Month: November 2022

On March 31, 2008, Ramya, G.; Renugadevi, C.; Rao, Chepuri R. K.; Trivedi, D. C. published an article.Application In Synthesis of Pyridine-3-sulfonic acid The title of the article was Investigations on pyridine-3-sulfonic acid doped polyaniline and polypyrrole: Metal loading through dopant molecules. And the article contained the following:

Polyniline and polypyrrole were chem. and electrochem. synthesized in presence of pyridine-3-sulfonic acid. These conducting polymers were characterized by FT-IR, UV-vis, XRD, TGA and SEM techniques. Polyaniline showed a conductivity of 4 × 10-4 S/cm while polypyrrole exhibited a conductivity of 6.2 × 10-2 S/cm. The presence of pyridine ring in the dopant enabled the polymers to anchor Pd/or PdO through which the composite can work as catalytic material. The experimental process involved the reaction of Pyridine-3-sulfonic acid(cas: 636-73-7).Application In Synthesis of Pyridine-3-sulfonic acid

The Article related to pyridine sulfonic acid dopant polyaniline polypyrrole metal conductivity elec, Plastics Manufacture and Processing: Physical Properties and Testing Methods and other aspects.Application In Synthesis of Pyridine-3-sulfonic acid

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

On June 3, 1992, Karaman, Rafik; Blasko, Andrei; Almarsson, Orn; Arasasingham, Ramesh; Bruice, Thomas C. published an article.Electric Literature of 636-73-7 The title of the article was Symmetrical and unsymmetrical quadruply aza-bridged, closely interspaced, cofacial bis(5,10,15,20-tetraphenylporphyrin)s. 2. Synthesis, characterization, and conformational effects of solvents. And the article contained the following:

Title compounds I [X = NR, R = 3-pyridylsulfonyl (R1), 1-methylpyridinium-3-sulfonyl (R2), CONH2, cyano, tosyl; X = OCO2, R = R1, cyano] have been synthesized and fully characterized by 2-dimensional 1H-1H NMR (COSY), 2-dimensional 13C-1H NMR, fast-atom-bombardment mass spectrometry, UV/vis, IR, and fluorescence spectral techniques. It was established, on the basis of 1H NMR, UV/vis, and emission spectrophotometries, that I (X = NR, R = R1, R2, tosyl) exist in more than one conformational in DMSO and in only one sym. conformation in CHCl3. Their biszinc complexes and tetraprotonated derivatives exist in one conformation regardless of the solvent. These observations have been attributed to an interaction between DMSO and the pyrrolic N-H protons of the porphyrin cores which is inhibited by metalation or protonation. Mol. dynamics calculations reveal that the intracavity interactions of I (X = NR, R = R1) with DMSO are more important than the intercavity interactions which result in discrete, unsym. conformations of the dimer. In contrast, I (X = OCO2, R = R1, cyano; X = NR, R = cyano, CONH2) do not show any conformational changes upon switching from CHCl3 to DMSO. This is attributed to the long interplanar distances calculated for the porphyrin dimers which prevent intracavity coordination of DMSO with both porphyrin moieties. 1H NMR variable-temperature experiments of I (X = NR, R = R1) in DMSO show that the conformation of the dimer is greatly affected by temperature While at room temperature I (X = NR, R = R1) exists in more than one conformation, at higher temperatures (150°) only one conformation is populated. It is proposed that at room temperature, the existence of a H-bonding network between DMSO and the dimer results in more than one conformation, while at higher temperatures the network is destroyed to furnish an average conformation. The experimental process involved the reaction of Pyridine-3-sulfonic acid(cas: 636-73-7).Electric Literature of 636-73-7

The Article related to porphyrin dimer preparation conformation, Biomolecules and Their Synthetic Analogs: Corrinoids, Porphyrins, and Bilines and other aspects.Electric Literature of 636-73-7

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

On August 31, 2011, Chisholm, Danielle M.; McDonald, Robert; McIndoe, J. Scott published an article.Recommanded Product: [2,2′-Bipyridine]-3,3′-diamine The title of the article was 3,3′-N,N’-Bis(amino)-2,2′-bipyridine – An unusually methylation-resistant amine. And the article contained the following:

Methylation of aromatic amino groups is usually straightforward, but the formation of two intramol. hydrogen bonds in 3,3′-N,N’-bis(amino)-2,2′-bipyridine and (or) the potential for ring methylation prevents the clean tetramethylation of this mol. Numerous attempts to make 3,3′-N,N’-bis(dimethylamino)-2,2′-bipyridine produced only complex mixtures of variously methylated products, and the only isolated mol. was 3,3′-N,N’-bis(methylamino)-2,2′-bipyridine, for which an X-ray crystal structure was obtained. The experimental process involved the reaction of [2,2′-Bipyridine]-3,3′-diamine(cas: 75449-26-2).Recommanded Product: [2,2′-Bipyridine]-3,3′-diamine

The Article related to bisaminobipyridine methylation resistant amine, Physical Organic Chemistry: Addition, Elimination, and Substitution Reactions and other aspects.Recommanded Product: [2,2′-Bipyridine]-3,3′-diamine

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Yi, Xiao; Chen, Jing; Xu, Xiuling; Ma, Yongmin published an article in 2017, the title of the article was Solvent and substituent effects on the conversion of 4-methoxypyridines to N-methyl-4-pyridones.Formula: C6H5Br2NO And the article contains the following content:

In the reaction of 4-methoxypyridine derivatives with alkyl iodides in the presence or absence of solvent, not only the pyridinium ions but also the related 1-methylpyridones are produced. The presence of solvent favors the formation of the 1-methylpyridone. Electron withdrawing groups on the pyridine ring also favor this conversion. A possible mechanism is presented. The experimental process involved the reaction of 3,5-Dibromo-4-methoxypyridine(cas: 25813-24-5).Formula: C6H5Br2NO

The Article related to solvent substituent effect methoxypyridine derivative alkyl iodide pyridone, Physical Organic Chemistry: Addition, Elimination, and Substitution Reactions and other aspects.Formula: C6H5Br2NO

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

On May 24, 1991, Karaman, Rafik; Bruice, Thomas C. published an article.Computed Properties of 636-73-7 The title of the article was Synthesis and characterization of the first water-soluble closely interspaced cofacial porphyrin dimer. And the article contained the following:

The only documented example of a quadruply-bridged, closely-interspaced cofacial porphyrin dimer was synthesized by Kagan (1977). The target of this communication is the synthesis and characterization of the first water soluble quadruply-bridged, closely-interspaced cofacial porphyrin I (R = R1). Reaction of meso-tetrakis(3-bromomethylphenyl)porphyrin with m-pyridinesulfonamide provides the closely-interspaced cofacial porphyrin dimer I (R = R2) which on quaternization with MeI provides the water soluble I (R = R1). Reactions of I with Zn(OAc)2 provided the corresponding bis-zinc complexes I. Porphyrins I and their bis-zinc complexes, exist in a closed down conformation with closely approaching porphyrin planes or in an open conformation. It was established, on the basis of 1H-NMR UV/vis, and emission spectrophotometries, and I (R = R2) exists in a closed down conformation in DMSO or acetone and a more open conformation is CHCl3. With zinc complexes of I (or protonated I) the conformation is open regardless of the solvent. The experimental process involved the reaction of Pyridine-3-sulfonic acid(cas: 636-73-7).Computed Properties of 636-73-7

The Article related to porphyrin dimer quadruply bridged conformation, tetrakisbromoethylphenylporphyrin alkylation pyridinesulfonamide, Biomolecules and Their Synthetic Analogs: Corrinoids, Porphyrins, and Bilines and other aspects.Computed Properties of 636-73-7

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

On February 28, 2011, Konstantopoulos, Nicky; Foletta, Victoria C.; Segal, David H.; Shields, Katherine A.; Sanigorski, Andrew; Windmill, Kelly; Swinton, Courtney; Connor, Tim; Wanyonyi, Stephen; Dyer, Thomas D.; Fahey, Richard P.; Watt, Rose A.; Curran, Joanne E.; Molero, Juan-Carlos; Krippner, Guy; Collier, Greg R.; James, David E.; Blangero, John; Jowett, Jeremy B.; Walder, Ken R. published an article.Synthetic Route of 132-20-7 The title of the article was A gene expression signature for insulin resistance. And the article contained the following:

Insulin resistance is a heterogeneous disorder caused by a range of genetic and environmental factors, and we hypothesize that its etiol. varies considerably between individuals. This heterogeneity provides significant challenges to the development of effective therapeutic regimes for long-term management of type 2 diabetes. We describe a novel strategy, using large-scale gene expression profiling, to develop a gene expression signature (GES) that reflects the overall state of insulin resistance in cells and patients. The GES was developed from 3T3-L1 adipocytes that were made “insulin resistant” by treatment with tumor necrosis factor-α (TNF-α) and then reversed with aspirin and troglitazone (“resensitized”). The GES consisted of five genes whose expression levels best discriminated between the insulin-resistant and insulin-resensitized states. We then used this GES to screen a compound library for agents that affected the GES genes in 3T3-L1 adipocytes in a way that most closely resembled the changes seen when insulin resistance was successfully reversed with aspirin and troglitazone. This screen identified both known and new insulin-sensitizing compounds including nonsteroidal anti-inflammatory agents, β-adrenergic antagonists, β-lactams, and sodium channel blockers. We tested the biol. relevance of this GES in participants in the San Antonio Family Heart Study (n = 1240) and showed that patients with the lowest GES scores were more insulin resistant (according to HOMA_IR and fasting plasma insulin levels; P < 0.001). These findings show that GES technol. can be used for both the discovery of insulin-sensitizing compounds and the characterization of patients into subtypes of insulin resistance according to GES scores, opening the possibility of developing a personalized medicine approach to type 2 diabetes. The experimental process involved the reaction of N,N-Dimethyl-3-phenyl-3-(pyridin-2-yl)propan-1-amine maleate(cas: 132-20-7).Synthetic Route of 132-20-7

The Article related to gene expression signature insulin resistance, Pharmacology: Effects Of Agents For Treating Metabolic and Endocrine Disorders and other aspects.Synthetic Route of 132-20-7

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

On June 1, 2011, Danila, Ion; Riobe, Francois; Piron, Flavia; Puigmarti-Luis, Josep; Wallis, John D.; Linares, Mathieu; Agren, Hans; Beljonne, David; Amabilino, David B.; Avarvari, Narcis published an article.Electric Literature of 75449-26-2 The title of the article was Hierarchical Chiral Expression from the Nano- to Mesoscale in Synthetic Supramolecular Helical Fibers of a Nonamphiphilic C3-Symmetrical π-Functional Molecule. And the article contained the following:

The controlled preparation of chiral structures is a contemporary challenge for supramol. science because of the interesting properties that can arise from the resulting materials, and here we show that a synthetic nonamphiphilic C3 compound containing π-functional tetrathiafulvalene units can form this kind of object. We describe the synthesis, characterization, and self-assembly properties in solution and in the solid state of the enantiopure materials. CD measurements show optical activity resulting from the presence of twisted stacks of preferential helicity and also reveal the critical importance of fiber nucleation in their formation. Mol. mechanics (MM) and mol. dynamics (MD) simulations combined with CD theor. calculations demonstrate that the (S) enantiomer provides the (M) helix, which is more stable than the (P) helix for this enantiomer. This relationship is for the first time established in this family of C3 sym. compounds In addition, we show that introduction of the “wrong” enantiomer in a stack decreases the helical reversal barrier in a nonlinear manner, which very probably accounts for the absence of a “majority rules” effect. Mesoscopic chiral fibers, which show inverted helicity, i.e. (P) for the (S) enantiomer and (M) for the (R) one, have been obtained upon reprecipitation from dioxane and analyzed by optical and electronic microscopy. The fibers obtained with the racemic mixture present, as a remarkable feature, opposite homochiral domains within the same fiber, separated by points of helical reversal. Their formation can be explained through an “oscillating” crystallization mechanism. Although C3 sym. disk-shaped mols. containing a central benzene core substituted in the 1,3,5 positions with 3,3′-diamido-2,2′-bipyridine based wedges have shown peculiar self-assembly properties for amphiphilic derivatives, the present result shows the benefits of reducing the nonfunctional part of the mol., in our case with short chiral isopentyl chains. The research reported herein represents an important step toward the preparation of functional mesostructures with controlled helical architectures. The experimental process involved the reaction of [2,2′-Bipyridine]-3,3′-diamine(cas: 75449-26-2).Electric Literature of 75449-26-2

The Article related to hierarchical chiral expression nanoscale mesoscale synthetic supramol helical fiber, Physical Organic Chemistry: Optical Rotatory Dispersion and Circular Dichroism and other aspects.Electric Literature of 75449-26-2

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

On January 31, 1996, Satoh, Hideharu; Tokuda, Koichi; Ohsaka, Takeo published an article.Synthetic Route of 52243-87-5 The title of the article was Observation of intermolecular charge-transfer spectra for propyl viologen dihalides in a series of polyether media. And the article contained the following:

1,1′-Dipropyl-4,4′-bipyridinium diiodide (PV2+·2I-) in a series of polyethers (PEOs, HO(CH2CH2O)nH, n = 1 ∼ 14) gave an intermol. charge-transfer spectrum, which shifted to longer wavelength with larger absorbance in less polar medium, in the visible region. An increase in temperature resulted in an increase in absorbance as a result of an ion-dipole interaction between PV2+ cation and polyether solvent. The experimental process involved the reaction of 1,1′-Dipropyl-[4,4′-bipyridine]-1,1′-diium bromide(cas: 52243-87-5).Synthetic Route of 52243-87-5

The Article related to intermol charge transfer spectra viologen polyether, uv spectra viologen polyether, Physical Properties of Synthetic High Polymers: Physical Properties Of Polymers and other aspects.Synthetic Route of 52243-87-5

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

On July 24, 1995, Kelly, T. Ross; Lang, Fengrui published an article.Quality Control of Methyl 6-bromo-5-methoxypicolinate The title of the article was Total synthesis of dimethyl sulfomycinamate. And the article contained the following:

The first total synthesis of di-Me sulfomycinamate is described. Highlights of the synthesis include a selective palladium-catalyzed coupling reaction on a bromo triflate, and a condensation reaction to form the oxazole ring. The experimental process involved the reaction of Methyl 6-bromo-5-methoxypicolinate(cas: 170235-18-4).Quality Control of Methyl 6-bromo-5-methoxypicolinate

The Article related to sulfomycinamate total synthesis, Biomolecules and Their Synthetic Analogs: Other Bacterial and Fungal Metabolites and other aspects.Quality Control of Methyl 6-bromo-5-methoxypicolinate

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

On April 24, 2014, Xu, Wei; Wang, Yong; Ma, Sunghoon; Koltun, Elena S.; Kim, Byung Gyu; Jeong, Joon Won; Dhar, T.g. Murali; Bannen, Lynn Canne published a patent.Recommanded Product: 4-Chloro-2,6-difluoropyridine The title of the patent was Pyrimidine derivatives as RORγ modulators and their preparation. And the patent contained the following:

Described are RORγ modulators of formula I, and N-oxides, pharmaceutically acceptable salts, solvates and hydrates thereof, and their compositions are useful in methods for modulating RORγ activity in a cell and methods for treating a subject suffering from a disease or disorder in which the subject would therapeutically benefit from modulation of RORγ activity, for example, autoimmune. Compounds of formula I wherein R1 is H, halo, CN, NO2, OH, etc.; dashed bonds are single and double bond; R2 is H, halo, CN, NO2, N3, etc.; R4 and R5 are independently H, Me and F; m and n are independently 0, 1, 2, and 3; each R6 is halo, CN, NO2, N3, OH, etc.; each Ra is H, halo, CN, NO2, etc.; Z is CO, CS, SO2 and CH2; G is a single bond, CH2, CHD, CD2, etc.; B is Ph, pyridyl, naphthyl, thiazolyl and pyrimidinyl; L is CONHCH2, CONHCH2CH2O, oxadiazolyl, etc.; A is Ph, pyridyl, pyrimidinyl, thiazolyl, pyrazolyl and pyrazinyl; and stereoisomeric forms, N-oxides, pharmaceutically acceptable salts, solvates and hydrates thereof, are claimed. Example compound II was prepared by a multistep procedure (procedure given). All the invention compounds were evaluated for their RORγ modulatory activity. From the assay, it was determined that compound II exhibited IC50 value of 4.7 nM. The experimental process involved the reaction of 4-Chloro-2,6-difluoropyridine(cas: 34968-33-7).Recommanded Product: 4-Chloro-2,6-difluoropyridine

The Article related to pyrimidine preparation rorgamma modulator, Heterocyclic Compounds (More Than One Hetero Atom): Pyrimidines and Quinazolines and other aspects.Recommanded Product: 4-Chloro-2,6-difluoropyridine

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem