Day: November 4, 2022

Habyalimana, Vedaste; Mbinze, Jeremie Kindenge; Tshilombo, Nicodeme Kalenda; Dispas, Amandine; Loconon, Achille Yemoa; Sacre, Pierre-Yves; Widart, Joeelle; De Tullio, Pascal; Counerotte, Stephane; Ntokamunda, Justin-Leonard Kadima; Ziemons, Eric; Hubert, Philippe; Djang’eing’a, Roland Marini published an article in 2015, the title of the article was Analytical tools and strategic approach to detect poor quality medicines, identify unknown components, and timely alerts for appropriate measures: case study of antimalarial medicines.Synthetic Route of 132-20-7 And the article contains the following content:

Nowadays, the circulation of poor quality medicines is becoming an alarming worldwide phenomenon with serious public health and socio-economic concerns. The situation is particularly critical in developing countries where drug quality assurance and regulatory systems for drug manufacturing, importation, distribution and sales are weak. A sustained vigilance on poor quality medicines that regroup counterfeit/falsified, substandard and degraded medicines is therefore required to ensure patient safety and genuine medicines integrity. A case situation is illustrated including a strategic approach and anal. tools that were found useful to detect poor quality medicines, identify unknown components, and timely alerts for appropriate measures against the spread of those harmful products. Several suspected medicines randomly sampled in several strategic Rwandan areas were firstly check-controlled by means of visual inspection and then applying several anal. techniques from simple to more complex ones. The following medicines were studied: quinine sulfate tablets, artemisinin-based combination tablets, and artesunate powders for injection. Taking into account the pharmaceutical forms and the chem. characteristics, the following tests were applied: uniformity of mass, friability, disintegration, fluorescence, identification and assay. They were followed by more complex anal. techniques that allowed more comprehension of abnormal findings among which the presence of a wrong active pharmaceutical ingredient in quinine sulfate tablets which is mainly discussed in this paper to illustrate a strategic approach and various anal. tools that can be used in detecting and identifying unknown component in poor quality medicines. The experimental process involved the reaction of N,N-Dimethyl-3-phenyl-3-(pyridin-2-yl)propan-1-amine maleate(cas: 132-20-7).Synthetic Route of 132-20-7

The Article related to antimalarial medicine drug quality assessment, Pharmaceutical Analysis: Synthetic Organic Compounds and other aspects.Synthetic Route of 132-20-7

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Raghu, M. S.; Basavaiah, K.; Prashanth, K. N.; Vinay, K. B. published an article in 2012, the title of the article was Acid-base titrimetric assay of pheniramine maleate in pharmaceuticals in hydro-alcoholic medium.Application of 132-20-7 And the article contains the following content:

Two simple titrimetric methods are described for the determination of pheniramine maleate (PAM) in pure form and in its dosage forms. The principle involved in the methods are simple acid-base reaction in which the carboxylic acid group of the drug was determined by titrating with an aqueous NaOH solution either visually using phenolphthalein as indicator (method A) or pH-metrically (method B) using glass-calomel electrode system. The methods were applicable over the range of 2-20 mg of PAM. The procedures were applied to the determination of PAM in tablets, injections, and the results were found to be in a good agreement with those obtained by the reference method. The precision results, expressed by intra-day and inter-day relative standard deviation values, were satisfactory (RSD ≤ 2.58%). The accuracy was satisfactory as well (RE ≤ 2.14%). Excipients used as additives in pharmaceutical formulations did not interfere in the proposed procedures as shown by placebo blank and synthetic mixture analyses and also by the recovery study via standard addition technique with percentage recoveries in the range 97.48 – 106.3% with a standard deviation of 1.76 – 3.42%. The experimental process involved the reaction of N,N-Dimethyl-3-phenyl-3-(pyridin-2-yl)propan-1-amine maleate(cas: 132-20-7).Application of 132-20-7

The Article related to pheniramine maleate determination acid base titrimetry, Pharmaceutical Analysis: Synthetic Organic Compounds and other aspects.Application of 132-20-7

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Sawant, Sakshi; Borkar, Nitin published an article in 2015, the title of the article was Validation of high performance liquid chromatographic method for the simultaneous determination of common cough and cold ingredients in multicomponent oral drug products.HPLC of Formula: 132-20-7 And the article contains the following content:

This research was done to develop a potential, reliable fast and efficient anal. method for various dosage forms eg. Syrup, tablet, suspension etc which could estimate all the major components of a cough and cold multicomponent formulation and also this method was validated. All common used components like pheniramine maleate, phenylephrine hydrochloride, acetaminohen, dextromethorphan hydrobromide, guafenesin, chlorpheniramine maleate, diphenhydramine in cough and cold category of products also covering more than one dosage forms eg. Syrups, suspensions, tablet etc was used thus making the methodol. by and large universal for the entire range of cough and cold products. This would help in using almost a common method of anal. for separation of most of the components instead of using a lot of sep. methods for the same product or using a common method of anal. for a range of different dosage form of cough and cold category for a common set of components. This would save time and cost and ensure optimum usage of resources. Mobile phase of 0.01M 1-octane sulfonic acid sodium salt monohydrate pH adjusted to 2.80 with 0rthophosphoric acid: Acetonitrile in a gradient ratio was used with a flow rate of 1.0 mL/min on a C18, 25 × 4.6 mm id, 5μ column at a wavelength of 264nm. This method was validated for parameters as accuracy, repeatability, reproducibility, robustness, linearity, limit of detection and limit of quantification. This HPLC method was found to be specific, linear, precise,accurate, reproducible and robust and can be easily used for determination of common cough and cold analytes in a formulation as the results were found to be well within the acceptance range. The experimental process involved the reaction of N,N-Dimethyl-3-phenyl-3-(pyridin-2-yl)propan-1-amine maleate(cas: 132-20-7).HPLC of Formula: 132-20-7

The Article related to cough cold ingredient high performance liquid chromatog, Pharmaceutical Analysis: Synthetic Organic Compounds and other aspects.HPLC of Formula: 132-20-7

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Xin, Xia; Pietraszkiewicz, Marek; Pietraszkiewicz, Oksana; Chernyayeva, Olga; Kalwarczyk, Tomasz; Gorecka, Ewa; Pociecha, Damian; Li, Hongguang; Holyst, Robert published an article in 2012, the title of the article was Eu(III)-coupled luminescent multi-walled carbon nanotubes in surfactant solutions.Synthetic Route of 75449-26-2 And the article contains the following content:

A carbon nanotube/inorganic hybrid material was fabricated by coupling Eu(III) complexes onto multi-walled carbon nanotubes (MWCNTs). Successful coupling was verified by XPS measurement where a clear signal from Eu3d was identified. When sonicated in hexaethylene glycol monododecyl ether (C12E6) or sodium dodecyl sulfate (SDS) aqueous solutions, the MWCNTs with Eu-complex attached (denoted as Eu-MWCNTs hereafter) can be dispersed. UV-visible measurements on a dilute dispersion of Eu-MWCNTs in SDS aqueous solution reveal the characteristic absorption from Eu(III) complexes, which gives further proof of the successful coupling. The strong luminescent properties of Eu-MWCNTs allow them to be observed directly under a fluorescence microscope. Eu-MWCNTs can undergo continuous movements in C12E6 or SDS dilute solutions When Eu-MWCNTs are incorporated into the lyotropic liquid crystal phase formed by C12E6 (above 40% by weight), however, movements were hindered. Small angle x-ray scattering measurements showed that Eu-MWCNTs are ordered in the lyotropic liquid crystal. Fluorescence microscopy observations reveal that the luminescent properties of the Eu-MWCNTs were not affected by the liquid crystalline surfactant matrix. The experimental process involved the reaction of [2,2′-Bipyridine]-3,3′-diamine(cas: 75449-26-2).Synthetic Route of 75449-26-2

The Article related to carbon nanotube dispersion surfactant luminescence solution, Surface Chemistry and Colloids: Solid-Liquid Systems and other aspects.Synthetic Route of 75449-26-2

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

On March 15, 2013, Youngvises, Napaporn; Chaida, Thanatcha; Khonyoung, Supada; Kuppithayanant, Nattawan; Tiyapongpattana, Warawut; Itharat, Arunporn; Jakmunee, Jaroon published an article.Category: pyridine-derivatives The title of the article was Greener liquid chromatography using a guard column with micellar mobile phase for separation of some pharmaceuticals and determination of parabens. And the article contained the following:

In this research, a greener chromatog. employing a short column, Zorbax SB C18 cartridge (12.5 × 4.6 mm, 5 μm) commonly used as a guard column in a reverse phase high performance liquid chromatog. (RP-HPLC), was utilized as the anal. column in conjunction with a more eco-friendly micellar mobile phase of sodium dodecyl sulfate (SDS) for separation tertiary mixtures of local anesthetics and antihistamines; and binary mixture of colds drugs; and quaternary mixture of some parabens with different separation conditions. The chromatog. behavior of these analytes was studied to demonstrate separation efficiency of this guard column in a micellar mobile phase. Moreover, this column and SDS mobile phase was exploited for determination of parabens in 64 samples of cosmetic product, both those that were produced locally in the community and those that were com. manufactured Linear calibration graphs of the parabens as detected at 254 nm were obtained in the range of 1-100 μmol L-1 with R2>0.9990. Percentage recoveries were 92.4-109.2 with %RSD<3, and the limit of detection and quantitation were 0.04-0.10 and 0.20-0.80 μmol L-1, resp. This anal. system is not only greener but also faster and employing simpler sample preparation than a conventional liquid chromatog. system. The experimental process involved the reaction of N,N-Dimethyl-3-phenyl-3-(pyridin-2-yl)propan-1-amine maleate(cas: 132-20-7).Category: pyridine-derivatives

The Article related to green liquid chromatog micelle mobile pharmaceutical paraben, Pharmaceutical Analysis: Synthetic Organic Compounds and other aspects.Category: pyridine-derivatives

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

On March 31, 2012, Raghu, M. S.; Basavaiah, K.; Ramesh, P. J.; Abdulrahman, Sameer A. M.; Vinay, K. B. published an article.SDS of cas: 132-20-7 The title of the article was Development and validation of a UV-spectrophotometric method for the determination of pheniramine maleate and its stability studies. And the article contained the following:

A sensitive, precise, and cost-effective UV-spectrophotometric method is described for the determination of pheniramine maleate (PAM) in bulk drug and tablets. The method is based on the measurement of absorbance of a PAM solution in 0.1 N HCl at 264 nm. As per the International Conference on Harmonization (ICH) guidelines, the method was validated for linearity, accuracy, precision, limits of detection (LOD) and quantification (LOQ), and robustness and ruggedness. A linear relationship between absorbance and concentration of PAM in the range of 2-40 μg/mL with a correlation coefficient (r) of 0.9998 was obtained. The LOD and LOQ values were found to be 0.18 and 0.39 μg/mL PAM, resp. The precision of the method was satisfactory: the value of relative standard deviation (RSD) did not exceed 3.47%. The proposed method was applied successfully to the determination of PAM in tablets with good accuracy and precision. Percentages of the label claims ranged from 101.8% to 102.01% with the standard deviation (SD) from 0.64% to 0.72%. The accuracy of the method was further ascertained by recovery studies via a standard addition procedure. In addition, the forced degradation of PAM was conducted in accordance with the ICH guidelines. Acidic and basic hydrolysis, thermal stress, peroxide, and photolytic degradation were used to assess the stability-indicating power of the method. A substantial degradation was observed during oxidative and alk. degradations No degradation was observed under other stress conditions. The experimental process involved the reaction of N,N-Dimethyl-3-phenyl-3-(pyridin-2-yl)propan-1-amine maleate(cas: 132-20-7).SDS of cas: 132-20-7

The Article related to pheniramine maleate determination uv spectrophotometry stability, Pharmaceutical Analysis: Synthetic Organic Compounds and other aspects.SDS of cas: 132-20-7

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Franco, Marina; Jasionowska, Renata published an article in 2013, the title of the article was Quick single run Capillary Zone Electrophoresis determination of active ingredients and preservatives in pharmaceutical products.Product Details of 132-20-7 And the article contains the following content:

The paper deals with the development of a rapid and efficient Capillary Zone Electrophoresis (CZE) method for Quality Control anal. of pharmaceutical preparations containing antihistamines, decongestants, anticholinergic remedies and preservatives. Active ingredients of interest are: ChlorPheniramine Maleate (CPM), DiPhenhydramine Hydrochloride (DPH), Ephedrine hydrochloride (E), Isopropamide Iodide (II), Pheniramine Maleate (PM), Lidocaine hydrochloride (L), Tetracaine hydrochloride (T), Clopamide Hydrochloride (CH) , DiHydroErgochristine (DHE), PhenylEphrine hydrochloride (PE) and Acetaminophen (A). Preservatives studied are: MethylParaben (MeP), EthylParaben (EtP), PropylParaben (PrP), ButylParaben (BuP), p-HydroxyBenzoic Acid (p-HBA). All these analytes were separated in a single run using 60 mM tetraborate buffer solution (TBS) pH = 9.2 as a BackGround Electrolyte (BGE) by an uncoated fused silica capillary of I.D. = 50 μm and applying a voltage of 25 kV in the first part of the electrophoretic run (up to 5.8 min) and 30 kV for the remaining time. The hydrodynamic pressurization of the inlet vial was 20 psi at 7.2 min. up to the end of anal. Total separation time was of 7.5 min. The method was then successfully validated and applied to the simultaneous determination of active ingredients and preservatives. Good repeatability, linearity, and sensitivity were demonstrated. Precision of migration time ™ was RSD% <0.53% and of corrected peak area (Ac) was RSD% <6.15%. The linearity evaluation gave 0.9928 < r2 < 1.000. LOD and LOQ, accuracy (recovery) and ruggedness were evaluated for each analyte demonstrating the good reliability of the method. Analyses of some pharmaceutical real samples were performed. The experimental process involved the reaction of N,N-Dimethyl-3-phenyl-3-(pyridin-2-yl)propan-1-amine maleate(cas: 132-20-7).Product Details of 132-20-7

The Article related to pharmaceutical preservative analysis capillary zone electrophoresis, Pharmaceutical Analysis: Synthetic Organic Compounds and other aspects.Product Details of 132-20-7

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Mehmood, Yasir; Saleem, Noviara; Mahmood, Rana Khalid; Riaz, Humayun; Atif, Raza Syed published an article in 2016, the title of the article was Analytical method development and validation of pheniramine maleate injection.SDS of cas: 132-20-7 And the article contains the following content:

Pheniramine Maleate assay in its injection formulation was performed using spectrophotometric estimation in UV/Vis-region and non-aqueous titration method. The method have been developed and validated in spectrophotometric Method and water was used as diluent which does not shows any interference in spectrophotometric estimations ICH guidelines were used to determine the anal. parameter. RSD and %RSD were obtained statistically along with neat chromatograms. Precision and accuracy of the results were obtained also which showed that the method is very accurate for quant. estimation of Pheniramine Maleate in injection dosage forms. Another simple titrimetric method is described for the determination of Pheniramine Maleate (PM) in pure form and in injection dosage forms. The principle involved in the method is simple acid-base reaction in which the perchloric acid is used as titrant and naphthol benzene as indicator. The experimental process involved the reaction of N,N-Dimethyl-3-phenyl-3-(pyridin-2-yl)propan-1-amine maleate(cas: 132-20-7).SDS of cas: 132-20-7

The Article related to pheniramine maleate injection dosage form uv visible spectrophotometry, Pharmaceutical Analysis: Synthetic Organic Compounds and other aspects.SDS of cas: 132-20-7

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Pandey, Ajay Kumar; Dwivedi, Dharmendra published an article in 2018, the title of the article was Titrimetric assay of some antihistamines with pyridinium fluoro chromate (PFC) reagent.Computed Properties of 132-20-7 And the article contains the following content:

In the present paper, simple, convenient accurate, precise and cost effective titrimetric (Visual volumetric) method has been reported for the estimation of some antihistamine drugs e.g. Cyproheptadine hydrochloride (CPH), Fexofenadine hydrochloride (FFH), Promethazine hydrochloride (PMH) and Pheniramine maleate (PM) in pure form and in their pharmaceutical preparations such as Ciplactin (Tab), Allegra (Tab), Phenergan (Tab and Inj) and Avil (Tab and Inj) with Pyridinium fluoro chromate (PFC) reagent. The principle of this method is based on the fact, that each pharmaceutical drug consists of certain organic functional group which on oxidation by a known excess of potassium iodate in sulfuric acid medium followed by iodometric titration in presence of reagent Pyridinium fluoro chromate (PFC) establishes stoichiometric relationship between drug mol. and an oxidising reagent Pyridinium fluoro chromate (PFC). Different results obtained for each drug during experiment, has been validated by different statistical parameters such as percentage error, standard deviation (SD) and coefficient of variation (CV). Results obtained from these statistical parameters proves the accuracy and precision of adopted method. The experimental process involved the reaction of N,N-Dimethyl-3-phenyl-3-(pyridin-2-yl)propan-1-amine maleate(cas: 132-20-7).Computed Properties of 132-20-7

The Article related to titrimetry ciplactin allegra phenergan avil pyridinium fluoro chromate, Pharmaceutical Analysis: Synthetic Organic Compounds and other aspects.Computed Properties of 132-20-7

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Pandey, Ajay Kumar; Dwivedi, Dharmendra published an article in 2019, the title of the article was Oxidative determination of some antihistamine drugs in pure form and their pharmaceutical preparations by using Pyridinium fluoro chromate (PFC) reagent.Computed Properties of 132-20-7 And the article contains the following content:

In this paper Chromium (VI) based Pyridinium fluoro chromate (PFC) reagent has been used as an oxidant for the determination of some antihistamine drugs e.g. Promethazine hydrochloride (PMH) and Pheniramine maleate (PM) in pure form and their pharmaceutical preparations such as Phenergan (Injection and tablet) and Avil (Tablet and injection) resp. The main principle of this method is based on the fact, that each pharmaceutical drug contains a specific organic functional group, which on oxidation in the presence of selected oxidant (Here PFC is used as an oxidant) provides the new oxidized product. This type of oxidation reaction between the drug mol. and an oxidant establishes a stoichiometric relationship between the drug mol. and an oxidant. This relationship is the basis of quant. estimation of drugs in pure form and their pharmaceutical preparations In this research, oxidizing reagent Pyridinium fluoro chromate (PFC) oxidizes the sulfur atom of Promethazine hydrochloride (PMH) to the corresponding sulfoxide, whereas in case of Pheniramine maleate (PM) it oxides one hydroxyl (-OH) group of carboxylic (-COOH) group to corresponding aldehydic (-CHO) group. Thus an oxidant PFC establishes a 1:1 ratio with both Promethazine hydrochloride (PMH) and Pheniramine maleate (PM) drug. Oxidative determination of these drugs was carried out by adopting the iodometric titration (Visual volumetric) method. The applied technique was very simple, convenient, accurate, precise and economical. To examine the accuracy and precision of results various statistical anal. such as percentage error, standard deviation (SD) and coefficient of variation (CV) was also calculated for each sample. The proposed method was validated by recovery anal., by drug addition method. The experimental process involved the reaction of N,N-Dimethyl-3-phenyl-3-(pyridin-2-yl)propan-1-amine maleate(cas: 132-20-7).Computed Properties of 132-20-7

The Article related to antihistamine oxidation pyridinium fluoro chromate iodometric titration, Pharmaceutical Analysis: Synthetic Organic Compounds and other aspects.Computed Properties of 132-20-7

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem