Month: November 2022

Winterling, Erik; Ivlev, Sergei; Meggers, Eric published their research in Organometallics in 2021. The article was titled 《Chiral-at-Ruthenium Catalysts with Mixed Normal and Abnormal N-Heterocyclic Carbene Ligands》.SDS of cas: 624-28-2 The article contains the following contents:

We recently reported a new class of chiral ruthenium catalysts in which two achiral bidentate N-(2-pyridyl)-substituted N-heterocyclic carbene ligands in addition to two labile acetonitriles are coordinated to a central ruthenium and generate a stereogenic metal center which is responsible for the overall chirality. Here we now report our discovery of related chiral-at-ruthenium catalysts in which normal and abnormal N-heterocyclic carbene (NHC) ligands are present at the same time. The synthesis of racemic complexes, their resolution into individual enantiomers by a chiral auxiliary approach, and a catalytic application are reported. The mixed normal/abnormal NHC complexes display significantly increased turnover numbers and turnover frequencies for a nitrene-mediated enantioselective C(sp3)-H amination. In the experiment, the researchers used 2,5-Dibromopyridine(cas: 624-28-2SDS of cas: 624-28-2)

2,5-Dibromopyridine(cas: 624-28-2) belongs to pyridine. Pyridine is very deactivated towards electrophilic substitution with respect to benzene. For this reason classical formylation, using methods such as the Gattermann or Vilsmeier reactions, are not generally successful. SDS of cas: 624-28-2

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Martinez, Kristina; Benson, Kaitlyn; Paul, Jared; Schmehl, Russell H. published an article in 2021. The article was titled 《Photophysics of Ru(II) complexes with hydroxylated diimine ligands: Photoinduced electron/proton transfer to anthraquinone》, and you may find the article in Polyhedron.Application In Synthesis of 2-Pyridinylboronic acid The information in the text is summarized as follows:

This manuscript reports the reaction of the 3MLCT excited states of two luminescent chromophores, [(bpy)2Ru(OHbpy)]2+ and [(bpy)2Ru(OMebpy)]2+ (bpy = 2,2′-bipyridine, OHbpy = 4-hydroxy-2,2′-bipyridine, OMebpy = 4-methoxy-2,2′-bipyridine), with anthraquinone (AQ). A series of luminescence, electrochem., spectrophotometric and transient absorption studies were done in order to determine free energies for the potential reaction paths between the photoexcited complexes and AQ. For the OMebpy complex, only excited state electron transfer (ET*) from the 3MLCT state of the complex to AQ was possible. However, for the OHbpy complex, the excited state could react with AQ via a variety of pathways including excited state electron transfer, ET*, excited state proton transfer (PT*) and excited state proton coupled electron transfer (PCET*). The thermodn. anal. revealed that, for the OHbpy complex PT* was very endergonic and not a viable reaction pathway, however both ET* and PCET* could occur. Luminescence quenching studies revealed that both the OHbpy and the OMebpy excited complexes reacted with AQ (kq ∼ 109 M-1s-1 for both). Transient absorption anal. showed that, for the OMebpy complex, no photoproducts escaped the encounter complex associated with the quenching reaction. The result is consistent with strong electrostatic association of the 3+/1- encounter complex. For the OHbpy complex transient absorption results clearly show the formation of PCET* products from the encounter complex. The result represents one of a small number of examples of excited states of chromophores reacting via proton coupled electron transfer within an encounter complex. The results came from multiple reactions, including the reaction of 2-Pyridinylboronic acid(cas: 197958-29-5Application In Synthesis of 2-Pyridinylboronic acid)

2-Pyridinylboronic acid(cas: 197958-29-5) belongs to pyridine. Pyridine is very deactivated towards electrophilic substitution with respect to benzene. For this reason classical formylation, using methods such as the Gattermann or Vilsmeier reactions, are not generally successful. Application In Synthesis of 2-Pyridinylboronic acid

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Liang, Qiuming; Song, Datong published an article in 2021. The article was titled 《Syntheses and Reactivity of Piano-Stool Iron Complexes of Picolyl-Functionalized N-Heterocyclic Carbene Ligands》, and you may find the article in Organometallics.Recommanded Product: 2-(Bromomethyl)pyridine hydrobromide The information in the text is summarized as follows:

[FeClCp*(HL)] (1; HL = 3-methyl-1-(2-picolyl)-imidazol-2-ylidene) was synthesized from the reaction of in situ generated HL ligand and [FeClCp*(TMEDA)] (TMEDA is N,N,N’,N’-tetramethylethylenediamine). The deprotonation of 1 with KHMDS led to removal of a pyridylic proton and the dearomatization of the pyridine ring of the HL ligand, forming [Cp*(L)Fe(μ-N2)FeCp*(L)] (2) under N2 or [(FeCp*)2(μ-H)(μ-L)] (3) under Ar. Complex 2 splits H2 across the L- ligands and the Fe centers to give [FeCp*(H)(HL)] (4). Complex 4 readily converts to [Cp*(L”)Fe(μ-N2)FeCp*(L”)] (5) under N2, where the L”- ligand chelates to the metal center through the carbene C and a pyridyl C. The reactions of 2 with PhSiH3 and Ph2SiH2 give silyl complexes 6 and 7, resp. Compounds of 2, 4, and 5 are active (pre)catalysts for the dehydrogenative coupling of dimethylamine borane. The results came from multiple reactions, including the reaction of 2-(Bromomethyl)pyridine hydrobromide(cas: 31106-82-8Recommanded Product: 2-(Bromomethyl)pyridine hydrobromide)

2-(Bromomethyl)pyridine hydrobromide(cas: 31106-82-8) belongs to pyridine. Pyridine is a relatively complex molecule and exhibits a number of different bands in IR spectra. Among others, the bands characterizing the ν8a and ν19b modes have been found to be sensitive to the coordination or protonation of the molecule. Note that the band that is diagnostic for the PyH+ ion at about 1545 cm− 1 (ν19b mode) does not overlap with any of the other bands.Recommanded Product: 2-(Bromomethyl)pyridine hydrobromide

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Xie, Chao; Lin, Longfei; Huang, Liang; Wang, Zixin; Jiang, Zhiwei; Zhang, Zehui; Han, Buxing published an article in 2021. The article was titled 《Zn-Nx sites on N-doped carbon for aerobic oxidative cleavage and esterification of C(CO)-C bonds》, and you may find the article in Nature Communications.Name: 4-Acetylpyridine The information in the text is summarized as follows:

Zn/NC-X catalysts, in which Zn2+ coordinated with N species on microporous N-doped carbon (NC) and X denoted the pyrolysis temperature, could effectively catalyze aerobic oxidative cleavage of C(CO)-C bonds and quant. converted acetophenone to Me benzoate with a yield of 99% at 100°C was reported. The Zn/NC-950 could be applied for a wide scope of acetophenone derivatives as well as more challenging alkyl ketones. Detail mechanistic investigations revealed that the catalytic performance of Zn/NC-950 could be attributed to the coordination between Zn2+ and N species to change the electronic state of the metal, synergetic effect of the Zn single sites with their surrounding N atoms, as well as the microporous structure with the high surface area and structural defects of the NC. In addition to this study using 4-Acetylpyridine, there are many other studies that have used 4-Acetylpyridine(cas: 1122-54-9Name: 4-Acetylpyridine) was used in this study.

4-Acetylpyridine(cas: 1122-54-9) belongs to pyridine. Pyridine is a relatively complex molecule and exhibits a number of different bands in IR spectra. Among others, the bands characterizing the ν8a and ν19b modes have been found to be sensitive to the coordination or protonation of the molecule. Note that the band that is diagnostic for the PyH+ ion at about 1545 cm− 1 (ν19b mode) does not overlap with any of the other bands.Name: 4-Acetylpyridine

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

In 2022,Wang, Yiran; Fukuda, Masayuki; Nikolaev, Sergey; Miyake, Atsushi; Griffith, Kent J.; Nisbet, Matthew L.; Hiralal, Emily; Gautier, Romain; Fisher, Brandon L.; Tokunaga, Masashi; Azuma, Masaki; Poeppelmeier, Kenneth R. published an article in Inorganic Chemistry. The title of the article was 《Two Distinct Cu(II)-V(IV) Superexchange Interactions with Similar Bond Angles in a Triangular “”CuV2″” Fragment》.Reference of 4,4′-Dimethyl-2,2′-bipyridine The author mentioned the following in the article:

The strength and sign of superexchange interactions are often predicted on the basis of the bond angles between magnetic ions, but complications may arise in situations with a nontrivial arrangement of the magnetic orbitals. We report on a novel mol. tetramer compound [Cu(H2O)dmbpy]2[V2O2F8] (dmbpy = 4,4′-dimethyl-2,2′-bipyridyl) that is composed of triangular “”CuV2″” fragments and displays a spin gap behavior. By combining first-principles calculations and electronic models, we reveal that superexchange Cu-V interactions carry drastically different coupling strengths along two Cu-F-V pathways with comparable bond angles in the triangular “”CuV2″” fragment. Counterintuitively, their strong disparity is found to originate from the restricted symmetry of the half-filled Cu dx2-y2 orbital stabilized by the crystal field, leading to one dominating antiferromagnetic Cu-V coupling in each fragment. We revisit the magnetic properties of the reported spin-gapped chain compound [enH2]Cu(H2O)2[V2O2F8] (enH2 = ethylene diammonium) containing similar triangular “”CuV2″” fragments, and the magnetic behavior of the mol. tetramer and the chain compounds is rationalized as that of weakly coupled spin dimers and spin trimers, resp. This work demonstrates that fundamentally different magnetic couplings can be observed between magnetic ions with similar bond angles in a single spin motif, thus providing a strategy to introduce various exchange interactions combined with low dimensionality in heterometallic Cu(II)-V(IV) compounds The experimental process involved the reaction of 4,4′-Dimethyl-2,2′-bipyridine(cas: 1134-35-6Reference of 4,4′-Dimethyl-2,2′-bipyridine)

4,4′-Dimethyl-2,2′-bipyridine(cas: 1134-35-6) is used as a chemical Intermediate. It can be used for the determination of ferrous and cyanide compounds.Reference of 4,4′-Dimethyl-2,2′-bipyridine Furthermore, 4,4′-Dimethyl-2,2′-bipyridine is used in the synthesis of a series of o-phenanthroline-substituted ruthenium(II) complexes.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

In 2022,Siddiqa, Ayesha; Zubair, Muhammad; Bilal, Muhammad; Rasool, Nasir; Qamar, Muhammad Usman; Khalid, Aqsa; Ahmad, Gulraiz; Imran, Muhammad; Mahmood, Sajid; Ashraf, Ghulam Abbas published an article in Pharmaceuticals. The title of the article was 《Synthesis of Functionalized N-(4-Bromophenyl)furan-2-carboxamides via Suzuki-Miyaura Cross-Coupling: Anti-Bacterial Activities against Clinically Isolated Drug Resistant A. baumannii, K. pneumoniae, E. cloacae and MRSA and Its Validation via a Computational Approach》.HPLC of Formula: 1692-25-7 The author mentioned the following in the article:

N-(4-Bromophenyl)furan-2-carboxamide I [R = Br] was synthesized by the reaction furan-2-carbonyl chloride and 4-bromoaniline in the presence of Et3N in excellent yields of 94%. The carboxamide I [R = Br] was arylated by employing triphenylphosphine palladium as a catalyst and K3PO4 as a base to afford N-(4-bromophenyl)furan-2-carboxamide analogs I [R = 4-MeC6H4, 4-MeOC6H4, 4-ClC6H4, etc.] in moderate to good yields (43-83%). Furthermore, in vitro anti-bacterial activities of the resp. compounds against clin. isolated drug-resistant bacteria A. baumannii, K. pneumoniae, E. cloacae and S. aureus was investigated. The mol. I [R = Br] was found to be the most effective activity against these bacteria, particularly NDM-pos. bacteria A. baumannii as compared to various com. available drugs. Docking studies and MD simulations further validated it, expressing the active site and mol. interaction stability. After reading the article, we found that the author used Pyridin-3-ylboronic acid(cas: 1692-25-7HPLC of Formula: 1692-25-7)

Pyridin-3-ylboronic acid(cas: 1692-25-7) belongs to pyridine. Pyridine is very deactivated towards electrophilic substitution with respect to benzene. For this reason classical formylation, using methods such as the Gattermann or Vilsmeier reactions, are not generally successful. HPLC of Formula: 1692-25-7

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Related Products of 103-74-2In 2017 ,《Mechanism and Stereocontrol in Isotactic rac-Lactide Polymerization with Copper(II) Complexes》 appeared in ACS Catalysis. The author of the article were Daneshmand, Pargol; van der Est, Art; Schaper, Frank. The article conveys some information:

Reaction of N-R,N’-R’-2,5-diiminopyrroles (R = R’ = S-CH(Me)Ph; R = R’ = CH2Ph; R = S-CH(Me)Ph, R’ = H) with Cu(OMe)2 in the presence of chelating alcs., ROH (R1 = C2H4NMe2, R2 = C2H4Py, R3 = CH2Py, R4 = CMe2Py) yielded the dinuclear, alkoxide-bridged complexes L2Cu2(OR)2. The complexes catalyze the polymerization of rac-lactide at room temperature with catalyst concentrations of 1-3 mM in 4-24 h (v = k[cat][monomer] with k = [2.3(5)] × 102 – [6.5(6)] × 102 M-1 h-1). EPR and mechanistic studies indicate that the complexes remain dinuclear during the polymerization reaction. In complexes with OR1, both alkoxides of the dimer initiate polymerization, with OR2 or OR3 only one alkoxide initiates polymerization, and OR4 is inactive in polymerization The nature of the bridging ligand in the dinuclear complex determines stereocontrol. Independent of the spectator ligand L, complexes which retain an OR3 or OR4 bridging ligand in the active species show preference for isotactic polymerizations (Pm = 0.60-0.75), while those with only polymeryloxo bridges or OR2 as the bridging ligand provide atactic polymer. Stereocontrol follows a chain-end control mechanism, with the catalytic site likely adapting to the configuration of the chain end. In the part of experimental materials, we found many familiar compounds, such as 2-(2-Hydroxyethyl)pyridine(cas: 103-74-2Related Products of 103-74-2)

2-(2-Hydroxyethyl)pyridine(cas: 103-74-2) belongs to pyridine. The basicity and metallophilic high donor number of these π-deficient systems has long favored them as ligands in metal catalysis. The last decade saw pyridine assume a stronger role as functional group for directed C–H oxidation/activation.Related Products of 103-74-2

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Quality Control of Bis(pyridin-2-ylmethyl)amineIn 2019 ,《Two telomerase-targeting Pt(II) complexes of jatrorrhizine and berberine derivatives induce apoptosis in human bladder tumor cells》 appeared in Dalton Transactions. The author of the article were Qin, Qi-Pin; Wang, Zhen-Feng; Huang, Xiao-Ling; Tan, Ming-Xiong; Luo, Zhi-Hui; Wang, Shu-Long; Zou, Bi-Qun; Liang, Hong. The article conveys some information:

Two novel Pt(IIi) complexes, [Pt(B-TFA)Cl]Cl (Pt1) and [Pt(J-TFA)Cl]Cl (Pt2) with jatrorrhizine and berberine derivatives (B-TFA and J-TFA) were first prepared as desirable luminescent agents for cellular applications and potent telomerase inhibitors, which can induce bladder T-24 tumor cell apoptosis by targeting telomerase, together with induction of mitochondrial dysfunction, telomere DNA damage and cell-cycle arrest. Importantly, T-24 tumor inhibition rate (TIR) was 50.4% for Pt2, which was higher than that of Pt1 (26.4%) and cisplatin (37.1%). Taken together, all the results indicated that jatrorrhizine and berberine derivatives Pt1 and Pt2 show low toxicity and could be novel Pt-based anti-cancer drug candidates. The results came from multiple reactions, including the reaction of Bis(pyridin-2-ylmethyl)amine(cas: 1539-42-0Quality Control of Bis(pyridin-2-ylmethyl)amine)

Bis(pyridin-2-ylmethyl)amine(cas: 1539-42-0) is a secondary amine with two picolyl substituents. The compound is a tridentate ligand in coordination chemistry and commonly used to produce Zn-based chemosensors/probes, such as Zinpry.Quality Control of Bis(pyridin-2-ylmethyl)amine

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

COA of Formula: C6H4N2In 2020 ,《A luminescent zinc(II) coordination polymer as a highly selective and sensitive chemosensor for Fe(III) cation and Cr(VI) anions detection in aqueous solution》 appeared in Inorganica Chimica Acta. The author of the article were Li, Ling; Deng, Zhao-Yang; Xie, Xin; Zou, Ji-Yong; You, Sheng-Yong; Chen, Kai-Hong; Le, Jin-Feng. The article conveys some information:

A double-bent-mixed-ligand supported 2-periodic coordination polymer (CP) {[Zn2(FDA)2(4-abpt)2(H2O)2]}n (1) was synthesized from the unique combination of a bent furan-2,5-dicarboxylic acid (H2FDA) ligand and a bent 4-amino-3,5-bis(4-pyridyl)-1,2,4-triazole (4-abpt) coligand. The CP 1 demonstrates readily dispersible two-dimensional (2D) 2-periodic layer structure and considerable chemostability in aqueous media. Luminescence titration experiments indicate that CP 1 can serve as chemosensors for sensitively and selectively detecting Fe3+ cation, CrO42- and Cr2O72- anions in water solution via an environmentally friendly manner. Besides, the luminescent selective quenching mechanism of CP 1 toward Fe3+ cation, CrO42- and Cr2O72- anions is comprehensively studied in the light of absorption of the excitation energy of the host framework by individual analytes. In addition to this study using 4-Cyanopyridine, there are many other studies that have used 4-Cyanopyridine(cas: 100-48-1COA of Formula: C6H4N2) was used in this study.

4-Cyanopyridine(cas: 100-48-1) belongs to pyridine. The basicity and metallophilic high donor number of these π-deficient systems has long favored them as ligands in metal catalysis. The last decade saw pyridine assume a stronger role as functional group for directed C–H oxidation/activation.COA of Formula: C6H4N2

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Safety of 2-(2-Hydroxyethyl)pyridineIn 2018 ,《Preparation of the Ru3(CO)8-pyridine-alcohol cluster and its use for the selective catalytic transformation of primary to secondary amines》 appeared in Dalton Transactions. The author of the article were Singh, Ajeet; Mobin, Shaikh M.; Mathur, Pradeep. The article conveys some information:

The synthesis of pyridine alc. based ruthenium carbonyl clusters Ru3(hep)2(CO)8 , Ru3(hpp)2(CO)8 , and Ru3(bhmp-H)2(CO)8 {hep-H = 2-(2-hydroxyethyl)pyridine, hpp-H = 2-(3-hydroxypropyl)pyridine and bhmp-H2 = 2,6-bis(hydroxymethyl)pyridine} was carried out by the reaction of the corresponding pyridine-alc. ligands with Ru3(CO)12. Clusters Ru3(hep)2(CO)8 , Ru3(hpp)2(CO)8 , and Ru3(bhmp-H)2(CO)8 were characterized using elemental anal., NMR, FTIR, mass spectrometry and single-crystal x-ray structures. The clusters were explored for the selective catalytic transformation of primary amines into secondary amines using alcs. as the mono-alkylating agents via hydrogen transfer reactions. All three display efficient catalytic activity with 1 being the most effective.2-(2-Hydroxyethyl)pyridine(cas: 103-74-2Safety of 2-(2-Hydroxyethyl)pyridine) was used in this study.

2-(2-Hydroxyethyl)pyridine(cas: 103-74-2) belongs to pyridine. The basicity and metallophilic high donor number of these π-deficient systems has long favored them as ligands in metal catalysis. The last decade saw pyridine assume a stronger role as functional group for directed C–H oxidation/activation.Safety of 2-(2-Hydroxyethyl)pyridine

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem