Day: November 8, 2022

Electric Literature of C6H4N2In 2022 ,《Strongly Bound π-Hole Tetrel Bonded Complexes between H2SiO and Substituted Pyridines. Influence of Substituents》 was published in ChemPhysChem. The article was written by Bhattarai, Sumitra; Sutradhar, Dipankar; Chandra, Asit K.. The article contains the following contents:

Ab initio calculation at the MP2/aug-cc-pVTZ level has been performed on the π-hole based N…Si tetrel bonded complexes between substituted pyridines and H2SiO. The primary aim of the study is to find out the effect of substitution on the strength and nature of this tetrel bond, and its similarity/difference with the N…C tetrel bond. Correlation between the strength of the N…Si bond and several mol. properties of the Lewis acid (H2SiO) and base (pyridines) are explored. The properties of the tetrel bond are analyzed using AIM, NBO, and symmetry-adapted perturbation theory calculations The complexes are characterized with short N…Si intermol. distances and high binding energies ranging between -142.72 and -115.37 kJ/mol. The high value of deformation energy indicates significant geometrical distortion of the monomer units. The AIM and NBO anal. reveal significant coordinate covalent bond character of the N…Si π-hole bond. Sharp differences are also noticed in the orbital interactions present in the N…Si and N…C tetrel bonds. In the experimental materials used by the author, we found 4-Cyanopyridine(cas: 100-48-1Electric Literature of C6H4N2)

4-Cyanopyridine(cas: 100-48-1) belongs to pyridine. Pyridine and pyridine-derived structures are privileged pharmacophores in medicinal chemistry and an essential functionality for organic chemists. As the prototypical π-deficient heterocycle, pyridine illustrates distinctive chemistry as both substrate and reagent. Electric Literature of C6H4N2

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Synthetic Route of C7H5NIn 2019 ,《Water as a Hydrogenating Agent: Stereodivergent Pd-Catalyzed Semihydrogenation of Alkynes》 was published in Organic Letters. The article was written by Zhao, Chuan-Qi; Chen, Yue-Gang; Qiu, Hui; Wei, Lei; Fang, Ping; Mei, Tian-Sheng. The article contains the following contents:

Palladium-catalyzed transfer semihydrogenation of alkynes using H2O as the hydrogen source and Mn as the reducing reagent is developed, affording cis- and trans-alkenes selectively under mild conditions. In addition, this method provides an efficient way to access various cis-1,2-dideuterioalkenes and trans-1,2-dideuterioalkenes by using D2O instead of H2O. After reading the article, we found that the author used 4-Ethynylpyridine(cas: 2510-22-7Synthetic Route of C7H5N)

4-Ethynylpyridine(cas: 2510-22-7) belongs to pyridine. Pyridines, quinolines, and isoquinolines have found a function in almost all aspects of organic chemistry. Pyridine has found use as a solvent, base, ligand, functional group, and molecular scaffold. As structural elements, these moieties are potent electron-deficient groups, metal-directing functionalities, fluorophores, and medicinally important pharmacophores. Synthetic Route of C7H5N

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Category: pyridine-derivativesIn 2017 ,《Structure-Activity Relationship of Propargylamine-Based HDAC Inhibitors》 was published in ChemMedChem. The article was written by Wuensch, Matthias; Senger, Johanna; Schultheisz, Philipp; Schwarzbich, Sabrina; Schmidtkunz, Karin; Michalek, Carmela; Klass, Michaela; Goskowitz, Stefanie; Borchert, Philipp; Praetorius, Lucas; Sippl, Wolfgang; Jung, Manfred; Sewald, Norbert. The article contains the following contents:

As histone deacetylases (HDACs) play an important role in the treatment of cancer, their selective inhibition has been the subject of various studies. These continuous investigations have given rise to a large collection of pan- and selective HDAC inhibitors, containing diverse US Food and Drug Administration (FDA)-approved representatives. In previous studies, a class of alkyne-based HDAC inhibitors was presented. We modified this scaffold in two previously neglected regions and compared their cytotoxicity and affinity toward HDAC1, HDAC6, and HDAC8. We were able to show that R-configured propargylamines contribute to increased selectivity for HDAC6. Docking studies on available HDAC crystal structures were carried out to rationalize the observed selectivity of the compounds Substitution of the aromatic portion by a thiophene derivative results in high affinity and low cytotoxicity, indicating an improved drug tolerance. In the part of experimental materials, we found many familiar compounds, such as Methyl 5-bromopicolinate(cas: 29682-15-3Category: pyridine-derivatives)

Methyl 5-bromopicolinate(cas: 29682-15-3) belongs to pyridine. Pyridines, quinolines, and isoquinolines have found a function in almost all aspects of organic chemistry. Pyridine has found use as a solvent, base, ligand, functional group, and molecular scaffold. As structural elements, these moieties are potent electron-deficient groups, metal-directing functionalities, fluorophores, and medicinally important pharmacophores. Category: pyridine-derivatives

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Name: 5-Bromo-2-chloropyridineIn 2017 ,《Sequential one pot double C-H heteroarylation of thiophene using bromopyridines to synthesize unsymmetrical 2,5-bipyridylthiophenes》 was published in Tetrahedron. The article was written by Kieffer, Charline; Babin, Victor; Jouanne, Marie; Slimani, Ikram; Berhault, Yohann; Legay, Remi; Sopkova-de Oliveira Santos, Jana; Rault, Sylvain; Voisin-Chiret, Anne Sophie. The article contains the following contents:

We present C-H heteroarylation reactions between thiophene and variously substituted bromopyridines. The objective was to synthesize unsym. 2,5-bipyridylthiophenes. We studied the reaction conditions allowing to a sequential one-pot double C-H heteroarylation, in a view to introduce two different pyridyl moieties at positions 2 and 5 of the thiophene ring using bromopyridines. 11 original unsym. 2,5-bipyridylthiophenes were synthesized and characterized, including 2,5-di(pyridin-2-yl)thiophenes for which the preparation by classical cross-coupling reactions is challenging. Finally, with the addnl. synthesis of both an unsym. 2,5-biarylthiophene and an original pyrimidin-thiophene-furan scaffold, we shown that our methodol. was also an efficient tool to access to new heterocyclic sequences. In the part of experimental materials, we found many familiar compounds, such as 5-Bromo-2-chloropyridine(cas: 53939-30-3Name: 5-Bromo-2-chloropyridine)

5-Bromo-2-chloropyridine(cas: 53939-30-3) belongs to pyridine. Pyridines, quinolines, and isoquinolines have found a function in almost all aspects of organic chemistry. Pyridine has found use as a solvent, base, ligand, functional group, and molecular scaffold. As structural elements, these moieties are potent electron-deficient groups, metal-directing functionalities, fluorophores, and medicinally important pharmacophores. Name: 5-Bromo-2-chloropyridine

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

《A chitosan-based fluorescent hydrogel for selective detection of Fe2+ ions in gel-to-sol mode and turn-off fluorescence mode》 was published in Polymer Chemistry in 2019. These research results belong to Fan, Kaiqi; Wang, Xiaobo; Yu, Shuyan; Han, Guanglu; Xu, Die; Zhou, Liming; Song, Jian. Product Details of 112881-51-3 The article mentions the following:

A novel chitosan-based fluorescent hydrogel has been synthesized by chem. bonding terpyridine-bearing aldehydes onto chitosan via an acid condensation reaction. More interestingly, such a hydrogel works as a dual-mode chemosensor for selective, rapid, gel-to-sol, and turn-off fluorescence sensing of Fe2+ ions. In the gel-to-sol mode, the detection limit for Fe2+ ions is 0.28 ppm, and in the turn-off fluorescence mode, the detection limit is 3.8 ppb. Such hydrogel-based fluorescent chemosensors are potentially suitable for the monitoring of Fe2+ in biol. and environmental applications. In the part of experimental materials, we found many familiar compounds, such as 4′-(4-Pyridyl)-2,2′:6′,2”-terpyridine(cas: 112881-51-3Product Details of 112881-51-3)

4′-(4-Pyridyl)-2,2′:6′,2”-terpyridine(cas: 112881-51-3) belongs to pyridine derivatives. The ring atoms in the pyridine molecule are sp2-hybridized. The nitrogen is involved in the π-bonding aromatic system using its unhybridized p orbital. Product Details of 112881-51-3 Pyridine has a conjugated system of six π electrons that are delocalized over the ring.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

《Accelerating proton-coupled electron transfer of metal hydrides in catalyst model reactions》 was written by Liu, Tianfei; Guo, Meiyuan; Orthaber, Andreas; Lomoth, Reiner; Lundberg, Marcus; Ott, Sascha; Hammarstroem, Leif. Product Details of 62734-08-1 And the article was included in Nature Chemistry on August 31 ,2018. The article conveys some information:

Metal hydrides are key intermediates in catalytic proton reduction and dihydrogen oxidation There is currently much interest in appending proton relays near the metal center to accelerate catalysis by proton-coupled electron transfer (PCET). However, the elementary PCET steps and the role of the proton relays are still poorly understood, and direct kinetic studies of these processes are scarce. Here, authors report a series of tungsten hydride complexes as proxy catalysts, with covalently attached pyridyl groups as proton acceptors. The rate of their PCET reaction with external oxidants is increased by several orders of magnitude compared to that of the analogous systems with external pyridine on account of facilitated proton transfer. Moreover, the mechanism of the PCET reaction is altered by the appended bases. A unique feature is that the reaction can be tuned to follow three distinct PCET mechanisms-electron-first, proton-first or a concerted reaction-with very different sensitivities to oxidant and base strength. Such knowledge is crucial for rational improvements of solar fuel catalysts. In addition to this study using 2-(Chloromethyl)-4-methoxypyridine hydrochloride, there are many other studies that have used 2-(Chloromethyl)-4-methoxypyridine hydrochloride(cas: 62734-08-1Product Details of 62734-08-1) was used in this study.

2-(Chloromethyl)-4-methoxypyridine hydrochloride(cas: 62734-08-1) belongs to pyridine. Pyridine-based materials are valued for their optical and physical properties as well as their medical potential. Additionally, pyridine-based natural products continue to be discovered and studied for their properties and to understand their biosynthesis.Product Details of 62734-08-1

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

《Chlorinated yellow phosphorescent cyclometalated neutral iridophosphors featuring broad emission bandwidths for white electroluminescence》 was written by Tao, Peng; Zheng, Xiao-Kang; Wei, Xiao-Zhen; Lau, Mei-Tung; Lee, Yuk-Ki; Li, Zi-Kang; Guo, Ze-Ling; Zhao, Fang-Qing; Liu, Xing; Liu, Shu-Juan; Zhao, Qiang; Miao, Yan-Qin; Wong, Wai-Yeung. Recommanded Product: 98-98-6This research focused onyellow phosphorescent cyclometalated neutral iridophosphor electroluminescence broad emission bandwidth. The article conveys some information:

The efficient yellow phosphors with broad emission bandwidths play quite important roles in the realization of high-performance two-color white organic light-emitting devices (OLEDs). Herein, by using a chlorine-functionalization method, we designed three efficient yellow iridium(III) complexes (Ir1-Ir3) bearing chlorine atoms. At room temperature, these phosphors exhibit bright yellow phosphorescence with emission wavelengths of 549-574 nm and high photoluminescence efficiency of 0.49-0.73 in the N2-saturated dichloromethane. Importantly, these complexes feature extremely broad emission bandwidths (reaching 104 nm), making them the record-high values in the yellow iridium(III) phosphors reported so far. Using these complexes as the triplet dopants, the prepared OLEDs show yellow phosphorescence with the emission maximum at 565, 548, and 551 nm, resp. The extremely high external quantum efficiency of 23.8% was realized for the as-prepared yellow OLEDs. Furthermore, Ir2-based two-color white OLED with high spectral quality was also realized, and the color rendering index and CIE coordinates for two-color white OLED are 74 and (0.32, 0.34), resp. The broad yellow emission band and high-efficiency of the device proved that these phosphors show great potentials in developing high-performance yellow and white electroluminescence.Picolinic acid(cas: 98-98-6Recommanded Product: 98-98-6) was used in this study.

Picolinic acid(cas: 98-98-6) is used as a chelate for alkaline earth metals. Used to prepare picolinato ligated transition metal complexes. In synthetic organic chemistry, has been used as a substrate in the Mitsunobu reaction and in the Hammick reaction.Recommanded Product: 98-98-6

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

《Direct (Hetero)arylation of Heteroarenes Catalyzed by Unsymmetrical Pd-PEPPSI-NHC Complexes under Mild Conditions》 was written by Song, A-Xiang; Zeng, Xiao-Xiao; Ma, Bei-Bei; Xu, Chang; Liu, Feng-Shou. Synthetic Route of C5H3BrClNThis research focused onunsym palladium heterocyclic carbene PEPPSI complex preparation arylation catalyst; crystal structure unsym palladium heterocyclic carbene PEPPSI type complex; mol structure unsym palladium heterocyclic carbene PEPPSI type complex; palladium carbene catalyzed heteroarylation heteroarene; muscle relaxant drug dantrolene conjugated mesopolymer preparation. The article conveys some information:

With the aim of developing a facile and efficient method to access structurally intriguing and valuable functionalized (hetero)aryls, two unsym. Pd-PEPPSI-type NHC complexes (PEPPSI, pyridine-enhanced precatalyst preparation, stabilization, and initiation; NHC, N-heterocyclic carbene) were designed and synthesized to catalyze the direct arylation of heteroarenes with (hetero)aryl bromides. The use of this unsym. strategy led to much higher efficiency in comparison to the commonly used C2-sym. Pd-PEPPSI-type NHC complexes. Also, a broad range of heteroaromatics and (hetero)aryl bromide partners with a wide variety of functional groups were all amenable to the developed protocol even at ≥0.05 mol % catalyst loading and under aerobic conditions. More importantly, along with the authors’ study, also the present protocol could provide expedient access to the gram-scale synthesis of the muscle relaxant drug dantrolene and conjugated mesopolymers. The experimental process involved the reaction of 5-Bromo-2-chloropyridine(cas: 53939-30-3Synthetic Route of C5H3BrClN)

5-Bromo-2-chloropyridine(cas: 53939-30-3) belongs to pyridine. Pyridine-based materials are valued for their optical and physical properties as well as their medical potential. Additionally, pyridine-based natural products continue to be discovered and studied for their properties and to understand their biosynthesis.Synthetic Route of C5H3BrClN

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

《Green to blue-green-emitting cationic iridium complexes with a CF3-substituted phenyl-triazole type cyclometalating ligand: synthesis, characterization and their use for efficient light-emitting electrochemical cells》 was written by Yu, Renyou; Song, Yongjun; Chen, Mengzhen; He, Lei. Electric Literature of C12H12N2This research focused ontrifluoromethyl phenyltriazole green preparation iridium complexation; cyclometalated trifluoromethyl phenyltriazole iridium complex preparation electrochem cell; crystal mol structure electroluminescence cyclometalated trifluoromethyl phenyltriazole iridium complex. The article conveys some information:

Green to blue-green-emitting cationic iridium complexes free of sp2 C-F bonds, namely [Ir(CF3-dPhTAZ)2(bpy)]PF6 (1), [Ir(CF3-dPhTAZ)2(dmebpy)]PF6 (2) and [Ir(CF3-dPhTAZ)2(phpyim)]PF6 (3), have been designed and synthesized with 3,4-diphenyl-5-(trifluoromethyl)-4H-1,2,4-triazole (CF3-dPhTAZ) as the cyclometalating ligand (C^N) and 2,2′-bipyridine (bpy), 4,4′-dimethyl-2,2′-bipyridine (dmebpy) or 2-(1-phenyl-1H-imidazol-2-yl)pyridine (phpyim) as the ancillary ligand (N^N). In CH3CN solution, complexes 1-3 afford green to blue-green emission centered at 521, 508 and 498 nm, resp. The electron-withdrawing CF3 group attached at the triazole ring in CF3-dPhTAZ largely blue-shifts (by over 20 nm) the emission of the complex through stabilizing the HOMO. In doped films, the complexes afford sky-blue emission with near-unity phosphorescent efficiencies. In neat films, the complexes show largely suppressed phosphorescence concentration-quenching, with phosphorescent efficiencies of up to 0.66. Theor. calculations reveal that the emission of the complexes can arise from either charge-transfer (Ir → C^N/C^N → N^N) or C^N/N^N-centered 3π-π* states, depending on the local environment of the complexes. Solid-state light-emitting electrochem. cells (LECs) based on the complexes afford green to blue-green electroluminescence centered at 525, 517 and 509 nm, resp., with high current efficiencies of up to 35.1 cd A-1. The work reveals that CF3-dPhTAZ is a promising C^N ligand free of sp2 C-F bonds for constructing efficient cationic iridium complexes with blue-shifted emission. In the experiment, the researchers used many compounds, for example, 4,4′-Dimethyl-2,2′-bipyridine(cas: 1134-35-6Electric Literature of C12H12N2)

4,4′-Dimethyl-2,2′-bipyridine(cas: 1134-35-6) is used in the synthesis of a series of o-phenanthroline-substituted ruthenium(II) complexes.Electric Literature of C12H12N2 Furthermore, 4,4′-Dimethyl-2,2′-bipyridine is used as a chemical Intermediate. It can be used for the determination of ferrous and cyanide compounds.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

《Metal free [4+1] and [5+1] annulation reactions to prepare heterocycles using DMF and its derivatives as one-carbon source》 was written by Xu, Yiwen; Shen, Bei; Liu, Lingfeng; Qiao, Chunhua. Name: 5-Bromo-2-chloropyridineThis research focused ontriazolopyridine preparation; hydrazinylpyridine amide annulation imidazolium chloride catalyst; triazine preparation; biguanide amide annulation imidazolium chloride catalyst. The article conveys some information:

A highly efficient and practical method using DMF and its derivative for the [4+1] and [5+1] annulation reactions to prepare 1,2,4-triazolo[3,4-a]pyridines, e.g., I and triazines II [R = H, Me, Ph, 2-MeC6H4, 3-ClC6H4; R1 = H, Me; RR1 = (CH2)2O(CH2)2; R2 = H, Ph] was reported. This metal free reaction took advantages of shelf stable DMF as solvent and carbon donor, imidazolium chloride as a catalyst, the mild reaction condition tolerated a broad substrate range and substitutes. The prepared 3-unsubstituted 1,2,4-triazolo[3,4-a]pyridine and derivatives allowed further introduction of a variety of functional groups at 3-position.5-Bromo-2-chloropyridine(cas: 53939-30-3Name: 5-Bromo-2-chloropyridine) was used in this study.

5-Bromo-2-chloropyridine(cas: 53939-30-3) belongs to pyridine. Pyridine-based materials are valued for their optical and physical properties as well as their medical potential. Additionally, pyridine-based natural products continue to be discovered and studied for their properties and to understand their biosynthesis.Name: 5-Bromo-2-chloropyridine

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem