Day: November 7, 2022

On March 31, 2003, Frosini, Maria; Sesti, Casilde; Dragoni, Stefania; Valoti, Massimo; Palmi, Mitri; Dixon, Henry B. F.; Machetti, Fabrizio; Sgaragli, Giampietro published an article.SDS of cas: 636-73-7 The title of the article was Interactions of taurine and structurally related analogues with the GABAergic system and taurine binding sites of rabbit brain. And the article contained the following:

The aim of this study was to find taurinergic compounds that do not interact with brain GABAergic systems. Washed synaptic membranes (SM) from whole rabbit brain were able to bind [3H]muscimol. Saturation experiments of the binding of [3H]GABA to GABAB receptors showed that SM possess two binding components; twice Triton X-100-treated SM contained 0.048 mmol endogenous taurine/kg protein and bound [3H]taurine in a saturable manner (Kd = 249.0 nM and Bmax = 3.4 pmol mg-1 prot). Among the 19 structural analogs of taurine, 6-aminomethyl-3-methyl-4H-1,2,4-benzothiadiazine 1,1-dioxide (TAG), 2-aminoethylarsonic (AEA), 2-hydroxyethanesulfonic (ISE) and (±)cis-2-aminocyclohexane sulfonic acids (CAHS) displaced [3H]taurine binding (Ki = 0.13, 0.13, 13.5 and 4.0 μM, resp.). These analogs did not interact with GABAA and GABAB receptors and did not affect taurine- and GABA-uptake systems and GABA-transaminase activity. 3-Aminopropanesulfonic acid (OMO), β-alanine, pyridine-3-sulfonic acid, N,N,N-trimethyltaurine (TMT), 2-(guanidino)ethanesulfonic acid (GES), ethanolamine-O-sulfate, N,N-dimethyltaurine (DMT), taurine and (±)piperidine-3-sulfonic acid (PSA) inhibited [3H]muscimol binding to GABAA receptors with different affinities (Ki = 0.013, 7.9, 24.6, 47.5, 52.0, 91.0, 47.5, 118.1 and 166.3 μM, resp.). Taurine, 2-aminoethylphosphonic acid, DMT, TMT and OMO inhibited the binding of [3H]GABA to GABAB receptors with Ki’s in the μM range (0.8, 3.5, 4.4, 11.3 and 5.0, resp.). GES inhibited taurine uptake (IC50 = 3.72 μM) and PSA GABA transaminase activity (IC50 = 103.0 μM). In conclusion, AEA, TAG, ISE and CAHS fulfill the criteria for taurinergic agents. The experimental process involved the reaction of Pyridine-3-sulfonic acid(cas: 636-73-7).SDS of cas: 636-73-7

The Article related to taurine analog gabaergic system receptor brain, Mammalian Hormones: Neurotransmitters and other aspects.SDS of cas: 636-73-7

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Lopez-Fontal, Elkin; Grochmal, Anna; Foran, Tom; Milanesi, Lilia; Tomas, Salvador published an article in 2018, the title of the article was Ship in a bottle: confinement-promoted self-assembly.Application In Synthesis of Pyridine-3-sulfonic acid And the article contains the following content:

Understanding self-assembly in confined spaces is essential to fully understand mol. processes in confined cell compartments and will offer clues on the behavior of simple confined systems, such as protocells and lipid-vesicle based devices. Using a model system composed of lipid vesicles, a membrane impermeable receptor and a membrane-permeable ligand, we have studied in detail how compartmentalization modulates the interaction between the confined receptor and its ligand. We demonstrate that confinement of one of the building blocks stabilizes complex self-assembled structures to the extent that dilution leads, counterintuitively, to the formation of long range assemblies. The behavior of the system can be explained by considering a confinement factor that is analogus, although not identical, to the effective molarity for intramol. binding events. The confinement effect renders complex self-assembled species robust and persistent under conditions where they do not form in bulk solution Moreover, we show that the formation of stable complex assemblies in systems compartmentalized by semi-permeable membranes does not require the prior confinement of all components, but only that of key membrane impermeable building blocks. To use a macroscopic analogy, lipid vesicles are like ship-in-a bottle constructs that are capable of directing the assembly of the confined ship following the confinement of a few key wooden planks. Therefore, we believe that the confinement effect described here would have played an important role in shaping the increase of chem. complexity within protocells during the first stages of abiogenesis. Addnl., we argue that this effect can be exploited to design increasingly efficient functional devices based on comparatively simple vesicles for applications in biosensing, nanoreactors and drug delivery vehicles. The experimental process involved the reaction of Pyridine-3-sulfonic acid(cas: 636-73-7).Application In Synthesis of Pyridine-3-sulfonic acid

The Article related to self assembly polymerization nucleation scattering, Surface Chemistry and Colloids: Other and other aspects.Application In Synthesis of Pyridine-3-sulfonic acid

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

On January 15, 1980, Freyne, Eddy J.; Esmans, Eddy L.; Lepoivre, Josef A.; Alderweireldt, Frank C. published an article.Name: 5-Isopropylnicotinic acid The title of the article was Stereospecific synthesis of a novel series of pyridine nucleosides. And the article contained the following:

Condensation of 3,5-di-O-benzoyl-β-D-ribofuranosyl chloride severally with 3-acetyl-5-alkylpyridines, 5-alkyl-3-methoxycarbonylpyridines (alkyl = Me, Et, Pr, and Me2CH), 5-isopropylnicotinamide, and 3,5-diacetylpyridine bis(ethylene acetal) in MeCN at -5° gave the corresponding 1-(3,5-di-O-benzoyl-β-D-ribofuranosyl)-3,5-disubstituted pyridinium chlorides in excellent yield (90%). From the reaction of a series of 2,3-O-isopropylidene-β-D-ribofuranosyl halides with 3-acetyl-5-methylpyridine at room temperature, the α-nucleosides were obtained. The experimental process involved the reaction of 5-Isopropylnicotinic acid(cas: 73591-69-2).Name: 5-Isopropylnicotinic acid

The Article related to pyridine nucleoside, stereospecific ribosylation pyridine, Carbohydrates: Nucleosides, Nucleotides and other aspects.Name: 5-Isopropylnicotinic acid

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

On August 31, 2010, Phatthiyaphaibun, K.; Som-Aum, W.; Srisa-ard, M.; Threeprom, J. published an article.Safety of N,N-Dimethyl-3-phenyl-3-(pyridin-2-yl)propan-1-amine maleate The title of the article was Chiral separation of pheniramine by capillary electrophoresis partial-filling technique using hydroxypropyl-β-cyclodextrin as chiral selector. And the article contained the following:

A simple capillary electrophoresis partial-filling technique for the enantioseparation of pheniramine is presented. Phosphate buffer and hydroxypropyl-β-cyclodextrin (HP-β-CD) were used as the electrolyte and chiral selector, resp. Several exptl. parameters such as HP-β-CD concentration, HP-β-CD plug length, CE temperature and applied voltage were studied. Under the selected conditions, pheniramine enantiomers can be separated within <14 min. The assay was validated for linearity (5.0 × 10-6 - 5.0 × 10-4 M; R2 = 0.9987), limit of detection (5.0 × 10-7 M), limit of quantitation (5.0 × 10-6 M), anal. precision (%RSD ≤ 9.8) and accuracy (%recovery = 101 ± 3). The proposed methodol. was then applied to the anal. of a com. available pharmaceutical eye drop preparation The results are in good agreement with that declared by the manufacturer. The proposed methodol. provides adequate results in terms of simplicity, cost, sample throughput, repeatability and accuracy for quality control of pheniramine enantiomers in pharmaceutical preparations The experimental process involved the reaction of N,N-Dimethyl-3-phenyl-3-(pyridin-2-yl)propan-1-amine maleate(cas: 132-20-7).Safety of N,N-Dimethyl-3-phenyl-3-(pyridin-2-yl)propan-1-amine maleate

The Article related to pheniramine enantiosepn capillary electrophoresis partial filling technique hydroxypropylcyclodextrin selector, Organic Analytical Chemistry: Separations and other aspects.Safety of N,N-Dimethyl-3-phenyl-3-(pyridin-2-yl)propan-1-amine maleate

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Gasior, Justyna; Kawa-Rygielska, Joanna; Kucharska, Alicja Z. published an article in 2020, the title of the article was Carbohydrates profile, polyphenols content and antioxidative properties of beer worts produced with different dark malts varieties or roasted barley grains.Synthetic Route of 132-20-7 And the article contains the following content:

The aim of this study was to assess the possibility of shaping properties of beers at the stage of brewing wort production with the use of various types of special malts (chocolate pale, chocolate dark, wheat chocolate, brown barley) and roasted barley grains. The carbohydrate profile, polyphenols content, antioxidant capacity, 5-hydroxymethylfurfural content, and the browning index level were analyzed. Statistical anal. showed significant differences in the values of the examined features between the samples. The sugars whose content was most affected by the addition of special malts were maltose and dextrins. The polyphenol content in worts with 10% of additive was 176.02-397.03 mg GAE/L, ferric reducing antioxidant power (FRAP) 1.32-2.07 mmol TE/L, and capacity to reduction radical generated from 2,2′-Azino-bis(3-ethylbenzothiazoline-6-sulfonic acid) diammonium salt (ABTS•+) 1.46-2.70 mmol TE/L. Wort with 40% dark malt showed the highest content of polyphenolic compounds and antioxidant activity (FRAP and ABTS•+). The HMF content and the browning index value were higher for wort with the addition of darker-colored malts (EBC) and increased with increasing dark malt dose. The experimental process involved the reaction of N,N-Dimethyl-3-phenyl-3-(pyridin-2-yl)propan-1-amine maleate(cas: 132-20-7).Synthetic Route of 132-20-7

The Article related to carbohydrate polyphenol antioxidative beer wort malt barley grain, antioxidants, barley, beer, dark malt, malt, melanoidins, polyphenols, roasting, specialty malt, wort, Pharmaceuticals: Pharmacognostic Products and other aspects.Synthetic Route of 132-20-7

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

On August 15, 1997, Lee, Hon Cheung; Aarhus, Robert published an article.Quality Control of Pyridine-3-sulfonic acid The title of the article was Structural determinants of nicotinic acid adenine dinucleotide phosphate important for its calcium-mobilizing activity. And the article contained the following:

Nicotinic acid adenine dinucleotide phosphate (NAADP) mobilizes Ca2+ through a mechanism totally independent of cyclic ADP-ribose or inositol trisphosphate. The structural determinants important for its Ca2+ release activity were investigated using a series of analogs. It is shown that changing the 3-carboxyl group of the nicotinic acid (NA) moiety in NAADP to either an uncharged carbinol or from the 3-position to the 4-position of the pyridine ring totally eliminates the Ca2+ release activity. Conversion of the 3-carboxyl to other neg. charged groups, either 3-sulfonate, 3-acetate, or 3-quinoline carboxylate, retains the Ca2+ release activity, although their half-maximal effective concentrations (EC50) are 100-200-fold higher. Changing the 6-amino group of the adenine to a hydroxyl group results in more than a 1000-fold decrease in the Ca2+ release activity. Conversion of the 2′-phosphate to 2′,3′-cyclic phosphate or 3′-phosphate likewise increases the EC50 by about 5- and 20-fold, resp. Similar to NAADP, all of the active analogs can also desensitize the Ca2+ release mechanism at subthreshold concentrations, suggesting that this novel property is intrinsic to the release mechanism. The series of analogs used was produced by using ADP-ribosyl cyclase to catalyze the exchange of the nicotinamide group of various analogs of NADP with various analogs of NA. An important determinant in NA that is crucial to the base exchange reaction was shown to be the 2-position of the pyridine ring. Neither pyridine-2-carboxylate nor 2-methyl-NA support the exchange reaction. The neg. charge and the position of the 3-carboxyl group ware nonessential since both pyridine-3-carbinol and pyridine-4-carboxylate support the base exchange reaction. In addition to the information on the structure-activity relationships of NAADP and NA, this study also demonstrates the utility of the base exchange reaction as a general approach for synthesizing NAADP analogs. The experimental process involved the reaction of Pyridine-3-sulfonic acid(cas: 636-73-7).Quality Control of Pyridine-3-sulfonic acid

The Article related to naadp na calcium transport cyclase, General Biochemistry: Subcellular Processes and other aspects.Quality Control of Pyridine-3-sulfonic acid

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Wang, Zeyang; Lu, Song; Fu, Yan; Wang, Hui; Zhao, Guannan published an article in 2016, the title of the article was Sodium borohydride promotes drug molecules preparation.Name: N,N-Dimethyl-3-phenyl-3-(pyridin-2-yl)propan-1-amine maleate And the article contains the following content:

Sodium borohydride reduction is an excellent performance of “universal reducing agent”, which commonly used in a variety of reduction of organic functional groups, After the modified sodium borohydride reduction was greatly expanded in the field of application, can be used to restore the carboxylic acids, carboxylic acid esters, alcs., indole, enyne other substances, under certain reduction system, when compared with a sodium borohydride reduction good reduction On the other hand, due to the high amount of sodium borohydride hydrogen storage, mild reaction conditions, making it the people developed “green energy” hot hydrogen raw materials, and therefore there are many catalytic hydrogen production catalysts are finding out, it was discover the advantages of composite sodium borohydride hydrogen production The experimental process involved the reaction of N,N-Dimethyl-3-phenyl-3-(pyridin-2-yl)propan-1-amine maleate(cas: 132-20-7).Name: N,N-Dimethyl-3-phenyl-3-(pyridin-2-yl)propan-1-amine maleate

The Article related to sodium borohydride drug mol reduction, Placeholder for records without volume info and other aspects.Name: N,N-Dimethyl-3-phenyl-3-(pyridin-2-yl)propan-1-amine maleate

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Lombardini, J. B.; Props, C. published an article in 1997, the title of the article was Analogs of taurine as inhibitors of the phosphorylation of an ≈20 K molecular weight protein present in a mitochondrial fraction of the rat retina.Computed Properties of 636-73-7 And the article contains the following content:

It was previously demonstrated that taurine inhibits the phosphorylation of a ≈20 K apparent mol. weight protein present in the mitochondrial fraction of the rat retina. Analogs of taurine were tested for their inhibitory activity on the phosphorylation of this 20 K protein. The most potent analogs were (±)trans-2-aminocyclopentanesulfonic acid (TAPS) and 1,2,3,4-tetrahydroquinoline-8-sulfonic acid (THQS), which were 21 and 7 times more potent than the parent compound, taurine, resp. Median-effect plots were used to calculate the inhibitory median effect and combination index values for the combined effects of taurine and taurine analogs. It was determined that the inhibitory taurine analogs were antagonistic to taurine when used in combination with taurine to inhibit the phosphorylation of the 20 K apparent mol. weight protein. It was concluded that the distance between the N and S atoms in the taurine structure was important for inhibitory activity. If the N atom was either within or attached to an unsaturated ring structure, the inhibitory potency was decreased. If both the S and N atoms were present within the ring structure, the analog has no activity. The experimental process involved the reaction of Pyridine-3-sulfonic acid(cas: 636-73-7).Computed Properties of 636-73-7

The Article related to retina protein phosphorylation inhibition taurine analog, General Biochemistry: Subcellular Processes and other aspects.Computed Properties of 636-73-7

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

On January 31, 2020, Jin, Lei; Yang, Jia-Qiang; Yang, Fang-Zu; Wu, De-Yin; Tian, Zhong-Qun published an article.Application In Synthesis of Pyridine-3-sulfonic acid The title of the article was Electrochemistry and coordination behaviors of hypoxanthine-Au (III) ion in the cyanide-free gold electrodeposition. And the article contained the following:

Alkaloid hypoxanthine is a novel complexant for green cyanide-free Au(III) electrodeposition. The electrochem. and coordination behaviors of hypoxanthine-Au(III) ion in the green cyanide-free bath were studied. The electrochem. behavior confirms that hypoxanthine-Au(III) ion is in the irreversible two-step electro-reductions with the 1st controlled by diffusion and the 2nd by diffusion and electrochem. The stability constant of hypoxanthine-Au(III) ion is 4.8 × 1030. DFT calculations further indicate that the optimal coordination structure is N3-Au-N7 with the N-Au average bond energy of 11.03 eV. The bath component of K citrate plays almost no influence, whereas the additive of sulfocompounds shows a significant effect on the electro-reduction of hypoxanthine-Au(III) ion. Based on the cyanide-free Au(III) electrodeposition bath, the obtained Au coating is fine and compact in grains without organic inclusion and in the resistivity of 2.84 × 10-8 Ω m. The experimental process involved the reaction of Pyridine-3-sulfonic acid(cas: 636-73-7).Application In Synthesis of Pyridine-3-sulfonic acid

The Article related to electrochem coordination hypoxanthine gold electrodeposition, Placeholder for records without volume info and other aspects.Application In Synthesis of Pyridine-3-sulfonic acid

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

On February 28, 2019, Steinlechner, Christoph; Spannenberg, Anke; Junge, Henrik; Beller, Matthias published an article.Related Products of 109660-12-0 The title of the article was Tetracarbonyl[4,4-dimethyl-2-(pyridin-2-yl)-2-oxazoline-κ2N,N′]molybdenum(0). And the article contained the following:

In the title compound, [Mo(C10H12N2O)(CO)4], the molybdenum(0) center is surrounded by a bidentate diimine [4,4-dimethyl-2-(pyridin-2-yl)-2-oxazoline] and four carbonyl ligands in a distorted octahedral coordination geometry. The diimine ligand coordinates via the two nitrogen atoms. The experimental process involved the reaction of 2-(4,5-Dihydro-4,4-dimethyl-2-oxazolyl)pyridine(cas: 109660-12-0).Related Products of 109660-12-0

The Article related to tetracarbonyl dimethyl pyridinyl oxazoline molybdenum crystallization, Placeholder for records without volume info and other aspects.Related Products of 109660-12-0

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem