Day: November 24, 2022

Theabrownin modulates the gut microbiome and serum metabolome in aging mice induced by D-galactose was written by Lei, Shuwen;Zhang, Zhifang;Xie, Guihua;Zhao, Chunyan;Miao, Yue;Chen, Dehong;Zhang, Guangren;Liu, Hao;Peng, Chunxiu;Hou, Yan;Gong, Jiashun. And the article was included in Journal of Functional Foods in 2022.Recommanded Product: 54-47-7 The following contents are mentioned in the article:

Theabrownin (TB) is a complex oxidized polyphenol formed during the microbial fermentation of Pu-erh tea. It offers some health benefits such as weight loss, blood glucose reduction, and oxidation resistance; however, the anti-aging effect and the related mechanism have not yet been explored. In this study, symptoms of aging were induced in mice using D-galactose. Morris water maze test, hematoxylin-eosin staining, 16S rDNA high-throughput sequencing, and UHPLC-QE-MS metabolomics were used to reveal the anti-aging effects and potential mechanism of TB. TB improved the learning and memory ability, the liver oxidative stress (SOD, GSH-Px, and MDA), inflammation (IL-2, IL-6, and TNF-伪), and degeneration of the small intestine in the aging mice. Further anal. showed that TB pretreatment increased the relative abundance of Lactobacillus_murinus and Bacteroides_acidifaciens, and regulated 19 metabolites in the serum. In addition, TB treatment increased the relative abundance of Akkermansia_muciniphila, and regulated 12 metabolites. In conclusion, the anti-aging effect of TB is exerted by the targeted regulation of intestinal microorganisms, which could prevent and delay aging. This study involved multiple reactions and reactants, such as (4-Formyl-5-hydroxy-6-methylpyridin-3-yl)methyl dihydrogen phosphate (cas: 54-47-7Recommanded Product: 54-47-7).

(4-Formyl-5-hydroxy-6-methylpyridin-3-yl)methyl dihydrogen phosphate (cas: 54-47-7) belongs to pyridine derivatives. Pyridine’s the lone pair does not contribute to the aromatic system but importantly influences the chemical properties of pyridine, as it easily supports bond formation via an electrophilic attack. Pyridine groups exist in countless molecules, and their applications include catalysis, drug design, molecular recognition, and natural product synthesis.Recommanded Product: 54-47-7

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Theabrownin modulates the gut microbiome and serum metabolome in aging mice induced by D-galactose was written by Lei, Shuwen;Zhang, Zhifang;Xie, Guihua;Zhao, Chunyan;Miao, Yue;Chen, Dehong;Zhang, Guangren;Liu, Hao;Peng, Chunxiu;Hou, Yan;Gong, Jiashun. And the article was included in Journal of Functional Foods in 2022.Recommanded Product: (4-Formyl-5-hydroxy-6-methylpyridin-3-yl)methyl dihydrogen phosphate The following contents are mentioned in the article:

Theabrownin (TB) is a complex oxidized polyphenol formed during the microbial fermentation of Pu-erh tea. It offers some health benefits such as weight loss, blood glucose reduction, and oxidation resistance; however, the anti-aging effect and the related mechanism have not yet been explored. In this study, symptoms of aging were induced in mice using D-galactose. Morris water maze test, hematoxylin-eosin staining, 16S rDNA high-throughput sequencing, and UHPLC-QE-MS metabolomics were used to reveal the anti-aging effects and potential mechanism of TB. TB improved the learning and memory ability, the liver oxidative stress (SOD, GSH-Px, and MDA), inflammation (IL-2, IL-6, and TNF-伪), and degeneration of the small intestine in the aging mice. Further anal. showed that TB pretreatment increased the relative abundance of Lactobacillus_murinus and Bacteroides_acidifaciens, and regulated 19 metabolites in the serum. In addition, TB treatment increased the relative abundance of Akkermansia_muciniphila, and regulated 12 metabolites. In conclusion, the anti-aging effect of TB is exerted by the targeted regulation of intestinal microorganisms, which could prevent and delay aging. This study involved multiple reactions and reactants, such as (4-Formyl-5-hydroxy-6-methylpyridin-3-yl)methyl dihydrogen phosphate (cas: 54-47-7Recommanded Product: (4-Formyl-5-hydroxy-6-methylpyridin-3-yl)methyl dihydrogen phosphate).

(4-Formyl-5-hydroxy-6-methylpyridin-3-yl)methyl dihydrogen phosphate (cas: 54-47-7) belongs to pyridine derivatives. Pyridine’s the lone pair does not contribute to the aromatic system but importantly influences the chemical properties of pyridine, as it easily supports bond formation via an electrophilic attack. One of the examples of pyridines is the well-known alkaloid lithoprimidine, which is an A3 adenosine receptor antagonist and N,N-dimethylaminopyridine (DMAP) analog, commonly used in organic synthesis.Recommanded Product: (4-Formyl-5-hydroxy-6-methylpyridin-3-yl)methyl dihydrogen phosphate

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Effect of the pendent groups on biobased polymers, obtained from click chemistry suitable, for the adsorption of organic pollutants from water was written by Brirmi, Nour El Houda;Chabbah, Taha;Chatti, Saber;Schiets, Frederic;Casabianca, Herve;Marestin, Catherine;Mercier, Regis;Weidner, Steffen M.;Errachid, Abdelhamid;Jaffrezic-Renault, Nicole;Romdhane, Hatem Ben. And the article was included in Polymers for Advanced Technologies in 2022.SDS of cas: 700-16-3 The following contents are mentioned in the article:

In this work, four triazole-based poly(ether-pyridine)s polymers were synthesized and used as an adsorbent for the removal of phenolic compounds from aqueous solutions For this purpose, new fluoromonomers containing 1,2,3-triazole units were prepared by the Cu(I)-catalyzed 1,3-dipolar cycloaddition reaction and then used for the elaboration of novel poly(ether-pyridine-triazole)s (PEPTs) by direct polycondensation with isosorbide and bisphenol A. Chem. structure of fluorinated pyridinic monomers as well as resulting polymers was confirmed by ¹H and ¹⁹F NMR spectroscopic methods. The thermal behavior of the obtained PEPTs was characterized using differential scanning calorimetry and thermogravimetric anal. Results of sorption showed that polymers can be effectively used as a sorbent for the removal of polar organic pollutants. The isosorbide-based poly(ether-pyridine-triazole) which contains hydrophilic hydroxyl groups as pendants chains (P4) exhibited the highest sorption efficiencies (78%-100% after 1 h). In order to explain the results an adsorption mechanism mainly based on 蟺-蟺 interactions and hydrogen bonding with the pendent groups is proposed. This study involved multiple reactions and reactants, such as 2,3,4,5,6-Perfluoropyridine (cas: 700-16-3SDS of cas: 700-16-3).

2,3,4,5,6-Perfluoropyridine (cas: 700-16-3) belongs to pyridine derivatives. Pyridine is diamagnetic and has a diamagnetic susceptibility of 鈭?8.7 脳 10鈭? cm3路mol鈭?.The molecular electric dipole moment is 2.2 debyes. The standard enthalpy of formation is 100.2 kJ路mol鈭? in the liquid phase and 140.4 kJ路mol鈭? in the gas phase. Pyridine groups exist in countless molecules, and their applications include catalysis, drug design, molecular recognition, and natural product synthesis.SDS of cas: 700-16-3

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Evolutionary origin and functional diversification of aminotransferases was written by Koper, Kaan;Han, Sang-Woo;Pastor, Delia Casas;Yoshikuni, Yasuo;Maeda, Hiroshi A.. And the article was included in Journal of Biological Chemistry in 2022.Category: pyridine-derivatives The following contents are mentioned in the article:

Aminotransferases (ATs) are pyridoxal 5鈥?phosphate-dependent enzymes that catalyze the transamination reactions between amino acid donor and keto acid acceptor substrates. Modern AT enzymes constitute 鈭?% of all classified enzymic activities, play central roles in nitrogen metabolism, and generate multitude of primary and secondary metabolites. ATs likely diverged into four distinct AT classes before the appearance of the last universal common ancestor and further expanded to a large and diverse enzyme family. Although the AT family underwent an extensive functional specialization, many AT enzymes retained considerable substrate promiscuity and multifunctionality because of their inherent mechanistic, structural, and functional constraints. This review summarizes the evolutionary history, diverse metabolic roles, reaction mechanisms, and structure-function relationships of the AT family enzymes, with a special emphasis on their substrate promiscuity and multifunctionality. Comprehensive characterization of AT substrate specificity is still needed to reveal their true metabolic functions in interconnecting various branches of the nitrogen metabolic network in different organisms. This study involved multiple reactions and reactants, such as (4-Formyl-5-hydroxy-6-methylpyridin-3-yl)methyl dihydrogen phosphate (cas: 54-47-7Category: pyridine-derivatives).

(4-Formyl-5-hydroxy-6-methylpyridin-3-yl)methyl dihydrogen phosphate (cas: 54-47-7) belongs to pyridine derivatives. Pyridine’s the lone pair does not contribute to the aromatic system but importantly influences the chemical properties of pyridine, as it easily supports bond formation via an electrophilic attack. One of the examples of pyridines is the well-known alkaloid lithoprimidine, which is an A3 adenosine receptor antagonist and N,N-dimethylaminopyridine (DMAP) analog, commonly used in organic synthesis.Category: pyridine-derivatives

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Colorimetric detection of alkaline phosphatase activity based on pyridoxal phosphate-induced chromatic switch of polydiacetylene nanoliposomes was written by Wang, Dong-En;You, Shangqi;Huo, Wenjing;Han, Xiang;Xu, Huiyun. And the article was included in Microchimica Acta in 2022.Computed Properties of C8H10NO6P The following contents are mentioned in the article:

A colorimetric assay based on polydiacetylenes (PDA) nano-liposomes is reported for facile and sensitive detection of alk. phosphatase (ALP) activity. The critical basis of this method is that the interaction of pyridoxal phosphate (PLP) with nitrogenous group functionalized PDA nano-liposomes induces distinct blue-to-red color changes of PDA nano-liposomes. In the presence of ALP, as a nature substrate, PLP is enzymically hydrolyzed to form pyridoxal, which cannot interact with PDA nano-liposomes. As a result, the concentration of PLP is reduced and the color change of PDA nano-liposomes is retarded, which is associated with ALP level. Under optimal conditions, the proposed method showed good linear relationship with ALP activity in the range 10-200 U/L with a limit of detection of 2.8 U/L. The detection process could be vividly observed with the naked eye. Addnl. attempts by using the method for the evaluation of inhibitor efficiency were also achieved with satisfying results. The method was further challenged with real human serum samples, showing consistent results when compared with a com. standard assay kit. Such simple and easy-to-use approach may provide a new alternative for clin. and biol. detection of ALP. This study involved multiple reactions and reactants, such as (4-Formyl-5-hydroxy-6-methylpyridin-3-yl)methyl dihydrogen phosphate (cas: 54-47-7Computed Properties of C8H10NO6P).

(4-Formyl-5-hydroxy-6-methylpyridin-3-yl)methyl dihydrogen phosphate (cas: 54-47-7) belongs to pyridine derivatives. Pyridine has a conjugated system of six 蟺 electrons that are delocalized over the ring. The molecule is planar and, thus, follows the H眉ckel criteria for aromatic systems. Reduced pyridines, namely tetrahydropyridines, dihydropyridines and piperidines, are found in numerous natural and synthetic compounds. The synthesis and reactivity of these compounds have often been driven by the fact many of these compounds have interesting and unique pharmacological properties. Computed Properties of C8H10NO6P

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Colorimetric detection of alkaline phosphatase activity based on pyridoxal phosphate-induced chromatic switch of polydiacetylene nanoliposomes was written by Wang, Dong-En;You, Shangqi;Huo, Wenjing;Han, Xiang;Xu, Huiyun. And the article was included in Microchimica Acta in 2022.Category: pyridine-derivatives The following contents are mentioned in the article:

A colorimetric assay based on polydiacetylenes (PDA) nano-liposomes is reported for facile and sensitive detection of alk. phosphatase (ALP) activity. The critical basis of this method is that the interaction of pyridoxal phosphate (PLP) with nitrogenous group functionalized PDA nano-liposomes induces distinct blue-to-red color changes of PDA nano-liposomes. In the presence of ALP, as a nature substrate, PLP is enzymically hydrolyzed to form pyridoxal, which cannot interact with PDA nano-liposomes. As a result, the concentration of PLP is reduced and the color change of PDA nano-liposomes is retarded, which is associated with ALP level. Under optimal conditions, the proposed method showed good linear relationship with ALP activity in the range 10-200 U/L with a limit of detection of 2.8 U/L. The detection process could be vividly observed with the naked eye. Addnl. attempts by using the method for the evaluation of inhibitor efficiency were also achieved with satisfying results. The method was further challenged with real human serum samples, showing consistent results when compared with a com. standard assay kit. Such simple and easy-to-use approach may provide a new alternative for clin. and biol. detection of ALP. This study involved multiple reactions and reactants, such as (4-Formyl-5-hydroxy-6-methylpyridin-3-yl)methyl dihydrogen phosphate (cas: 54-47-7Category: pyridine-derivatives).

(4-Formyl-5-hydroxy-6-methylpyridin-3-yl)methyl dihydrogen phosphate (cas: 54-47-7) belongs to pyridine derivatives. Pyridine is diamagnetic and has a diamagnetic susceptibility of 鈭?8.7 脳 10鈭? cm3路mol鈭?.The molecular electric dipole moment is 2.2 debyes. The standard enthalpy of formation is 100.2 kJ路mol鈭? in the liquid phase and 140.4 kJ路mol鈭? in the gas phase. Pyridine groups exist in countless molecules, and their applications include catalysis, drug design, molecular recognition, and natural product synthesis.Category: pyridine-derivatives

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Predicting solvent effects in ionic liquids: Extension of a nucleophilic aromatic substitution reaction on a benzene to a pyridine was written by Hawker, Rebecca R.;Haines, Ronald S.;Harper, Jason B.. And the article was included in Journal of Physical Organic Chemistry in 2018.Quality Control of 2,3,4,5,6-Perfluoropyridine The following contents are mentioned in the article:

A nucleophilic aromatic substitution reaction involving a halopyridine electrophile was examined in a series of ionic liquid solvents. This reaction was chosen to test the known solvent effects of ionic liquids on this type of reaction mechanism, previously described with a halobenzene electrophile. The effect of varying the proportion of the ionic liquid in solution was determined, and it was shown that the more ionic liquid present in the reaction mixture, the greater the rate constant enhancement. Temperature-dependent kinetic analyses yielded activation parameters that showed that the rate constant enhancements are controlled by a balance between enthalpic and entropic effects, depending upon the proportion of ionic liquid present. Overall, the rate enhancement is entropically driven, due to organization of the ionic liquid about the electrophile. These results are consistent with what has been observed previously for the nucleophilic aromatic substitution reaction involving a halobenzene electrophile, demonstrating that the solvent effects observed for ionic liquids are general for this type of reaction mechanism and opening the possibility for extending their use through rational selection for reaction control. This study involved multiple reactions and reactants, such as 2,3,4,5,6-Perfluoropyridine (cas: 700-16-3Quality Control of 2,3,4,5,6-Perfluoropyridine).

2,3,4,5,6-Perfluoropyridine (cas: 700-16-3) belongs to pyridine derivatives. In contrast to benzene, Pyridine’s electron density is not evenly distributed over the ring, reflecting the negative inductive effect of the nitrogen atom. Pyridine derivatives are also useful as small-molecule 伪-helix mimetics that inhibit protein-protein interactions, as well as functionally selective GABA ligands.Quality Control of 2,3,4,5,6-Perfluoropyridine

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Expression, purification, and characterization of glutamate decarboxylase from human gut-originated Lactococcus garvieae MJF010 was written by Lim, Hyo Jung;Jung, Dong-Hyun;Cho, Eui-Sang;Seo, Myung-Ji. And the article was included in World Journal of Microbiology & Biotechnology in 2022.Safety of (4-Formyl-5-hydroxy-6-methylpyridin-3-yl)methyl dihydrogen phosphate The following contents are mentioned in the article:

Human gut-originated lactic acid bacteria were cultivated, and high 纬-aminobutyric acid (GABA)-producing Lactococcus garvieae MJF010 was identified. To date, despite the importance of GABA, no studies have investigated GABA-producing Lactococcus species, except for Lc. lactis. A recombinant glutamate decarboxylase of the strain MJF010 (rLgGad) was successfully expressed in Escherichia coli BL21(DE3) with a size of 53.9 kDa. rLgGad could produce GABA, which was verified using the silylation-derivative fragment ions of GABA. The purified rLgGad showed the highest GABA-producing activity at 35掳C and pH 5. rLgGad showed a melting temperature of 43.84掳C. At 30掳C, more than 80% of the activity was maintained even after 7 h; however, it rapidly decreased at 50掳C. The kinetic parameters, Km, Vmax, and kcat, of rLgGad were 2.94 mM, 0.023 mM/min, and 12.3 min- 1, resp. The metal reagents of CaCl2, MgCl2, and ZnCl2 significantly had pos. effects on rLgGad activity. However, most coenzymes including pyridoxal 5-phosphate showed no significant effects on enzyme activity. In conclusion, this is the first report of Gad from Lc. garvieae species and provides important enzymic information related to GABA biosynthesis in the Lactococcus genus. This study involved multiple reactions and reactants, such as (4-Formyl-5-hydroxy-6-methylpyridin-3-yl)methyl dihydrogen phosphate (cas: 54-47-7Safety of (4-Formyl-5-hydroxy-6-methylpyridin-3-yl)methyl dihydrogen phosphate).

(4-Formyl-5-hydroxy-6-methylpyridin-3-yl)methyl dihydrogen phosphate (cas: 54-47-7) belongs to pyridine derivatives. Pyridine is diamagnetic and has a diamagnetic susceptibility of 鈭?8.7 脳 10鈭? cm3路mol鈭?.The molecular electric dipole moment is 2.2 debyes. The standard enthalpy of formation is 100.2 kJ路mol鈭? in the liquid phase and 140.4 kJ路mol鈭? in the gas phase. Pyridine derivatives are also useful as small-molecule 伪-helix mimetics that inhibit protein-protein interactions, as well as functionally selective GABA ligands.Safety of (4-Formyl-5-hydroxy-6-methylpyridin-3-yl)methyl dihydrogen phosphate

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Expression, purification, and characterization of glutamate decarboxylase from human gut-originated Lactococcus garvieae MJF010 was written by Lim, Hyo Jung;Jung, Dong-Hyun;Cho, Eui-Sang;Seo, Myung-Ji. And the article was included in World Journal of Microbiology & Biotechnology in 2022.COA of Formula: C8H10NO6P The following contents are mentioned in the article:

Human gut-originated lactic acid bacteria were cultivated, and high 纬-aminobutyric acid (GABA)-producing Lactococcus garvieae MJF010 was identified. To date, despite the importance of GABA, no studies have investigated GABA-producing Lactococcus species, except for Lc. lactis. A recombinant glutamate decarboxylase of the strain MJF010 (rLgGad) was successfully expressed in Escherichia coli BL21(DE3) with a size of 53.9 kDa. rLgGad could produce GABA, which was verified using the silylation-derivative fragment ions of GABA. The purified rLgGad showed the highest GABA-producing activity at 35掳C and pH 5. rLgGad showed a melting temperature of 43.84掳C. At 30掳C, more than 80% of the activity was maintained even after 7 h; however, it rapidly decreased at 50掳C. The kinetic parameters, Km, Vmax, and kcat, of rLgGad were 2.94 mM, 0.023 mM/min, and 12.3 min- 1, resp. The metal reagents of CaCl2, MgCl2, and ZnCl2 significantly had pos. effects on rLgGad activity. However, most coenzymes including pyridoxal 5-phosphate showed no significant effects on enzyme activity. In conclusion, this is the first report of Gad from Lc. garvieae species and provides important enzymic information related to GABA biosynthesis in the Lactococcus genus. This study involved multiple reactions and reactants, such as (4-Formyl-5-hydroxy-6-methylpyridin-3-yl)methyl dihydrogen phosphate (cas: 54-47-7COA of Formula: C8H10NO6P).

(4-Formyl-5-hydroxy-6-methylpyridin-3-yl)methyl dihydrogen phosphate (cas: 54-47-7) belongs to pyridine derivatives. Pyridines are an important class of heterocycles and occur in polysubstituted forms in many naturally occurring biologically active compounds, drug molecules and chiral ligands. Pyridine derivatives are also useful as small-molecule 伪-helix mimetics that inhibit protein-protein interactions, as well as functionally selective GABA ligands.COA of Formula: C8H10NO6P

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

蟺-Hole路路路d_z²[Pt^II] Interactions with Electron-Deficient Arenes Enhance the Phosphorescence of Pt^II-Based Luminophores was written by Rozhkov, Anton V.;Ananyev, Ivan V.;Gomila, Rosa M.;Frontera, Antonio;Kukushkin, Vadim Yu.. And the article was included in Inorganic Chemistry in 2020.Application In Synthesis of 2,3,4,5,6-Perfluoropyridine The following contents are mentioned in the article:

Two phosphorescent Pt^II-based cyclometalated complexes were co-crystallized with perfluorinated arenes to give 1:1 co-crystals. The X-ray study revealed that each of the complexes is embraced by arenes^F to give infinite reverse sandwich structures. In four out of six structures, a d_z² orbital of Pt^II is directed to the arenes^F ring via 蟺-hole路路路d_z²[Pt^II] interactions, whereas in the other two structures, the filled d_z² orbital is directed toward the arene C atoms. Computed mol. electrostatic potential surfaces of the arenes^F and the complexes, noncovalent interaction indexes for the co-crystals, and natural bond orbital calculations indicate that 蟺-hole路路路d_z²[Pt^II] contacts (and, generally, the stacking) are of electrostatic origin. The solid-state photophys. study revealed up to 3.5-fold luminescence quantum yield and 15-fold lifetime enhancements in the co-crystals. This increase is associated with the strength of the 蟺-hole路路路d_z²[Pt^II] contact that is dependent on the 蟺-acidity of the arene^F and its spatial characteristics. This study involved multiple reactions and reactants, such as 2,3,4,5,6-Perfluoropyridine (cas: 700-16-3Application In Synthesis of 2,3,4,5,6-Perfluoropyridine).

2,3,4,5,6-Perfluoropyridine (cas: 700-16-3) belongs to pyridine derivatives. The ring atoms in the pyridine molecule are sp2-hybridized. The nitrogen is involved in the 蟺-bonding aromatic system using its unhybridized p orbital. The lone pair is in an sp2 orbital, projecting outward from the ring in the same plane as the 蟽 bonds. Many analogues of pyridine are known where N is replaced by other heteroatoms . Substitution of one C鈥揌 in pyridine with a second N gives rise to the diazine heterocycles (C4H4N2), with the names pyridazine, pyrimidine, and pyrazine.Application In Synthesis of 2,3,4,5,6-Perfluoropyridine

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem