Month: November 2022

On June 10, 2021, Bartolome-Nebreda, Jose Manuel; Trabanco-Suarez, Andres Avelino; De Lucas Olivares, Ana Isabel published a patent.Related Products of 1227595-34-7 The title of the patent was Synthesis of heterocyclic Oga inhibitors treating tauopathies, in particular Alzheimer’s and Parkinson’s diseases. And the patent contained the following:

The present invention relates to O-GlcNAc hydrolase (OGA) inhibitors I, tautomers, or stereoisomers such that Ra can be a six- or five-membered heteroaryl ring system or nine, ten membered bicyclic heterocyclic ring; L is selected from O, OCH2, or CH2O; R1a-b an R2a-b are independently H, Me or (un)substituted C1-3 alkyl; R is H or methyl; Rb can be a bicyclic heteroaryl ring systems are prepared as pharmaceutically acceptable salts and solvates. Of note, II was prepared for the prevention and treatment of disorders in which inhibition of OGA is beneficial, such as tauopathies, in particular Alzheimer’s disease or progressive supranuclear palsy; and neurodegenerative diseases accompanied by a tau pathol., in particular amyotrophic lateral sclerosis or frontotemporal lobe dementia caused by C9ORF72 mutations; or alpha synucleinopathies, in particular Parkinson’s disease, dementia due to Parkinson’s (or neurocognitive disorder due to Parkinson’s disease), dementia with Lewy bodies, multiple system atrophy, or alpha synucleinopathy caused by Gaucher’s disease. The experimental process involved the reaction of 4-(Chloromethyl)-2-methoxy-6-methylpyridine(cas: 1227595-34-7).Related Products of 1227595-34-7

The Article related to heterocyclic oga inhibitor preparation alzheimers parkinson tauopathy, Heterocyclic Compounds (More Than One Hetero Atom): Other 6-Membered Rings, Two Hetero Atoms and other aspects.Related Products of 1227595-34-7

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

On May 20, 2019, Kim, Jae Hyeon; Kim, Gi Han; Kim, Chung Hyo published a patent.Name: 1,1′-Dipropyl-[4,4′-bipyridine]-1,1′-diium bromide The title of the patent was Light control device and transparent display device including the same. And the patent contained the following:

The present invention relates to a light control device capable of realizing a fast response speed, and a transparent display device including the same. The light control device includes a first substrate and a second substrate facing each other, a first barrier rib and a second barrier rib that maintain a gap between the first substrate and the second substrate, and disposed between the first substrate and the second substrate, a first electrode disposed on a side surface of the first bulk head and facing the second bulkhead; a second electrode disposed on a side surface of the second bulk head facing the first bulk head and a light control cell changing the light transmittance according to the voltage applied to the first electrode and the second electrode including electrochromic materials, and disposed between the first electrode and the second electrode. The experimental process involved the reaction of 1,1′-Dipropyl-[4,4′-bipyridine]-1,1′-diium bromide(cas: 52243-87-5).Name: 1,1′-Dipropyl-[4,4′-bipyridine]-1,1′-diium bromide

The Article related to light control transparent display device, Radiation Chemistry, Photochemistry, and Photographic and Other Reprographic Processes: Other and other aspects.Name: 1,1′-Dipropyl-[4,4′-bipyridine]-1,1′-diium bromide

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Kamogawa, Hiroyoshi; Amemiya, Suguru published an article in 1984, the title of the article was Synthesis of novel organic functional substances. II. Spontaneous generation of viologen radical cations in polar aprotic solvents.Reference of 1,1′-Dipropyl-[4,4′-bipyridine]-1,1′-diium bromide And the article contains the following content:

Viologens, when dissolved in polar aprotic solvents (such as N-methyl-2-pyrrolidone or HMPA) under deaerated conditions, gave a blue color (λmax = 608-609nm) indicating the spontaneous generation of the viologen radical cation. Electron transfer from the counter anion of viologen to the viologen cation was proposed. The experimental process involved the reaction of 1,1′-Dipropyl-[4,4′-bipyridine]-1,1′-diium bromide(cas: 52243-87-5).Reference of 1,1′-Dipropyl-[4,4′-bipyridine]-1,1′-diium bromide

The Article related to viologen electron transfer solvent effect, Physical Organic Chemistry: Oxidation-Reduction, Including Dehydrogenation and Hydrogenolysis and other aspects.Reference of 1,1′-Dipropyl-[4,4′-bipyridine]-1,1′-diium bromide

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

On June 5, 1988, Shosenji, Hideto; Nakano, Yasuhiro; Yamada, Kimiho published an article.Reference of 1,1′-Dipropyl-[4,4′-bipyridine]-1,1′-diium bromide The title of the article was Catalytic reduction of diphenylacetylene by zinc over palladium-carbon using viologens as electron mediators. And the article contained the following:

PhCCPh was reduced over Pd/C in methanol-water in presence of zinc using N,N’-dialkyl-4,4′-bipyridinium ions (viologens) as mediators to give cis-stilbene as the major product and bibenzyl as the minor one. The reaction involved direct contact of zinc with the catalyst and electron transfer from zinc to Pd via the viologen. The Pd- reduced a proton from H2O to generate H. The experimental process involved the reaction of 1,1′-Dipropyl-[4,4′-bipyridine]-1,1′-diium bromide(cas: 52243-87-5).Reference of 1,1′-Dipropyl-[4,4′-bipyridine]-1,1′-diium bromide

The Article related to reduction diphenylacetylene zinc viologen palladium, Physical Organic Chemistry: Oxidation-Reduction, Including Dehydrogenation and Hydrogenolysis and other aspects.Reference of 1,1′-Dipropyl-[4,4′-bipyridine]-1,1′-diium bromide

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

On January 16, 2002, Horikiri, Tomonari published a patent.HPLC of Formula: 75449-26-2 The title of the patent was Liquid crystal composition and liquid crystal device and liquid crystal apparatus including the composition. And the patent contained the following:

A liquid crystal composition is principally constituted by at least a liquid crystal and a gel-forming compound forming a gel with the liquid crystal. The gel-forming compound has a discotic liquid crystal phase and has a property of assuming a supermol. structure when it is in mixture with the liquid crystal. The supermol. structure may preferably have at least one intermol. interacting side having at least one -CONH- group allowing multidimensional intermol. interaction. The experimental process involved the reaction of [2,2′-Bipyridine]-3,3′-diamine(cas: 75449-26-2).HPLC of Formula: 75449-26-2

The Article related to liquid crystal display gelation agent intermol hydrogen bond, Radiation Chemistry, Photochemistry, and Photographic and Other Reprographic Processes: Other and other aspects.HPLC of Formula: 75449-26-2

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

On November 4, 2021, Behenna, Douglas; Deckhut, Charlotte; Rovira, Alexander; Goldberg, Steven; Kummer, David; Keith, John; Woods, Craig; Rhorer, Timothy; Tanis, Virginia; Martin, Connor; Meduna, Steven; McCarver, Stefan; Valdes, Alexander; Loskot, Steven; Xue, Xiaohua published a patent.Safety of 5-Isopropylnicotinic acid The title of the patent was Imidazopyridazines as modulators of IL-17 in the treatment of inflammatory disorders. And the patent contained the following:

The invention relates compounds of formula I, preparation and use in treating or ameliorating an IL-17 mediated syndrome, disorder and/or disease. Compound I, wherein R1 is (un)substituted C1-6 alkyl, (un)substituted C0-2 alkyl-C3-6 cycloalkyl, and (un)substituted 5- and 6-membered heterocyclyl having 1 and 2 nitrogen atoms; R2 is H, C3-5 cycloalkyl and (un)substituted C1-4 alkyl; R3 is (un)substituted C0-1 alkyl-C3-6 cycloalkyl, (un)substituted C3-6 alkyl and (un)substituted C1-2 alkyl-O-C1-3 alkyl; R4 is (un)substituted C3-6 cycloalkyl, (un)substituted Ph and (un)substituted 5- and 6-membered heteroaryl having 1 to 4 heteroatoms selected from N, O and S; R5 is H and halo; and pharmaceutically acceptable salts thereof, are claimed. Compound II was prepared using a multistep procedure (procedure given). Compound II was evaluated for IL-17A modulatory activity resulting in an IC50 of 0.18μM and 0.30μM using Eu-HTRF and NHK assays, resp. Compounds of the invention were evaluated for IL-17A modulatory activity (data given). The experimental process involved the reaction of 5-Isopropylnicotinic acid(cas: 73591-69-2).Safety of 5-Isopropylnicotinic acid

The Article related to imidazopyridazine preparation modulator il 17 inflammatory disorder, Heterocyclic Compounds (More Than One Hetero Atom): Pyridazines, Cinnolines, and Phthalazines and other aspects.Safety of 5-Isopropylnicotinic acid

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

On April 2, 2009, Yi, Chae S.; Kwon, Ki-Hyeok; Lee, Do W. published an article.Category: pyridine-derivatives The title of the article was Aqueous Phase C-H Bond Oxidation Reaction of Arylalkanes Catalyzed by a Water-Soluble Cationic Ru(III) Complex [(pymox-Me2)2RuCl2]+BF4-. And the article contained the following:

The cationic complex [(pymox-Me2)RuCl2]+BF4- was found to be a highly effective catalyst for the C-H bond oxidation reaction of arylalkanes in water. For example, the treatment of ethylbenzene (1.0 mmol) with t-BuOOH (3.0 mmol) and 1.0 mol % of the Ru catalyst in water (3 mL) cleanly produced PhCOCH3 at room temperature Both a large kinetic isotope effect (kH/kD = 14) and a relatively large Hammett value (ρ = -1.1) suggest a solvent-caged oxygen rebounding mechanism via a Ru(IV)-oxo intermediate species. The experimental process involved the reaction of 2-(4,5-Dihydro-4,4-dimethyl-2-oxazolyl)pyridine(cas: 109660-12-0).Category: pyridine-derivatives

The Article related to aqueous carbon hydrogen bond oxidation arylalkane cationic ruthenium complex, Physical Organic Chemistry: Oxidation-Reduction, Including Dehydrogenation and Hydrogenolysis and other aspects.Category: pyridine-derivatives

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

On February 29, 1984, Xiao, Xu Rui; Wang, Ching Bore; Tien, H. Ti published an article.COA of Formula: C16H22Br2N2 The title of the article was Photoreduction of alkyl viologens by zinc tetraphenylporphyrin in organic solvent-water systems. And the article contained the following:

Light-induced redox reactions between Zn meso-tetraphenylporphyrin (ZnTPP) and alkyl viologens (CnV2+) in organic solvent-surfactant-H2O solutions were studied as functions of the organic-solvent content of the solutions, the surfactant charge, and the alkyl viologen hydrophobicity. The best system was an oil-in-water emulsion containing 5 × 10-5 M ZnTPP and 10-3M C10V2+ stabilized by n-C16H33NMe3+ X- (X = Br, Cl) and 6% DMF, AcNMe2 or DMSO in H2O. The experimental process involved the reaction of 1,1′-Dipropyl-[4,4′-bipyridine]-1,1′-diium bromide(cas: 52243-87-5).COA of Formula: C16H22Br2N2

The Article related to photoreduction alkyl viologen zinc tetraphenylporphyrin, reduction photochem alkyl viologen, Physical Organic Chemistry: Oxidation-Reduction, Including Dehydrogenation and Hydrogenolysis and other aspects.COA of Formula: C16H22Br2N2

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Kaczmarek, Lukasz; Nantka-Namirski, Pawel published an article in 1979, the title of the article was Bipyridines. XI. Synthesis of 4,5-diazacarbazole.Category: pyridine-derivatives And the article contains the following content:

3,3′-Dinitro-2,2′-bipyridine (I) was reduced with SnCl2 in concentrated HCl to give 71% 3,3′-diamino-2,2′-bipyridine (II), which was also prepared in 34% yield by heating 2-chloro-3-acetylaminopyridine with Cu in DMF and subsequently deacetylating the product in acidic medium. Hydrogenation of I (Pd/C, 2.5 atm) converted both NO2 groups into NHOH groups in 79% yield; subsequent cyclization in polyphosphoric acid at 300° gave 77% III. II with H2SO4-HNO3 gave 40% IV (R = NO2), with PhNCO, 94% IV (R = CONHPh), with Ac2O, 65% IV (R = Ac, V), with CS2, 25% VI, and with ZnCl2 at 350-400°, 55% VII. V was converted in 70% yield into the N,N’-dioxide by the action of 3-ClC6H4CO3H. in vivo Biol. tests with sarcoma 180 and leukemias were neg. The experimental process involved the reaction of [2,2′-Bipyridine]-3,3′-diamine(cas: 75449-26-2).Category: pyridine-derivatives

The Article related to bipyridinediamine preparation reaction, diazacarbazole, dipyridopyrazine, dipyridodiazepinethione, dipyridopyrrole, neoplasm inhibitor bipyridinediamine derivative, Heterocyclic Compounds (More Than One Hetero Atom): Pyridazines, Cinnolines, and Phthalazines and other aspects.Category: pyridine-derivatives

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

On March 20, 1997, Kawano, Eiji; Nagai, Masashi; Inubushi, Atsurou; Shimada, Keiichi; Tobari, Hiroko published a patent.Category: pyridine-derivatives The title of the patent was Nitrogen monoxide synthetase inhibitor comprising 2-aminopyridines as active ingredient. And the patent contained the following:

A nitrogen monoxide synthetase (NOS) inhibitor which contains as the active ingredient 2-aminopyridines or pharmaceutically acceptable salts thereof. It has been found that 2-aminopyridines and pharmaceutically acceptable salts thereof have potent effects of inhibiting nitrogen monoxide synthetase. Namely, a medicinal composition containing 2-aminopyridines and pharmaceutically acceptable salts thereof is useful as a nitrogen monoxide formation inhibitor for treatment of NOS-related diseases e.g. septic shock, rheumatism, allergy, parkinsonism, cardiovascular diseases, obesity, and pain. The experimental process involved the reaction of 3-Methylpyridine-2,6-diamine(cas: 51566-22-4).Category: pyridine-derivatives

The Article related to nitrogen monoxide synthetase inhibitor aminopyridine preparation, Pharmacology: Effects Of Nervous System- and Behavior-Affecting Drugs and Neuromuscular Agents and other aspects.Category: pyridine-derivatives

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem