Month: November 2022

On December 11, 2014, Van Gool, Michiel Luc Maria; Alonso-De Diego, Sergio-Alvar; Cid-Nunez, Jose Maria; Delgado-Gonzalez, Oscar; Decorte, Annelies Marie Antonius; Macdonald, Gregor James; Megens, Antonius Adrianus Hendrikus Petrus; Trabanco-Suarez, Andres Avelino; Garcia-Molina, Aranzazu; Andres-Gil, Jose Ignacio published a patent.Category: pyridine-derivatives The title of the patent was Preparation of 6,7-dihydropyrazolo[1,5-a]pyrazin-4(5h)-one compounds and their use as negative allosteric modulators of mGluR2 receptors. And the patent contained the following:

Title compounds I [R1 = substituted Ph or 2-pyridinyl; R2 = substituted pyridinyl; R3 = H or alkyl; R4 = H, alkyl, mono- or polyhalo-alkyl, alkyl-O-alkyl or alkyl-OH], or a N-oxide, or a pharmaceutically acceptable salt or a solvate, are prepared as neg. allosteric modulators (NAMs) of the metabotropic glutamate receptor subtype 2 (mGluR2). Thus, e.g., II was prepared by reaction of (7S)-methyl-3-(2-methylpyridin-4-yl)-6,7-dihydro-5H-pyrazolo[1,5-a]pyrazin-4-one with 4-bromobenzotrifluoride. Compound II showed pIC50 value of 8.05 against hmGluR2 in GTPγS binding assay. The invention is also directed to pharmaceutical compositions comprising such compounds, to processes for preparing such compounds and compositions, and to the use of such compounds and compositions for the prevention or treatment of disorders in which the mGluR2 subtype of metabotropic receptors is involved, especially CNS disorders. The experimental process involved the reaction of 4-Bromo-2-isopropylpyridine(cas: 908267-63-0).Category: pyridine-derivatives

The Article related to dihydropyrazolopyrazine preparation neg allosteric mglur2 receptors cns disorder, Heterocyclic Compounds (More Than One Hetero Atom): Pyrazines and Quinoxalines (Including Piperazines) and other aspects.Category: pyridine-derivatives

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

On March 20, 2014, Soll, Mark David; Le Hir de Fallois, Loic Patrick; Huber, Scot Kevin; Lee, Hyoung Ik; Wilkinson, Douglas Edward; Jacobs, Robert Toms published a patent.Formula: C6H3ClN2O3 The title of the patent was Preparation of arylazol-2-yl cyanoethylamino derivatives useful as pesticides. And the patent contained the following:

The invention relates to arylazol-2-yl-cyanoethylamino derivatives of formula I and their preparation, useful as pesticides, particularly for controlling endoparasitic or ectoparasitic pests on animals. Compounds of formula I, in which group P is N; Q is CR2 and N; V is CR8; W is CR9 and N; X is CR10 and N; Y is CR11 and N; R2, R8, R9, R10, and R11 are each independently H, amino, amido, CN, etc.; R3, R4, and R5 are each independently H, halo, alkyl, etc.; and CR4R5 taken together form cycloalkyl ring; n = 1 – 3; R6 and R7 are independently H, (alkoxy)alkyl, alkylcarbonyl, etc.; Z is direct bond, CO, CS, and S(O)p; p = 0 – 2; or salts thereof, are claimed. Example compound II was prepared by amidation of 2-amino-3-(5-chloro-2H-benzotriazol-2-yl)-2-methylpropionitrile with 4-trifluoromethoxybenzoyl chloride. Invention compounds were evaluated for their pesticidal activity. From the assay, it was determined that compound II exhibited >95% reduction in nematode infestation after 3 days. The experimental process involved the reaction of 5-Chloro-3-nitropicolinaldehyde(cas: 1086838-13-2).Formula: C6H3ClN2O3

The Article related to arylazole benzotriazole indazole pyrazolopyridine cyanoethylamine preparation pesticide, Heterocyclic Compounds (More Than One Hetero Atom): Other 6-Membered Rings, Three Or More Hetero Atoms and other aspects.Formula: C6H3ClN2O3

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

On November 26, 2018, Kim, Jae Hyeon; Kim, Gi Han; Kim, Chung Hyo published a patent.Related Products of 52243-87-5 The title of the patent was Optical control device and transparent display device including the same with improved light transmittance. And the patent contained the following:

An optical control device and transparent display device including the same having improved light transmittance and quality is provided. The optical control device comprises a first and second substrate facing each other, a first and a second partition disposed between both the substrate, both the partition holds the gap between the two substrates, first electrode disposed on a side surface of the first partition facing the second partition, second electrode disposed on a side surface of the second partition facing the first partition, light control cell disposed between the first and the second electrode, and a light control cell including a light transmissive variable material that changes light transmittance according to a voltage applied to the first and second electrode. The experimental process involved the reaction of 1,1′-Dipropyl-[4,4′-bipyridine]-1,1′-diium bromide(cas: 52243-87-5).Related Products of 52243-87-5

The Article related to optical control transparent display device, Optical, Electron, and Mass Spectroscopy and Other Related Properties: Spectrometers and Optical Apparatus and other aspects.Related Products of 52243-87-5

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

On June 15, 2011, Jung, Hyeon Cheol; Yoo, In Seon; Lee, Jeong Ae; Park, Seong Hui published a patent.Product Details of 39919-70-5 The title of the patent was Organic electroluminescent device having novel electron transport/injection materials comprising aromatic compound. And the patent contained the following:

The title organic electroluminescent device comprises stacked anode, hole injection layer, hole transport layer, host + dopant layer, electron transport layer, electron injection layer, and cathode. The compound shown in chem. formula I is used in the electron transport layer and the electron injection layer, wherein, R1, R2 and R3 are the same or not, and are substituted or unsubstituted aromatic groups, heterocyclic groups or aliphatic groups. The experimental process involved the reaction of 6-(tert-Butyl)pyridin-3-amine(cas: 39919-70-5).Product Details of 39919-70-5

The Article related to organic electroluminescent device electron injection transport aromatic, Optical, Electron, and Mass Spectroscopy and Other Related Properties: Spectrometers and Optical Apparatus and other aspects.Product Details of 39919-70-5

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

On July 5, 2018, Groarke, Michelle; Shiomi, Takushi; Kawamura, Masahiro; Nagashima, Hideaki published a patent.Electric Literature of 75449-26-2 The title of the patent was Nitrogen-containing heterocyclic compounds for organic light emitting devices. And the patent contained the following:

A compound represented by a chem. formula I (A1, A2, A3 = (un)substituted C6-C30 ring aromatic hydrocarbon, (un)substituted C5-C30 heterocyclic group; Z1 = N, CR1; R1 = H, (un)substituted C1-C30 alkyl, (un)substituted C3-C30 cycloalkyl etc.; B1 = H, CN, (un)substituted C6-C30 ring aromatic hydrocarbon, etc.; L = single bond, (un)substituted alkylene having C1-C30; (un)substituted C3-C30 cycloalkylene; l = 1, 2 or 3), a material for an organic electroluminescence device comprising at least one compound of formula I; an organic electroluminescence device which comprises an organic thin film layer between a cathode and an anode, wherein the organic thin film layer comprises one or more layers and comprises a light emitting layer, and at least one layer of the organic thin film layer comprises at least one compound with formula I; an electronic equipment. The experimental process involved the reaction of [2,2′-Bipyridine]-3,3′-diamine(cas: 75449-26-2).Electric Literature of 75449-26-2

The Article related to nitrogen heterocyclic organic light emitting device electroluminescent material, Optical, Electron, and Mass Spectroscopy and Other Related Properties: Spectrometers and Optical Apparatus and other aspects.Electric Literature of 75449-26-2

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

On October 24, 2019, Yu, Henry; Clark, Michael; Bemis, Guy; Boyd, Michael; Chandupatla, Kishan; Collier, Philip; Deng, Hongbo; Dong, Huijun; Dorsch, Warren; Hoover, Russell R.; Johnson, Mac Arthur, Jr.; Kukarni, Shashank; Penney, Marina; Ronkin, Steven; Takemoto, Darin; Tang, Qing; Waal, Nathan D.; Wang, Tiansheng published a patent.Recommanded Product: 1227002-03-0 The title of the patent was Preparation of substituted oxazepanyl pyrimidinamines as antiproliferation compounds. And the patent contained the following:

The present invention provides compounds I [ring A = Ph, 5-7 membered saturated or partially unsaturated carbocyclic ring, 8-12 membered saturated or partially unsaturated bicyclic heterocyclic ring having 1-2 heteroatoms independently selected from N, O, or S, etc.; each R1 = (independently) H, or (halo)alkyl; or two R1 groups are optionally taken together with their intervening atoms to form 5-8 membered partially unsaturated fused carbocyclic ring; each of R2 = (independently) H, halo, CN, etc.; or two R2 groups are optionally taken together to form :O; or two R2 groups are optionally taken together with their intervening atoms to form 3-8 membered saturated spirocyclic ring having 0-2 heteroatoms independently selected from N, O or S; each R3 = (independently) H, OH, or alkyl; or two R3 groups are optionally taken together to form :O or :CH2; or two R3 groups are optionally taken together with their intervening atoms to form 3-8 membered saturated spirocyclic ring having 0-2 heteroatoms independently selected from N, O or S; or 5-8 membered saturated bridged bicyclic ring having 0-2 heteroatoms independently selected from N, O or S; X = O, S, CH2, etc.; m = 0-2; n = 0-5; p = 0-2] or pharmaceutically acceptable salts thereof, pharmaceutical compositions thereof, and methods of use thereof for treating cellular proliferative disorders (e.g., cancer). E.g., a multi-step synthesis of (R)-II and (S)-II, starting from 3-(tributylstannylmethoxy)propan-1-amine and 2-chloro-5-nitrobenzaldehyde, was described. Exemplified compounds I were evaluated in the Colo 205 reporter assay, HepG2 XBP1 reporter assay, and in the Calcium Flux assay (data given for representative compounds I). The experimental process involved the reaction of Methyl 2-amino-5-chloroisonicotinate(cas: 1227002-03-0).Recommanded Product: 1227002-03-0

The Article related to oxazepanyl pyrimidinamine preparation antiproliferative antitumor, Heterocyclic Compounds (More Than One Hetero Atom): Other 7-Membered Rings and other aspects.Recommanded Product: 1227002-03-0

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Kaczmarek, Lukasz published an article in 1985, the title of the article was Bipyridines. Part XVI. Synthesis of novel 1,2,3,7-oxatriazepine and 1,2,3-triazine fused systems by the diazotization of [2,2′-bipyridine]-3,3′-diamine.Computed Properties of 75449-26-2 And the article contains the following content:

In the diazotization reaction of [2,2′-bipyridine]-3,3′-diamine the corresponding tetrazonium salt I was formed. I was transformed, depending upon pH of the post-reaction solution, into 3a,4,5,8a,9,10-hexaaza-3a,8a-dihydropyrene 3a-oxide (II) or 6-oxa-4,5,6a,10,11,11a-hexaaza-6,6a,11a-trihydrocyclohepta[d,e,f]phenanthrene (III). III is isomerized to II in acidic media. Both isomers were transformed in acid into a mixture of (3-nitrosamino-2-pyridyl)-2-pyridin-3-ol and (3-amino-2-pyridyl)-2-pyridin-3-ol. The experimental process involved the reaction of [2,2′-Bipyridine]-3,3′-diamine(cas: 75449-26-2).Computed Properties of 75449-26-2

The Article related to oxahexaazacycloheptaphenanthrene, hexazapyrene oxide, oxatriazepine fused, triazine fused, bipyridinediamine diazotization, Heterocyclic Compounds (More Than One Hetero Atom): Other 7-Membered Rings and other aspects.Computed Properties of 75449-26-2

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

On February 5, 2004, Kwan, Tricia Ann; Lagreca, Susan Deborah; Lippa, Blaise Scott; Morris, Joel; Wessel, Matthew David published a patent.Formula: C8H10BrN The title of the patent was Preparation of isothiazole derivatives as anticancer agents. And the patent contained the following:

The title compounds I [X = O or S; R1 = (substituted)heterocyclic aromatic ring; R2 = H, (cyclo)alkyl, alkenyl, alkynyl, etc.] were prepared Compounds I are useful as as anticancer agents (no data). Thus, reaction of 3-methanesulfonyl-5-(pyridin-4-ylamino)-isothiazole-4-carboxylic acid amide (preparation given) with (4-chlorophenyl)-methanethiol yielded compound II. The experimental process involved the reaction of 4-Bromo-2-isopropylpyridine(cas: 908267-63-0).Formula: C8H10BrN

The Article related to isothiazole derivative preparation anticancer, Heterocyclic Compounds (More Than One Hetero Atom): Thiazoles, Isothiazoles and other aspects.Formula: C8H10BrN

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

On February 28, 1995, Liang, Zhaoxi; Wang, Xiaoyun; Yi, He published an article.Electric Literature of 52243-87-5 The title of the article was Electroreduction kinetics of alkyl polyviologens studied by in situ spectroscopy. And the article contained the following:

The electroreduction kinetics of several alkyl polyviologens (I), such as polypropyl viologen, polybutyl viologen, polyhexyl viologen as well as their resp. low mol. analogs (II) and a bisviologen were studied by in situ spectroscopy. The reaction order (α) and rate constant (κ) of the 1st electroreduction were calculated The effect of alkyl chain length (n) is obvious for II, κ values decrease in the order: PrV>BV>HxV. κ Values of I are lower than those of II and depend slightly on n. These facts may be attributed to the diffusion-controlled nature of the electroreduction process. The influences of viologen concentration, the supporting electrolyte and the pH value also were studied. In general, the memory time of I is longer than those of II. The experimental process involved the reaction of 1,1′-Dipropyl-[4,4′-bipyridine]-1,1′-diium bromide(cas: 52243-87-5).Electric Literature of 52243-87-5

The Article related to electroreduction kinetics alkyl polyviologen spectroscopy, Electrochemistry: Electrodes, Electrode Reactions, and Electrode Potentials and other aspects.Electric Literature of 52243-87-5

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

On March 1, 2019, Steinlechner, Christoph; Roesel, Arend F.; Oberem, Elisabeth; Paepcke, Ayla; Rockstroh, Nils; Gloaguen, Frederic; Lochbrunner, Stefan; Ludwig, Ralf; Spannenberg, Anke; Junge, Henrik; Francke, Robert; Beller, Matthias published an article.Application of 109660-12-0 The title of the article was Selective Earth-Abundant System for CO2 Reduction: Comparing Photo- and Electrocatalytic Processes. And the article contained the following:

The valorization of CO2 via photo- or electrocatalytic reduction constitutes a promising approach toward the sustainable production of fuels or value-added chems. using intermittent renewable energy sources. For this purpose, mol. catalysts are generally studied independently with respect to the photo- or the electrochem. application, although a unifying approach would be much more effective with respect to the mechanistic understanding and the catalyst optimization. In this context, we present a combined photo- and electrocatalytic study of three Mn diimine catalysts, which demonstrates the synergistic interplay between the two methods. The photochem. part of our study involves the development of a catalytic system containing a heteroleptic Cu photosensitizer and the sacrificial BIH reagent. The system shows exclusive selectivity for CO generation and renders turnover numbers which are among the highest reported thus far within the group of fully earth-abundant photocatalytic systems. The electrochem. part of our investigations complements the mechanistic understanding of the photochem. process and demonstrates that in the present case the sacrificial reagent, the photosensitizer, and the irradiation source can be replaced by the electrode and a weak Bronsted acid. The experimental process involved the reaction of 2-(4,5-Dihydro-4,4-dimethyl-2-oxazolyl)pyridine(cas: 109660-12-0).Application of 109660-12-0

The Article related to carbon dioxide reduction photo electrocatalytic process earth, Electrochemistry: Electrodes, Electrode Reactions, and Electrode Potentials and other aspects.Application of 109660-12-0

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem