Month: November 2022

On January 17, 2019, Ahmad, Nadia; Anderson, Corey; Arumugam, Vijayalaksmi; Asgian, Iuliana Luci; Camp, Joanne Louise; Fanning, Lev Tyler Dewey; Hadida Ruah, Sara Sabina; Hurley, Dennis; Schmidt, Yvonne; Shaw, David; Sheth, Urvi Jagdishbhai; Thomson, Stephen Andrew published a patent.Recommanded Product: Methyl 5-amino-4-methylpicolinate The title of the patent was Preparation of (hetero)aromatic carboxamides as modulators of sodium channels for the treatment of diseases. And the patent contained the following:

The invention relates to preparation of aryl heteroaryl carboxamides and pharmaceutically acceptable salts thereof, useful as inhibitors of sodium channels. The example compound I was prepared by multistep synthesis (procedure given). Also provided are pharmaceutical compositions comprising the compounds or pharmaceutically acceptable salts and methods of using the compounds, pharmaceutically acceptable salts, and pharmaceutical compositions in the treatment of various disorders, including pain. The experimental process involved the reaction of Methyl 5-amino-4-methylpicolinate(cas: 868551-99-9).Recommanded Product: Methyl 5-amino-4-methylpicolinate

The Article related to aryl heteroaryl carboxamide preparation sodium channel modulator disease treatment, Benzene, Its Derivatives, and Condensed Benzenoid Compounds: Amides, Amidines, Imidic Esters, Hydrazides, and Hydrazonic Esters and other aspects.Recommanded Product: Methyl 5-amino-4-methylpicolinate

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

On March 12, 1998, Daines, Robert A. published a patent.Name: N,3-Dimethylpyridin-2-amine The title of the patent was Preparation of 3,4-dinitrobenzamides as calcitonin gene related peptide receptor ligands.. And the patent contained the following:

Title compounds [I; R1 = H, Me, alkyl, phenylalkyl, heterocyclylalkyl, aminoalkyl, carboxyalkyl, alkoxycarbonylalkyl, etc.; R2 = (substituted) aryl, heteroaryl, arylalkyl, heteroarylalkyl; R1R2N = (benzo-fused) 5-6 membered heterocyclyl], were prepared Thus, N-methylaniline in CH2Cl2 was treated with Et3N and then with 3,4-dinitrobenzoyl chloride and the mixture was shaken overnight to give N-methyl-N-phenyl-3,4-dinitrobenzamide. I antagonized CGRP receptors with IC50 = 0.001-100 μM. The experimental process involved the reaction of N,3-Dimethylpyridin-2-amine(cas: 156267-13-9).Name: N,3-Dimethylpyridin-2-amine

The Article related to nitrobenzamide preparation cgrp related disease treatment, calcitonin gene related peptide antagonist dinitrobenzamide, Benzene, Its Derivatives, and Condensed Benzenoid Compounds: Amides, Amidines, Imidic Esters, Hydrazides, and Hydrazonic Esters and other aspects.Name: N,3-Dimethylpyridin-2-amine

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

On July 31, 2008, Diehl, Donald R.; Eiff, Shari L.; Landry-Coltrain, Christine J.; Russo, Gary M. published a patent.Related Products of 28489-43-2 The title of the patent was Stabilized dyes for thermal dye transfer materials. And the patent contained the following:

The present invention relates to a cyan dye donor element for thermal transfer imaging comprising a support having thereon a dye layer comprising a mixture of at least two cyan dyes dispersed in a polymeric binder, wherein at least one of the at least two cyan dyes is a light stabilizing dye represented by Formula I and a thermal image recording method utilizing the same cyan dye donor element, wherein R1 and R2 are substituted or unsubstituted alkyl, cycloalkyl, or aryl, or combine to form a carbocyclic or heterocyclic ring; R3 is hydrogen, halogen, alkoxy, substituted or unsubstituted alkyl, NHCOR1, NHSO2R1, or combine s with either R1 or R2 to form a carbocyclic or heterocyclic ring; X is halogen; Y is alkyl; Z is carbon or nitrogen; J is NHCOR4; R4 is R5Phenyl(OR7)m; R5 is -(CHR6)n- or -(CH2)pO-; R6 is hydrogen, substituted or unsubstituted alkyl; R7 is substituted or unsubstituted alkyl, carbocycle or heterocycle; m is 2-5; n is 0-6; p is 2-5; the formula weight of R4 does not exceed 230. The present invention also relates to a cyan ink-jet dye comprising a light stabilizing cyan dye represented by Formula I. The experimental process involved the reaction of N,N-DIethyl-6-methyl-5-nitro-2-pyridinamine(cas: 28489-43-2).Related Products of 28489-43-2

The Article related to stabilized dye thermal transfer sheet, Radiation Chemistry, Photochemistry, and Photographic and Other Reprographic Processes: Impact and Nonimpact Printing, Platemaking and other aspects.Related Products of 28489-43-2

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

On March 14, 1995, Komamura, Tawara; Kato, Katsunori; Tanaka, Tatsuo published a patent.Application of 28489-43-2 The title of the patent was Aminopicoline-derived cyan dye and thermal-transfer printing material. And the patent contained the following:

The dye comprise cyano structure I [X = NR3R4, OH; R1 = H, halo, monovalent substitute; R2 = (substituted) aliphatic or aromatic group; R3, R4 = (substituted) alkyl, alkenyl aryl, aralkyl, cycloalkyl; substitutes of R3, R4 may form ring with R1; Y1 and/or Y2 = N, other is C]. The thermal-transfer printing material includes a colorant layer containing I associated with a binder. The dye, e.g., I (X = NEt2, Y1 = C, Y2 = N; R1 = 2-Me, R2 = CMe3), is prepared The experimental process involved the reaction of N,N-DIethyl-6-methyl-5-nitro-2-pyridinamine(cas: 28489-43-2).Application of 28489-43-2

The Article related to cyano dye thermal transfer printing, aminopicoline derived cyano dye printing, Radiation Chemistry, Photochemistry, and Photographic and Other Reprographic Processes: Impact and Nonimpact Printing, Platemaking and other aspects.Application of 28489-43-2

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

On November 30, 1998, Yang, Fang-zu; Xu, Shu-kai; Huang, Ling; Zhang, Xue-ying; Zhou, Shao-min published an article.SDS of cas: 636-73-7 The title of the article was A study on the effect of bath composition on the internal stress of a palladium electrodeposit. And the article contained the following:

The effects of bath composition on the internal stress of palladium electrodeposits are studied in neutral media with Pd(NH3)2Cl2, K3C6H5O7, (NH4)2C2O4 and the additives of the mixture of the synthesized products of nicotinic acid and nicotiamide (NANA), pyridine-3-sulfonic acid (PSA), α-furan formic acid (FF) and cetyl tri-Me ammonium bromide (CTMAB). The internal stress of electrodeposits is quite changeable at the beginning of electrodeposition, later becoming stable gradually. Deposits obtained from pulse electrodeposition have lower stress than that from d.c. After electrodeposition, all the deposits keep the tensile stress which increases with time. The experimental process involved the reaction of Pyridine-3-sulfonic acid(cas: 636-73-7).SDS of cas: 636-73-7

The Article related to palladium electroplating residual stress, Nonferrous Metals and Alloys: Surface Treatment, Metallic and Nonmetallic Coating, Sealing, Cleaning, Polishing, Etching, and Pickling and other aspects.SDS of cas: 636-73-7

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

On May 7, 2021, Milic, Mira; Targos, Karina; Tellez Chavez, Magda; Thompson, Madison A. M.; Jennings, Julia J.; Franz, Annaliese K. published an article.Reference of 2-(4,5-Dihydro-4,4-dimethyl-2-oxazolyl)pyridine The title of the article was NMR Quantification of Hydrogen-Bond-Accepting Ability for Organic Molecules. And the article contained the following:

The hydrogen-bond-accepting abilities for more than 100 organic mols. are quantified using 19F and 31P NMR spectroscopy with pentafluorobenzoic acid (PFBA) and phenylphosphinic acid (PPA) as com. available, inexpensive probes. Anal. of pyridines and anilines with a variety of electronic modifications demonstrates that changes in NMR shifts can predict the secondary effects that contribute to H-bond-accepting ability, establishing the ability of PFBA and PPA binding to predict electronic trends. The H-bond-accepting abilities of various metal-chelating ligands and organocatalysts are also quantified. The measured Δδ(31P) and Δδp(19F) values correlate strongly with Hammett parameters, pKa of the protonated HBA, and proton-transfer basicity (pKBH+). The experimental process involved the reaction of 2-(4,5-Dihydro-4,4-dimethyl-2-oxazolyl)pyridine(cas: 109660-12-0).Reference of 2-(4,5-Dihydro-4,4-dimethyl-2-oxazolyl)pyridine

The Article related to hydrogen bond accepting ability nmr chem shift, Physical Organic Chemistry: Resonance Spectra (Electron Spin, Nuclear Magnetic and Fourier Transform Nuclear Magnetic, Quadrupole, etc.) and other aspects.Reference of 2-(4,5-Dihydro-4,4-dimethyl-2-oxazolyl)pyridine

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

On October 31, 2004, Schilf, Wojciech published an article.Electric Literature of 75449-26-2 The title of the article was The spectroscopic study of hydrogen bonding in some 3,3′-derivatives of 2,2′-bipyridyl. And the article contained the following:

Four 3,3′-derivatives of 2,2′-bipyridyl have been investigated by multinuclear NMR, IR and X-ray methods. In all cases the weak intramol. hydrogen bonds between exocyclic nitrogen-containing substituent and pyridine-type ring nitrogen atom were found. In contrast to the previous results the nitrogen chem. shifts of pyridine ring atom do not provide valuable information about hydrogen bond strength. The presence of intramol. hydrogen bonds was confirmed by nitrogen chem. shifts of exocyclic amino and acetamide groups, deuterium isotope effects in the solid state and IR measurements in both chloroform solution and the solid state. The X-ray structures obtained for asym. 3-amino-3′-methylamino and 3,3′-diacetamide derivatives confirmed conclusions made on the base of spectral results. The experimental process involved the reaction of [2,2′-Bipyridine]-3,3′-diamine(cas: 75449-26-2).Electric Literature of 75449-26-2

The Article related to hydrogen bond bipyridyl derivative nmr ir crystallog, Physical Organic Chemistry: Resonance Spectra (Electron Spin, Nuclear Magnetic and Fourier Transform Nuclear Magnetic, Quadrupole, etc.) and other aspects.Electric Literature of 75449-26-2

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

On November 1, 1981, Dommisse, Roger; Freyne, Eddy; Esmans, Eddy; Lepoivre, Josef; Alderweireldt, Frank published an article.Product Details of 73591-69-2 The title of the article was Carbon-13 NMR shift increments for 3-substituted pyridines. And the article contained the following:

The 13C NMR spectra of sixteen 3-substituted and 3,5-disubstituted pyridines are assigned. The substituent shift increment for the 3-Ac group is reassigned, and new shift increments for 3- and 5-substituents are proposed. The experimental process involved the reaction of 5-Isopropylnicotinic acid(cas: 73591-69-2).Product Details of 73591-69-2

The Article related to nmr pyridine substituent effect, acetylpyridine carbon nmr, Physical Organic Chemistry: Resonance Spectra (Electron Spin, Nuclear Magnetic and Fourier Transform Nuclear Magnetic, Quadrupole, etc.) and other aspects.Product Details of 73591-69-2

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Pham, Ngoc H.; Wenzel, Thomas J. published an article in 2011, the title of the article was A sulfonated calix[4]resorcinarene with α-methyl-L-prolinylmethyl groups as a water-soluble chiral NMR solvating agent.Category: pyridine-derivatives And the article contains the following content:

A water-soluble calix[4]resorcinarene containing α-methyl-L-prolinylmethyl groups was investigated as a chiral NMR solvating agent. Substrates form complexes by insertion of the aromatic ring into the cavity of the calix[4]resorcinarene. Amino acid derivatives with Ph or indole rings, ammonium substrates with pyridyl, indane or dihydroindole rings, and phenyl-containing substrates with carboxylic acid and/or hydroxyl groups were studied. The effectiveness of the α-methyl-L-prolinylmethyl calix[4]resorcinarene is compared to similar reagents with proline and hydroxyproline moieties that have previously been reported. The α-methyl-L-prolinylmethyl derivative causes larger enantiomeric discrimination of one or more 1H resonances than the previous systems for most of the substrates. The experimental process involved the reaction of N,N-Dimethyl-3-phenyl-3-(pyridin-2-yl)propan-1-amine maleate(cas: 132-20-7).Category: pyridine-derivatives

The Article related to chiral nmr solvating agent sulfonated calixarene prolinylmethyl derivative, Physical Organic Chemistry: Resonance Spectra (Electron Spin, Nuclear Magnetic and Fourier Transform Nuclear Magnetic, Quadrupole, etc.) and other aspects.Category: pyridine-derivatives

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

On October 1, 2019, Sun, Jiyun; Tang, Ruikun; Wang, Lu; Xu, Hao; Zhang, Xiaofei; Fan, Wei published a patent.Product Details of 1820711-82-7 The title of the patent was GluN2B subunit-targeted positron tracer for central nervous system and preparation thereof. And the patent contained the following:

The invention relates to GluN2B subunit-targeted positron tracer for central nervous system and preparation thereof, which has the advantages of stable structure, low metabolic rate, good electron tracing effect, mild reaction condition and high purity. In particular, the present invention relates to GluN2B subunit-targeted positron tracer for central nervous system with general formula I, wherein, R1 = Ph, benzene derivative, thienyl, thiophene derivatives GluN2B subunit-targeted positron tracer for central nervous system with general formulaIwas prepared by the following steps: methylation of the intermediate II with 11CH3I to obtain final product. The experimental process involved the reaction of tert-Butyl 6-bromo-1H-pyrrolo[3,2-b]pyridine-1-carboxylate(cas: 1820711-82-7).Product Details of 1820711-82-7

The Article related to glun2b subunit targeted positron tracer preparation central nervous system, Heterocyclic Compounds (More Than One Hetero Atom): Fused-Ring Systems With Two Or More Hetero Atoms, No More Than One Hetero Atom Per Ring and other aspects.Product Details of 1820711-82-7

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem