Month: November 2022

In 2019,Organic Letters included an article by Xia, Peng-Ju; Ye, Zhi-Peng; Hu, Yuan-Zhuo; Song, Dan; Xiang, Hao-Yue; Chen, Xiao-Qing; Yang, Hua. Recommanded Product: 197958-29-5. The article was titled 《Photocatalytic, Phosphoranyl Radical-Mediated N-O Cleavage of Strained Cycloketone Oximes》. The information in the text is summarized as follows:

In the presence of the iridium photocatalyst [Ir[dF(CF3)ppy]2(dtbbpy)]PF6, four-membered cyclic ketoximes such as cyclobutanone oxime underwent ring opening and addition reactions with aryl alkenes such as 1,1-diphenylethylene or with α-trifluoromethylstyrenes such as PhC(CF3):CH2 mediated by Ph3P (via its photogenerated phosphoranyl radical cation) under blue LED light to yield 6-arylhexanenitriles such as Ph2CH(CH2)4CN or (aryl)(difluoromethylene)hexanenitriles such as F2C:CPh(CH2)4CN. In the part of experimental materials, we found many familiar compounds, such as 2-Pyridinylboronic acid(cas: 197958-29-5Recommanded Product: 197958-29-5)

2-Pyridinylboronic acid(cas: 197958-29-5) belongs to pyridine. In industry and in the lab, pyridine is used as a reaction solvent, particularly when its basicity is useful, and as a starting material for synthesizing some herbicides, fungicides, and antiseptics.Recommanded Product: 197958-29-5

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

In 2019,Tetrahedron Letters included an article by Sun, Song; Zhou, Cong; Cheng, Jiang. COA of Formula: C33H24IrN3. The article was titled 《Synthesis of 4-cyanoethylated benzoxazines by visible-light-promoted radical oxycyanomethylation of olefinic amides with bromoacetonitrile》. The information in the text is summarized as follows:

A facile and efficient protocol for the visible-light-promoted radical oxycyanomethylation of olefinic amides 2-R1C(O)NHC6H4C(=CH2)R2 (R1 = Me, Ph, naphthalen-1-yl, cyclohexyl, thiophen-2-yl, etc.; R2 = Me, phenyl) with bromoacetonitrile has been developed, affording a series of 4-cyanoethylated benzoxazine derivatives I in moderate to excellent yields. The reaction featured with diverse functional group tolerance and mild reaction conditions. The experimental part of the paper was very detailed, including the reaction process of fac-Tris(2-phenylpyridine)iridium(cas: 94928-86-6COA of Formula: C33H24IrN3)

fac-Tris(2-phenylpyridine)iridium(cas: 94928-86-6) belongs to pyridine. Pyridine’s structure is isoelectronic with that of benzene, but its properties are quite different. Pyridine is completely miscible with water, whereas benzene is only slightly soluble. Like all hydrocarbons, benzene is neutral (in the acid–base sense), but because of its nitrogen atom, pyridine is a weak base.COA of Formula: C33H24IrN3

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

The author of 《Palladium-Catalyzed Electrochemical C-H Alkylation of Arenes》 were Yang, Qi-Liang; Li, Chuan-Zeng; Zhang, Liang-Wei; Li, Yu-Yan; Tong, Xiaofeng; Wu, Xin-Yan; Mei, Tian-Sheng. And the article was published in Organometallics in 2019. Related Products of 3510-66-5 The author mentioned the following in the article:

2-Arylpyridines were electrochem. ortho-alkylated by RBF3K, the reaction being performed in undivided cell in aqueous solutions catalyzed by Pd(OAc)2. Palladium-catalyzed electrochem. C-H functionalization reactions have emerged as attractive tools for organic synthesis. This process offers an alternative to conventional methods that require harsh chem. oxidants. However, this electrolysis requires divided cells to avoid catalyst deactivation by cathodic reduction Herein, we report the first example of palladium-catalyzed electrochem. C-H alkylation of arenes using undivided electrochem. cells in water, thereby providing a practical solution for the introduction of alkyl group into arenes. The experimental process involved the reaction of 2-Bromo-5-methylpyridine(cas: 3510-66-5Related Products of 3510-66-5)

2-Bromo-5-methylpyridine(cas: 3510-66-5) belongs to pyridine. Pyridine is very deactivated towards electrophilic substitution with respect to benzene. For this reason classical formylation, using methods such as the Gattermann or Vilsmeier reactions, are not generally successful. Related Products of 3510-66-5

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

The author of 《Photoredox-catalyzed stereoselective alkylation of enamides with N-hydroxyphthalimide esters via decarboxylative cross-coupling reactions》 were Guo, Jing-Yu; Zhang, Ze-Yu; Guan, Ting; Mao, Lei-Wen; Ban, Qian; Zhao, Kai; Loh, Teck-Peng. And the article was published in Chemical Science in 2019. HPLC of Formula: 94928-86-6 The author mentioned the following in the article:

Stereoselective β-C(sp2)-H alkylation of enamides with redox-active N-hydroxyphthalimide esters via a photoredox-catalyzed decarboxylative cross-coupling reaction was demonstrated. This methodol. featured an operational simplicity, broad substrate scopes and excellent stereoselectivities and functional group tolerance, affording a diverse array of geometrically defined and synthetically valuable enamides bearing primary, secondary or tertiary alkyl groups in satisfactory yields. In the experiment, the researchers used many compounds, for example, fac-Tris(2-phenylpyridine)iridium(cas: 94928-86-6HPLC of Formula: 94928-86-6)

fac-Tris(2-phenylpyridine)iridium(cas: 94928-86-6) belongs to pyridine. Pyridine is very deactivated towards electrophilic substitution with respect to benzene. For this reason classical formylation, using methods such as the Gattermann or Vilsmeier reactions, are not generally successful. HPLC of Formula: 94928-86-6

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

The author of 《Diacetyl as a “”traceless”” visible light photosensitizer in metal-free cross-dehydrogenative coupling reactions》 were Huang, Chia-Yu; Li, Jianbin; Liu, Wenbo; Li, Chao-Jun. And the article was published in Chemical Science in 2019. Reference of 4-Cyanopyridine The author mentioned the following in the article:

Minisci alkylation is of prime importance for its applicability in functionalizing diverse heteroarenes, which are core structures in many bioactive compounds In alkyl radical generation processes, precious metal catalysts, high temperatures and excessive oxidants are generally involved, which lead to sustainability and safety concerns. Herein a new strategy using diacetyl (2,3-butanedione) as an abundant, visible light-sensitive and “”traceless”” hydrogen atom abstractor to achieve metal-free cross-dehydrogenative Minisci alkylation under mild conditions is reported. Mechanistic studies supported hydrogen atom transfer (HAT) between an activated C(sp3)-H substrate and diacetyl. Moreover, with the assistance of di-tert-Bu peroxide (DTBP), the scope of the reaction could be extended to strong aliphatic C-H bonds via diacetyl-mediated energy transfer. The robustness of this strategy was demonstrated by functionalizing complex mols. such as quinine, fasudil, nicotine, menthol and alanine derivatives In the experiment, the researchers used 4-Cyanopyridine(cas: 100-48-1Reference of 4-Cyanopyridine)

4-Cyanopyridine(cas: 100-48-1) belongs to pyridine. Pyridines form stable salts with strong acids. Pyridine itself is often used to neutralize acid formed in a reaction and as a basic solvent. Reference of 4-Cyanopyridine

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

The author of 《Synthesis and biological properties of tetranuclear ruthenium complexes containing the bis[4(4′-methyl-2,2′-bipyridyl)]-1,7-heptane ligand》 were Sun, Biyun; Sundaraneedi, Madhu K.; Southam, Hannah M.; Poole, Robert K.; Musgrave, Ian F.; Keene, F. Richard; Collins, J. Grant. And the article was published in Dalton Transactions in 2019. Reference of 4,4′-Dimethyl-2,2′-bipyridine The author mentioned the following in the article:

Linear and non-linear tetranuclear ruthenium(II) complexes containing the bridging ligand bis[4(4′-methyl-2,2′-bipyridyl)]-1,7-heptane have been synthesized and their biol. properties examined The min. inhibitory concentrations (MIC) and the min. bactericidal concentrations (MBC) of the ruthenium(II) complexes were determined against six strains of bacteria: Gram-pos. Staphylococcus aureus (S. aureus) and methicillin-resistant S. aureus (MRSA); and the Gram-neg. Escherichia coli (E. coli) strains MG1655, APEC, UPEC and Pseudomonas aeruginosa (P. aeruginosa). The results showed that both tetranuclear complexes had significant antimicrobial activity, with the non-linear (branched) species (Rubb7-TNL) having slightly higher activity than the corresponding linear analog (Rubb7-TL). The corresponding toxicity against three eukaryotic cell lines – BHK (baby hamster kidney), Caco-2 (heterogeneous human epithelial colorectal adenocarcinoma) and Hep-G2 (liver carcinoma) – have also been determined Interestingly, both Rubb7-TNL and Rubb7-TL were as toxic to the eukaryotic cells as they were to the bacteria, a rarity for kinetically-inert cationic polypyridylruthenium(II) complexes, and exhibited lower IC50 values than cisplatin over 24-, 48- or 72-h incubation times. Fluorescence spectroscopy was used to study the binding of the ruthenium complexes with human serum albumin (HSA). Rubb7-TNL and Rubb7-TL exhibited strong HSA binding, with equilibrium binding constants in the order of 107 M-1. Confocal microscopy was used to examine the cellular localization of Rubb7-TNL in BHK cells. The results indicated that the ruthenium complex localized in the nucleolus. Significant accumulation was also observed in the cytoplasm, but not in the mitochondria. Taken together, the results of this study suggest that Rubb7-TNL is an unlikely candidate as an antimicrobial agent, but may have potential as an anticancer drug.4,4′-Dimethyl-2,2′-bipyridine(cas: 1134-35-6Reference of 4,4′-Dimethyl-2,2′-bipyridine) was used in this study.

4,4′-Dimethyl-2,2′-bipyridine(cas: 1134-35-6) is used as a chemical Intermediate. It can be used for the determination of ferrous and cyanide compounds.Reference of 4,4′-Dimethyl-2,2′-bipyridine Furthermore, 4,4′-Dimethyl-2,2′-bipyridine is used in the synthesis of a series of o-phenanthroline-substituted ruthenium(II) complexes.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

The author of 《Synthesis and characterization of a novel 18F-labeled 2,5-diarylnicotinamide derivative targeting orexin 2 receptor》 were Watanabe, Hiroyuki; Matsushita, Naoki; Shimizu, Yoichi; Iikuni, Shimpei; Nakamoto, Yuji; Togashi, Kaori; Ono, Masahiro. And the article was published in MedChemComm in 2019. Quality Control of Pyridin-3-ylboronic acid The author mentioned the following in the article:

Orexin 2 receptor (OX2R) is thought to play an important role in the arousal-promoting function, but its distribution and function in the pathophysiol. of orexin-mediated disorders remains to be fully elucidated. In the present study, we synthesized and characterized a novel 18F-labeled 2,5-diarylnicotinamide (DAN) derivative as a potential positron emission tomog. (PET) probe for in vivo imaging of OX2R. In in vitro binding experiments, [18F]DAN-1 selectively bound to OX2R. In a biodistribution study using normal mice, [18F]DAN-1 displayed moderate brain uptake (2.10% ID per g at 10 min post-injection). In addition, the radioactivity in the mouse brain at 30 min post-injection was significantly decreased by co-injection with nonradioactive DAN-1, but high nonspecific binding was observed These results suggested that further structural modifications of [18F]DAN-1 are needed to use it for imaging OX2R in the brain. In the part of experimental materials, we found many familiar compounds, such as Pyridin-3-ylboronic acid(cas: 1692-25-7Quality Control of Pyridin-3-ylboronic acid)

Pyridin-3-ylboronic acid(cas: 1692-25-7) belongs to pyridine. When pyridine is adsorbed on oxide surfaces or in porous materials, the following species are commonly observed: (i) pyridine coordinated to Lewis acid sites, (ii) pyridine H-bonded to weakly acidic hydroxyls, and (iii) protonated pyridine. At high coverage, physisorbed pyridine and protonated dimers can also be observed.Quality Control of Pyridin-3-ylboronic acid

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

《Iron-catalyzed remote functionalization of inert C(sp3)-H bonds of alkenes via 1,n-hydrogen-atom-transfer by C-centered radical relay》 was published in Chemical Science in 2020. These research results belong to Bian, Kang-Jie; Li, Yan; Zhang, Kai-Fan; He, Yan; Wu, Tian-Rui; Wang, Cheng-Yu; Wang, Xi-Sheng. Recommanded Product: 2-(2-Hydroxyethyl)pyridine The article mentions the following:

Enabled by 1,n (n = 5, 6)-hydrogen atom transfer (HAT), a most prevalent moiety, alkene, as the precursor to an sp3 C-centered radical to promote selective cleavage of inert C(sp3)-H bonds for the generation of azidotrifluoromethylated mols. I [R1 = Me, n-Bu, Ph, etc.; R2 = H, Me, Et, n-octyl; R1R2 = (CH2)3, (CH2)4, (CH2)2O(CH2)2, etc.; X = C(CO2Et)2, C(CH2OBz)2, NTs] was used. Mild conditions, broad scope and excellent regioselective control (>20 : 1) were observed in the reactions. Deuterium labeling studies disclosed the kinetic characteristics of the transformations and verify a direct 1,n-HAT pathway. The key to this C-centered radical relay was that iron played a dual role as a radical initiator and terminator to incorporate the azide functionality through radical oxidation via azido-ligand-transfer. The methods and the later derivatization promised expeditious synthesis of CF3-containing organic azides, γ-lactam and triazoles that were widely used in designing new fluorescent tags and functional materials. In the experiment, the researchers used 2-(2-Hydroxyethyl)pyridine(cas: 103-74-2Recommanded Product: 2-(2-Hydroxyethyl)pyridine)

2-(2-Hydroxyethyl)pyridine(cas: 103-74-2) belongs to pyridine. Pyridine’s structure is isoelectronic with that of benzene, but its properties are quite different. Pyridine is completely miscible with water, whereas benzene is only slightly soluble. Like all hydrocarbons, benzene is neutral (in the acid–base sense), but because of its nitrogen atom, pyridine is a weak base.Recommanded Product: 2-(2-Hydroxyethyl)pyridine

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

《Pyridyl CO2 Fixation Enabled by a Secondary Hydrogen Bonding Coordination Sphere》 was published in ACS Omega in 2020. These research results belong to Gayton, Jacqueline N.; Li, Qing; Sanders, Lakeeta; Rodrigues, Roberta R.; Hill, Glake; Delcamp, Jared H.. SDS of cas: 141-86-6 The article mentions the following:

Reversible CO2 binders under ambient conditions are of significant interest for multiple applications in sensing and capture technologies. In this paper, a general systematic way to evaluate CO2 receptors with π-systems is put forward. A series of receptors (five pyridine-based and one triazine-based) are evaluated as CO2 binders in terms of number of hydrogen bonding sites, strength of hydrogen bond donors, and number of nucleophilic sites. The binding of CO2 to the receptors was probed by computational models, absorption spectroscopy, fluorescence spectroscopy, cyclic voltammetry, and 1H NMR studies. Multiple solvents with varying ionic strength additives are probed to analyze the effects on CO2-bound intermediates. The receptors were screened progressively down-selecting through the different anal. techniques arriving at a promising pyridine receptor, which shows evidence of CO2 binding with each of the anal. techniques. The diaminopyridine motif demonstrates reversible CO2 binding and has convenient substitution sites for derivatization to incorporate into functional sensor systems. In the part of experimental materials, we found many familiar compounds, such as 2,6-Diaminopyridine(cas: 141-86-6SDS of cas: 141-86-6)

2,6-Diaminopyridine(cas: 141-86-6) belongs to pyridine. Pyridine and its simple derivatives are stable and relatively unreactive liquids, with strong penetrating odours that are unpleasant.SDS of cas: 141-86-6

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

《Organic-Inorganic Hybrid Cerium-Encapsulated Selenotungstate Including Three Building Blocks and Its Electrochemical Detection of Dopamine and Paracetamol》 was published in Inorganic Chemistry in 2020. These research results belong to Jiang, Jun; Liu, Lulu; Liu, Guoping; Wang, Dan; Zhang, Yan; Chen, Lijuan; Zhao, Junwei. Product Details of 1692-25-7 The article mentions the following:

A novel organic-inorganic hybrid cerium-encapsulated selenotungstate comprising three polyoxotungstate building units Na16H6{[Ce3W4O10(H2O)9(CH3COO)3]2(Se2W7O30)(B-α-SeW9O33)4}·(C5H8NBO3)·119H2O (1) was synthesized by the portfolio approach of an in situ self-assembly reaction and step-by-step synthesis. The hybrid polyoxoanion of 1 is constructed from an acetate-coordinated heterometallic {[(Ce3W4O10)(H2O)9(CH3COO)3]2(Se2W7O30)}10+ core encompassing four trilacunary [B-α-SeW9O33]8- subunits. Interestingly, the heterometallic core contains a remarkable [Se2W7O30]10- building block in which seven WVI atoms form a W7 plane and two SeIV atoms are situated on two opposite faces of the W7 plane. In addition, the electrochem. performances of the 1@CFMCN composite (CFMCN: carboxyl-functionalized multiwalled carbon nanotube) were investigated. The 1@CFMCN/GCE (GCE: glass carbon electrode) sensor demonstrates a promising potential in electrochem. sensing dopamine (DPA) or paracetamol (PCM) or even simultaneously detecting DPA and PCM with low limits of 0.053μM for DPA and 2.03μM for PCM over a wide linear range at high sensitivity. A novel organic-inorganic hybrid selenotungstate was synthesized via the portfolio approach of an in situ self-assembly reaction and step-by-step synthesis. Its electrochem. sensing properties toward DPA and PCM were investigated. In addition to this study using Pyridin-3-ylboronic acid, there are many other studies that have used Pyridin-3-ylboronic acid(cas: 1692-25-7Product Details of 1692-25-7) was used in this study.

Pyridin-3-ylboronic acid(cas: 1692-25-7) belongs to pyridine. Pyridine is very deactivated towards electrophilic substitution with respect to benzene. For this reason classical formylation, using methods such as the Gattermann or Vilsmeier reactions, are not generally successful. Product Details of 1692-25-7

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem