Day: November 4, 2022

Huang, Taomin; Chen, Nianzu; Wang, Donglei; Lai, Yonghua; Cao, Zhijuan published an article in 2014, the title of the article was A validated stability-indicating HPLC method for the simultaneous determination of pheniramine maleate and naphazoline hydrochloride in pharmaceutical formulations.Computed Properties of 132-20-7 And the article contains the following content:

Background: A simple, rapid, and accurate stability-indicating reverse phase liquid chromatog. method was developed and validated for the simultaneous determination of pheniramine maleate and naphazoline hydrochloride in bulk drugs and pharmaceutical formulations. Results: Optimum chromatog. separations among pheniramine maleate, naphazoline hydrochloride and stress-induced degradation products have been achieved within 10 min by using an Agilent zorbax eclipse XDB C18 column (150 mm × 4.6 mm, 5 μm) as the stationary phase with a mobile phase consisted of 10 mM phosphate buffer pH 2.8 containing 0.5% triethlamine and methanol (68:32, volume/volume) at a flow rate of 1 mL min-1. Detection was performed at 280 nm using a diode array detector. Theor. plates for pheniramine maleate and naphazoline hydrochloride were calculated to be 6762 and 6475, resp. The method was validated in accordance with ICH guidelines with respect to linearity, accuracy, precision, robustness, specificity, limit of detection and quantitation. Regression anal. showed good correlations (R2 > 0.999) for pheniramine maleate in the concentration range of 150-1200 μg mL-1 and naphazoline hydrochloride in 12.5-100 μg mL-1. The method results in excellent separation of both the analytes and degradation products. The peak purity factor is ≥980 for both analytes after all types of stress, indicating complete separation of both analyte peaks from the stress induced degradation products. Conclusions: Overall, the proposed stability-indicating method was suitable for routine quality control and drug anal. of pheniramine maleate and naphazoline hydrochloride in pharmaceutical formulations. The experimental process involved the reaction of N,N-Dimethyl-3-phenyl-3-(pyridin-2-yl)propan-1-amine maleate(cas: 132-20-7).Computed Properties of 132-20-7

The Article related to naphazoline hydrochloride pharmaceutical formulation quality control rphplc, Pharmaceutical Analysis: Synthetic Organic Compounds and other aspects.Computed Properties of 132-20-7

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Caglar, Hatice; Bueyuektuncel, Ebru published an article in 2014, the title of the article was HPLC method development and validation: simultaneous determination of active ingredients in cough and cold pharmaceuticals.Name: N,N-Dimethyl-3-phenyl-3-(pyridin-2-yl)propan-1-amine maleate And the article contains the following content:

Objective: This study aimed to develop a simple reversed-phase high performance chromatog. method for simultaneous determination of pseudoephdrine HCI, pheniramine maleate, acetaminophen, guaifenisin, pyrilamine maleate, chlorpheniramine maleate, triprolidine HCI, dextromethorphan HBr, diphenhydramine HCI in cough and cold pharmaceuticals. Methods: The separation of these compounds was achieved within 37.9 min on a Nucleodur gravity C18 column (250 x 4.0 mm, 5μm). The chromatog. separation of these compounds performed in a single run by using isocratic mobile phase consisting of methanol:buffer mixture (38:62, volume/volume) at room temperature, with flow rate of 0.75 mL.min-1. An UV absorption at 210 nm was monitored. 2,4,6-trimethoxybenzaldehyde was used as an internal standard (ISTD). The selectivity, linearity of calibration, accuracy, intraday and interday precision and forced degradation studies were examined as parts of the method validation. Results: The concentration-response relationship was linear over a concentration range of 0.2-250 μg.mL-1 for acetaminophen, 0.5-250 μg.mL-1 for pseudoephdrine HCI and pheniramine maleate, 1-250 μg.mL-1 for guaifenisin, 2.5-250 μg.mL-1 for chlorpheniramine maleate and triprolidine HCI, 5-250 μg.mL-1 for pyrilamine maleate and diphenhydramine HCI, 10-20 μg.mL-1 for dextromethorphan HBr with correlation coefficients better than 0.9993. The relative standard deviations of the intraday and interday were all less than 4%. Conclusion: The proposed liquid chromatog. method was successfully applied for the routine anal. of these compounds in different cough and cold pharmaceutical preparations such as syrups and tablets. The experimental process involved the reaction of N,N-Dimethyl-3-phenyl-3-(pyridin-2-yl)propan-1-amine maleate(cas: 132-20-7).Name: N,N-Dimethyl-3-phenyl-3-(pyridin-2-yl)propan-1-amine maleate

The Article related to reversed phase high performance chromatog, cough cold pharmaceutical active ingredient, Pharmaceutical Analysis: Synthetic Organic Compounds and other aspects.Name: N,N-Dimethyl-3-phenyl-3-(pyridin-2-yl)propan-1-amine maleate

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

On November 30, 2013, Raghu, M. S.; Basavaiah, K.; Abdulrahaman, Sameer A. M.; Prashanth, K. N.; Vinay, K. B. published an article.Name: N,N-Dimethyl-3-phenyl-3-(pyridin-2-yl)propan-1-amine maleate The title of the article was Sensitive and selective spectrophotometric methods for the determination of pheniramine maleate in bulk drug and in its formulations using sodium hypochlorite. And the article contained the following:

Two simple, selective and sensitive spectrophotometric methods for the determination of pheniramine maleate (PAM; H1 histamine receptor antagonist) in pharmaceutical pure and dosage forms are described. The methods are based on the reaction of PAM with Na hypochlorite in Kolthoff phosphate-borate buffer pH 7.0 leading to the PAM chloro derivative, subsequent decomposition of excess hypochlorite by Na nitrite (the PAM chloro derivative is not affected under optimized conditions), followed by the oxidation of K iodide with the PAM chloro derivative to iodine (I3-) colored product, which is measured either directly at 355 (method A; yellow product) or after reaction with starch at 590 nm (method B; blue product). The optimal conditions for the PAM-hypochlorite reaction were detd; under these conditions the linear relationship was found in the concentration ranges of 2-50 and 1-25 μg PAM/mL with methods A and B, resp. The calculated molar absorptivity values were 7.26 × 103 and 1.28 × 104 L/(mol cm) for methods A and B, resp. Sandell sensitivity values, limits of detection (LOD), and limits of quantification (LOQ) were calculated The proposed methods were used for the determination of PAM in tablets and injection solutions with good accuracy and precision and without interferences from common pharmaceutical additives. The obtained results compared favorably with those of the reference method. The accuracy and reliability of the proposed methods were further checked by recovery studies via standard addition procedure. The experimental process involved the reaction of N,N-Dimethyl-3-phenyl-3-(pyridin-2-yl)propan-1-amine maleate(cas: 132-20-7).Name: N,N-Dimethyl-3-phenyl-3-(pyridin-2-yl)propan-1-amine maleate

The Article related to pharmaceutical analysis pheniramine maleate spectrophotometry sodium hypochlorite reagent, Pharmaceutical Analysis: Synthetic Organic Compounds and other aspects.Name: N,N-Dimethyl-3-phenyl-3-(pyridin-2-yl)propan-1-amine maleate

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Raghu, M. S.; Basavaiah, K. published an article in 2012, the title of the article was Rapid and Sensitive Extraction-Free Spectrophotometric Methods for the Determination of Pheniramine Maleate Using Three Sulphonthalein Dyes.Formula: C20H24N2O4 And the article contains the following content:

Three extraction-free spectrophotometric methods which are simple, selective and sensitive are described for the quantitation of pheniramine maleate (PAM), an antiallergic drug, in pure form and in its formulations. The methods are based on formation of yellow colored ion-pair complexes between PAM and 3 sulfonthalein dyes viz., bromothymol blue (method A), and bromocresol purple (method B) in dichloromethane, and bromocresol green (method C) in chloroform medium. The exptl. variables such as reagent concentration, solvent medium and reaction time were carefully optimized to achieve the highest sensitivity. Beer’s law is obeyed over the concentration ranges 1.0-16.0 for method A and method B, and 0.6-12 μg ml-1 PAM for method C with correlation coefficient of 0.999 for method A and method B, and 0.997 for method C. The molar absorptivity values are calculated to be 2.3 × 104, 2.5 × 104 and 3.0 × 104 l mol-1 cm-1 for the methods in the same order. The composition of the ion-pairs was found to be 1:1 by Job’s method of continuous variations and the conditional stability constant (K f) of the complexes were calculated The proposed methods were applied successfully to the determination of PAM in tablets and injection with good accuracy and precision and without interferences from common additives. The results obtained by the proposed methods were compared favorably with those of the reference method. The experimental process involved the reaction of N,N-Dimethyl-3-phenyl-3-(pyridin-2-yl)propan-1-amine maleate(cas: 132-20-7).Formula: C20H24N2O4

The Article related to pheniramine maleate determination spectrophotometry bromothymol blue bromocresol purple green, Pharmaceutical Analysis: Synthetic Organic Compounds and other aspects.Formula: C20H24N2O4

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

On October 31, 2011, Raghu, M. S.; Basavaiah, K. published an article.Recommanded Product: N,N-Dimethyl-3-phenyl-3-(pyridin-2-yl)propan-1-amine maleate The title of the article was Two charge-transfer complexation reactions for spectrophotometric determination of pheniramine maleate using π-acceptors. And the article contained the following:

This study presents two simple, selective and rapid spectrophotometric methods for determination of pheniramine maleate (PAM) in pure form and in its formulations. Both methods are based on the formation of charge-transfer (CT) reaction of PAM with p-chloranilic acid (CAA) or 2,3-dichloro-5,6-dicyanoquinone (DDQ) in 1,4-dioxan-acetonitrile medium. CT complexes were quantified at 530 and 590 nm for CAA and DDQ methods, resp. Beer’s law is obeyed (concentrate ranges, 12.5-200 μg/mL-1 for CAA and 5-80 μg/mL-1 for DDQ method), with correlation coefficients (r) of 0.9999 and 0.9991. Apparent molar absorptivities are calculated to be 1.27 × 103 and 3.06 × 103 l/mol-1/cm-1, resp. and corresponding Sandell sensitivities are 0.281 and 0.112 μg/cm-2. Developed methods were successfully applied for determination of PAM in tablets and injections. The experimental process involved the reaction of N,N-Dimethyl-3-phenyl-3-(pyridin-2-yl)propan-1-amine maleate(cas: 132-20-7).Recommanded Product: N,N-Dimethyl-3-phenyl-3-(pyridin-2-yl)propan-1-amine maleate

The Article related to charge transfer complexation spectrophotometric determination pheniramine maleate pi acceptor, Pharmaceutical Analysis: Synthetic Organic Compounds and other aspects.Recommanded Product: N,N-Dimethyl-3-phenyl-3-(pyridin-2-yl)propan-1-amine maleate

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

On January 7, 2011, Mueller, Marion K.; Petkau, Katja; Brunsveld, Luc published an article.Related Products of 75449-26-2 The title of the article was Protein assembly along a supramolecular wire. And the article contained the following:

Discotic mols. self-assemble into supramol. wires that act as platforms for directed protein assembly via appended biotin functionalities. The experimental process involved the reaction of [2,2′-Bipyridine]-3,3′-diamine(cas: 75449-26-2).Related Products of 75449-26-2

The Article related to protein assembly supramol wire biotin streptavidin discotic monomer, General Biochemistry: Proteins and Their Constituents and other aspects.Related Products of 75449-26-2

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

On May 31, 1999, Decristoforo, Clemens; Mather, Stephen J. published an article.Product Details of 636-73-7 The title of the article was 99M-technetium-labelled peptide-HYNIC conjugates: Effects of lipophilicity and stability on biodistribution. And the article contained the following:

The aim of this study was to explore the effects of lipophilicity and stability on the biodistribution of 99mTc labeled peptides through the use of different co-ligands. 6-Hydrazinopyridine-3-carboxylic acid (HYNIC) was coupled to the somatostatin analog RC160 and radiolabeled using a range of ethylenediaminediacetic acid (EDDA) and EDTA derivatives as well as tricine and pyridine/tricine as co-ligands. After labeling with technetium-99m, chromatog., stability, protein-binding, and rat biodistribution studies were performed. For most co-ligands, biodistribution correlated well with in vitro properties. Lipophilic substitution on EDDA resulted in higher protein binding, increased liver uptake, and intestinal excretion. Stabilization of tricine with pyridines reduced blood levels and lowered liver uptake. EDTA derivatives showed high instability in vitro and in vivo. The experimental process involved the reaction of Pyridine-3-sulfonic acid(cas: 636-73-7).Product Details of 636-73-7

The Article related to technetium 99m somatostatin analog complex biodistribution, rc160 hynic technetium 99m complex biodistribution, Radiation Biochemistry: Disease Diagnosis and Therapy and other aspects.Product Details of 636-73-7

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Kaya Oeztuerk, Dilara; Baki, Birol; Oeztuerk, Recep; Karayuecel, Sedat; Uzun Goeren, Guelsen published an article in 2019, the title of the article was Determination of growth performance, meat quality and colour attributes of large rainbow trout (Oncorhynchus mykiss) in the southern Black Sea coasts of Turkey.Name: N,N-Dimethyl-3-phenyl-3-(pyridin-2-yl)propan-1-amine maleate And the article contains the following content:

The aim of this study was to determine the growth performance, meat quality and color attributes of large rainbow trout (Oncorhynchus mykiss) in net cage systems in the southern Black Sea coasts of Turkey. In the study, large rainbow trout with an initial weight of 1,322.07 ± 57.72 g were reached to 3,385.30 ± 140.98 g and the survival rates were 95.69 ± 1.32% in 5-mo production period. Crude protein and crude fat values of fish meat were ranged between 16.75 ± 0.07-20.18 ± 0.90% and 9.22 ± 0.15-12.29 ± 0.42%, resp. (p < .05). The essential and non-essential amino acid values were between 12.92 ± 0.02-13.09 ± 0.01 g/100 g and 11.97 ± 0.14-11.47 ± 0.01 g/100 g, resp. (p > .05). C20:5n-3, C22:6n-3, ɷ3 and ɷ6 values in fish meat were between 4.32 ± 0.02-4.30 ± 0.08% (p < .05), 8.31 ± 0.10-7.72 ± 0.15% (p < .05), 13.41 ± 0.10-12.93 ± 0.23% (p < .05) and 21.85 ± 0.06%-19.74 ± 0.36 (p < .05), resp. As a result, it can be concluded that large rainbow trout cultured in the southern Black Sea coasts of Turkey is a rich source of food in terms of fatty and amino acid compositions and atherogenicity index, thrombogenicity index and hypocholesterolemic/hypercholesterolemic values. The experimental process involved the reaction of N,N-Dimethyl-3-phenyl-3-(pyridin-2-yl)propan-1-amine maleate(cas: 132-20-7).Name: N,N-Dimethyl-3-phenyl-3-(pyridin-2-yl)propan-1-amine maleate

The Article related to meat food quality color amino acid oncorhynchus turkey, Food and Feed Chemistry: Meat, Eggs, Fish, and Seafood and other aspects.Name: N,N-Dimethyl-3-phenyl-3-(pyridin-2-yl)propan-1-amine maleate

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

On November 30, 2007, Wu, Chang-Ju; Chen, Ju-Na; Shi, Jing-Min published an article.Recommanded Product: 75449-26-2 The title of the article was Tris(3,3′-diamino-2,2′-bipyridine)zinc(II) dinitrate. And the article contained the following:

In the title complex, [Zn(C10H10N4)3](NO3)2, the six-coordinate ZnII atom lies at the intersection of three 2-fold axes in a slightly distorted octahedral coordination environment. The N atom of a nitrate anion is located on a 3-fold axis. In the crystal structure, intermol. N-H···N and N-H···O H bonds between cations and anions form a two-dimensional network perpendicular to the c axis. Crystallog. data and at. coordinates are given. The experimental process involved the reaction of [2,2′-Bipyridine]-3,3′-diamine(cas: 75449-26-2).Recommanded Product: 75449-26-2

The Article related to mol structure zinc aminobipyridine nitrate, crystal structure zinc aminobipyridine nitrate, hydrogen bond zinc aminobipyridine nitrate, Crystallography and Liquid Crystals: Crystal Structure and other aspects.Recommanded Product: 75449-26-2

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Sgaragli, Gianpietro; Frosini, Maria; Palmi, Mitri; Dixon, Henry B. F.; Desmond-Smith, Nicholas; Bianchi, Loria; Della Corte, Laura published an article in 1996, the title of the article was Role of taurine in thermoregulation and motor control: behavioral and cellular studies.HPLC of Formula: 636-73-7 And the article contains the following content:

Taurine may have a role in the striatonigral system of the rat. Considering that, whether a neurotransmitter or a neuromodulator, taurine must be recognized before initiating its action, in the present contribution a structure-activity relationship study is presented which gives some information on the nature of a possible recognition site in the rabbit brain, helping to explain the role of endogenous taurine in the central mechanisms of thermoregulation. The experimental process involved the reaction of Pyridine-3-sulfonic acid(cas: 636-73-7).HPLC of Formula: 636-73-7

The Article related to thermoregulation taurine structure activity relationship, Mammalian Biochemistry: General Physiological Chemistry and other aspects.HPLC of Formula: 636-73-7

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem