Month: November 2022

Quality Control of 4,4′-Bis(chloromethyl)-2,2′-bipyridineOn March 1, 2019, Woo, Sung-Jun; Choi, Sunghan; Kim, So-Yoen; Kim, Pil Soo; Jo, Ju Hyoung; Kim, Chul Hoon; Son, Ho-Jin; Pac, Chyongjin; Kang, Sang Ook published an article in ACS Catalysis. The article was 《Highly Selective and Durable Photochemical CO2 Reduction by Molecular Mn(I) Catalyst Fixed on a Particular Dye-Sensitized TiO2 Platformã€? The article mentions the following:

A new Mn(I)-based hybrid system (OrgD-|TiO2|-MnP) for photocatalytic CO2 reduction is designed to be a co-assembly of Mn(4,4′-Y2-bpy)(CO)3Cl (MnP; Y = CH2PO(OH)2) and (E)-3-[5-(4-(diphenylamino)phenyl)-2,2′-bithiophen-2′-yl]-2-cyanoacrylicacid(OrgD) on TiO2 semiconductor particles. The OrgD-|TiO2|-MnP hybrid reveals persistent photocatalytic behavior, giving high turnover numbers and excellent product selectivity (HCOO- vs. CO) that surpass the catalytic activities of the related homogeneous and other heterogenized Mn photocatalytic systems reported so far. As a typical run, visible-light irradiation of the hybrid catalyst in the presence of 0.1M electron donor (ED) and 0.001M LiClO4 persistently produced HCOO- with a >99% selectivity accompanied by a trace amount of CO; the turnover number (TONformate) reached âˆ?10 after 25 h irradiation The product selectivity (HCOO-/CO) is controlled by changing the loading amount of MnP on the TiO2 surface. In-situ FTIR anal. of the hybrid during photocatalysis revealed that at low Mn concentration, the Mn-H monomeric mechanism associated with HCOO- formation is dominant, whereas at high Mn concentration, CO is formed via an Mn-Mn dimer mechanism. In the part of experimental materials, we found many familiar compounds, such as 4,4′-Bis(chloromethyl)-2,2′-bipyridine(cas: 138219-98-4Quality Control of 4,4′-Bis(chloromethyl)-2,2′-bipyridine)

4,4′-Bis(chloromethyl)-2,2′-bipyridine(cas: 138219-98-4) belongs to pyridine derivatives. The ring atoms in the pyridine molecule are sp2-hybridized. The nitrogen is involved in the π-bonding aromatic system using its unhybridized p orbital. Quality Control of 4,4′-Bis(chloromethyl)-2,2′-bipyridine Pyridine has a conjugated system of six π electrons that are delocalized over the ring.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Product Details of 138219-98-4On March 25, 2003, Peter, Katja; Thelakkat, Mukundan published an article in Macromolecules. The article was 《Synthesis and Characterization of Bifunctional Polymers Carrying Tris(bipyridyl)ruthenium(II) and Triphenylamine Unitsã€? The article mentions the following:

The synthesis, characterization, and properties of a highly soluble bifunctional polymer are described in which a tris(bipyridyl)Ru(II) unit acts as dye and triphenylamine units act as charge transport moieties. First a macro-ligand, a bipyridine carrying two poly(4-bromostyrene) chains, was synthesized by atom transfer radical polymerization (ATRP) of 4-bromostyrene in bulk using CuCl/PMDETA as the catalytic system and bis(chloromethyl) bipyridine as the initiator. The target polymer was then obtained via a polymer amination reaction in which the bromophenyl group was converted into a triphenylamine followed by metalation of the bipyridine unit of the macro-ligand with Ru(II) bis(bipyridine). The reaction conditions of ATRP and polymer amination reaction were optimized, and the degree of conversion for both steps was determined by gas chromatog. (GC) anal. of rest monomer content and elemental anal. of unreacted bromine, resp. The control in mol. weight was achieved maintaining a narrow distribution in the desired low mol. weight range of bulk polymerization of 4-bromostyrene. The polymer amination reaction using the Pd(OAc)2 and P(t-Bu)3 system was efficient, and the reaction was complete within 2 h. The metalation reaction could be followed by UV/vis spectroscopy. MALDI-TOF MS of the three polymers was carried out to obtain absolute mol. weights and their distribution. A comparison of these mol. weights gave addnl. information about the degree of polymer amination and metalation reaction. The thermal properties of the different polymers suggest that the thermal stability and the glass transition temperature increases from the starting macro-ligand which carries poly(4-bromostyrene) chains to the intermediate polymer having poly(vinyltriphenylamine) chains and finally to the bifunctional Ru(II) polymer complex. The results came from multiple reactions, including the reaction of 4,4′-Bis(chloromethyl)-2,2′-bipyridine(cas: 138219-98-4Product Details of 138219-98-4)

4,4′-Bis(chloromethyl)-2,2′-bipyridine(cas: 138219-98-4) belongs to pyridine derivatives. Several pyridine derivatives play important roles in biological systems. While its biosynthesis is not fully understood, nicotinic acid (vitamin B3) occurs in some bacteria, fungi, and mammals. Product Details of 138219-98-4

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Beccalli, Egle M.; Broggini, Gianluigi; Paladino, Giuseppe; Zoni, Caterina published an article in Tetrahedron. The title of the article was 《Palladium-mediated approach to dibenzo[b,e][1,4]diazepines and benzopyrido-analogues. An efficient synthesis of tarpaneã€?Recommanded Product: 1028-86-0 The author mentioned the following in the article:

An original synthetic route toward dibenzo[b,e][1,4]diazepin-11-ones, e.g., I, and analogs pyridobenzodiazepinones has been developed. The method relied upon an intramol. amination process between an (hetero)aryl halide and the appropriate aniline moiety. In the experimental materials used by the author, we found N-(2-Chloropyridin-3-yl)-2-nitrobenzamide(cas: 1028-86-0Recommanded Product: 1028-86-0)

N-(2-Chloropyridin-3-yl)-2-nitrobenzamide(cas: 1028-86-0) belongs to anime. To avoid the problem of multiple alkylation, methods have been devised for “blockingâ€?substitution so that only one alkyl group is introduced. The Gabriel synthesis is one such method; it utilizes phthalimide, C6H4(CO)2NH, whose one acidic hydrogen atom has been removed upon the addition of a base such as KOH to form a salt.Recommanded Product: 1028-86-0

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

In 1968,Tetrahedron included an article by Pala, Gianfranco; Crescenzi, Elda; Bietti, G.. SDS of cas: 16985-07-2. The article was titled 《New synthesis of 4,4′-dihydroxydiphenyl(2-pyridyl)-methaneã€? The information in the text is summarized as follows:

Condensing phenol with 2-pyridine carboxaldehyde was shown to give 4,4′-dihydroxydiphenyl(2-pyridyl)methane (I) together with 24-29% of its isomer 2,4′-dihydroxydiphenyl(2-pyridyl)methane (II). Recrystallization of the mixture, required to obtain I free from II, caused the yield of I to fall to scarcely 25%, based on 2-pyridine carboxaldehyde. To prevent or reduce formation of ortho condensation products, 2-pyridine carboxaldehyde was made to react with phenols halo-substituted in both or in a single ortho position. Reductive dehalogenation of the compounds thus obtained gave I in 65-70% yield. The results came from multiple reactions, including the reaction of 2,2′-(Pyridin-2-ylmethylene)diphenol(cas: 16985-07-2SDS of cas: 16985-07-2)

2,2′-(Pyridin-2-ylmethylene)diphenol(cas: 16985-07-2) belongs to pyridine derivatives. The ring atoms in the pyridine molecule are sp2-hybridized. The nitrogen is involved in the π-bonding aromatic system using its unhybridized p orbital. SDS of cas: 16985-07-2The lone pair is in an sp2 orbital, projecting outward from the ring in the same plane as the σ bonds.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

The author of 《Catalytic enantioselective borane reduction of benzyl oximes: preparation of (S)-1-pyridin-3-yl-ethylamine bis hydrochlorideã€?were Huang, Kun; Ortiz-Marciales, Margarita. And the article was published in Organic Syntheses in 2010. Quality Control of (S)-1-(Pyridin-3-yl)ethanamine dihydrochloride The author mentioned the following in the article:

The enantioselective preparation of (S)-1-(pyridin-3-yl)ethylamine bis hydrochloride is achieved by chiral spiroborate ester-catalyzed borane reduction of (E)-1-(pyridin-3-yl)ethanone O-benzyl-oxime in 88% yield, and 94% ee. In the part of experimental materials, we found many familiar compounds, such as (S)-1-(Pyridin-3-yl)ethanamine dihydrochloride(cas: 40154-84-5Quality Control of (S)-1-(Pyridin-3-yl)ethanamine dihydrochloride)

(S)-1-(Pyridin-3-yl)ethanamine dihydrochloride(cas: 40154-84-5) belongs to anime. Nitrous acid converts secondary amines (aliphatic or aromatic) to N-nitroso compounds (nitrosamines): R2NH + HNO2 â†?R2N―NO. Some nitrosamines are potent cancer-inducing substances, and their possible formation is a serious consideration when nitrites, which are salts of nitrous acid, are present in foods or pharmaceutical preparations. Tertiary amines give rise to nitrosamines more slowly; an alkyl group is eliminated as an aldehyde or ketone, along with nitrous oxide, N2O.Quality Control of (S)-1-(Pyridin-3-yl)ethanamine dihydrochloride

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

In 2014,Lafaye, Kevin; Nicolas, Lionel; Guerinot, Amandine; Reymond, Sebastien; Cossy, Janine published 《Lewis Basicity Modulation of N-Heterocycles: A Key for Successful Cross-Metathesisã€?Organic Letters published the findings.Reference of 5-Bromo-2-chloropyridine The information in the text is summarized as follows:

Introducing a chloro or other substituent neighboring the nitrogen atom of azaheterocycle-containing alkenes decreased their Lewis basicity sufficiently that, in most cases, they underwent olefin cross-metathesis with alkenes such as Me acrylates and (Z)-2-butene-1,4-diol diacetate in the presence of the second-generation Hoveyda-Grubbs ruthenium metathesis catalyst to give azaheteroaryl-substituted alkenes diastereoselectively. A variety of electron-deficient and electron-rich olefins and styrenes underwent metathesis, while chloro-, bromo-, fluoro-, trifluoromethyl-, trifloxy-, methoxy-, and tert-butyl-substituted pyridinylalkenes and chloro-substituted pyrimidinyl, isoquinolinyl, imidazolyl, and pyrazolyl alkenes were effective metathesis substrates. The experimental process involved the reaction of 5-Bromo-2-chloropyridine(cas: 53939-30-3Reference of 5-Bromo-2-chloropyridine)

5-Bromo-2-chloropyridine(cas: 53939-30-3) belongs to pyridine. Pyridine’s structure is isoelectronic with that of benzene, but its properties are quite different. Pyridine is completely miscible with water, whereas benzene is only slightly soluble. Like all hydrocarbons, benzene is neutral (in the acid–base sense), but because of its nitrogen atom, pyridine is a weak base.Reference of 5-Bromo-2-chloropyridine

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

In 2016,Hyde, Alan M.; Liu, Zhijian; Kosjek, Birgit; Tan, Lushi; Klapars, Artis; Ashley, Eric R.; Zhong, Yong-Li; Alvizo, Oscar; Agard, Nicholas J.; Liu, Guiquan; Gu, Xiuyan; Yasuda, Nobuyoshi; Limanto, John; Huffman, Mark A.; Tschaen, David M. published 《Synthesis of the GPR40 Partial Agonist MK-8666 through a Kinetically Controlled Dynamic Enzymatic Ketone Reductionã€?Organic Letters published the findings.Electric Literature of C5H3BrClN The information in the text is summarized as follows:

A scalable and efficient synthesis of the GPR40 agonist MK-8666 was developed from a simple pyridine building block. The key step to set the stereochem. at two centers relied on an enzymic dynamic kinetic reduction of an unactivated ketone. Directed evolution was leveraged to generate an optimized ketoreductase that provided the desired trans alc. in >30:1 dr and >99% ee. Further, it was demonstrated that all four diastereomers of this hydroxy-ester could be prepared in high yield and selectivity. Subsequently, a challenging intramol. displacement was carried out to form the cyclopropane ring system with perfect control of endo/exo selectivity. The endgame coupling strategy relied on a Pd-catalyzed C-O coupling to join the headpiece chloropyridine with the benzylic alc. tailpiece. After reading the article, we found that the author used 5-Bromo-2-chloropyridine(cas: 53939-30-3Electric Literature of C5H3BrClN)

5-Bromo-2-chloropyridine(cas: 53939-30-3) belongs to pyridine. Pyridine is very deactivated towards electrophilic substitution with respect to benzene. For this reason classical formylation, using methods such as the Gattermann or Vilsmeier reactions, are not generally successful. Electric Literature of C5H3BrClN

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

In 2016,Feng, Xiujuan; Li, Lingyu; Yu, Xiaoqiang; Yamamoto, Yoshinori; Bao, Ming published 《Copper-catalyzed conversion of aryl and heteroaryl bromides into the corresponding iodideã€?Catalysis Today published the findings.Name: 6-Bromopyridin-3-amine The information in the text is summarized as follows:

An efficient method for the synthesis of aryl iodides RI (R = 4-H3CC6H4, 1-naphthyl, 4-H3CC(O)C6H4, etc.) and heteroaryl iodides, R1I (R1 = quinolin-3-yl, 5-fluoro-pyridin-2-yl, thiophen-3-yl, etc.) has been described. The reactions of aryl bromides such as 1-bromo-4-methyl-benzene, 1-bromonaphthalene, 1-bromo-4-chloro-benzene, etc. and heteroaryl bromides such as 2-bromo-pyridine, 3-bromo-thiophene, 6-bromo-nicotinonitrile, etc. with potassium iodide proceeded smoothly in the presence of a copper catalyst under mild reaction conditions to produce the corresponding iodides in satisfactory to excellent yields. The experimental process involved the reaction of 6-Bromopyridin-3-amine(cas: 13534-97-9Name: 6-Bromopyridin-3-amine)

6-Bromopyridin-3-amine(cas: 13534-97-9) belongs to anime. Amine, any member of a family of nitrogen-containing organic compounds that is derived, either in principle or in practice, from ammonia (NH3). Naturally occurring amines include the alkaloids, which are present in certain plants; the catecholamine neurotransmitters (i.e., dopamine, epinephrine, and norepinephrine); and a local chemical mediator, histamine, that occurs in most animal tissues.Name: 6-Bromopyridin-3-amine

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

In 2018,Chotsaeng, Nawasit; Laosinwattana, Chamroon; Charoenying, Patchanee published 《Inhibitory effects of a variety of aldehydes on Amaranthus tricolor L. and Echinochloa crus-galli (L.) Beauv.ã€?Molecules published the findings.Recommanded Product: 128071-75-0 The information in the text is summarized as follows:

Thirty-seven com. aldehydes containing aliphatic chains and aromatic rings as well as heteroaromatic rings were evaluated for their inhibitory activities against Chinese amaranth (Amaranthus tricolor L.) and barnyardgrass (Echinochloa crus-galli (L.) Beauv). Polysorbate 80 (Tween@ 80) was used as a surfactant and the research was preliminarily conducted at 400 μM of all aldehydes. Among these aldehydes, (E)-cinnamaldehyde (7) showed the greatest inhibitory effect on seed germination, shoot and root growth of Chinese amaranth by 54.55%, 75.53%, and 85.13% resp. Similarly, (E)-crotonaldehyde (5), a related α,β-unsaturated aldehyde, inhibited the germination and seedling growth of the tested species at a high percentage. Apart from these two unsaturated aldehydes, no other aliphatic aldehydes had a harmful effect on Chinese amaranth. In terms of benzaldehyde (6), it had no effect on the tested plant; however, many of its derivatives displayed some inhibitory activity. Furthermore, for the ten common heteroaromatic aldehydes, picolinaldehyde (32) had a high inhibitory effect on Chinese amaranth which closely related to the effect of (E)-crotonaldehyde (5) and (E)-cinnamaldehyde (7), whereas, other heteroaromatic aldehydes showed lower effects. In the case of a monocot plant, barnyardgrass, no tested aldehydes reduced seed germination, however, (E)-cinnamaldehyde (7), 2,4,6-trimethoxybenzaldehyde (16) and 4-(dimethylamino)benzaldehyde (24) could inhibit the seedling growth of the plant with low to moderate levels. The herbicidal effects of the most active aldehydes were then further investigated in order to find the min. concentration of these aldehydes suppressing the germination and growth of the tested plants. At concentrations as low as 50-100 μM some aldehydes could inhibit the seedling growth of the tested species. The structure-activity relationship (SAR) study reported here demonstrates the chem. clues governing the inhibitory activity of aldehydes which could be utilized in the development of highly effective herbicides in the near future. In the part of experimental materials, we found many familiar compounds, such as 2-Bromonicotinaldehyde(cas: 128071-75-0Recommanded Product: 128071-75-0)

2-Bromonicotinaldehyde(cas: 128071-75-0) belongs to pyridine. Pyridine is widely used in the precursor to agrochemicals and pharmaceuticals. Also, it is used as an important reagent and organic solvent.Recommanded Product: 128071-75-0

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

In 2018,Mohammad, Akbar; Ansari, Shagufi Naz; Chaudhary, Archana; Ahmad, Khursheed; Rajak, Richa; Tauqeer, Mohd.; Mobin, Shaikh M. published 《Enthralling Adsorption of Different Dye and Metal Contaminants from Aqueous Systems by Cobalt/Cobalt Oxide Nanocomposites Derived from Single-Source Molecular Precursorsã€?ChemistrySelect published the findings.SDS of cas: 103-74-2 The information in the text is summarized as follows:

The cobalt/cobalt oxide nanocomposites (Co/CoO NCs), NC-1 and NC-2 were synthesized from our recently reported single-source mol. precursors (SSMPs) [Co(hep-H)(H2O)4]SO4, (1) and [Co(hep-H)2(H2O)2](NO3)2, (2), [hep-H= 2-(2-hydroxylethyl) pyridine], resp., via wet-chem. reduction method. Our purpose was to study the effect of different counter anions (i. e. SO42- and NO3-) of precursors on the surface properties of synthesized materials. Both the nanocomposites were characterized by Powder X-ray diffraction (PXRD), SEM (SEM), energy-dispersive X-ray anal. (EDAX), transmission electron microscopy (TEM), Fourier transform IR (FTIR) spectroscopy and Brunauer-Emmett-Teller (BET) anal. Two distinct morphol. as well as surface features have been obtained using 1 and 2 viz. variable spheres (NC-1) with low surface area and flakes (NC-2) with high surface area. The adsorption behavior of these nanocomposites on industrial dyes and heavy metals showed excellent dye adsorption (99.6% to 97.2%) and good to moderate metal adsorption efficiency of NC-1. The NC-1 could be recycled up to five times for dyes and three times for metals, advocating its practical applications in industry. The experimental process involved the reaction of 2-(2-Hydroxyethyl)pyridine(cas: 103-74-2SDS of cas: 103-74-2)

2-(2-Hydroxyethyl)pyridine(cas: 103-74-2) belongs to pyridine. Pyridines are often used as catalysts or reagents; particular notice has been paid recently to how pyridine coordinates to metal centers enabling a wide range of valuable reactions. SDS of cas: 103-74-2

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem