Month: November 2022

Kaczmarek, Lukasz published an article in 1985, the title of the article was Bipyridines. Part XVII. A convenient synthesis of some bipyridinediols and furodipyridines.SDS of cas: 75449-26-2 And the article contains the following content:

A convenient method of preparation of some bipyridinediols e.g. I, II and furodipyridines III (X or X1 or X2 = N) based on diazotization of corresponding diamines in H2SO4 has been described. The experimental process involved the reaction of [2,2′-Bipyridine]-3,3′-diamine(cas: 75449-26-2).SDS of cas: 75449-26-2

The Article related to bipyridinediamine diazotization cyclization, bipyridinediol, furodipyridine, Heterocyclic Compounds (More Than One Hetero Atom): Fused-Ring Systems With Two Or More Hetero Atoms, No More Than One Hetero Atom Per Ring and other aspects.SDS of cas: 75449-26-2

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

On October 31, 1978, Da Settimo, A.; Biagi, G.; Primofiore, G.; Ferrarini, P. L.; Livi, O. published an article.Related Products of 68638-67-5 The title of the article was Synthesis of some 11H-indolo[3,2-c][1,8]naphthyridines. And the article contained the following:

Twelve 11H-indolo[3,2-c][1,8]naphthyridines I (R = OEt, OH, SH, H; R1 = H, F, Br, Me, MeO, OH; R2 = H, MeO, OH) were prepared in 11.9-93.6% yield by 2 methods, e.g., by the Fischer indole synthesis. The UV of I were discussed. Several I were prepared from II, which was prepared in 70.9% yield from 7-bromo-2,3-dihydro-1,8-naphthyridin-4(1H)-one. II displayed a passive cutaneous anaphylaxis inhibition when administered i.p. in the rat at a dose of 25 mg/kg, but it exhibited no oral activity. The experimental process involved the reaction of 3-((6-Bromopyridin-2-yl)amino)propanoic acid(cas: 68638-67-5).Related Products of 68638-67-5

The Article related to anaphylaxis ethoxydihydronaphthyridinone, indolonaphthyridine uv nmr preparation, fischer indole synthesis indolonaphthyridine, Heterocyclic Compounds (More Than One Hetero Atom): Fused-Ring Systems With Two Or More Hetero Atoms, No More Than One Hetero Atom Per Ring and other aspects.Related Products of 68638-67-5

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

On November 3, 2005, Dress, Klaus Ruprecht; Hu, Qiyue; Johnson, Ted William; Plewe, Michael Bruno; Tanis, Steven Paul; Wang, Hai; Yang, Anle; Yin, Chunfeng; Zhang, Junhu published a patent.Category: pyridine-derivatives The title of the patent was Preparation of N-hydroxy pyrrolopyrimidinecarboxamides as inhibitors of HIV integrase.. And the patent contained the following:

Title compounds [I; R1 = H, (substituted) alkyl, alkenyl, heteroalkyl; R2, R5 = H; R3 = (CR8R9)tNR10R11, (substituted) heteroalkyl; R4 = H, halo, alkyl, heteroalkyl, (substituted) alkenyl, alkynyl, OR12a, NR12aR12b; R6 = H, alkyl, heteroalkyl, (substituted) alkenyl; R8, R9 = H, alkyl; R10R11N = (substituted) cycloheteroalkyl; R12a, R12b, R12c = H, alkyl; t = 1-3], were prepared Thus, 1-(2,4-difluorobenzyl)-1H-pyrrolo[2,3-c]pyridine-5-carboxylic acid (preparation given) was stirred with O-(7-azabenzotriazol-1-yl)-1,1,3,3-tetramethyluronium hexafluorophosphate, Et3N, and NH2OH.HCl in DMF for 16 h to give 48% N-hydroxy-1-(2,4-difluorobenzyl)-1H-pyrrolo[2,3-c]pyridine-5-carboxamide. The latter showed an EC50 = 0.00795 μM in an HIV-1 cell protection assay. The experimental process involved the reaction of Methyl 5-amino-4-methylpicolinate(cas: 868551-99-9).Category: pyridine-derivatives

The Article related to pyrrolopyrimidinecarboxamide hydroxy preparation hiv integrase inhibitor, aids arc treatment hydroxamide pyrrolopyrimidine preparation, Heterocyclic Compounds (More Than One Hetero Atom): Fused-Ring Systems With Two Or More Hetero Atoms, No More Than One Hetero Atom Per Ring and other aspects.Category: pyridine-derivatives

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Zahn, Stefan; Reckien, Werner; Kirchner, Barbara; Staats, Holger; Matthey, Jens; Luetzen, Arne published an article in 2009, the title of the article was Towards allosteric receptors: adjustment of the rotation barrier of 2,2′-bipyridine derivatives.Computed Properties of 75449-26-2 And the article contains the following content:

Quantum-chem. calculations at the BP86/TZVP level of theory were performed to determine the energy differences between the syn and the anti conformers, as well as the energy barrier for the rotation of the aryl-aryl bond of 2,2′-bipyridine mols. and a number of disubstituted derivatives Substituents with hydrogen-bond donor (or electron acceptor) functions or hydrogen-bond acceptors (or electron donors) are generally found to have large effects on the difference and the barrier. Substitution with a hydrogen-bond donor (or an electron acceptor) at position 6 and 6′ leads to a decrease owing to a charge transfer from the pyridine nitrogen lone pair to the donor, which is caused by the formation of weak intramol. hydrogen bonds and/or dipolar interactions, resp. Conversely, substitution at position 4 and 4′ causes an increase in the energy barrier. Substitution with a hydrogen-bond accept- or (or an electron donor) shows the opposite behavior, which can be explained by the weak intramol. interactions. Interestingly, even very weak CH hydrogen-bond donors (electron acceptors) such as Me groups have a significant influence. This indicates the importance of such weak interactions for the structure and energetics of supramol. systems. The energy differences are mainly governed by the substituents directly attached to the bipyridine core as the introduction of sterically demanding groups in the periphery hardly influences the barriers or energy differences of the conformers. These findings are important for the design of heterotropic pos. cooperative allosteric receptors with 2,2′-bipyridines as the allosteric center. The experimental process involved the reaction of [2,2′-Bipyridine]-3,3′-diamine(cas: 75449-26-2).Computed Properties of 75449-26-2

The Article related to allosterism electron donor receptor rotation barrier bipyridine, Physical Organic Chemistry: Stereochemistry and Stereochemical Relationships, Including Conformational Inversions and Rotational Isomerization and other aspects.Computed Properties of 75449-26-2

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Vela, Sonia; Berrocal, Jose Augusto; Atienza, Carmen; Meijer, E. W.; Martin, Nazario published an article in 2017, the title of the article was Mesoscopic helical architectures via self-assembly of porphyrin-based discotic systems.Category: pyridine-derivatives And the article contains the following content:

Mesoscopic super-helixes with preferred helicity were serendipitously formed from the self-assembly of electroactive extended core discotic mols. The study at dilute concentrations reveals intramol. hydrogen-bonding and π-π stacking interactions as the driving force of the chiral self-assembly at different length scales. The experimental process involved the reaction of [2,2′-Bipyridine]-3,3′-diamine(cas: 75449-26-2).Category: pyridine-derivatives

The Article related to mesoscopic helical architecture chiral selfassembly porphyrin discotic, Physical Organic Chemistry: Stereochemistry and Stereochemical Relationships, Including Conformational Inversions and Rotational Isomerization and other aspects.Category: pyridine-derivatives

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Li, Zi-Qi; Fu, Yue; Deng, Ruohan; Tran, Van T.; Gao, Yang; Liu, Peng; Engle, Keary M. published an article in 2020, the title of the article was Ligand-controlled regiodivergence in nickel-catalyzed hydroarylation and hydroalkenylation of alkenyl carboxylic acids.Safety of 2-(4,5-Dihydro-4,4-dimethyl-2-oxazolyl)pyridine And the article contains the following content:

A nickel-catalyzed regiodivergent hydroarylation and hydroalkenylation of unactivated alkenyl carboxylic acids is reported, whereby the ligand environment around the metal center dictates the regiochem. outcome. Markovnikov hydrofunctionalization products are obtained under mild ligand-free conditions, with up to 99% yield and >20:1 selectivity. Alternatively, anti-Markovnikov products can be accessed with a novel 4,4-disubstituted Pyrox ligand I in excellent yield and >20:1 selectivity. Both electronic and steric effects on the ligand contribute to the high yield and selectivity. Mechanistic studies suggest a change in the turnover-limiting and selectivity-determining step induced by the optimal ligand. DFT calculations reveal that in the anti-Markovnikov pathway, repulsion between the ligand and the alkyl group is minimized (by virtue of it being 1° vs. 2°) in the rate- and regioselectivity-determining transmetalation transition state. The experimental process involved the reaction of 2-(4,5-Dihydro-4,4-dimethyl-2-oxazolyl)pyridine(cas: 109660-12-0).Safety of 2-(4,5-Dihydro-4,4-dimethyl-2-oxazolyl)pyridine

The Article related to hydroarylation regiodivergent alkenyl carboxylic acid boronic acid nickel catalyst, hydroalkenylation regiodivergent alkenyl carboxylic acid boronic acid nickel catalyst, Benzene, Its Derivatives, and Condensed Benzenoid Compounds: Carboxylic Acids and Peroxycarboxylic Acids and Their Sulfur-Containing Analogs and Salts and other aspects.Safety of 2-(4,5-Dihydro-4,4-dimethyl-2-oxazolyl)pyridine

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

On February 15, 1987, Kamogawa, Hiroyoshi; Suzuki, Tsuyoshi published an article.Category: pyridine-derivatives The title of the article was Photochromism of viologen crystals. And the article contained the following:

Some viologen crystals bearing a p-toluenesulfonate anion as a counter ion exhibit reversible photoreductions (photochromism) either in air or in vacuum. In a poly(N-vinyl-2-pyrrolidone) matrix all investigated viologens indicated reversible photocolor developments. Amphoteric ions such as 1,1′-bis(3-sulfonatoporpyl)-4,4′-bipyridinium also developed colors with high stabilities. The experimental process involved the reaction of 1,1′-Dipropyl-[4,4′-bipyridine]-1,1′-diium bromide(cas: 52243-87-5).Category: pyridine-derivatives

The Article related to photochromism viologen crystal toluenesulfonate counterion, Radiation Chemistry, Photochemistry, and Photographic and Other Reprographic Processes: Photochromic, Thermochromic, and Electrochromic Imaging Systems and other aspects.Category: pyridine-derivatives

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Mortimer, Roger J.; Dillingham, Joanne L. published an article in 1997, the title of the article was Electrochromic 1,1′-dialkyl-4,4′-bipyridinium-incorporated Nafion electrodes.Application of 52243-87-5 And the article contains the following content:

The sym. 1,1′-dialkyl-4,4′-bipyridynium salts (alkyl = Me, Et, Pr, Bu, n-pentyl, n-hexyl) can be electrostatically incorporated into Nafion films to produce electrochromic electrodes. A trend from purple to pink in the color of the radical-cation redox state is observed This has been interpreted by in situ visible absorption spectroelectrochem. measurements as being due to a higher incidence of radical-cation dimers in the Nafion films with increase in alkyl chain length. Response times for coloration are shorter than for bleaching, owing to the slower phys. diffusion of the radical-cation dimers. The 1,1′-di-n-heptyl-4,4′-bipyridinium system was not incorporated into the Nafion structure and impede extensive incorporation into the bulk of the anionic polyelectrolyte. The presence of an inner Prussian blue layer in a Prussian blue/Nafion (1,1′-dialkyl-4,4′-bipyridinium) bilayer configuration permits five-color polyelectrochromicity at a single electrode. The experimental process involved the reaction of 1,1′-Dipropyl-[4,4′-bipyridine]-1,1′-diium bromide(cas: 52243-87-5).Application of 52243-87-5

The Article related to nafion alkylbipyridinum salt electrochromic electrode, electrochromism nafion incorporated alkylbipyridinum salt, Radiation Chemistry, Photochemistry, and Photographic and Other Reprographic Processes: Photochromic, Thermochromic, and Electrochromic Imaging Systems and other aspects.Application of 52243-87-5

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

On February 28, 1997, Kim, Sung Hoon; Bae, Jin Seok; Hwang, Seok Hwan; Gwon, Tae Sun; Doh, Myung Ki published an article.Electric Literature of 52243-87-5 The title of the article was Dimer formation of viologen derivatives and their electrochromic properties. And the article contained the following:

The electrochromic properties of 1,1′-diethyl-4,4′-bipyridinium dibromide (EV), 1,1′-dipropyl-4,4′-bipyridinium dibromide (PV), 1,1′-dibutyl-4,4′-bipyridinium dibromide (BV) and 1-ethyl-1′-Bu bipyridinium dibromide (EBV) were studied using a propylene-carbonate/methanol solution with Bu4NBF4 as the supporting electrolyte. A monomer-dimer equilibrium is proposed to explain the observation that the EV and EBV cation radical solutions are violet at an applied voltage of 1.7-3.0 V, but become blue in the open-circuit condition. The experimental process involved the reaction of 1,1′-Dipropyl-[4,4′-bipyridine]-1,1′-diium bromide(cas: 52243-87-5).Electric Literature of 52243-87-5

The Article related to electrochromism viologen derivative monomer dimer equilibrium, viologen derivative cation radical electrochromic cell, Radiation Chemistry, Photochemistry, and Photographic and Other Reprographic Processes: Photochromic, Thermochromic, and Electrochromic Imaging Systems and other aspects.Electric Literature of 52243-87-5

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

On September 25, 2014, Schwiebert, Erik; Streiff, John; Dixon, John; Gao, Hongwu published a patent.Computed Properties of 25813-24-5 The title of the patent was Coumarin derivatives and methods of use in treating cystic fibrosis, chronic obstructive pulmonary disease, and misfolded protein disorders. And the patent contained the following:

The invention relates to coumarin derivatives of formula I or pharmaceutically acceptable salts or prodrugs thereof as novel CFTR corrector compounds that are effective in rescuing halide efflux, delF508-CFTR protein processing, and apical functional chloride ion transport in a cell are provided. Coumarin derivatives of formula I or pharmaceutically acceptable salts or prodrugs thereof, wherein R1, R2, R3, R4, X, and Y are as defined in the disclosure, are claimed. Example compounds such as II were prepared by multistep synthesis and evaluated in vitro and in vivo for their activity as CFTR correctors (data shown). Also provided are methods for treating protein folding disorders (e.g., cystic fibrosis and chronic obstructive pulmonary diseases). The methods include administering a CFTR corrector compound or pharmaceutically acceptable salt or prodrug thereof. Methods of rescuing halide efflux in a cell, correcting a processing defect of a delF508-CFTR protein in a cell, and correcting functional delF508-CFTR chloride channels in a cell are also provided. The experimental process involved the reaction of 3,5-Dibromo-4-methoxypyridine(cas: 25813-24-5).Computed Properties of 25813-24-5

The Article related to coumarin preparation cftr corrector chronic obstructive pulmonary disease treatment, Heterocyclic Compounds (One Hetero Atom): Benzopyrans (Including Coumarins, Isocoumarins, Chromones, Benzopyrones, Dibenzopyrans, and Other Arenopyrans) and other aspects.Computed Properties of 25813-24-5

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem