Month: November 2022

On September 20, 2011, Minter, Aaron; Stokes, Berlin published a patent.Name: 3-Methylpyridine-2,6-diamine The title of the patent was Process for the synthesis of diaminopyridines from glutaronitriles. And the patent contained the following:

A liquid-phase process is provided for the manufacture from glutaronitriles and related compounds of 2,6-diaminopyridine and related compounds, which are used industrially as compounds and as components in the synthesis of a variety of useful materials. The synthesis proceeds by means of a dehydrogenative aromatization process. The experimental process involved the reaction of 3-Methylpyridine-2,6-diamine(cas: 51566-22-4).Name: 3-Methylpyridine-2,6-diamine

The Article related to glutaronitrile amination dehydrogenation diaminopyridine preparation, Industrial Organic Chemicals, Leather, Fats, and Waxes: Manufacture Of Industrial Organic Chemicals and other aspects.Name: 3-Methylpyridine-2,6-diamine

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

On June 18, 2021, Lee, Jong Ho published a patent.Name: 2-(2-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)pyridine The title of the patent was Transparent polyimide prepared using single-port synthesis. And the patent contained the following:

Title polymer is prepared by dissolving a tetracarboxylic dianhydride, a diamine, and a catalyst and it has excellent properties such as optical transparency, hydrophobicity, water absorption, dielec. constant, thermal-mech. stability, and short production time. The experimental process involved the reaction of 2-(2-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)pyridine(cas: 1349171-28-3).Name: 2-(2-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)pyridine

The Article related to transparent polyimide single port tetracarboxylic dianhydride diamine catalyst, Industrial Organic Chemicals, Leather, Fats, and Waxes: Manufacture Of Industrial Organic Chemicals and other aspects.Name: 2-(2-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)pyridine

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

On January 15, 2021, Oderinde, Martins S.; Ramirez, Antonio; Dhar, T. G. Murali; Cornelius, Lyndon A. M.; Jorge, Christine; Aulakh, Darpandeep; Sandhu, Bhupinder; Pawluczyk, Joseph; Sarjeant, Amy A.; Meanwell, Nicholas A.; Mathur, Arvind; Kempson, James published an article.Recommanded Product: Methyl 5-bromo-1H-pyrrolo[2,3-b]pyridine-2-carboxylate The title of the article was Photocatalytic Dearomative Intermolecular [2 + 2] Cycloaddition of Heterocycles for Building Molecular Complexity. And the article contained the following:

Indole and indoline rings are important pharmacophoric scaffolds found in marketed drugs, agrochems., and biol. active mols. The [2 + 2] cycloaddition reaction is a versatile strategy for constructing architecturally interesting, sp3-rich cyclobutane-fused scaffolds with potential applications in drug discovery programs. A general platform for visible-light mediated intermol. [2 + 2] cycloaddition of indoles with alkenes has been realized. A substrate-based screening approach led to the discovery of tert-butyloxycarbonyl (Boc)-protected indole-2-carboxyesters as suitable motifs for the intermol. [2 + 2] cycloaddition reaction. Significantly, the reaction proceeds in good yield with a wide variety of both activated and unactivated alkenes, including those containing free amines and alcs., and the transformation exhibits excellent regio- and diastereoselectivity. Moreover, the scope of the indole substrate is very broad, extending to previously unexplored azaindole heterocycles that collectively afford fused cyclobutane containing scaffolds that offer unique properties with functional handles and vectors suitable for further derivatization. DFT computational studies provide insights into the mechanism of this [2 + 2] cycloaddition, which is initiated by a triplet-triplet energy transfer process. The photocatalytic reaction was successfully performed on a 100 g scale to provide the dihydroindole analog. The experimental process involved the reaction of Methyl 5-bromo-1H-pyrrolo[2,3-b]pyridine-2-carboxylate(cas: 1234616-83-1).Recommanded Product: Methyl 5-bromo-1H-pyrrolo[2,3-b]pyridine-2-carboxylate

The Article related to regioselective diastereoselective photocatalytic dearomative intermol cycloaddition indole alkene, Heterocyclic Compounds (One Hetero Atom): Indoles, Indolizines, Carbazoles, and Other Arenopyrroles and other aspects.Recommanded Product: Methyl 5-bromo-1H-pyrrolo[2,3-b]pyridine-2-carboxylate

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

On November 7, 1995, Dobrusin, Ellen M.; Showalter, Howard D. H.; Denny, William A.; Palmer, Brian D.; Rewcastle, Gordon W.; Tercel, Moana; Thompson, Andrew M. published a patent.Related Products of 156267-13-9 The title of the patent was Preparation of 2-indolyldisulfides and analogs as protein tyrosine kinase inhibitors and antitumor agents. And the patent contained the following:

Title compounds [I; R1 = H, halo, alkyl, alkoxy, etc.; R2 = (acyl)alkyl, acyl, CH:CHCO2H, etc.; R3 = H, alkyl, CH2Ph; R4 = SH, SnR, SeH, SenR, etc.; R = H, alkyl, (hetero)aryl, I in which R4 = bond, etc.; R4R5 = S, Se; R5R6 = bond; R6 = H; n = 1-3] were prepared 2Hus, 1-methyl-2-indolinone was treated with P2S5 and the product condensed with PhNCO to give, after oxidation, title compound II which had IC50 of 3-4μM against growth factor mediated mitogenesis in vitro. The experimental process involved the reaction of N,3-Dimethylpyridin-2-amine(cas: 156267-13-9).Related Products of 156267-13-9

The Article related to indolyldisulfide preparation protein tyrosine kinase inhibitor, antitumor indolyldisulfide preparation, Heterocyclic Compounds (One Hetero Atom): Indoles, Indolizines, Carbazoles, and Other Arenopyrroles and other aspects.Related Products of 156267-13-9

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

On March 3, 1994, Rewcastle, Gordon W.; Denny, William A. published an article.Quality Control of N,3-Dimethylpyridin-2-amine The title of the article was Lithiation routes to oxindoles and 2-indolinethiones: precursors to 2,2′-dithiobisindoles with tyrosine kinase inhibitory properties. And the article contained the following:

N-Substituted oxindoles, e.g. I, and 2-indolinethiones can be prepared by lithiation of carboxyl protected N,2-dimethylanilines followed by quenching with CO2 or CS2 resp. 2-Indolinethione derivatives are also available via demethylation of 2-methylthioindoles, which are prepared by lithiation of N-substituted indoles and treatment with di-Me disulfide. The experimental process involved the reaction of N,3-Dimethylpyridin-2-amine(cas: 156267-13-9).Quality Control of N,3-Dimethylpyridin-2-amine

The Article related to dithiobisindole preparation tyrosine kinase inhibitory, oxindole substituted, indolinethione substituted, Heterocyclic Compounds (One Hetero Atom): Indoles, Indolizines, Carbazoles, and Other Arenopyrroles and other aspects.Quality Control of N,3-Dimethylpyridin-2-amine

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

On May 31, 2014, Zhao, Hongwu; Meng, Wei; Yang, Zhao; Tian, Ting; Sheng, Zhihui; Li, Hailong; Song, Xiuqing; Zhang, Yutong; Yang, Sen; Li, Bo published an article.SDS of cas: 75449-26-2 The title of the article was Organocatalytic Stereoselective Synthesis of 3-Alkyl-3-hydroxy-2-oxindoles Catalyzed by Novel Water-compatible Axially Unfixed Biaryl-based Bifunctional Organocatalysts. And the article contained the following:

In this work, six novel axially unfixed biaryl-based water-compatible bifunctional organocatalysts were designed and synthesized for the organocatalytic access to a variety of 3-alkyl-3-hydroxy-2-oxindole derivatives I (R1 = H, 5-O2N, 5-Br; R2 = H, Bn; R3, R4 = -(CH2)2-, -CH2OCH2-, -CH2SCH2-, etc.) via aldol reactions in water. Organocatalyzed by II, the direct aldol reactions of isatins with enolisable ketones underwent readily in water, furnishing the structurally diverse I in various stereoselectivities (up to>99% dr and >99% ee). Moreover, a plausible transition state of the conducted aldol reactions was hypothesized to shed light on the observed stereoselectivities of the obtained I. The experimental process involved the reaction of [2,2′-Bipyridine]-3,3′-diamine(cas: 75449-26-2).SDS of cas: 75449-26-2

The Article related to alkyl hydroxy oxindole enantioselective preparation, isatin ketone aldol biaryl organocatalyst water compatible, Heterocyclic Compounds (One Hetero Atom): Indoles, Indolizines, Carbazoles, and Other Arenopyrroles and other aspects.SDS of cas: 75449-26-2

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

On December 27, 2007, Arnold, James; Berg, Stefan; Chessari, Gianni; Congreve, Miles; Edwards, Phil; Holenz, Joerg; Kers, Annika; Kolmodin, Karin; Murray, Christopher; Patel, Sahil; Rakos, Laszlo; Rotticci, Didier; Sylvester, Mark; Oehberg, Liselotte published a patent.Computed Properties of 908267-63-0 The title of the patent was Substituted isoindoles as BACE inhibitors and their preparation, pharmaceutical compositions and use in the treatment of cognitive impairment, Alzheimers disease, neurodegeneration and dementia. And the patent contained the following:

This invention relates to compounds having the structural formula I and to their pharmaceutically acceptable salt, compositions and methods of use. These compounds provide a treatment or prophylaxis of cognitive impairment, Alzheimer disease, neurodegeneration and dementia. Compounds of formula I wherein R1 is H, NO2, CN, C1-6 alkyl, C2-6 alkenyl, C2-6 alkynyl;, CONH-C1-6 alkyl, etc.; R2 is Me, (un)substituted C0-3 alkyl-C3-6 cycloalkyl, NO2, CN, substituted C2-4 alkenyl, etc.; R3 is H, halo, C1-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, C3-6 cycloalkyl, etc.; m is 0, 1, 2, and 3; and their pharmaceutically acceptable salts, solvates, salts of solvates thereof are claimed. Example compound II•TFA was prepared by Suzuki cross-coupling of [3-(3-bromo-4-hydroxyphenyl)-3-(4-methoxyphenyl)-3H-isoindol-1-yl]carbamic acid tert-Bu ester with 3-methoxyphenylboronic acid; the resulting [3-(6-hydroxy-3′-methoxybiphenyl-3-yl)-3-(4-methoxyphenyl)-3H-isoindol-1-yl]carbamic acid tert-Bu ester underwent hydrolysis to give compound II•TFA. All the invention compounds were evaluated for their BACE inhibitory activity. From the assay, it was determined that compound II exhibited an IC50 value of 67 nM. The experimental process involved the reaction of 4-Bromo-2-isopropylpyridine(cas: 908267-63-0).Computed Properties of 908267-63-0

The Article related to substituted isoindole preparation bace inhibitor, treatment alzheimer disease neurodegeneration dementia cognitive impairment isoindole preparation, Heterocyclic Compounds (One Hetero Atom): Indoles, Indolizines, Carbazoles, and Other Arenopyrroles and other aspects.Computed Properties of 908267-63-0

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

On December 15, 2017, Wei, Na; Zhang, Yue; Liu, Lin; Han, Zheng-Bo; Yuan, Da-Qiang published an article.Recommanded Product: 1431292-15-7 The title of the article was Pentanuclear Yb(III) cluster-based metal-organic frameworks as heterogeneous catalysts for CO2 conversion. And the article contained the following:

Two porous metal-organic frameworks (MOFs) incorporating pentanuclear Yb(III) clusters and pyridyl-supported tetracarboxylates or pyridyl carboxylic acid-supported tetracarboxylates, Yb-DDPY and Yb-DDIA, are presented, in which the pentanuclear Yb(III) cluster shows uncommon trigonal bipyramidal geometry. Furthermore, the pentanuclear Yb(III) clusters are extended by tetracarboxylates to form a 3D porous framework with uniform M12L8-cages constructed by 12 pentanuclear Yb(III) clusters and 8 tetracarboxylates with the size of ∼20 Å × 17 Å. Their highly CO2 uptake capacity and the existence of Lewis acidic sites make these MOFs promising catalysts for the chem. conversion of CO2. These MOFs demonstrate good catalytic activities and recyclability in the cycloaddition of CO2 and epoxides at 60° under 1.0 MPa pressure or at room temperature and atm. pressure. In addition, the synergistic effect of the Bronsted acidic -COOH groups and the Lewis acidic Yb(III) sites makes Yb-DDIA exhibit higher catalytic activity towards the cycloaddition of CO2 and epoxides. The experimental process involved the reaction of 5,5′-(Pyridine-2,5-diyl)diisophthalic acid(cas: 1431292-15-7).Recommanded Product: 1431292-15-7

The Article related to pentanuclear ytterbium metal organic framework catalyst carbon dioxide cycloaddition, carbon dioxide epoxide cycloaddition catalyst cyclic carbonate, Industrial Organic Chemicals, Leather, Fats, and Waxes: Manufacture Of Industrial Organic Chemicals and other aspects.Recommanded Product: 1431292-15-7

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

On June 24, 1994, Rewcastle, Gordon W.; Palmer, Brian D.; Dobrusin, Ellen M.; Fry, David W.; Kraker, Alan J.; Denny, William A. published an article.COA of Formula: C7H10N2 The title of the article was Tyrosine Kinase Inhibitors. 3. Structure-Activity Relationships for Inhibition of Protein Tyrosine Kinases by Nuclear-Substituted Derivatives of 2,2′-Dithiobis(1-methyl-N-phenyl-1H-indole-3-carboxamide). And the article contained the following:

A series of indole-substituted 2,2′-dithiobis(1-methyl-N-phenyl-1H-indole-3-carboxamides) I (R = H, 5-Cl, 6-Me, 7-OH, 5-MeO, etc.) were prepared and evaluated for their ability to inhibit the tyrosine kinase activity of both the epidermal growth factor receptor (EGFR) and the nonreceptor pp60v-src tyrosine kinase. The compounds were synthesized by conversion of appropriate 1-methyloxindoles to 1-methyl-2-indolinethiones with P2S5 followed by subsequent reaction with NaH and Ph isocyanate and oxidative dimerization of the resulting 2,3-dihydro-N-phenyl-2-thioxo-1H-indole-3-carboxamides. The parent compound and many of the substituted analogs were moderately potent inhibitors of both kinase enzymes, but no clear relationships were seen between substitution on the indole ring and inhibitory activity. While 4-substituted compounds were generally inactive, 5-substituted derivatives with electron-withdrawing groups showed inhibitory activity. However, none of the substituted compounds showed significantly better activity than the unsubstituted parent compound There was generally a good correlation between activity against the EGFR and pp60v-src kinases, but several compounds did show some specificity (>20-fold) of inhibition; 5-Cl and 5-Br derivatives preferentially inhibited pp60v-src, while the 5-CF3 compound preferentially inhibited EGFR. Selected compounds from the series were found to inhibit the growth of Swiss 3T3 fibroblasts with IC50s in the range 2-25 μM, the most active being 4-substituted derivatives The compounds inhibited bFGF-mediated protein tyrosine phosphorylation in intact cells more effectively than EGFR- or PDGF-mediated phosphorylation. The experimental process involved the reaction of N,3-Dimethylpyridin-2-amine(cas: 156267-13-9).COA of Formula: C7H10N2

The Article related to dithiobismethylphenylindolecarboxamide protein tyrosine kinases inhibitor, indolecarboxamide dithiobismethylphenyl protein tyrosine kinases inhibitor, Heterocyclic Compounds (One Hetero Atom): Indoles, Indolizines, Carbazoles, and Other Arenopyrroles and other aspects.COA of Formula: C7H10N2

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

On April 23, 1997, Onodera, Akira; Ninomiya, Hidetaka; Ohya, Hidenobu; Ishibashi, Daisuke; Komamura, Tawara; Katoh, Katsunori; Tanaka, Tatsuo; Morimoto, Hitoshi published a patent.Computed Properties of 28489-43-2 The title of the patent was Azomethine dyes and their use in ink-jet recording inks. And the patent contained the following:

A recording method comprises the step of ejecting an ink-jet recording ink on a receptor using an ink-jet printer, the ink comprising a dye represented by the formula I [R1, R2 = H, halogen, NH2, organic group; X = OH, NR3R4; R3, R4 = H, hydrocarbyl, heterocyclyl, or R1R3 or R3R4 form a ring; Y1, Y2 = N, CR; R = H, alkyl, acylamino; Y1 or Y2 = N; Z completes an (un)substituted 5- or 6-membered ring, which may bear another condensed ring; R2 or a substituent on Z has Hammett σp -0.3 to +1.0]. Thus, II was prepared in a 9-step synthesis from 6-methyl-2-pyridinamine and 5-tert-butyl-2-hydrazino-6H-1,3,4-thiadiazine. An ink with good color tone and storage stability was prepared from a I 3, H(OCH2CH2)2OH 10, Bu(OCH2CH2)3OH 7, PrOH 3, and H2O 77%. The experimental process involved the reaction of N,N-DIethyl-6-methyl-5-nitro-2-pyridinamine(cas: 28489-43-2).Computed Properties of 28489-43-2

The Article related to azomethine dye jet printing ink, pyrazolotriazole azomethine dye, aminopyridine azomethine dye, Dyes, Organic Pigments, Fluorescent Brighteners, and Photographic Sensitizers: Azo Dyes and Pigments and other aspects.Computed Properties of 28489-43-2

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem