Day: November 8, 2022

Quality Control of Bis(pyridin-2-ylmethyl)amineIn 2019 ,《Two telomerase-targeting Pt(II) complexes of jatrorrhizine and berberine derivatives induce apoptosis in human bladder tumor cells》 appeared in Dalton Transactions. The author of the article were Qin, Qi-Pin; Wang, Zhen-Feng; Huang, Xiao-Ling; Tan, Ming-Xiong; Luo, Zhi-Hui; Wang, Shu-Long; Zou, Bi-Qun; Liang, Hong. The article conveys some information:

Two novel Pt(IIi) complexes, [Pt(B-TFA)Cl]Cl (Pt1) and [Pt(J-TFA)Cl]Cl (Pt2) with jatrorrhizine and berberine derivatives (B-TFA and J-TFA) were first prepared as desirable luminescent agents for cellular applications and potent telomerase inhibitors, which can induce bladder T-24 tumor cell apoptosis by targeting telomerase, together with induction of mitochondrial dysfunction, telomere DNA damage and cell-cycle arrest. Importantly, T-24 tumor inhibition rate (TIR) was 50.4% for Pt2, which was higher than that of Pt1 (26.4%) and cisplatin (37.1%). Taken together, all the results indicated that jatrorrhizine and berberine derivatives Pt1 and Pt2 show low toxicity and could be novel Pt-based anti-cancer drug candidates. The results came from multiple reactions, including the reaction of Bis(pyridin-2-ylmethyl)amine(cas: 1539-42-0Quality Control of Bis(pyridin-2-ylmethyl)amine)

Bis(pyridin-2-ylmethyl)amine(cas: 1539-42-0) is a secondary amine with two picolyl substituents. The compound is a tridentate ligand in coordination chemistry and commonly used to produce Zn-based chemosensors/probes, such as Zinpry.Quality Control of Bis(pyridin-2-ylmethyl)amine

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

COA of Formula: C6H4N2In 2020 ,《A luminescent zinc(II) coordination polymer as a highly selective and sensitive chemosensor for Fe(III) cation and Cr(VI) anions detection in aqueous solution》 appeared in Inorganica Chimica Acta. The author of the article were Li, Ling; Deng, Zhao-Yang; Xie, Xin; Zou, Ji-Yong; You, Sheng-Yong; Chen, Kai-Hong; Le, Jin-Feng. The article conveys some information:

A double-bent-mixed-ligand supported 2-periodic coordination polymer (CP) {[Zn2(FDA)2(4-abpt)2(H2O)2]}n (1) was synthesized from the unique combination of a bent furan-2,5-dicarboxylic acid (H2FDA) ligand and a bent 4-amino-3,5-bis(4-pyridyl)-1,2,4-triazole (4-abpt) coligand. The CP 1 demonstrates readily dispersible two-dimensional (2D) 2-periodic layer structure and considerable chemostability in aqueous media. Luminescence titration experiments indicate that CP 1 can serve as chemosensors for sensitively and selectively detecting Fe3+ cation, CrO42- and Cr2O72- anions in water solution via an environmentally friendly manner. Besides, the luminescent selective quenching mechanism of CP 1 toward Fe3+ cation, CrO42- and Cr2O72- anions is comprehensively studied in the light of absorption of the excitation energy of the host framework by individual analytes. In addition to this study using 4-Cyanopyridine, there are many other studies that have used 4-Cyanopyridine(cas: 100-48-1COA of Formula: C6H4N2) was used in this study.

4-Cyanopyridine(cas: 100-48-1) belongs to pyridine. The basicity and metallophilic high donor number of these π-deficient systems has long favored them as ligands in metal catalysis. The last decade saw pyridine assume a stronger role as functional group for directed C–H oxidation/activation.COA of Formula: C6H4N2

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Safety of 2-(2-Hydroxyethyl)pyridineIn 2018 ,《Preparation of the Ru3(CO)8-pyridine-alcohol cluster and its use for the selective catalytic transformation of primary to secondary amines》 appeared in Dalton Transactions. The author of the article were Singh, Ajeet; Mobin, Shaikh M.; Mathur, Pradeep. The article conveys some information:

The synthesis of pyridine alc. based ruthenium carbonyl clusters Ru3(hep)2(CO)8 , Ru3(hpp)2(CO)8 , and Ru3(bhmp-H)2(CO)8 {hep-H = 2-(2-hydroxyethyl)pyridine, hpp-H = 2-(3-hydroxypropyl)pyridine and bhmp-H2 = 2,6-bis(hydroxymethyl)pyridine} was carried out by the reaction of the corresponding pyridine-alc. ligands with Ru3(CO)12. Clusters Ru3(hep)2(CO)8 , Ru3(hpp)2(CO)8 , and Ru3(bhmp-H)2(CO)8 were characterized using elemental anal., NMR, FTIR, mass spectrometry and single-crystal x-ray structures. The clusters were explored for the selective catalytic transformation of primary amines into secondary amines using alcs. as the mono-alkylating agents via hydrogen transfer reactions. All three display efficient catalytic activity with 1 being the most effective.2-(2-Hydroxyethyl)pyridine(cas: 103-74-2Safety of 2-(2-Hydroxyethyl)pyridine) was used in this study.

2-(2-Hydroxyethyl)pyridine(cas: 103-74-2) belongs to pyridine. The basicity and metallophilic high donor number of these π-deficient systems has long favored them as ligands in metal catalysis. The last decade saw pyridine assume a stronger role as functional group for directed C–H oxidation/activation.Safety of 2-(2-Hydroxyethyl)pyridine

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Computed Properties of C5H3Br2NIn 2021 ,《Reductive Dimerization of Macrocycles Activated by BBr3》 appeared in Organic Letters. The author of the article were Kijewska, Monika; Siczek, Milosz; Pawlicki, Milosz. The article conveys some information:

Dimeric dipyridyl-carbazolyl boron dicationic complex I was prepared by BBr3-promoted dimerization of dipyridyl carbazole carbonyl-bridged macrocycle. A macrocyclic motif composed of carbazole and pyridine subunits linked by a carbonyl bridge (C:O) forms a skeleton with a peripheral reactivity that leads to a pinacol-like coupling activated by BBr3, eventually entrapping a substantially elongated C-C bond. Slightly modified conditions lead to the efficient transformation of the C=O unit to a CH2 linker that, after exposure to air, gives a dimeric mol. with multiple bonds between two macrocyclic units, as documented in spectroscopy and x-ray anal. The experimental process involved the reaction of 2,6-Dibromopyridine(cas: 626-05-1Computed Properties of C5H3Br2N)

2,6-Dibromopyridine(cas: 626-05-1) belongs to pyridine. Pyridine and pyridine-derived structures are privileged pharmacophores in medicinal chemistry and an essential functionality for organic chemists. As the prototypical π-deficient heterocycle, pyridine illustrates distinctive chemistry as both substrate and reagent. Computed Properties of C5H3Br2N

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Related Products of 128071-75-0In 2020 ,《Selective Insertion of Alkynes into C-C σ Bonds of Indolin-2-ones: Transition-Metal-Free Ring Expansion Reactions to Seven-Membered-Ring Benzolactams or Chromone Derivatives》 was published in Organic Letters. The article was written by Wang, Mengdan; Yang, Yajie; Song, Bo; Yin, Liqiang; Yan, Shuhui; Li, Yanzhong. The article contains the following contents:

An unprecedented ring expansion reaction of indolin-2-ones with alkynyl ketones under transition-metal-free conditions has been developed. Base-promoted selective cleavage of a C-C σ bond of the amide is the key in this process, which provides a straightforward and efficient way to synthesize seven-membered-ring benzolactams or chromone derivatives The significant advantages of this method include readily accessible starting materials, wide scope and functional group tolerance, and high atom economy. In the experimental materials used by the author, we found 2-Bromonicotinaldehyde(cas: 128071-75-0Related Products of 128071-75-0)

2-Bromonicotinaldehyde(cas: 128071-75-0) belongs to pyridine. Pyridine and pyridine-derived structures are privileged pharmacophores in medicinal chemistry and an essential functionality for organic chemists. As the prototypical π-deficient heterocycle, pyridine illustrates distinctive chemistry as both substrate and reagent. Related Products of 128071-75-0

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Electric Literature of C5H6BNO2In 2022 ,《Solvent and Counteranion Assisted Dynamic Self-Assembly of Molecular Triangles and Tetrahedral Cages》 was published in Inorganic Chemistry. The article was written by Kumar, Atul; Banerjee, Ranit; Zangrando, Ennio; Mukherjee, Partha Sarathi. The article contains the following contents:

Self-assembly of naked PdII ions sep. with newly designed bis(3-pyridyl)benzothiadiazole (L1) and bis(3-pyridyl)thiazolo[5,4-d]thiazole (L2) donors sep., under varying exptl. conditions, yielded Pd4L8 (L = L1 or L2) tetrahedral cages and their homologous Pd3L6 (L = L1 or L2) double-walled triangular macrocycles. The resulting assemblies exhibited solvent, temperature, and counteranion induced dynamic equilibrium Treatment of L1 with Pd(BF4)2 in acetonitrile (ACN) resulted in selective formation of a tetrahedral cage [Pd4(L1)8](BF4)8 (1a), which is in dynamic equilibrium with its homolog triangle [Pd3(L1)6](BF4)6 (2a) in DMSO. However, similar self-assembly using L2 instead of L1 yielded an equilibrium mixture of tetrahedral cage [Pd4(L2)8](BF4)8 (3a) and triangle [Pd3(L2)6](BF4)6 (4a) forms in both ACN and DMSO. The assembles were characterized by multinuclear NMR and ESI-MS while the structure of the tetrahedral cage (1a) was determined by single crystal x-ray diffraction. Existence of a dynamic equilibrium between the assemblies in solution was studied via variable temperature 1H NMR. The equilibrium constant K = ([Pd4L8]3/[Pd3L6]4) was calculated at each exptl. temperature and fitted with the Van’t Hoff equation to determine the standard enthalpy (ΔH°) and entropy (ΔS°) associated with the interconversion of the double-walled triangle to tetrahedral cage. The thermodn. feasibility of structural interconversion was analyzed from the change in ΔG°, which suggests favorable conversion of Pd3L6 triangle to Pd4L8 cage at elevated temperature for L1 in DMSO and L2 in ACN. Similar self-assembly reactions of L1 and L2 with Pd(NO3)2 instead of Pd(BF4)2 resulted in selective formation of a tetrahedral cage [Pd4(L1)8](NO3)8 (1b) and double-walled triangle [Pd3(L2)6](NO3)6 (4b), resp. In the part of experimental materials, we found many familiar compounds, such as Pyridin-3-ylboronic acid(cas: 1692-25-7Electric Literature of C5H6BNO2)

Pyridin-3-ylboronic acid(cas: 1692-25-7) belongs to pyridine. Pyridine and pyridine-derived structures are privileged pharmacophores in medicinal chemistry and an essential functionality for organic chemists. As the prototypical π-deficient heterocycle, pyridine illustrates distinctive chemistry as both substrate and reagent. Electric Literature of C5H6BNO2

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

《Bipyridine-Directed Syntheses of Uranyl Compounds Containing Semirigid Dicarboxylate Linkers: Diversity and Consistency in Uranyl Speciation》 was written by An, Shu-wen; Mei, Lei; Hu, Kong-qiu; Li, Fei-ze; Xia, Chuan-qin; Chai, Zhi-fang; Shi, Wei-qun. HPLC of Formula: 1134-35-6This research focused onuranyl phenylsulfonecarboxylate pyridine complex preparation photoluminescence; crystal structure uranyl phenylsulfonecarboxylate pyridine. The article conveys some information:

Bipyridine organic bases are beneficial to the synthesis of novel uranyl-organic hybrid materials, but the relationship between their mol. structures and specific roles as structure-directing agents, especially for the semirigid dicarboxylate systems, is still unclear. Here we demonstrate how the bipyridine ligands direct the coordination assembly of uranyl-organic compounds with a semirigid dicarboxylate linker, 4,4′-dicarboxybiphenyl sulfone (H2dbsf), by utilizing a series of bipyridine ligands, 1,10-phenanthroline (phen), 2,2′-bipyridine (2,2′-bpy), 5,5′-dimethylbipyridine (5,5′-dmbpy), 4,4′-bipyridine (4,4′-bpy), or 1,3-di(4-pyridyl)propane (bpp). Under hydrothermal conditions, eight uranyl-organic coordination polymers (UCPs), four of which [[UO2(dbsf)(phen)] (1), [UO2(dbsf)(phen)]·H2O (1′), [U4O10(dbsf)3]2[H2bpp]2 (6), and [U4O10(dbsf)3]2[H2bpp] (6′)] were reported previously, were synthesized and divided into two types based on the chelate or template effect of these bipyridine ligands. 1, 1′, [UO2(dbsf)(2,2′-bpy)] (2), and [(UO2)2(dbsf)2(5,5′-dmbpy)2] (3) are springlike triple helixes with bipyridine ligands (phen, 2,2′-bpy, or 5,5′-dmbpy) as chelate ligands, while [U4O10(dbsf)3][H2(4,4′-bpy)] (4), [U4O10(dbsf)3]2[H(4,4′-bpy)]2[Ni(H2O)6] (5), 6, and 6′ are tetranuclear uranyl-mediated 2-fold-interpenetrating networks with 4,4′-bpy or bpp as template ligands and charge-balancing agents. The participation or not in uranyl coordination of different bipyridine ligands promotes not only diversity in uranyl speciation and final topol. structures among different classes of organic bases but also consistency for the same types of bipyridine ligands, which thus endows the possibility of the rational design of UCPs based on semirigid dicarboxylate ligands with the aid of cautiously selected bipyridine ligands. In addition to this study using 4,4′-Dimethyl-2,2′-bipyridine, there are many other studies that have used 4,4′-Dimethyl-2,2′-bipyridine(cas: 1134-35-6HPLC of Formula: 1134-35-6) was used in this study.

4,4′-Dimethyl-2,2′-bipyridine(cas: 1134-35-6) is used in the synthesis of a series of o-phenanthroline-substituted ruthenium(II) complexes.HPLC of Formula: 1134-35-6 Furthermore, 4,4′-Dimethyl-2,2′-bipyridine is used as a chemical Intermediate. It can be used for the determination of ferrous and cyanide compounds.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

COA of Formula: C5H5BrN2On November 20, 2020 ,《I(III)-Catalyzed Oxidative Cyclization-Migration Tandem Reactions of Unactivated Anilines》 appeared in Organic Letters. The author of the article were Deng, Tianning; Shi, Emily; Thomas, Elana; Driver, Tom G.. The article conveys some information:

An I(III)-catalyzed oxidative cyclization-migration tandem reaction using Selectfluor as the oxidant was developed that converts unactivated anilines into 3H-indoles is reported herein. The reaction requires as little as 1 mol % of the iodocatalyst and is mild, tolerating pyridine and thiophene functional groups, and the dependence of the diastereoselectivity of the process on the identity of the iodoarene or iodoalkane precatalyst suggests that the catalyst is present for the stereochem. determining C-N bond forming step. After reading the article, we found that the author used 2-Bromopyridin-3-amine(cas: 39856-58-1COA of Formula: C5H5BrN2)

2-Bromopyridin-3-amine(cas: 39856-58-1) belongs to anime. Amines characteristically form salts with acids; a hydrogen ion, H+, adds to the nitrogen. With the strong mineral acids (e.g., H2SO4, HNO3, and HCl), the reaction is vigorous. Salt formation is instantly reversed by strong bases such as NaOH. Neutral electrophiles (compounds attracted to regions of negative charge) also react with amines; alkyl halides (R′X) and analogous alkylating agents are important examples of electrophilic reagents.COA of Formula: C5H5BrN2

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Synthetic Route of C5H5BrN2On June 7, 2021, Adamek, Rebecca N.; Suire, Caitlin N.; Stokes, Ryjul W.; Brizuela, Monica K.; Cohen, Seth M.; Leissring, Malcolm A. published an article in ChemMedChem. The article was 《Hydroxypyridinethione Inhibitors of Human Insulin-Degrading Enzyme》. The article mentions the following:

Insulin-degrading enzyme (IDE) is a human mononuclear Zn2+-dependent metalloenzyme that is widely regarded as the primary peptidase responsible for insulin degradation Despite its name, IDE is also critically involved in the hydrolysis of several other disparate peptide hormones, including glucagon, amylin, and the amyloid β-protein. As such, the study of IDE inhibition is highly relevant to deciphering the role of IDE in conditions such as type-2 diabetes mellitus and Alzheimer disease. There have been few reported IDE inhibitors, and of these, inhibitors that directly target the active-site Zn2+ ion have yet to be fully explored. In an effort to discover new, zinc-targeting inhibitors of IDE, a library of ∼350 metal-binding pharmacophores was screened against IDE, resulting in the identification of 1-hydroxypyridine-2-thione (1,2-HOPTO) as an effective Zn2+-binding scaffold. Screening a focused library of HOPTO compounds identified 3-sulfonamide derivatives of 1,2-HOPTO as inhibitors of IDE (Ki values of ∼50μM). Further structure-activity relationship studies yielded several thiophene-sulfonamide HOPTO derivatives with good, broad-spectrum activity against IDE that have the potential to be useful pharmacol. tools for future studies of IDE. After reading the article, we found that the author used 2-Bromopyridin-3-amine(cas: 39856-58-1Synthetic Route of C5H5BrN2)

2-Bromopyridin-3-amine(cas: 39856-58-1) belongs to anime. The methylamines occur in small amounts in some plants. Many polyfunctional amines (i.e., those having other functional groups in the molecule) occur as alkaloids in plants—for example, mescaline, 2-(3,4,5-trimethoxyphenyl)ethylamine; the cyclic amines nicotine, atropine, morphine, and cocaine; and the quaternary salt choline, N-(2-hydroxyethyl)trimethylammonium chloride, which is present in nerve synapses and in plant and animal cells.Synthetic Route of C5H5BrN2

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Smith, Adam P.; Fraser, Cassandra L. published an article on January 29 ,2002. The article was titled 《Metal-Centered Heteroarm Polymers: Chelation of Polystyrene-b-polycaprolactone with a Bipyridine Donor at the Block Junction》, and you may find the article in Macromolecules.Electric Literature of C12H10Cl2N2 The information in the text is summarized as follows:

A dual functional ligand initiator, 4-chloromethyl-4′-hydroxymethyl-2,2′-bipyridine, bpy-(CH2Cl)(CH2OH), was used in a tandem atom transfer radical polymerization-ring-opening polymerization sequence to generate polystyrene-polycaprolactone copolymers with bpy binding sites at the block interface. The coordination of bpy(PS)-(PCl) subunits to Ru, Fe, and Pt centers to form linear and star-shaped structures is described. The results came from multiple reactions, including the reaction of 4,4′-Bis(chloromethyl)-2,2′-bipyridine(cas: 138219-98-4Electric Literature of C12H10Cl2N2)

4,4′-Bis(chloromethyl)-2,2′-bipyridine(cas: 138219-98-4) belongs to pyridine derivatives. Several pyridine derivatives play important roles in biological systems. While its biosynthesis is not fully understood, nicotinic acid (vitamin B3) occurs in some bacteria, fungi, and mammals. Electric Literature of C12H10Cl2N2

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem