Day: November 8, 2022

Category: pyridine-derivativesOn September 5, 2007 ,《Facile derivatization of pyridyloxazole-type fluorophore via click chemistry》 was published in Chemistry Letters. The article was written by Shi, Jing; Liu, Lei; He, Jing; Meng, Xiangming; Guo, Qingxiang. The article contains the following contents:

New derivatives of the arylpyridyloxazole-type fluorophore were synthesized in high efficiency through click chem. This method is potentially useful for the combinatory screening of fluorescent labels to target specific biol. processes. Using this method, we successfully developed three new pyrazole ratiometric dual-fluorescent pH sensors.4-Ethynylpyridin-2-amine(cas: 1094679-27-2Category: pyridine-derivatives) was used in this study.

4-Ethynylpyridin-2-amine(cas: 1094679-27-2) belongs to anime. Examples of direct uses of amines and their salts are as corrosion inhibitors in boilers and in lubricating oils (morpholine), as antioxidants for rubber and roofing asphalt (diarylamines), as stabilizers for cellulose nitrate explosives (diphenylamine), as protectants against damage from gamma radiation (diarylamines), as developers in photography (aromatic diamines), as flotation agents in mining, as anticling and waterproofing agents for textiles, as fabric softeners, in paper coating, and for solubilizing herbicides.Category: pyridine-derivatives

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Application In Synthesis of 2-Bromopyridin-3-amineOn March 22, 2022, Ferlin, Francesco; Anastasiou, Ioannis; Salameh, Nihad; Miyakoshi, Takeru; Baudoin, Olivier; Vaccaro, Luigi published an article in ChemSusChem. The article was 《C(sp3)-H Arylation Promoted by a Heterogeneous Palladium-N-Heterocyclic Carbene Complex in Batch and Continuous Flow》. The article mentions the following:

A heterogeneous reusable palladium(II)-bis(N-heterocyclic carbene) catalyst was prepared and shown to catalyze the intramol. C(sp3)-H activation/cyclization of N-alkyl-2-bromoanilines furnishing indolines. This new catalytic system was based on a bis-imidazolium ligand immobilized on a spaced cross-linked polystyrene support. The iodide ligands on the catalyst played a central role in the efficiency of the process occurring through a “”release and catch”” mechanism. The heterogeneous nature of the catalyst was further exploited in the design of a continuous-flow protocol that allowed a more efficient recovery and reuse of the catalyst, as well as a very fast and safe procedure. In addition to this study using 2-Bromopyridin-3-amine, there are many other studies that have used 2-Bromopyridin-3-amine(cas: 39856-58-1Application In Synthesis of 2-Bromopyridin-3-amine) was used in this study.

2-Bromopyridin-3-amine(cas: 39856-58-1) belongs to anime.Typically the presence of an amine functional group is deduced by a combination of techniques, including mass spectrometry as well as NMR and IR spectroscopies. 1H NMR signals for amines disappear upon treatment of the sample with D2O. In their infrared spectrum primary amines exhibit two N-H bands, whereas secondary amines exhibit only one.Application In Synthesis of 2-Bromopyridin-3-amine

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Formula: C5H5BrN2On October 4, 2019 ,《Silver-Mediated Trifluoromethoxylation of (Hetero)aryldiazonium Tetrafluoroborates》 was published in Organic Letters. The article was written by Yang, Yu-Ming; Yao, Jian-Fei; Yan, Wei; Luo, Zhuangzhu; Tang, Zhen-Yu. The article contains the following contents:

Here we report a silver-mediated trifluoromethoxylation of (hetero)aryldiazonium tetrafluoroborates by converting an aromatic amino group into an OCF3 group. This method, which can be considered to be a trifluoromethoxylation variation of the classic Sandmeyer-type reaction, uses readily available aryl and heteroaromatic amines as starting materials and AgOCF3 as trifluoromethoxylating reagents. The broad substrate scope and simple, mild reaction condition made this transformation a valuable method in constructing aryl-OCF3 bonds. In addition to this study using 2-Bromopyridin-3-amine, there are many other studies that have used 2-Bromopyridin-3-amine(cas: 39856-58-1Formula: C5H5BrN2) was used in this study.

2-Bromopyridin-3-amine(cas: 39856-58-1) belongs to anime. Amine, any member of a family of nitrogen-containing organic compounds that is derived, either in principle or in practice, from ammonia (NH3). Naturally occurring amines include the alkaloids, which are present in certain plants; the catecholamine neurotransmitters (i.e., dopamine, epinephrine, and norepinephrine); and a local chemical mediator, histamine, that occurs in most animal tissues.Formula: C5H5BrN2

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Quality Control of 2,6-Bis((4S,5S)-4,5-diphenyl-4,5-dihydrooxazol-2-yl)pyridineOn June 1, 2018, Li, Tian-Ren; Zhang, Mao-Mao; Wang, Bao-Cheng; Lu, Liang-Qiu; Xiao, Wen-Jing published an article in Organic Letters. The article was 《Synthesis of 3,3′-Biindoles through a Copper-Catalyzed Friedel-Crafts Propargylation/Hydroamination/Aromatization Sequence》. The article mentions the following:

A copper-catalyzed Friedel-Crafts propargylation/hydroamination/aromatization sequence is described. In the presence of a catalytic amount of CuI, this sequential reaction can convert ethynyl benzoxazinanones and indoles into a diverse set of 3,3′-biindoles with high efficiency and selectivity. Moreover, the synthesis of other indole-heteroaryl mols. and the catalytic asym. formation of axially chiral 3,3′-biindoles are demonstrated. In the experimental materials used by the author, we found 2,6-Bis((4S,5S)-4,5-diphenyl-4,5-dihydrooxazol-2-yl)pyridine(cas: 410092-98-7Quality Control of 2,6-Bis((4S,5S)-4,5-diphenyl-4,5-dihydrooxazol-2-yl)pyridine)

2,6-Bis((4S,5S)-4,5-diphenyl-4,5-dihydrooxazol-2-yl)pyridine(cas: 410092-98-7) belongs to pyridine derivatives. The ring atoms in the pyridine molecule are sp2-hybridized. The nitrogen is involved in the π-bonding aromatic system using its unhybridized p orbital. Quality Control of 2,6-Bis((4S,5S)-4,5-diphenyl-4,5-dihydrooxazol-2-yl)pyridineThe lone pair is in an sp2 orbital, projecting outward from the ring in the same plane as the σ bonds.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Liang, Ren-Xiao; Zhong, Chao; Liu, Zhi-Hong; Yang, Miao; Tang, Heng-Wei; Chen, Jian-Fei; Yang, Yun-Fang; Jia, Yi-Xia published an article on February 5 ,2021. The article was titled 《Enantioselective Arylation of Tetrasubstituted Enamines: Access to Enantioenriched Indolenine and 1H-Indole Derivatives》, and you may find the article in ACS Catalysis.Recommanded Product: 2-Bromopyridin-3-amine The information in the text is summarized as follows:

Palladium-catalyzed intramol. enantioselective β-arylation of tetrasubstituted endocyclic and exocyclic enamines was developed. A range of optically active medium-ring fused indolenines or 3,3′-spiroindolenines were achieved in enantiomeric ratios up to 98:2 with Cs2CO3 or K3PO4 as the base in the presence of chiral PHOX ligands. The use of Ag3PO4 as a base led to enantioenriched 1H-indoles in good enantiomeric ratios (up to 89:11) with (S)-DIFLUORPHOS as a chiral ligand, which proceeded via a possible domino enamine-isomerization/β-arylation sequence. The experimental part of the paper was very detailed, including the reaction process of 2-Bromopyridin-3-amine(cas: 39856-58-1Recommanded Product: 2-Bromopyridin-3-amine)

2-Bromopyridin-3-amine(cas: 39856-58-1) belongs to anime. Reaction with nitrous acid (HNO2), which functions as an acylating agent that is a source of the nitrosyl group (―NO), converts aliphatic primary amines to nitrogen and mixtures of alkenes and alcohols corresponding to the alkyl group in a complex process. This reaction has been used for analytical determination of primary amino groups in a procedure known as the Van Slyke method.Recommanded Product: 2-Bromopyridin-3-amine

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

The author of 《A bifunctional small molecular photocatalyst with a redox center and a Lewis acid site for one-pot tandem oxidation-acetalization》 were Rao, Cai-Hui; Ma, Shuai; Cui, Jing-Wang; Jia, Meng-Ze; Yao, Xin-Rong; Zhang, Jie. And the article was published in Green Chemistry in 2022. Electric Literature of C20H14N4 The author mentioned the following in the article:

By combining the double identity of a redox center and a Lewis acid site of the pyridinium derivative, the first bifunctional small mol. photocatalyst was developed for the one-pot tandem oxidation-acetalization reaction. A mechanism study revealed that pyridinium-mediated electron transfer and the photoactivation of mol. oxygen greatly facilitate the transformation of benzyl alcs. into the corresponding aldehydes, while the Lewis acid site of this bifunctional photocatalyst promoted a highly efficient acetalization reaction without any significant loss in activity after multiple reaction cycles, thus achieving the direct conversion of various alcs. into either cyclic or acyclic acetals in good yields under mild conditions without any additives. After reading the article, we found that the author used 4′-(4-Pyridyl)-2,2′:6′,2”-terpyridine(cas: 112881-51-3Electric Literature of C20H14N4)

4′-(4-Pyridyl)-2,2′:6′,2”-terpyridine(cas: 112881-51-3) belongs to pyridine derivatives. The ring atoms in the pyridine molecule are sp2-hybridized. The nitrogen is involved in the π-bonding aromatic system using its unhybridized p orbital. Electric Literature of C20H14N4 Pyridine has a conjugated system of six π electrons that are delocalized over the ring.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

In 2015,Ryan, Sarah J.; Schimler, Sydonie D.; Bland, Douglas C.; Sanford, Melanie S. published 《Acyl Azolium Fluorides for Room Temperature Nucleophilic Aromatic Fluorination of Chloro- and Nitroarenes》.Organic Letters published the findings.COA of Formula: C5H3BrClN The information in the text is summarized as follows:

The reaction of acid fluorides with N-heterocyclic carbenes (NHCs) produces anhydrous acyl azolium fluorides. With appropriate selection of the acid fluoride and NHC, these salts can be used for the room temperature SNAr fluorination of a variety of aryl chlorides and nitroarenes. E.g., in presence of N-heterocyclic carbene (I) and 4-MeOC6H4COF, fluorination of aryl chloride (II) gave 99% aryl fluoride (III). In the experiment, the researchers used 5-Bromo-2-chloropyridine(cas: 53939-30-3COA of Formula: C5H3BrClN)

5-Bromo-2-chloropyridine(cas: 53939-30-3) belongs to pyridine. Pyridine is very deactivated towards electrophilic substitution with respect to benzene. For this reason classical formylation, using methods such as the Gattermann or Vilsmeier reactions, are not generally successful. COA of Formula: C5H3BrClN

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

In 2016,Deutsch, Amrei; Jessen, Christoph; Deutsch, Carl; Karaghiosoff, Konstantin; Hoffmann-Roeder, Anja published 《One-Pot Synthesis of Substituted Trifluoromethylated 2,3-Dihydro-1H-imidazoles》.Organic Letters published the findings.Recommanded Product: 5-Bromo-2-chloropyridine The information in the text is summarized as follows:

An operationally simple one-pot reaction for the preparation of a novel class of racemic trifluoromethylated 2,3-dihydro-1H-imidazoles derived from electron-poor N,O-acetals and aryl Grignard reagents is described. In addition, access to highly functionalized 2-trifluoromethyl-2,3-dihydro-1H-imidazoles was accomplished by reaction of N-aryl hemiaminal ethers and N-aryl trifluoroethylamines in the presence of an excess of n-butyllithium. In the part of experimental materials, we found many familiar compounds, such as 5-Bromo-2-chloropyridine(cas: 53939-30-3Recommanded Product: 5-Bromo-2-chloropyridine)

5-Bromo-2-chloropyridine(cas: 53939-30-3) belongs to pyridine. Pyridines form stable salts with strong acids. Pyridine itself is often used to neutralize acid formed in a reaction and as a basic solvent. Recommanded Product: 5-Bromo-2-chloropyridine

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

In 2017,Duong, Hung A.; Wu, Wenqin; Teo, Yu-Yuan published 《Cobalt-Catalyzed Cross-Coupling Reactions of Arylboronic Esters and Aryl Halides》.Organometallics published the findings.Computed Properties of C5H3BrClN The information in the text is summarized as follows:

An efficient cobalt catalyst system for the Suzuki-Miyaura cross-coupling reaction of arylboronic esters and aryl halides has been identified. In the presence of cobalt(II)/terpyridine catalyst and potassium methoxide, a diverse array of (hetero)biaryls have been prepared in moderate to excellent yields. In the experimental materials used by the author, we found 5-Bromo-2-chloropyridine(cas: 53939-30-3Computed Properties of C5H3BrClN)

5-Bromo-2-chloropyridine(cas: 53939-30-3) belongs to pyridine. In industry and in the lab, pyridine is used as a reaction solvent, particularly when its basicity is useful, and as a starting material for synthesizing some herbicides, fungicides, and antiseptics.Computed Properties of C5H3BrClN

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

In 2017,Tsupova, Svetlana; Cadu, Alban; Stuck, Fabian; Rominger, Frank; Rudolph, Matthias; Samec, Joseph S. M.; Hashmi, A. Stephen K. published 《Dual Gold(I)-catalyzed Cyclization of Dialkynyl Pyridinium Salts》.ChemCatChem published the findings.HPLC of Formula: 128071-75-0 The information in the text is summarized as follows:

Novel dialkynyl pyridines were synthesized and protected as alkyl salts for dual gold(I)-catalyzed cycloisomerization. Different alkyl groups and counter ions were screened for the salts, with benzyl and hexafluorophosphate providing the best results. The cyclization led to NMR yields of >95% being obtained for a number of substrates. Step-wise hydrogenation of products was performed in one-pot by Pd/C, with selective reduction of the double bonds, followed by deprotection of the benzyl group. In the experimental materials used by the author, we found 2-Bromonicotinaldehyde(cas: 128071-75-0HPLC of Formula: 128071-75-0)

2-Bromonicotinaldehyde(cas: 128071-75-0) belongs to pyridine. Pyridine is very deactivated towards electrophilic substitution with respect to benzene. For this reason classical formylation, using methods such as the Gattermann or Vilsmeier reactions, are not generally successful. HPLC of Formula: 128071-75-0

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem