beta diketonate substituted bipyridin complex; cyclic voltammetry terbium asym beta diketonate substituted bipyridin complex; chromaticity terbium asym beta diketonate substituted bipyridin complex.

Chromophoric 1,3-diketone ligand was used to prepare novel ternary complexes of terbium with differently substituted 2,2′-bipyridines as auxiliary ligands. These prepared complexes were thoroughly studied with the help of numerous spectroscopic techniques. IR spectral anal. suggested the coordination of diketone and ancillary ligand to the Tb(III) ion through oxygen and nitrogen atom, resp. Photoluminescence emission spectra of complexes have displayed only characteristic peaks of Tb3+ ion suggesting the efficient sensitization of metal ion by chromophoric ligands. Emission spectra of all complexes have displayed the ligand sensitized green emission due to the 5D4→7F5 transition situated at ∼548 nm. Colorimetric study and color purity of complexes reveal the green luminous character of synthesized complexes. Thermogravimetric measurements revealed the thermal stability of the complexes. Optical and electronic band gaps are in good agreement with each other that shows their importance as semiconductor material. These trivalent complexes of terbium could be used as the green component in displays and light emissive materials.

Inorganica Chimica Acta published new progress about Absorption spectra. 366-18-7 belongs to class pyridine-derivatives, and the molecular formula is C10H8N2, Formula: C10H8N2.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Cheng, Xiayun; Taylor, Alexandria P.; Zhu, Kaicheng published the artcile< Synthesis of Substituted 2-Pyridones via 6π-Electrocyclization of Dienyl Isocyanates>, Name: Methyl 3-bromo-2-pyridinecarboxylate, the main research area is substituted pyridone preparation; dienyl isocyanate pi electrocyclization Curtius.

A one-pot Curtius rearrangement of dienyl carboxylic acids followed by a 6π-electrocyclization process to form substituted 2-pyridone products was developed. Dienyl isocyanates generated from aliphatic acids were more reactive than their aromatic counterparts. Addnl., substitution patterns of the carboxylic acids had an impact on the efficiency of the cyclization.

Journal of Organic Chemistry published new progress about Alkenes Role: RCT (Reactant), SPN (Synthetic Preparation), RACT (Reactant or Reagent), PREP (Preparation). 53636-56-9 belongs to class pyridine-derivatives, and the molecular formula is C7H6BrNO2, Name: Methyl 3-bromo-2-pyridinecarboxylate.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Shi, Buyin; Xu, Yang; Wang, Tianqi; Gao, Shengguang; Meng, Guojie; Huang, Kun published the artcile< Ag nanoparticles encapsulated in carboxyl-functionalized hollow microporous organic nanospheres for highly efficient catalysis applications>, Recommanded Product: 1,2-Di(pyridin-2-yl)disulfane, the main research area is carboxyl functionalized hollow microporous organic nanosphere silver nanoparticle; catalysis application.

In this work, we present a novel synthesis of Ag nanoparticles encapsulated in carboxyl-functionalized hollow microporous organic nanospheres (Ag@COOH-HMONs) by a combination of hyper-crosslinking mediated self-assembly and simply impregnation method, in which the COOH-HMONs supports were prepared via a Friedel-Crafts alkylation reaction by using polylactide-b-poly(tertbutyl acrylate)-b-polystyrene (PLA-b-PtBA-b-PS) triblock copolymer as precursors. Owing to the abundant carboxyl groups in the cavity of COOH-HMONs, highly dispersed silver nanoparticles can be successfully anchored into COOH-HMONs to produce Ag@COOH-HMONs via an ion exchange with AgNO3 following by an in-situ reduction of sodium borohydride (NaBH4). The obtained Ag@COOH-HMONs exhibit the high catalytic activities for the reduction of MB and nitroarom. compounds as well as selective oxidation of thiol and styrene due to their high surface area, hierarchical porosity and yolk-shell nanostructure. This approach of constructing novel metal@porous organic polymers is expected to open doors for new types of yolk-shell structural catalysts for practical applications.

Applied Catalysis, A: General published new progress about Aromatic nitro compounds Role: RCT (Reactant), RACT (Reactant or Reagent). 2127-03-9 belongs to class pyridine-derivatives, and the molecular formula is C10H8N2S2, Recommanded Product: 1,2-Di(pyridin-2-yl)disulfane.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Sung, Hui-Ling; Hu, Zhi-Jia; Chen, Chong-You; Wu, Jing-Yun published the artcile< Thermally stable dinuclear Co(II) and Zn(II) complexes of tetra-phosphonate and 2,2'-bipyridine>, Quality Control of 366-18-7, the main research area is tetrakis phosphorylmethyl benzene dinuclear cobalt zinc bipyridine preparation structure; crystal mol structure dinuclear cobalt zinc bipyridine tetra phosphonate.

Two dinuclear phosphonate-based transition metal complexes, [Co2(H6tpmb)2(2,2′-bipy)2(H2O)2] (1) and [Zn2(H6tpmb)2(2,2′-bipy)2] (2), have been synthesized at 60° by the reactions of 1,2,4,5-tetrakis(phosphorylmethyl)benzene (H8tpmb) and 2,2′-bipyridine (2,2′-bipy) ligands, with CoCl2·6H2O and Zn(NO3)2·6H2O, resp. These two complexes are characterized by single-crystal x-ray diffraction, XRD, IR and elemental anal. Complexes 1 and 2 both adopt dinuclear macrocycle structures in which the Co(II) center in the former has an octahedral coordination geometry of {CoN2O4} while the Zn(II) center in the latter shows a square pyramidal coordination geometry of {ZnN2O3} with a τ value of 0.01. The H8tpmb ligand adopting the cis,trans,cis,trans conformation was partially deprotonated to be the H6tpmb2- dianion in both complexes 1 and 2. TG anal. shows that complexes 1 and 2 both are thermally stable upon heating to 250°.

Inorganica Chimica Acta published new progress about Coordination sphere. 366-18-7 belongs to class pyridine-derivatives, and the molecular formula is C10H8N2, Quality Control of 366-18-7.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Jin, Songyang; Geng, Xinxin; Li, Yujun; Zheng, Ke published the artcile< Phosphoric Acid Mediated Light-Induced Minisci C-H Alkylation of N-Heteroarenes>, Recommanded Product: 3-(Methoxycarbonyl)pyridine, the main research area is green phosphate catalyst Minisci alkylation heteroarene redox active ester.

Herein, we report an environmentally-friendly light-induced Minisci alkylation of N-heteroarenes with a broad substrate scope using di-Ph phosphate as catalyst under metal- and photocatalyst-free conditions. The radical precursor redox-active esters (RAEs) were introduced as alkylating reagents for the functionalization of N-heteroarene derivatives including pyridine, quinoline, and isoquinoline. Mechanistic studies suggested that di-Ph phosphate played a key role via hydrogen bonding in the catalytic cycle.

European Journal of Organic Chemistry published new progress about Alkylation (Minisci). 93-60-7 belongs to class pyridine-derivatives, and the molecular formula is C7H7NO2, Recommanded Product: 3-(Methoxycarbonyl)pyridine.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Ritter, Helmut; Kaiser, M. published the artcile< Proton NMR spectra of nitrated aminopyridines>, Recommanded Product: 6-Amino-3-nitro-2-picoline, the main research area is NMR nitrated aminopyridine hydrogen bond; pyridine aminonitro NMR; steric hindrance hydrogen bond aminonitropyridine.

The 1H NMR spectra of 26 nitrated aminopyridines were measured and interpreted. Chem. shift assignments were based on existing chem. shift rules for substituted pyridines and spectral comparison with compounds of similar structure. Some o-aminonitropyridines were found to give a splitting of the amino signals due to intermol. hydrogen bonding; steric hindrance is shown to influence this bonding.

Magnetic Resonance in Chemistry published new progress about Intramolecular hydrogen bond. 22280-62-2 belongs to class pyridine-derivatives, and the molecular formula is C6H7N3O2, Recommanded Product: 6-Amino-3-nitro-2-picoline.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem