Month: November 2022

In 2022,He, Peipei; Chen, Bo; Huang, Liang; Liu, Xixi; Qin, Jingzhong; Zhang, Zehui; Dai, Wen published an article in Chem. The title of the article was 《Heterogeneous manganese-oxide-catalyzed successive cleavage and functionalization of alcohols to access amides and nitriles》.Recommanded Product: 103-74-2 The author mentioned the following in the article:

Herein, a novel and efficient protocol that enables the direct synthesis of amides via heterogeneous manganese-oxide-catalyzed successive cleavage and amidation of C-C bonds in alcs was reported. A wide range of primary and secondary alcs., 1,2-diols, and even β-O-4 and β-1 lignin model compounds can undergo C-C bond cleavage smoothly to deliver one- or multiple-carbon shorter amides. Moreover, a slight modification of reaction conditions allows for the cleavage and cyanation of alcs. to access sterically hindered nitriles. Detailed characterizations and d. functional theory (DFT) calculations indicate that high sp. surface area, abundant oxygen vacancies, and moderate acid sites contribute to the high catalytic performance of the manganese oxides. In the part of experimental materials, we found many familiar compounds, such as 2-(2-Hydroxyethyl)pyridine(cas: 103-74-2Recommanded Product: 103-74-2)

2-(2-Hydroxyethyl)pyridine(cas: 103-74-2) belongs to pyridine. Pyridine is a relatively complex molecule and exhibits a number of different bands in IR spectra. Among others, the bands characterizing the ν8a and ν19b modes have been found to be sensitive to the coordination or protonation of the molecule. Note that the band that is diagnostic for the PyH+ ion at about 1545 cm− 1 (ν19b mode) does not overlap with any of the other bands.Recommanded Product: 103-74-2

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

《Iron-Catalyzed Direct Cross-Coupling of Ethers and Thioether with Alcohols for the Synthesis of Mixed Acetals》 was written by Han, Wei; Cheng, Lu; Zhao, Hongyuan. COA of Formula: C7H9NO And the article was included in Synlett in 2020. The article conveys some information:

An iron-catalyzed direct O-alkylation of alcs. via α-C(sp 3)-H activation of ethers and a thioether was established that tolerates cyclic and acyclic ethers and alcs. containing aromatic N-heterocyclic moieties, providing an efficient and green method for the synthesis of mixed acetals with good to excellent yields. The robustness of this protocol is demonstrated by the late-stage oxidation of a structurally complex natural product. The experimental part of the paper was very detailed, including the reaction process of 2-(2-Hydroxyethyl)pyridine(cas: 103-74-2COA of Formula: C7H9NO)

2-(2-Hydroxyethyl)pyridine(cas: 103-74-2) belongs to pyridine. Pyridine is a relatively complex molecule and exhibits a number of different bands in IR spectra. Among others, the bands characterizing the ν8a and ν19b modes have been found to be sensitive to the coordination or protonation of the molecule. Note that the band that is diagnostic for the PyH+ ion at about 1545 cm− 1 (ν19b mode) does not overlap with any of the other bands.COA of Formula: C7H9NO

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

The author of 《In Vivo Chemoselective Photoacoustic Imaging of Copper(II) in Plant and Animal Subjects》 were Zeng, Leli; Ma, Gongcheng; Xu, Han; Mu, Jing; Li, Fan; Gao, Xiaoting; Deng, Zhuoting; Qu, Junle; Huang, Peng; Lin, Jing. And the article was published in Small in 2019. Name: Bis(pyridin-2-ylmethyl)amine The author mentioned the following in the article:

The detection of Cu2+ in living plants and animals is of great importance for environment monitoring and disease diagnosis. Here, a near-IR (NIR) turn-on photoacoustic (PA) probe (denoted as LET-2) is developed for Cu2+ detection in living subjects, such as soybean sprouts and mice. The absorbance band of LET-2 shifts from 625 to 715 nm after the interaction with Cu2+, thus producing strong PA signal output at 715 nm (PA715) as an indicator. The PA715 value is increased as a function of the concentration of Cu2+ (0 × 10-6-20 × 10-6M), with a calculated limit of detection of 10.8 × 10-9M. More importantly, both in vitro and in vivo studies in soybean sprouts and mice indicate that the as-prepared LET-2 PA probe is highly sensitive and selective for Cu2+ detection. These findings provide a solution for in vivo detection of metal ions by using chemoselective PA probes. The experimental part of the paper was very detailed, including the reaction process of Bis(pyridin-2-ylmethyl)amine(cas: 1539-42-0Name: Bis(pyridin-2-ylmethyl)amine)

Bis(pyridin-2-ylmethyl)amine(cas: 1539-42-0) is a secondary amine with two picolyl substituents. The compound is a tridentate ligand in coordination chemistry and commonly used to produce Zn-based chemosensors/probes, such as Zinpry.Name: Bis(pyridin-2-ylmethyl)amine

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

In 2022,Jia, Kai; Ma, Wenchao; Yan, Yintao; Zhang, Chenming; Jiang, Chao published an article in Synlett. The title of the article was 《A Mild and Efficient Synthesis of Pyrazolo[1,5-a]pyridines Mediated by Triphenylphosphine/Diiodine》.Application In Synthesis of 2-Bromo-5-methylpyridine The author mentioned the following in the article:

A synthesis of 2,3-diaryl-substituted pyrazolo[1,5-a]pyridines in moderate to good yields under metal-free and mild conditions was described. The intramol. cyclization of the oxime substrates was mediated by PPh3/I2, which led directly to pyrazolo[1,5-a]pyridines without the formation of a 2H-azirine intermediate. Various substituents on the aryl rings were compatible with the method.2-Bromo-5-methylpyridine(cas: 3510-66-5Application In Synthesis of 2-Bromo-5-methylpyridine) was used in this study.

2-Bromo-5-methylpyridine(cas: 3510-66-5) belongs to pyridine. Pyridine is very deactivated towards electrophilic substitution with respect to benzene. For this reason classical formylation, using methods such as the Gattermann or Vilsmeier reactions, are not generally successful. Application In Synthesis of 2-Bromo-5-methylpyridine

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

In 2022,Gui, Fukang; Jin, Qiu; Xiao, Dongdong; Xu, Xiaobin; Tan, Qinggang; Yang, Daijun; Li, Bing; Ming, Pingwen; Zhang, Cunman; Chen, Zheng; Siahrostami, Samira; Xiao, Qiangfeng published an article in Small. The title of the article was 《High-Performance Zinc-Air Batteries Based on Bifunctional Hierarchically Porous Nitrogen-Doped Carbon》.Application In Synthesis of 2,6-Diaminopyridine The author mentioned the following in the article:

Active and durable bifunctional electrocatalysts for the oxygen reduction reaction (ORR) and oxygen evolution reaction (OER) on the cathode are required for high-performance rechargeable metal-air batteries. Herein, the synthesis of hierarchically porous nitrogen-doped carbon (HPNC) with bifunctional oxygen electrocatalysis for Zn-air batteries is reported. The HPNC catalyst possesses a large surface area of 1459 m2 g-1 and exhibits superior electrocatalytic activity toward ORR and OER simultaneously with a low OER/ORR overpotential of 0.62 V, taking the difference between the potential at 10 mA cm-2 for OER and half-wave potential for ORR in 0.1 M KOH. Adopting HPNC as the air cathode, primary and rechargeable Zn-air batteries are fabricated. The primary batteries demonstrate a high open-circuit potential of 1.616 V, a specific capacity of 782.7 mAh gZn-1 and a superb peak power d. of 201 mW cm-2. The rechargeable batteries can be cycled stably for over 360 cycles or 120 h at the c.d. of 5 mA cm-2. As elucidated by d. functional theory, N-doping is preferred on defective sites with pentagon configuration and on the edge in the form of pyridinic-N-type. The high content of these two motifs in HPNC leads to the superior ORR and OER activities, resp. In the experiment, the researchers used 2,6-Diaminopyridine(cas: 141-86-6Application In Synthesis of 2,6-Diaminopyridine)

2,6-Diaminopyridine(cas: 141-86-6) belongs to pyridine. Pyridine and its simple derivatives are stable and relatively unreactive liquids, with strong penetrating odours that are unpleasant.Application In Synthesis of 2,6-Diaminopyridine

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

In 2018,Zeng, Yu; Zheng, Hao-liang; Yang, Zhao; Liu, Cheng-Kou; Fang, Zheng; Guo, Kai published 《Copper(I) Iodide-Catalyzed (Het)arylation of Diethyl Malonate with (Het)aryl Bromides by Using 1,3-Benzoxazole as a Ligand》.Synlett published the findings.Computed Properties of C5H3BrClN The information in the text is summarized as follows:

An efficient Ullmann-type coupling of aryl bromides with di-Et malonate in the presence of copper(I) iodide and 1,3-benzoxazole is presented. This method has a broad substrate scope (heterocyclic and Ph bromides) and good functional-group tolerance (OMe, Me, Ac, CN, NO2, F, and Cl). Moreover, less time is needed to reach full conversion (3-9 h). In the experiment, the researchers used many compounds, for example, 5-Bromo-2-chloropyridine(cas: 53939-30-3Computed Properties of C5H3BrClN)

5-Bromo-2-chloropyridine(cas: 53939-30-3) belongs to pyridine. In industry and in the lab, pyridine is used as a reaction solvent, particularly when its basicity is useful, and as a starting material for synthesizing some herbicides, fungicides, and antiseptics.Computed Properties of C5H3BrClN

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

In 2019,Talanta included an article by Liu, Dan; Liu, Sheng; Zhang, Xinyu; Zhang, Qiong; Yu, Jianhua; Yang, Mingdi; Yang, Xingyuan; Tian, Yupeng; Zhu, Xiaojiao; Zhou, Hongping. SDS of cas: 31106-82-8. The article was titled 《A water-soluble benzoxazole-based probe: Real-time monitoring PPi via situ reaction by two-photon cells imaging》. The information in the text is summarized as follows:

Pyrophosphate (PPi) played crucial roles in various fundamental physiol. processes. Herein, a two-photon absorption (TPA) “”On-Off-On”” type benzoxazole-based fluorescence probe BN (I) was designed and synthesized, which detected PPi through Cu2+ displacing method in situ system in aqueous medium. The on-off-on process of BN recognizing PPi was verified by mass spectra and theor. calculations, which was successfully applied in TPA cells imaging. In the part of experimental materials, we found many familiar compounds, such as 2-(Bromomethyl)pyridine hydrobromide(cas: 31106-82-8SDS of cas: 31106-82-8)

2-(Bromomethyl)pyridine hydrobromide(cas: 31106-82-8) belongs to pyridine. Pyridine’s structure is isoelectronic with that of benzene, but its properties are quite different. Pyridine is completely miscible with water, whereas benzene is only slightly soluble. Like all hydrocarbons, benzene is neutral (in the acid–base sense), but because of its nitrogen atom, pyridine is a weak base.SDS of cas: 31106-82-8

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Feng, Chao; Wuren, Qiqige; Zhang, Xinyu; Sun, Xiaoying; Na, Qin published their research in PLoS One in 2021. The article was titled 《Effects of dietary chromium picolinate supplementation on broiler growth performance: A meta-analysis》.Recommanded Product: Picolinic acid The article contains the following contents:

A meta-anal. was conducted to assess the effects of dietary chromium picolinate (CrPic) supplementation on broiler growth performance and to determine whether such effects are regulated by broiler strains, sex, environmental stress, or contextual factors including study area and years. Eligible studies were identified by searching the Web of Science, Springer, Elsevier, ScienceDirect, Taylor & Francis Online databases. Weighted average differences with corresponding 95% confidence intervals were computed with a random-effects model. We performed subgroup anal. stratified by study area, published years, broiler strains and sex, and environmental stress. Publication bias was assessed with Egger’s test method. A total of 15 studies eligible for inclusion. The results indicated that CrPic supplementation significantly improved broiler growth performance and subgroup anal. confirmed this conclusion. We also found that Ross 308 or male broilers might be more sensitive to CrPic supplementation and showed better growth performance. A model was used to obtain the amount of chromium addition under the optimal growth performance, which suggested that the maximum value of average daily gain (ADG) was reached when chromium addition was 1810μg/kg. The results of the sensitivity anal. showed low sensitivity and high stability of the meta-anal. CrPic supplementation had a pos. effect on the growth performance of broilers, and this meta-anal. provides a more accurate value of chromium addition, which may be beneficial for the practice of the broiler industry. After reading the article, we found that the author used Picolinic acid(cas: 98-98-6Recommanded Product: Picolinic acid)

Picolinic acid(cas: 98-98-6) is used in the preparation of 2-Aminodihydro[1,3]thiazines as BACE 2 inhibitors and their preparation and use in the treatment of diabetes.Recommanded Product: Picolinic acid

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

In 2022,Dhiman, Nisha; Pradhan, Debabrata; Mohanty, Paritosh published an article in Fuel. The title of the article was 《Heteroatom (N and P) enriched nanoporous carbon as an efficient electrocatalyst for hydrazine oxidation reaction》.Category: pyridine-derivatives The author mentioned the following in the article:

An efficient heteroatom enriched electrocatalyst (HPHMC900) with high sp. surface area (SABET) of 1634 m2 g-1 was synthesized by calcination of heteroatom enriched inorganic-organic hybrid material (HPHM) with low SABET of 16 m2 g-1. A 100-fold increase in the SABET was observed in this heteroatom enriched carbon, which was used to investigate the catalytic activity for hydrazine oxidation reaction. The HPHMC900 showed low onset potential of 0.25 V vs R. H. E. The maximum c.d. of 96 mA cm-2 was achieved at 0.9 mV. The HPHMC900 performance was further compared with the parent material HPHM as well as other synthesized electrocatalysts, HPHMC500 and HPHMC700. These materials have shown onset potential of 0.5 V (HPHM), 0.48 V (HPHMC500) and 0.45 V (HPHMC700) vs R. H. E. Also, the performance of HPHMC900 was compared with the best performing com. 20% Pt/C electrocatalyst. The specimen has a min. Tafel slope of 14 mV dec-1 and 100% stability for 12 h without any loss of activity. The high SABET with exposed heteroatoms/active sites has contributed for the superior activity of HPHMC900 compared to other electrocatalysts investigated in this research. In the experimental materials used by the author, we found 2,6-Diaminopyridine(cas: 141-86-6Category: pyridine-derivatives)

2,6-Diaminopyridine(cas: 141-86-6) belongs to pyridine. Pyridine and its simple derivatives are stable and relatively unreactive liquids, with strong penetrating odours that are unpleasant.Category: pyridine-derivatives

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Application of 2510-22-7In 2020 ,《Confinement Self-Assembly of Metal-Organic Cages within Mesoporous Carbon for One-Pot Sequential Reactions》 appeared in Chem. The author of the article were Zhu, Fan-Fan; Chen, Li-Jun; Chen, Shangjun; Wu, Gui-Yuan; Jiang, Wei-Ling; Shen, Ji-Chuang; Qin, Yi; Xu, Lin; Yang, Hai-Bo. The article conveys some information:

Herein, the first successful confinement self-assembly of (2,2,6,6-tetramethylpiperidin-1-yl)oxyl (TEMPO)-containing metal-organic cages within amino-functionalized mesoporous carbon to realize a new family of bifunctional heterogeneous catalyst (Cage@FDU-ED) for one-pot sequential oxidation/Knoevenagel condensation reactions of alcs. RCH2OH (R = 4-nitrophenyl, naphthalen-1-yl, cyclohexylmethyl, etc.) was presented. The orthogonal features of the isolated catalytically active sites within the obtained bifunctional catalyst lead to enhanced catalytic activities, selectivity, and recyclability with the overall transformation yielding up to 96% conversion. These results demonstrate that continuous chem. transformation with high efficiency is possible through careful design of catalytic sites in both metal-organic cages and mesoporous matrix isolatedly. This study paves a new way toward metal-organic cages as a promising platform for heterogeneous sequential reactions. In the experimental materials used by the author, we found 4-Ethynylpyridine(cas: 2510-22-7Application of 2510-22-7)

4-Ethynylpyridine(cas: 2510-22-7) belongs to pyridine. The basicity and metallophilic high donor number of these π-deficient systems has long favored them as ligands in metal catalysis. The last decade saw pyridine assume a stronger role as functional group for directed C–H oxidation/activation.Application of 2510-22-7

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem